Axis Labs Turmeric Curcumin with Bioperine (black pepper extract) is powerful and easy-to-use capsule supplement for the highly bioavailable benefits of curcumin. Clinical trials have found curcumin in turmeric to be a powerful antioxidant. It also has been found to help combat exercise-related pain & inflammation. Our bodies get subjected to oxidative stress through many mechanisms, including exercise, unhealthy body composition, our environment, and certain foods we eat. This type of stress can cause cell damage through the creation of free radicals, as well as speeding up the aging process. Turmeric's antioxidant properties help fight damage caused by oxidative stress. Studies have shown it to have many potential benefits, including improving blood flow and adding resilience to skin. Evidence has shown that supplementing curcumin with black pepper extract aids in its bioavailability and uptake.<\/p>\r\n
Turmeric Curcumin<\/p>\r\n
Getting the most out of your workout and pushing past plateaus often means encountering joint pain and inflammation. But don’t let that get in the way of your performance. Turmeric Curcumin effectively conquers the short-term pain from exercise-induced inflammation.<\/p>\r\n
Turmeric, an ancient herb often used in Indian cooking, contains the active ingredient curcumin, which studies have found to be helpful in decreasing inflammation.<\/p>\r\n
When consumed in the concentrated supplement form, Turmeric Curcumin’s effectiveness skyrockets. Our supplement also contains piperine, found in black pepper, which naturally enhances the absorption of curcumin, increasing the benefits.<\/p>\r\n
Each serving of our Turmeric Curcumin is formulated with a potent blend of 1,500 milligrams of turmeric root and 150 milligrams of turmeric extract for ultimate effectiveness. There’s no skimping on ingredients--we’ve even added a bonus 10mg BioPerine® black pepper extract for maximum absorption, making our supplement one of the most powerful blends on the market.<\/p>\r\n
Conquering persistent joint pain and inflammation has never been easier. Lose the pain, and get back to doing what you love.<\/p>\r\n
<\/p>\r\n
<\/p>","gtin13":"3401554182308","image":["https:\/\/siteimgs.com\/10017\/item\/ax-turmeric_1712929852-0.jpg"],"brand":"Axis Labs","url":"https:\/\/www.dpsnutrition.net\/i\/31869\/axis-labs-turmeric-curcumin-with-bioperine-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"13.99","url":"https:\/\/www.dpsnutrition.net\/i\/31869\/axis-labs-turmeric-curcumin-with-bioperine-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Axis Labs Turmeric Curcumin with Bioperine - 240 Cap (2 x 120 Cap) TWINPACK","sku":"AX2078","description":"
Axis Labs Turmeric Curcumin with Bioperine (black pepper extract) is powerful and easy-to-use capsule supplement for the highly bioavailable benefits of curcumin. Clinical trials have found curcumin in turmeric to be a powerful antioxidant. It also has been found to help combat exercise-related pain & inflammation. Our bodies get subjected to oxidative stress through many mechanisms, including exercise, unhealthy body composition, our environment, and certain foods we eat. This type of stress can cause cell damage through the creation of free radicals, as well as speeding up the aging process. Turmeric's antioxidant properties help fight damage caused by oxidative stress. Studies have shown it to have many potential benefits, including improving blood flow and adding resilience to skin. Evidence has shown that supplementing curcumin with black pepper extract aids in its bioavailability and uptake.<\/p>\r\n
Turmeric Curcumin<\/p>\r\n
Getting the most out of your workout and pushing past plateaus often means encountering joint pain and inflammation. But don’t let that get in the way of your performance. Turmeric Curcumin effectively conquers the short-term pain from exercise-induced inflammation.<\/p>\r\n
Turmeric, an ancient herb often used in Indian cooking, contains the active ingredient curcumin, which studies have found to be helpful in decreasing inflammation.<\/p>\r\n
When consumed in the concentrated supplement form, Turmeric Curcumin’s effectiveness skyrockets. Our supplement also contains piperine, found in black pepper, which naturally enhances the absorption of curcumin, increasing the benefits.<\/p>\r\n
Each serving of our Turmeric Curcumin is formulated with a potent blend of 1,500 milligrams of turmeric root and 150 milligrams of turmeric extract for ultimate effectiveness. There’s no skimping on ingredients--we’ve even added a bonus 10mg BioPerine® black pepper extract for maximum absorption, making our supplement one of the most powerful blends on the market.<\/p>\r\n
Conquering persistent joint pain and inflammation has never been easier. Lose the pain, and get back to doing what you love.<\/p>\r\n
<\/p>\r\n
<\/p>","gtin12":"665752697146","image":["https:\/\/siteimgs.com\/10017\/item\/ax-turmeric2_1712930060-0.jpg"],"brand":"Axis Labs","url":"https:\/\/www.dpsnutrition.net\/i\/32391\/axis-labs-turmeric-curcumin-with-bioperine-240-ca.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"23.99","url":"https:\/\/www.dpsnutrition.net\/i\/32391\/axis-labs-turmeric-curcumin-with-bioperine-240-ca.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Beverly International Joint Care - 90 Cap","sku":"BV007","description":" Joint pain shouldn't keep you from the physique you've worked so hard for and deserve to have! Now, you can train harder with greater comfort and increased joint integrity.<\/P>Joint Care<\/STRONG> - the most effective joint support formula ever developed supplies essential nutrition to:<\/SPAN> Beverly International's Joint Care is developed from the latest research on nutrients that can promote joint health. The result is a potent formula that combines three targeted ingredients scientifically proven to promote joint health with a precision array of synergistic vitamins, minerals and essential oils.<\/P> Supplement Facts<\/STRONG>: Serving(Size 3 Soft gels; Servings Per Container 30)<\/P> <\/P> *Daily Value not established<\/SMALL> <\/P> Directions<\/STRONG>: As a dietary supplement to maintain joint(integrity, take three capsules daily with meals. For existing joint discomfort: 3 - 4 capsules three times daily with meals.<\/P>","gtin12":"857254000818","image":["https:\/\/siteimgs.com\/10017\/item\/beverly-international-joi_56-0.jpg"],"brand":"Beverly International","url":"https:\/\/www.dpsnutrition.net\/i\/935\/beverly-joint-care-90-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"16.95","url":"https:\/\/www.dpsnutrition.net\/i\/935\/beverly-joint-care-90-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Chemix Joint - 90 Cap","sku":"CMX24","description":" Cissus Quadrangularis (std. for 2.5% ketosteroids):<\/strong> <\/span>Cissus quadrangularis has been used in traditional Eastern medicine for hundreds of years to treat many ailments such as obesity and even as a natural anabolic, but specifically what caught my attention was its use for accelerating bone fracture healing rates and pain relief properties. Cissus quadrangularis is loaded with antioxidants, ascorbic acid, calcium, carotene\/carotenoids, resveratrol and triterpinoids. Many studies show that the main healing bioactives in cissus quadrangularis were its ketosteroid content found in the stem: onocer -7-ene-3α, 21-β-diol and onocer -7-ene-3β, 21α-diol. <\/p>\r\n <\/p>\r\n Highlights\/Supports:<\/p>\r\n <\/p>\r\n <\/p>\r\n Joint Edge is an ultra-potent joint support supplement that contains 7 clinically researched branded ingredients including 6 branded ingredients, all in a convent 2 capsule per day formula.<\/p>\r\n Fitness enthusiasts and those living a healthy lifestyle have many health advantages going for them, but it can certainly take a toll on the joints and connective tissues.<\/p>\r\n Just as it’s important to use supplements to give you an edge for performance, results, and improved body-composition, it’s also important to use cutting edge high-end supplements to help protect your joints in order to help you be able to do the things that you love.<\/p>\r\n NEM® is an eggshell membrane ingredient with multiple published safety and effectiveness studies for joint health. Multiple human studies have shown fast and continued results for joint comfort and flexibility in as little as 7 to 10 days with a 500 mg. daily dose, the exact dose that is in Joint Edge.<\/p>\r\n NEM® has been shown in clinical studies to help reduce exercise induced pain and stiffness and to help protect against cartilage breakdown. It has also been shown to support healthy articular cartilage and surrounding synovial tissue by nourishing joints, as well as by supporting a balanced immune response to typical daily wear and tear.<\/p>\r\n Clinical studies have shown that NEM® can help to promote normal joint comfort and flexibility, usually within 7 to 10 days.<\/p>\r\n Tetrahydrocurcumin, sometimes abbreviated 4-HC, is a major metabolic constituent of curcumin that is commonly believed to be responsible for many of curcumin’s benefits.<\/p>\r\n Tetrahydrocurcumin has similar, if not stronger, properties to curcumin and it also helps overcome the poor oral bioavailability issues associated with curcumin.<\/p>\r\n Researchers have also shown that Tetrahydrocurcumin may reduce pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-\u237a, and prostaglandin E2.<\/p>\r\n CurcuPrime® Tetrahydrocurcumin is a branded ingredient from NNB Nutrition and is 100% naturally sourced and is extracted for purity and consistent potency from batch to batch.<\/p>\r\n TamaFlex® is the first plant-based blend of Tamarind Seed and Turmeric Root Extracts clinically shown to provide fast acting and long lasting joint relief. Clinical results in healthy subjects show that TamaFlex® is safe and effective in improving joint health, stiffness, and mobility in as little as 5 days.<\/p>\r\n As of the time of writing this, TamaFlex® has 3 published human studies involving over 300 participants.<\/p>\r\n Clinical studies in humans on TamaFlex® highlights\/supports:<\/p>\r\n TamaFlex® has been proven to be an effective new tool for optimal joint health & improved mobility.<\/p>\r\n Hyaluronic Acid is compound that is present in every tissue in the body, with the highest concentrations occurring in connective tissues such as skin and cartilage. It is an important constituent of joint fluid, where it serves as a lubricant and plays a role in resisting compressive forces.<\/p>\r\n Hyaluronic Acid is often taken as a supplement both to support joint health and lubrication as well as to promote retinal, skin, and hair health.<\/p>\r\n Boswellin® Super is obtained from the gum of Boswellia Serrata trees, commonly known as Frankincense, which has been used for its medicinal properties for hundreds of years.<\/p>\r\n In modern times, the most common uses for Boswellin supplements are for their anti-arthritic and anti-inflammatory benefits. Studies have shown that Boswellia Serrata has an anti-inflammatory action much like conventional non-steroidal anti-inflammatory drugs (NSAIDS) used for inflammatory conditions but without the side effects commonly associated with conventional NSAIDS. This makes Boswellia Serrata one of the most popular natural ingredients available for inflammation. However, not all Boswellia Serrata ingredients are equal as there are many different standardizations available and many lack the level of active ingredients to deliver on the potential of this awesome ingredient. That is why we picked Boswellin® Super for a very specific reason.<\/p>\r\n What makes Boswellin® Super so special?<\/strong><\/p>\r\n Boswellin® Super is a specific form of Boswellin that is standardized for 50% β-Boswellic acids of which 30% is Acetyl-11-keto- β -Boswellic Acid (AKBBA). There are four major pentacyclic triterpenic acids identified in Boswellin® Super: β-Boswellic Acid, Acetyl-β-Boswellic Acid, 11-keto- β -Boswellic Acid, and Acetyl-11-keto-β -Boswellic Acid (AKBBA). The significance of having such a high concentration of AKBBA is that AKBBA is reported to have the most potent anti-inflammatory action and is also reported to be active against a large number of inflammatory conditions including arthritis, chronic colitis, ulcerative colitis, Crohn’s disease, and bronchial asthma.<\/p>\r\n Note: Many dietary supplements on the market mislead consumers by quoting research on an ingredient but then not including the dosage of the ingredient that was used in the studies or hiding the mg. of the ingredient in a proprietary blend. Joint Edge contains a dosage of Boswellin® Super that has been used in studies and that is recommended by the patent holder for its joint support benefits.<\/p>\r\n AstraGin® is a natural patented ingredient complex comprised of highly fractionated Astragalus membranaceus and Panax notoginseng and created using pharmaceutical grade extraction and processing technology and designed to help enhance nutrient absorption.<\/p>\r\n In short, AstraGin® is designed to help make sure you properly absorb the other great ingredients in Joint Edge for maximum results.<\/p>\r\n Bioperine® is a standardized extract from the fruit of Piper nigrum L (Black Pepper) containing 95% piperine. Piperine has been shown to enhance the oral bioavailability of many supplements.<\/p>\r\n Bioperine® is included in Joint Edge because it has been shown in clinical studies to help increase the absorption of curcumin and boswellin, and also to help ensure that you properly absorb and get the maximum results out of all of the other awesome ingredients in the comprehensive Joint Edge formulation.<\/p>\r\n Joint Edge can be taken with M-Test, Anabolic Effect, Nattybolic, Super Swole, Cloma-Plex, LipoVantage, or a wide variety of other CEL products to help you reach your health & fitness goals.<\/p>\r\n <\/p>\r\n<\/div>\r\n","gtin12":"891192002503","image":["https:\/\/siteimgs.com\/10017\/item\/joint-2_1704811871-0.jpg"],"brand":"Competitive Edge Labs CEL","url":"https:\/\/www.dpsnutrition.net\/i\/33698\/competitive-edge-labs-joint-edge-2-x-60-cap-btls.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"69.98","url":"https:\/\/www.dpsnutrition.net\/i\/33698\/competitive-edge-labs-joint-edge-2-x-60-cap-btls.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Competitive Edge Labs Joint Edge - 60 Cap","sku":"CG036","description":" Highlights\/Supports:<\/p>\r\n <\/p>\r\n <\/p>\r\n Joint Edge is an ultra-potent joint support supplement that contains 7 clinically researched branded ingredients including 6 branded ingredients, all in a convent 2 capsule per day formula.<\/p>\r\n Fitness enthusiasts and those living a healthy lifestyle have many health advantages going for them, but it can certainly take a toll on the joints and connective tissues.<\/p>\r\n Just as it’s important to use supplements to give you an edge for performance, results, and improved body-composition, it’s also important to use cutting edge high-end supplements to help protect your joints in order to help you be able to do the things that you love.<\/p>\r\n NEM® is an eggshell membrane ingredient with multiple published safety and effectiveness studies for joint health. Multiple human studies have shown fast and continued results for joint comfort and flexibility in as little as 7 to 10 days with a 500 mg. daily dose, the exact dose that is in Joint Edge.<\/p>\r\n NEM® has been shown in clinical studies to help reduce exercise induced pain and stiffness and to help protect against cartilage breakdown. It has also been shown to support healthy articular cartilage and surrounding synovial tissue by nourishing joints, as well as by supporting a balanced immune response to typical daily wear and tear.<\/p>\r\n Clinical studies have shown that NEM® can help to promote normal joint comfort and flexibility, usually within 7 to 10 days.<\/p>\r\n Tetrahydrocurcumin, sometimes abbreviated 4-HC, is a major metabolic constituent of curcumin that is commonly believed to be responsible for many of curcumin’s benefits.<\/p>\r\n Tetrahydrocurcumin has similar, if not stronger, properties to curcumin and it also helps overcome the poor oral bioavailability issues associated with curcumin.<\/p>\r\n Researchers have also shown that Tetrahydrocurcumin may reduce pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-\u237a, and prostaglandin E2.<\/p>\r\n CurcuPrime® Tetrahydrocurcumin is a branded ingredient from NNB Nutrition and is 100% naturally sourced and is extracted for purity and consistent potency from batch to batch.<\/p>\r\n TamaFlex® is the first plant-based blend of Tamarind Seed and Turmeric Root Extracts clinically shown to provide fast acting and long lasting joint relief. Clinical results in healthy subjects show that TamaFlex® is safe and effective in improving joint health, stiffness, and mobility in as little as 5 days.<\/p>\r\n As of the time of writing this, TamaFlex® has 3 published human studies involving over 300 participants.<\/p>\r\n Clinical studies in humans on TamaFlex® highlights\/supports:<\/p>\r\n TamaFlex® has been proven to be an effective new tool for optimal joint health & improved mobility.<\/p>\r\n Hyaluronic Acid is compound that is present in every tissue in the body, with the highest concentrations occurring in connective tissues such as skin and cartilage. It is an important constituent of joint fluid, where it serves as a lubricant and plays a role in resisting compressive forces.<\/p>\r\n Hyaluronic Acid is often taken as a supplement both to support joint health and lubrication as well as to promote retinal, skin, and hair health.<\/p>\r\n Boswellin® Super is obtained from the gum of Boswellia Serrata trees, commonly known as Frankincense, which has been used for its medicinal properties for hundreds of years.<\/p>\r\n In modern times, the most common uses for Boswellin supplements are for their anti-arthritic and anti-inflammatory benefits. Studies have shown that Boswellia Serrata has an anti-inflammatory action much like conventional non-steroidal anti-inflammatory drugs (NSAIDS) used for inflammatory conditions but without the side effects commonly associated with conventional NSAIDS. This makes Boswellia Serrata one of the most popular natural ingredients available for inflammation. However, not all Boswellia Serrata ingredients are equal as there are many different standardizations available and many lack the level of active ingredients to deliver on the potential of this awesome ingredient. That is why we picked Boswellin® Super for a very specific reason.<\/p>\r\n What makes Boswellin® Super so special?<\/strong><\/p>\r\n Boswellin® Super is a specific form of Boswellin that is standardized for 50% β-Boswellic acids of which 30% is Acetyl-11-keto- β -Boswellic Acid (AKBBA). There are four major pentacyclic triterpenic acids identified in Boswellin® Super: β-Boswellic Acid, Acetyl-β-Boswellic Acid, 11-keto- β -Boswellic Acid, and Acetyl-11-keto-β -Boswellic Acid (AKBBA). The significance of having such a high concentration of AKBBA is that AKBBA is reported to have the most potent anti-inflammatory action and is also reported to be active against a large number of inflammatory conditions including arthritis, chronic colitis, ulcerative colitis, Crohn’s disease, and bronchial asthma.<\/p>\r\n Note: Many dietary supplements on the market mislead consumers by quoting research on an ingredient but then not including the dosage of the ingredient that was used in the studies or hiding the mg. of the ingredient in a proprietary blend. Joint Edge contains a dosage of Boswellin® Super that has been used in studies and that is recommended by the patent holder for its joint support benefits.<\/p>\r\n AstraGin® is a natural patented ingredient complex comprised of highly fractionated Astragalus membranaceus and Panax notoginseng and created using pharmaceutical grade extraction and processing technology and designed to help enhance nutrient absorption.<\/p>\r\n In short, AstraGin® is designed to help make sure you properly absorb the other great ingredients in Joint Edge for maximum results.<\/p>\r\n Bioperine® is a standardized extract from the fruit of Piper nigrum L (Black Pepper) containing 95% piperine. Piperine has been shown to enhance the oral bioavailability of many supplements.<\/p>\r\n Bioperine® is included in Joint Edge because it has been shown in clinical studies to help increase the absorption of curcumin and boswellin, and also to help ensure that you properly absorb and get the maximum results out of all of the other awesome ingredients in the comprehensive Joint Edge formulation.<\/p>\r\n Joint Edge can be taken with M-Test, Anabolic Effect, Nattybolic, Super Swole, Cloma-Plex, LipoVantage, or a wide variety of other CEL products to help you reach your health & fitness goals.<\/p>\r\n <\/p>\r\n<\/div>\r\n","gtin12":"891192002503","image":["https:\/\/siteimgs.com\/10017\/item\/joint-edge-rendering-fron_1704811599-0.jpg"],"brand":"Competitive Edge Labs CEL","url":"https:\/\/www.dpsnutrition.net\/i\/33690\/competitive-edge-labs-joint-edge-60-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"36.99","url":"https:\/\/www.dpsnutrition.net\/i\/33690\/competitive-edge-labs-joint-edge-60-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Controlled Labs Orange TRIad + Greens Orange - 30 Servings","sku":"CD226","description":" ORANGE TRIad + Greens™: Multivitamin and Greens Formula<\/strong><\/p>\r\n The JOINT and FLEX complexes help lubricate joints and cartilage as well as increase the resiliency of connective tissue, while the DIGESTION and IMMUNE complex includes natural anti-inflammatories, digestive aids, and nutrient partitioning agents to take your performance to the next level. The GREENS complexes are geared towards real athletes. The “Cardiovascular Complex” is full of vegetables that have been shown to increase endurance and cardiovascular health in exercising humans. The enzyme, probiotic and anti-oxidant blends will help the body absorb and utilize the highest level of nutrients from your diet and supplementation for maximum results. Not only is Orange TRIad + Greens™ healthful, but it tastes amazing too without the use of artificial colors or sweeteners.<\/p>\r\n Establish a STRONG foundation for maximum gains in the GYM and in LIFE with Orange TRIad + Greens™!<\/p>\r\n <\/p>\r\n <\/p>\r\n <\/p>\r\n <\/p>","gtin12":"895328001125","image":["https:\/\/siteimgs.com\/10017\/item\/triad-orange_1672341695-0.jpg"],"brand":"Controlled Labs","url":"https:\/\/www.dpsnutrition.net\/i\/32735\/controlled-labs-orange-triad-greens-orange-30.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"34.99","url":"https:\/\/www.dpsnutrition.net\/i\/32735\/controlled-labs-orange-triad-greens-orange-30.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Core Nutritionals FLEX - 240 Tablets","sku":"CU136","description":" Core FLEX<\/span><\/p> Comprehensive Joint Formula Core FLEX is an ultra-potent combination of 11 clinical ingredients, crafted to ensure the maintenance of strong and healthy tendons and ligaments. Best of all, its all-in-one blend combines the efficacy of single ingredient products, with the synergy of an entire joint product lineup.<\/span><\/p> 8 tablets per serving. We’ve all been there. You have a bit of cashed saved up, and a hard choice to make: do you buy the new, shiny toy, or fix that sort of irritating sound your engine is making? I mean, sure, maybe the engine breaks down, but that’s only a possibility – you will most certainly enjoy that new toy! Am I right?<\/span><\/p> Wrong. Just like a vehicle, our bodies are exposed to the constant wear and tear of demanding daily use, a fact especially true of athletes. As we put more and more weight on the bar, run faster and further, and push our bodies to the limit, our joints, tendons, and ligaments require regular maintenance to keep them in optimal health. We need to fix that sort of irritating sound our engine is making, in other words.<\/span><\/p> Core FLEX provides a superior way to do so. Core FLEX is an ultra-potent combination of 11 ingredients, verified by clinical research and included in clinical serving sizes, crafted to ensure the maintenance of strong and healthy tendons and ligaments. Best of all, Core FLEX’s all-in-one blend combines the efficacy of single ingredient products, with the synergy of an entire joint product lineup.<\/span><\/p> Physiological Properties and Effects:<\/span><\/p> Chondroitin and Glucosamine:<\/span><\/p> Chondroitin and Glucosamine are substances found naturally in the body, and in particular, in and around the cartilage and other connective tissues.Glucosamine falls within a class of compounds known as amino sugar, and is a precursor to a molecule called glycosaminoglycan. The human body produces and distributes both of these compounds as critical components in the production of cartilage and other connective tissue . It also aids in lubricating and providing thickness to the cartilage around damaged joints. Chondroitin sulfate is a type of glycosaminoglycan and complex carbohydrate rich in sulfur, and is a relative of glucosamine. Chondroitin is one of the major constituents of cartilage, not only providing structure and stability, but also water for the purpose of lubrication.<\/span><\/p> Methylsulfonylmethane (MSM):<\/span><\/p> MSM is a naturally occurring, organosulfur molecule that can be synthesized both naturally and synthetically from DSMO. While the majority of MSM present in the human body is ingested – either deliberately or accidentally – the compound does have a natural presence in certain tissues and fluids in the body, including cerebrospinal fluid. MSM appears to assist healthy biochemical communication between cells that may assist joint flexibility and mobility. While still emerging, certain data on MSM appears to show a promising role for the compound in the maintenance of proper joint function. Several studies demonstrate joint function increases on the WOMAC scale ranging from 20-35%, while animal data suggests equally significant results. Though not every trial on MSM reveals such significant results, a meta-analysis conducted in 2011 found that the overwhelming majority of clinical MSM trials featured function improvements over placebo.<\/span><\/p> Cissus quadrangularis:<\/span><\/p> Cissus quadrangularis (CQ) is a plant with a long history of use in traditional and folk medicinal systems, including thousands of years of documented use in the Siddha and Ayurvedic traditions. While the specific use of Cissus in these systems varied, the most common traditional preparations related to analgesia, general tonics, and bone fracture healing. More recent research has developed physiological explanations for CQ’s traditional efficacy, including the reduction of pro-inflammatory cytokines, modulation of the glucocorticoid system (in animal trials), and the proliferation of osteoblast (bone-forming cell) DNA.<\/span><\/p> Specific to bone formation, there is strong data to suggest that CQ increases the accumulation of compounds known as mucopolysaccharides – long chain sugar molecules that precede mineralization in the process of bone formation. Think of these compounds sort of like the wet newspaper before it becomes paper mache. As stated, separate research also suggests that extracts of CQ stimulated osteoblastogenesis, the process of forming bone cells.<\/span><\/p> Black cherry extract:<\/span><\/p> Black cherry extract contains a number of beneficial compounds, including high levels of anthocyanin – an extremely potent anti-inflammatory compound which some animal evidence has shown plays a role in the maintenance of articular jointsIt is rich in antioxidants and catechins, chlorogenic acid, and flavonal glycoside, and has been used to support healthy uric acid levels typically associated with complete joint health.<\/span><\/p> Turmeric (95% curcumin):<\/span><\/p> Tumeric is a root endemic to certain regions of Southeast Asia and India, and has been a staple in the Siddha traditional medicinal system for thousands of years. Tumeric is noted in Siddha texts for various uses, including as an ancient equivalent of an anti-microbial agent.<\/span><\/p> More recently, numerous studies seem to suggest that its primary bioactive constituent, curcumin, powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses.<\/span><\/p> Though Tumeric contains approximately 5% curcumin by weight, we have used a highly standardized extract of 95% - recognizing that the wealth of research on curcumin demands that it be included in clinical serving sizes.<\/span><\/p> Boswellia (37.5% boswellic acids):<\/span><\/p> Boswellia is a tree resin extract that is a traditional part of Indian medicine. In modern clinical trials the active agenct, boswellic acid, has been found to inhibit the production of pro-inflammatory leukotrienes. Similarly to curcumin, boswellic acids have demonstrated a significant attenuation of NF-kB production in various animal and in vitro assays.<\/span><\/p> Bromelain (2400GDU\/g):<\/span><\/p> Bromelain is a collection of protein-digesting enzymes found in pineapple juice and in the stem of pineapple plants. It has been shown to have a myriad of health benefits including speed of recovery, antioxidant properties, and assisting cardiovascular and circulatory health. The mechanism of the anti-inflammatory activity is not very well understood, but like curcumin and boswellia it appears to support inflammatory marker balance. Numerous studies have shown bromelain’s ability to assist and speed recovery time following various health related procedures.<\/span><\/p> Vitamin C:<\/span><\/p> Vitamin C is not only a powerful antioxidant, but also supports a healthy immune system, protects cells from oxidized particles and free radicals, and assists other physiological functions. A major study by the University of California at Berkeley found that supplementing with 500 milligrams of Vitamin C (the daily serving contained in Core FLEX) led to a 24% reduction in levels of C-reactive protein, a consistent marker of inflammation. In conjunction with the other ingredients, it is important component of strong joints and overall health.<\/span><\/p> Vitamin D3:<\/span><\/p> Vitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, , immune and cardiovascular health, muscle protein synthesis, and weight management. Although some foods contain Vitamin D3, the human body generates most of its Vitamin D3 needs from the skin through regular exposure to sunlight. Healthy and normal Vitamin D3 levels are essential to maintaining numerous bodily processes, including regulating the pro-inflammatory responses of joints and connective tissues to damage.<\/span><\/p> Piperine (95%):<\/span><\/p> Inflammation, aches and pains are an inescapable reality for anyone seriously engaged in bodybuilding or fitness. After all, building muscle literally involves tearing your own muscle fibers apart, forcing the body to respond with inflammation and pain. Yet the body doesn't always provide a proportional response and occasionally allows inflammation and pain to kick into overdrive. For some, the best approach to this is to be patient, let the body heal on its own time while dealing with the nagging injuries, aches and pain. For others, well, let's just say that some of us are unwilling to let anything stand in the way of our fitness goals. For those noble few, it's about pushing through the soreness as one more challenge to overcome, lest they miss out on further gains or fall behind the rest of the pack.<\/p>\r\n It goes without saying that rest is essential for growth and repair, however, you can’t stop living your life - especially if your goal is to CRUSH IT on the daily basis. To help ensure you lead that lifestyle day in and day out, you need to provide your body with certain nutrients capable of providing an additional layer of protection against the rigors of pain and inflammation.<\/p>\r\n This is exactly what Core SOOTHE offers - an additional layer of relief and protection. Formulated with clinically researched ingredients that have proven time and time again to support tissue repair, like those seen from Cissus quadragularis, antioxidant support, from Phyto-C™; and inflammatory suppression, from Boswellia, Curcumin and Ginger Extract. The synergistic nature of these ingredients is unmatched by any product that we have ever seen, as far as suppressing harmful free radical advancement, and aiding in strengthening vital supporting structures is concerned. That's what led us to developing this blend, and that's why you need Core SOOTHE.<\/p>\r\n Cissus quadrangularis (CQ) is a plant with a long history of use in traditional and folk medicinal systems, including thousands of years of documented use in the Siddha and Ayurvedic traditions. While the specific use of Cissus in these systems varied, the most common traditional preparations related to analgesia, general tonics, and bone fracture healing. More recent research has developed physiological explanations for CQ’s traditional efficacy, including the reduction of pro-inflammatory cytokines, modulation of the glucocorticoid system (in animal trials), and the proliferation of osteoblast (bone-forming cell) DNA.<\/p>\r\n Specific to bone formation, there is strong data to suggest that CQ increases the accumulation of compounds known as mucopolysaccharides – long chain sugar molecules that precede mineralization in the process of bone formation. Think of these compounds sort of like the wet newspaper before it becomes paper mache. As stated, separate research also suggests that extracts of CQ stimulated osteoblastogenesis, the process of forming bone cells.<\/p>\r\n In relation to its positive effects toward certain inflammatory markers, which are key factors that contribute to osteoarthritis and bone damage, CQ (along with Withania somnifera) showed promise as a remedy in some animal studies. When the model was placed under an overabundance of oxidative stress and toxicity and cell death was high, the administration of CQ inhibited the gene expression of cytokines and matrix metalloproteinases, which are known to cause bone damage and cartilage aggravation. Additionally, CQ and the combination of W. somnifera, was shown to enhance cartilage tissue formation and positively impact osteoarthritis markers. These results provide positive validation to Cissus quadrangularis effectiveness in suppressing damaging inflammatory markers and being a potential therapeutic remedy for rheumatic and other joint disorders and conditions.<\/p>\r\n There have also been several human studies performed to validate CQ effectiveness. One study conducted on exercise trained men with joint pain showed that the administration of CQ was able to suppress inflammatory responses as well as improve markers of osteoarthritis.<\/p>\r\n Boswellia Extract (Boswellia serrate) (Gum resin) (65% boswellic acids)<\/p>\r\n Boswellia is a tree resin extract that is a traditional part of Indian medicine. In modern clinical trials the active agent, boswellic acid, and the gum resin it contains possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids, and four pentacyclic triterpenic acids, which are responsible for the inhibition of pro-inflammatory enzymes. Out of the four pentracyclic triterpenic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. In human study’s, Boswellia has shown effectiveness in the managements of osteoarthritis and other joint related conditions. Several studies proved that Boswellia extract was effective at reducing pain and stiffness, increasing pain threshold, as well as improving overall joint function when compared to placebo. Similarly, to curcumin, boswellic acids have demonstrated a significant attenuation of NF-kB production in various animal and in vitro assays. Curcumin and Boswellia in combination as a treatment method for osteoarthritis has also showed beneficial results. One clinical human trial showed that this combination was able to increase the efficacy of osteoarthritis treatments due to its synergistic effects on oxidative stress reduction.<\/p>\r\n Curcumin (Curcuma longa) (95% Curcuminoids)<\/p>\r\n Curcumin, the primary polyphenol found in turmeric (a root known for its spice), has been the basis of many clinical studies for its therapeutic properties and ability to modulate multiple cells signaling pathways in certain inflammatory diseases known to humans.<\/p>\r\n Numerous studies seem to suggest that curcumin powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses. Conditions where curcumin can provide benefit is in the management of certain metabolic diseases, anxiety, arthritis, and exercise induced inflammation that contributes to muscle damage and soreness. Most of curcumins benefits stem from its inflammation suppressing qualities along with potent antioxidant activity.<\/p>\r\n Studies have shown that low quality curcumin has low bioavailability and benefit, which is why we have used a high standard curcumin with 95% curcuminoids and have also included the trademarked Bioperine® in this formula. These two ingredients have a largely cohesive impact that can drastically improve the health benefit. Studies have shown that Bioperine® significantly improved curcumin uptake by upwards of 2000% at doses that proved to be clinically beneficial.<\/p>\r\n Gingever® (Zingiber officinale) (root) (Ginger Extract 10%)<\/p>\r\n Ginger is a flowering plant from the Zingiberaceae family with a lengthy history of culinary and medicinal use largely attributed to the therapeutic value of its antioxidant and anti-inflammatory properties.<\/p>\r\n Modern clinical trials have attributed the therapeutic benefits of ginger to its unique phytochemical substances (the biologically active organic compounds created by the plant) and its overall chemical composition. Ginger derives its anti-inflammatory effects from the non-volatile components found within the plant, specifically gingerols, shogaols, paradols, and zingerone. Studies have shown that these non-volatile compounds have anti-inflammatory properties with the potential to provide therapeutic relief for degenerative disorders such as arthritis and joint disorders, digestive distress, cardiovascular disorders, and other ailments. Likewise, the potent antioxidative properties of the non-volatile compounds found within ginger help alleviate age-related oxidative stress markers and have been shown to protect against ethanol-induced hepatotoxicity through suppression of oxidative stresses.<\/p>\r\n Research has also shown that ginger serves an effective inflammatory mediator able to decrease swelling, pain, and other inflammatory markers, especially with through the actions of [6]-gingerol. Here, data suggests that the anti-inflammatory action of ginger occurs through the inhibition of macrophage and neutrophil activation, as well as negatively affecting monocyte and leukocyte migration. According to the results of a study conducted on rats, there was a marked decrease in inflammatory cells infiltration and swelling, as well as an increase in antioxidant capacity, after the administration of ginger and its bioactive components. Core Nutritionals has chosen to use the patented Gingever® as its source of Ginger for Life Line’s Soothe as it is a highly potent extract consisting of 10% of these beneficial gingerols<\/p>\r\n Phyto-C™ (Acerola extract, blueberry, strawberry, maqui berry, acai, tart cherry, kale, broccoli, green tea extract, green coffee bean extract, turmeric extract)<\/p>\r\n Phyto-C™ is a trademarked complex blend of antioxidant rich superfoods clinically formulated to deliver a host of immune system supporting benefits. Combining ingredients such as blueberries, acai, tart cherry, kale, broccoli, green tea, turmeric, and others, you are ensuring that your body is being provided clinically proven and laboratory tested superfoods that will protect against free radicals and other cell destroying compounds. This neutralization of free radicals can protect vital cells, prevent illnesses, and reduce overall inflammation. Inflammation can disrupt normal cell processes thus leading to cell damage and disease. Inflammatory cells produce mediators such as cytokines, arachidonic acid, and other factors, which can precipitate a cascading negative reaction within the body. If this inflammation is not addressed in a reasonable manner, potentially permanent cell damage can occur. The key is to reach a point of equilibrium between free radical formation and antioxidant defense mechanisms. As a potent antioxidant source, Phyto-C™ can provide beneficial antioxidants for the body that can aid in this equilibrium and work to boost the immune system and overall health of the human body<\/p>\r\n Bioperine® (Black Pepper Extract) (Piper nigrum) (fruit) (std. to 95% Piperine)<\/p>\r\n BioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of neighboring nutrients. When suppressing inflammation, overall efficiency and rapid delivery to the targeted cells have a multiplicative impact that enhances the overall therapeutic value of the administered compounds and nutrients. BioPerine® helps to increases the bioavailability and absorption of the aforementioned ingredients within Core Soothe.<\/p>\r\n BioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients. Several studies looking at BioPerine® and its impact on nutrient absorption have been conducted with promising results. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks onBioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.<\/p>\r\n With promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core Life Line’s inflammation suppressing product, Core Soothe.<\/p>\r\n <\/p>\r\n <\/p>","gtin12":"658580070588","image":["https:\/\/siteimgs.com\/10017\/item\/soothe1-650x_1636213274-0.jpg"],"brand":"Core Nutritionals","url":"https:\/\/www.dpsnutrition.net\/i\/31446\/core-nutritionals-soothe-90-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"54.99","url":"https:\/\/www.dpsnutrition.net\/i\/31446\/core-nutritionals-soothe-90-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Gaspari Ageless Anti-Inflammatory - 90 Cap","sku":"GP383","description":" GASPARI AGELESS Helps reduce brain fog <\/p>\r\n <\/p>\r\n *These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease<\/p>","gtin12":"051497201340","image":["https:\/\/siteimgs.com\/10017\/item\/agelessbottles-straight-a_1663098465-0.jpg"],"brand":"Gaspari Nutrition","url":"https:\/\/www.dpsnutrition.net\/i\/32362\/gaspari-ageless-anti-inflammatory-90-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"23.99","url":"https:\/\/www.dpsnutrition.net\/i\/32362\/gaspari-ageless-anti-inflammatory-90-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Gaspari Ageless Pain Relief Cream - 4 oz","sku":"GP386","description":" ATHLETIC PERFORMANCE FORMULA†<\/p> Gaspari Proven Joint is a focused, two-stage, sports joint support formula that contains a proven array of vitamins and minerals to support long term joint and bone health, as well as anti-inflammatory factors for immediate joint support. With an anti-inflammatory blend that includes bromelain, turmeric, white willow bark, and ginger, Gaspari Proven Joint is formulated to help reduce acute joint inflammation and stiffness due to overuse, minor injury and intense training. The second stage supports long term joint and bone care and protection with proven components such as glucosamine, chondroitin, calcium, manganese, boron and more. Intense training, particularly over the long term, can be very stressful on your joints. Gaspari Proven Joint is formulated to help provide immediate relief from the pain and limited mobility caused by inflammation, so you can train. Proven Joint also can help prevent joint injuries down the road with proven long-term support for joints and bone.<\/p> Statements on this website have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure, or prevent any disease.<\/p> <\/p><\/div><\/span>","gtin12":"646511027626","image":["https:\/\/siteimgs.com\/10017\/item\/gaspari-proven-joint-30_2152-0.jpg"],"brand":"Gaspari Nutrition","url":"https:\/\/www.dpsnutrition.net\/i\/29180\/gaspari-proven-joint-30-servings.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"27.99","url":"https:\/\/www.dpsnutrition.net\/i\/29180\/gaspari-proven-joint-30-servings.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"GAT Joint Support - 60 Tablets","sku":"GA106","description":"Joint Care<\/H2>
Glucosamine \/ MSM \/ Chondroitin Complex
The Perfect Solution for Aching Joints<\/H3><\/HEADER>Vitamin C (as Ascorbic Acid)
Vitamin E (as d-Alpha-Tocopherol
Manganese (as Manganese Aspartate)
Boron (as Boron Citrate)
Evening Primrose Oil
MSM (Methylsulfonylmethane)
Chondroitin Sulfate 2KCL<\/TD>Amount Per Serving <\/STRONG>
60 mg
10 I.U.
1 mg
1.5 mg
250 mg
750 mg
200 mg
1,000mg<\/TD>%Daily Value<\/STRONG>
100%
33%
50%
*
*
*
*
*
<\/TD><\/TR><\/TBODY><\/TABLE>
HOW DOES CHEMIX JOINT WORK?<\/strong><\/h2>\r\n
However, newer research shows that it seems to be more of a cumulative effect from influencing early regeneration and faster uptake of minerals in bone cells. The ketosteroids still play a major part in healing, but it’s more like the “entourage effect.” A 2010 study showed a week faster healing period vs the placebo. This was attributed to the faster stimulation of fibroblasts(synthesizes collagen), chondroblasts(helps grow collagen) and bone cells. One study showed that collagen synthesis increased by 86%! I truly believe this is an extremely undervalued ingredient when it comes to joint and collagen supplementation. We used a whopping 750mg per serving!<\/p>\r\n
Pamlmitoylethanolamide:<\/strong> <\/span>Palmitoylethanolamide (PEA, a mouthful) is your body’s main naturally produced anti-inflammatory agent. PEA is one of many fatty acids that have the enthanolamide functional group attached to it. Its origins go back to an obscure study in the 1940s showing that PEA derived from purified egg yolks exhibited anti-inflammatory and anti-allergic properties. In 1964, it was first isolated in mammalian tissues and has over 350 studies since. PEA binds to the nuclear receptor, where it then elicits a variety of biological activities including fighting inflammation and pain. PEA has been extensively studied, including a 1970 study showing similar pain relief and joint improvement to aspirin. As far as managing pain and inflammation, PEA seems to have multiple mechanisms of action. One such mechanism is the inhibition pro-inflammatory compounds like TNF-alpha and histamine, as well as reducing cyclooxygenase-2(COX-2), which is how most over-the-counter NSAIDs(ibuprofen) work. In 1993, the Nobel Prize was given out to Lvei-Montalcini, who worked for almost 40 years trying to explain how PEA and inflammation were connected, by showing its positive role on NGF(nerve growth factor) and how mast cells(immune cells) could be modulated by PEA. In 1990, it was shown that PEA’s mechanism could also be explained by its high affinity for peroxisome proliferator-activated receptor alpha(PPAR-a).
In 2017, a meta-analysis involving 10 studies and 786 participants showed that subjects given PEA had significantly reduced pain levels. Daily doses ranged from 300-1200mg, with an average of 600mg.<\/p>\r\n
Tamarind Seed Extract (10:1 Tamarindus indica):<\/strong> <\/span>Tamarind seed extract is a more recently studied compound for helping with joint pain, movement and overall antiarthritic properties. Originally thought to solely work based on its high antioxidant content, newer research has shown that tamarind seed extract can lower levels of pro-inflammatory cytokines like interleukin-1B(IL-1B), TNF-a, IL-6, and COX-2. After running an High performance liquid chromatography(HPLC) on the seed extract, the main components were found to be Threo-Isocitric acid, Galactosyl glycerol, Procyanidin B2, Areccatannin B1, Catechin, Rutin and Embelin. In a 2015 study, arthritic rats given tamarind seed extract showed significantly improvement. Appendage swelling was dramatically down(comparable to rats given ibuprofen). Not only that, but metalloproteinases(MMPs) which are responsible for degradation of cartilage activity was significantly lowered in arthritic rats receiving tamarind seed extract, similar to pre-arthritic state. Oxidative stress levels were significantly lowered, not to mention glutathione(GSH), the body’s main antioxidant levels decline during levels of high oxidative stress. Tamarind seed extract was able to reverse the decline of GSH by 91%! This wonder seed is exactly what you need for lowering inflammation by multiple pathways.
CurcuWIN (Curcuma longa L. 20%):<\/strong> <\/span>Curcumin is one of the main curcuminoids found in turmeric. There have been hundreds of studies on curcumin and its positive effects on inflammation and joint improvement, not to mention antioxidant properties, heart health and overall health. Curcumin interacts with multiple inflammation pathways, specifically negating the action of IkB Kinase and nuclear factor-kappa B(NF-kB). It has the ability to help with both acute and chronic inflammation, via constantly inhibiting pro-inflammatory cytokines and downregulation of inflammatory enzymes like COX-2 and leukotrienes. It’s polyphenolic molecular shape allows it to be an excellent antioxidant and free radical scavenger. Curcumin has actually been shown to increase endogenous levels of antioxidants. Sounds amazing right? The downfall to curcumin and curcuminoids is their poor bioavailability. CurcuWIN solves this problem using a proprietary delivery system called UltraSOL, which has been shown to increase the bioavailability of curcumin by 46X! Essentially, UltraSOL converts oil-soluble compounds(like curcumin) into more water dispersible compounds by using a polymer known as N-vinylpyrrolidone(NVP). NVP helps encase and disperse the curcuminoids to help them be more hydrophilic(water soluble). This allows your body to utilize much more of the active curcuminoids.<\/p>\r\n
Curcucmin<\/strong>
AprèsFlex Boswellia serrata gum resin std. for 20% AKBA:<\/strong> <\/span>The gum resin from Boswellia serrata has been used for centuries because its rich in terpene and triterpenic acids, known as boswellic acids that have anti-inflammatory enzyme properties. The most potent of them being 11-keto--boswellic acid and 3-O-acetly-11-keto--boswellic acid(AKBA). This compound specifically has a very strong ability to inhibit the enzyme 5-lipoxygenase(5-LOX), which is very proinflammatory. 5-LOX generates leukotrienes which can promote free radical damage and the migration of these compounds to inflamed areas. Another key benefit for boswellic acids in general is that they do not disrupt the synthesis of glycosaminoglycans like hyaluronic acid, chondroitin, heparin, keratin, ect, which can help with wound repair. Most over-the-counter NSAIDs do disrupt this and can actually hurt you in the long run and impair damage control. AprèsFlex is standardized to 20% pure AKBA to get maximum results from the strongest component in the gum resin. Studies show that taking 1 serving of AprèsFlex begins to work in as little as 5 days! No more taking big chalky pills for 30days to help.<\/p>\r\n
UC-II Standardized Chicken Cartilage(Providing 10mg Total Cartilage, Including Undenatured Type II Collagen):<\/strong> <\/span>Undenatured type-II collagen or UC-II has been extensively studies in humans to show improvements in almost all metrics used in testing(pain, flareups, joint mobility, ect). The key term here is UNDENATURED. This means the protein of the collagen is exactly has it is inside the body and includes all the necessary components like proteoglycans, glucosamine hyaluronic acid, and chondroitin sulfate. These make up the very basics of cartiliage and synovial fluid- the viscous, non-Newtonian fluid between your joints to reduce friction. Many human studies have all come to the same conclusion: supplementing with UC-II can significantly lower levels of inflammatory cytokines that have been linked to severity and incidence of signs of arthritic tendencies. Specifically, UC-II has been shown to lower TNF-alpha, IL-1Beta, and IL-6, all of which are prone to causing inflammation. But, helping increase\/preserve synovial fluid, that is something that can help your joints fight discomfort and keep them lubricated for either lifting weight in the gym or doing cardiovascular exercise.
Tetrahydrocurcumin:<\/strong> <\/span>We have already spoken about curcumin and its many benefits, we all as pitfalls. One major pitfall we spoke about was oral bioavailability, which I rectified using an highly-bioavailable form known as CurcuWin. However, we have yet to speak about one of the main metabolites of curcumin known as tetrahydrocurucmin. The “tetrahydro” means that there is a reduction in 2 double bonds on the molecule where 4 hydrogens are added in place. This dramatically improves the oral bioavailability of curcumin, especially in the intestinal tract. But, that’s not all. Tetrahydrocurcumin has been shown to have much higher antioxidant properties. Studies have shown it can lower cell damage via lipid peroxidation(damage from free radicals\/ROS). Tetrahydrocurcumin can also help to lower blood sugar levels and LDL(good cholesterol). In fact, in 2015, a meta-analysis was published comparing curcumin to tetrahydrocurcumin that included over 50 studies, both in vitro and in vivo. But perhaps more importantly, has been shown to hit different molecular targets than regular curcumin, which may have added benefits of its own. For example, vasoprotection seems to be a property of tetrahydrocurcumin vs curcumin, which as you guessed may be linked to helping control blood pressure.<\/p>\r\n
References:<\/strong>
1. Stohs, Sidney J., and Sidhartha D. Ray. \"A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts.\" Phytotherapy research 27.8 (2013): 1107-1114.
2. Jadhav, Atul N., et al. \"Ketosteroid standardized Cissus quadrangularis L. extract and its anabolic activity: Time to look beyond ketosteroid?.\" Pharmacognosy magazine 12.Suppl 2 (2016): S213.
3. Ghouse, Mr Mohammed Shakir. \"A pharmacognostical review on cissus quadrangularis linn.\" International Journal of Research 28 (2015).
4. Oben, Julius E., et al. \"The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress.\" Lipids in Health and Disease 6.1 (2007): 1-8.
5. Solorzano, Carlos, et al. \"Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.\" Proceedings of the National Academy of Sciences 106.49 (2009): 20966-20971.
6. Artukoglu, Bekir Berker, et al. \"Efficacy of palmitoylethanolamide for pain: a meta-analysis.\" Pain Physician 20.5 (2017): 353-362.
7. M Keppel Hesselink, Jan. \"New targets in pain, non-neuronal cells, and the role of palmitoylethanolamide.\" The Open Pain Journal 5.1 (2012).
8. Gabrielsson, Linda, Sofia Mattsson, and Christopher J. Fowler. \"Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy.\" British journal of clinical pharmacology 82.4 (2016): 932-942.
9. Sundaram, Mahalingam S., et al. \"Tamarind seed (Tamarindus indica) extract ameliorates adjuvant-induced arthritis via regulating the mediators of cartilage\/bone degeneration, inflammation and oxidative stress.\" Scientific reports 5.1 (2015): 1-13.
10. Oliver, Jonathan Michael, et al. \"Novel form of curcumin attenuates performance decrements following muscle damaging exercise.\" The FASEB Journal 31 (2017): lb415-lb415.
11. Juturu, Vijaya, et al. \"Antioxidant Properties and Safety Evaluation of Curcumin (CurcuWINTM).\" The FASEB Journal 29 (2015): 924-5.
12. Jäger, Ralf, et al. \"Curcumin reduces muscle damage and soreness following muscle‐damaging exercise.\" The Faseb Journal 31 (2017): lb766-lb766.
13. Kanwar, Jagat R., et al. \"Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling.\" Drug design, development and therapy 9 (2015): 2927.
14. Lugo, James P., et al. \"Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers.\" Journal of the International Society of Sports Nutrition 10.1 (2013): 1-12.
15. Crowley, David C., et al. \"Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.\" International journal of medical sciences 6.6 (2009): 312.
16. Bagchi, D., et al. \"Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration.\" International journal of clinical pharmacology research 22.3-4 (2002): 101-110.
17. Aggarwal, Bharat B et al; “Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.”; Molecules (Basel, Switzerland); vol. 20,1; 185-205; 24 Dec. 2014;
18. Sandur, Santosh K., et al. \"Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.\" Carcinogenesis 28.8 (2007): 1765-1773.
19. Sugiyama, Yosunori, Shunro Kawakishi, and Toshihiko Osawa. \"Involvement of the β-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin.\" Biochemical pharmacology 52.4 (1996): 519-525.
20. Zhang, Zhen-Biao, et al. \"Curcumin’s metabolites, tetrahydrocurcumin and octahydrocurcumin, possess superior anti-inflammatory effects in vivo through suppression of TAK1-NF-κB pathway.\" Frontiers in pharmacology 9 (2018): 1181.<\/p>","gtin12":"860003220467","image":["https:\/\/siteimgs.com\/10017\/item\/57f3826c-cf8d-4f40-984b-e_1620664215-0.jpg"],"brand":"Chemix","url":"https:\/\/www.dpsnutrition.net\/i\/30908\/chemix-joint-90-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"33.92","url":"https:\/\/www.dpsnutrition.net\/i\/30908\/chemix-joint-90-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Competitive Edge Labs Joint Edge - 2 x 60 Cap Btls TWINPACK","sku":"CG2036","description":"Joint Edge<\/h1> \r\n
\r\n
Fast Acting Proven Joint Support<\/span><\/h1>\r\n
Feel the Difference in As Little as 5 Days<\/span><\/h1>\r\n
\r\n
Joint Edge Highlights\/Supports:<\/span><\/strong><\/h3>\r\n
\r\n
Don’t let joint pain slow you down – give yourself an edge – Joint Edge.<\/span><\/h3>\r\n
\r\nLet’s Examine the Ingredients:<\/span><\/strong><\/h3>\r\n
\r\nNEM® Eggshell Membrane – 500 mg<\/span><\/strong><\/h4>\r\n
\r\nCurcuPrime® – 250 mg.<\/span><\/strong><\/h4>\r\n
\r\nTamaFlex® – 250 mg.<\/span><\/strong><\/h4>\r\n
\r\n
\r\nHyaluronic Acid – 200 mg.<\/span><\/strong><\/h4>\r\n
\r\nBoswellin® Super – 100 mg.<\/span><\/strong><\/h4>\r\n
\r\nAstraGin® – 25 mg.<\/span><\/strong><\/h4>\r\n
\r\nBioperine® – 10 mg.<\/span><\/strong><\/h4>\r\n
\r\nStacking & Synergy:<\/span><\/strong><\/h3>\r\n
Joint Edge<\/h1>\r\n
\r\n
Fast Acting Proven Joint Support<\/span><\/h1>\r\n
Feel the Difference in As Little as 5 Days<\/span><\/h1>\r\n
\r\n
Joint Edge Highlights\/Supports:<\/span><\/strong><\/h3>\r\n
\r\n
Don’t let joint pain slow you down – give yourself an edge – Joint Edge.<\/span><\/h3>\r\n
\r\nLet’s Examine the Ingredients:<\/span><\/strong><\/h3>\r\n
\r\nNEM® Eggshell Membrane – 500 mg<\/span><\/strong><\/h4>\r\n
\r\nCurcuPrime® – 250 mg.<\/span><\/strong><\/h4>\r\n
\r\nTamaFlex® – 250 mg.<\/span><\/strong><\/h4>\r\n
\r\n
\r\nHyaluronic Acid – 200 mg.<\/span><\/strong><\/h4>\r\n
\r\nBoswellin® Super – 100 mg.<\/span><\/strong><\/h4>\r\n
\r\nAstraGin® – 25 mg.<\/span><\/strong><\/h4>\r\n
\r\nBioperine® – 10 mg.<\/span><\/strong><\/h4>\r\n
\r\nStacking & Synergy:<\/span><\/strong><\/h3>\r\n
Serious athletes are unique in that they intentionally subject their bodies to incredible amounts of stress with training and cardio. Over time, the immune system can be compromised, and muscles, tendons, and ligaments take longer to recover which means you can’t train them as often as you would like. A deficiency can mean that you aren’t getting optimal results from your training. Designed for the serious athlete, ORANGE TRIad + Greens™, the Best Bodybuilding Dietary Supplement combines the most proven and effective vitamins, minerals, and nutrients for supporting optimal DIGESTION, IMMUNE system, and JOINT HEALTH into one “twice daily” dietary supplement.<\/p>\r\n
Don’t leave your recovery to chance.<\/span><\/p>
30 servings per container.
Soft tissue support.<\/span><\/p>COMPREHENSIVE INFLAMMATION MEDIATOR'<\/h3>\r\n
Cissus Quadrangularis Extract (stem) (5% ketosterones)<\/p>\r\n
ANTI-INFLAMMATORY
Gaspari's proven array of natural compounds, such as turmeric, white willow bark, ginger root, and cat's claw extracts, you can really help soothe aching joints, think more clearly, as well as help lower C-reactive protein. We also include type II collagen and bromelain, which are among those supplements used to treat osteoarthritis.<\/p>\r\n
Soothes aching joints
Proven anti-inflammatories
Think more clearly
Support for osteoarthritis<\/p>\r\n\r\n
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Reapply up to four times daily as needed for pain.<\/em>
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As a dietary supplement, take 1 serving (3 tablets) up to twice a day with food.<\/div>Serving Size: 2 Tablets<\/th><\/tr> Servings Per Container: 30<\/th><\/tr> Amount Per Serving<\/th> Serving<\/th> % DV<\/th><\/tr> Chondroitin Sulfate<\/td>