Since then the more \"popular\" research has caught up and they are actively looking for ways to thicken myelin (the insulation around nerves. Loss of insulation causes electrical \"diffusion\" and weaker signals), as well as seeing how we can strengthen the signals themselves.
Well, they are coming up behind me on a path I already blazed, so let's revisit and focus on the role of nerve signals in muscle growth, mind\/muscle connection, sympathetic\/parasympathetic functions, and reaction speed.<\/p>\r\n
Brain Derived Neurotrophic Factor (BDNF)- A neurotrophin active in the brain and periphery, aiding in growth, survival and differentiation of neurons and synapses, and a key player in long term memory.<\/p>\r\n Neurotrophins- An umbrella of NGFs including BDNF, NT-3 and NT-4\/5<\/p>\r\n Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve.<\/p>\r\n Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system.<\/p>\r\n Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon.<\/p>\r\n Protein Kinase C (PKC)- A family of enzymes that control the function of other proteins through the act of phosphorylation.<\/p>\r\n Schwann Cells- Cells that provide raw materials for myelination<\/p>\r\n Ingredients and Function<\/strong><\/p>\r\n 4-Methylcatechol (4-MC)<\/strong> What does it do? Thermosensitivity is basically the sensory perception of temperature changes, which is often damaged in nerve dysfunction. 4-MC has been shown to promote reinnervation and normalization of thermosensitivity in neuropathy (1).<\/p>\r\n Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. Several studies have found a huge benefit and reversal of these symptoms with 4-MC administration. One study showed in increase in NGF of 140% over controls (2), multiple other studies have confirmed the de novo NGF synthesis capability of 4-MC while also demonstrating its ability to significantly increase myelination and nerve blood flow (3–6).<\/p>\r\n Several studies have given animal models a nerve toxin known as acrylamide monomer (ACR), and examined the potential protective effect of 4-MC. They found similar results as the previously mentioned studies, 4-MC was able to increase MNCV, NGF, and myelination, and researchers noted that it can \"accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically\" (4,7).<\/p>\r\n Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF (8,9).<\/p>\r\n Salidroside <\/strong> What does it do? Methylcobalamin<\/strong> What does it do? - Correct nerve damage done from oxidative damage and impaired neural signaling of PKC (15). Palmitoylethanolamide (PEA)<\/strong><\/p>\r\n Where does it come from? What does it do? Chitooligosaccharide (COS)<\/strong><\/p>\r\n Where does it come from? What does it do? Other studies have shown COS to promote nerve regeneration and differentiation, functional recovery, and nerve cell adhesion (27,28).<\/p>\r\n Achyranthes bidentata polypeptides (ABP)<\/strong><\/p>\r\n Where does it come from? Also of interest, ABP has central as well as peripheral nerve preservation and restoration effects, shown in the Journal of Neuroscience Research to counteract the effect of overstimulated NMDA receptors in the brain by reversing intracellular ROS and mitochondrial damage to the hippocampus (32).<\/p>\r\n Ginsenoside Rg1 (GRg1)<\/strong><\/p>\r\n Where does it come from? What does it do? Pyridoxal-5-Phosphate (P5P)<\/strong><\/p>\r\n Where does it come from? What does it do? Dipsaci radix (water extract)<\/strong><\/p>\r\n Where does it come from? What does it do? Radix Hedysari<\/strong><\/p>\r\n Where does it come from? What does it do? Lion's Mane mushroom extract 4:1 (Hericium erinaceus)<\/strong><\/p>\r\n Where does it come from? What does it do? Earthworm extract (Dilong)<\/strong><\/p>\r\n Where does it come from? What does it do? Conclusion Nerve Restore...fire away.<\/p>\r\n <\/p>\r\n <\/p>\r\n 1. Hsiao T-H, Fu Y-S, Ho W-Y, Chen T-H, Hsieh Y-L. Promotion of thermal analgesia and neuropeptidergic skin reinnervation by 4-methylcatechol in resiniferatoxin-induced neuropathy. Kaohsiung J. Med. Sci. [Internet]. 2013 Aug [cited 2013 Dec 4];29(8):405–11. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23906230 Nothing is more frustrating than an impinged or injured nerve. Signal reduction triggers a whole landslide of negative effects: Weakness, pain, atrophy. After time, these side effects seem like they will last forever - and sometimes do...until now. Enter Nerve Restore. Nerve Restore is a nerve signal amplifier. In people with impingement or nerve injuries it will help alleiviate discomfort, weakness, and muscular atrophy. The enhanced nerve amplitude and velocity, in healthy people as well, should result in increased strength and quicker reflexes\/coordination.<\/p>\r\n Back in 2013 I researched, formulated, and released a product way ahead of its time. Nerve Restore deals with the function, dysfunction, and optimization of Nerve Signals. Since then the more \"popular\" research has caught up and they are actively looking for ways to thicken myelin (the insulation around nerves. Loss of insulation causes electrical \"diffusion\" and weaker signals), as well as seeing how we can strengthen the signals themselves. Brain Derived Neurotrophic Factor (BDNF)- A neurotrophin active in the brain and periphery, aiding in growth, survival and differentiation of neurons and synapses, and a key player in long term memory.<\/p>\r\n Neurotrophins- An umbrella of NGFs including BDNF, NT-3 and NT-4\/5<\/p>\r\n Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve.<\/p>\r\n Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system.<\/p>\r\n Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon.<\/p>\r\n Protein Kinase C (PKC)- A family of enzymes that control the function of other proteins through the act of phosphorylation.<\/p>\r\n Schwann Cells- Cells that provide raw materials for myelination<\/p>\r\n Ingredients and Function<\/strong><\/p>\r\n 4-Methylcatechol (4-MC)<\/strong> What does it do? Thermosensitivity is basically the sensory perception of temperature changes, which is often damaged in nerve dysfunction. 4-MC has been shown to promote reinnervation and normalization of thermosensitivity in neuropathy (1).<\/p>\r\n Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. Several studies have found a huge benefit and reversal of these symptoms with 4-MC administration. One study showed in increase in NGF of 140% over controls (2), multiple other studies have confirmed the de novo NGF synthesis capability of 4-MC while also demonstrating its ability to significantly increase myelination and nerve blood flow (3–6).<\/p>\r\n Several studies have given animal models a nerve toxin known as acrylamide monomer (ACR), and examined the potential protective effect of 4-MC. They found similar results as the previously mentioned studies, 4-MC was able to increase MNCV, NGF, and myelination, and researchers noted that it can \"accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically\" (4,7).<\/p>\r\n Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF (8,9).<\/p>\r\n Salidroside <\/strong> What does it do? Methylcobalamin<\/strong> What does it do? - Correct nerve damage done from oxidative damage and impaired neural signaling of PKC (15). Palmitoylethanolamide (PEA)<\/strong><\/p>\r\n Where does it come from? What does it do? Chitooligosaccharide (COS)<\/strong><\/p>\r\n Where does it come from? What does it do? Other studies have shown COS to promote nerve regeneration and differentiation, functional recovery, and nerve cell adhesion (27,28).<\/p>\r\n Achyranthes bidentata polypeptides (ABP)<\/strong><\/p>\r\n Where does it come from? Also of interest, ABP has central as well as peripheral nerve preservation and restoration effects, shown in the Journal of Neuroscience Research to counteract the effect of overstimulated NMDA receptors in the brain by reversing intracellular ROS and mitochondrial damage to the hippocampus (32).<\/p>\r\n Ginsenoside Rg1 (GRg1)<\/strong><\/p>\r\n Where does it come from? What does it do? Pyridoxal-5-Phosphate (P5P)<\/strong><\/p>\r\n Where does it come from? What does it do? Dipsaci radix (water extract)<\/strong><\/p>\r\n Where does it come from? What does it do? Radix Hedysari<\/strong><\/p>\r\n Where does it come from? What does it do? Lion's Mane mushroom extract 4:1 (Hericium erinaceus)<\/strong><\/p>\r\n Where does it come from? What does it do? Earthworm extract (Dilong)<\/strong><\/p>\r\n Where does it come from? What does it do? Conclusion Nerve Restore...fire away.<\/p>\r\n <\/p>\r\n <\/p>\r\n 1. Hsiao T-H, Fu Y-S, Ho W-Y, Chen T-H, Hsieh Y-L. Promotion of thermal analgesia and neuropeptidergic skin reinnervation by 4-methylcatechol in resiniferatoxin-induced neuropathy. Kaohsiung J. Med. Sci. [Internet]. 2013 Aug [cited 2013 Dec 4];29(8):405–11. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23906230 RECOVERY & ENDURANCE BCAA SUPERFUEL<\/span><\/p> An amino acid product that tastes great, and brings something new to the market to help you reach your goals. Utilizing only the best ingredients without added synthetic colors, we created a superior recovery and endurance BCAA superfuel.<\/span><\/p> RECOVERY & ENDURANCE BCAA SUPERFUEL When you push yourself to the limit, your muscles pay the price. AMINOLAST™ with AMMOJECT™ technology is the only product that delivers a high dose of BCAAs, powerful Leucine-enriched peptide amino acids, anti-cramping electrolytes, and AMMOJECT, to rid your muscles of waste products that can cause fatigue. Even better, you only need a single serving per training session instead of \"megadoses” which do nothing more than burn a hole in your wallet. From the very first dose . . . you’ll notice the difference.<\/span><\/p> Immediate. AMINOLAST was formulated to work from the first dose by providing accurately dosed amino acids and electrolytes to your hard-working muscles. Decreased muscle soreness and better hydration levels can be expected from AMINOLAST when used as directed.<\/span><\/p> Q: Can I stack AMINOLAST with other products?<\/span><\/p> Yes. AMINOLAST can complement virtually any product whether you are using a thermogenic such as DETONATE XT or a performance product such as GLYCOFUSE. You can mix it in with your vanilla MYOFUSION ADVANCED protein powders for a fruit flavored, high protein shake. You can also stack Aminolast with other Gaspari Nutrition products such as SUPERPUMP or ANAVITE POWDER, to help you achieve your fitness goals.<\/span><\/p> Q: How do I take AMINOLAST?<\/span><\/p> As always, read the label carefully and follow the directions. As a dietary supplement mix 1 level scoop (14 g) of AMINOLAST with 8-10 oz. of water. AMINOLAST can be consumed before training, between meals, while training, and post workout to boost your amino acid intake.<\/span><\/p> Q: Is the AMINOLAST formula based on real human clinical trials?<\/span><\/p> Yes. AMINOLAST took over 24 months to develop. You demanded a more cost-effective amino acid solution so we decided to finally launch this revolutionary breakthrough at a price that is just right for any budget. There is no doubt that BCAA’s are king when it comes to accelerating recovery and electrolytes are essential to performance as well. There are numerous human trials to support the doses used in AMINOLAST.<\/span><\/p> *These statements have not been evaluated by the Food and Drug Administration This product is not intended to diagnose, treat, cure or prevent any disease.<\/span><\/p>","gtin12":"646511008403","image":["https:\/\/siteimgs.com\/10017\/item\/aminolast-watermelonblast_1624032079-0.jpg"],"brand":"Gaspari Nutrition","url":"https:\/\/www.dpsnutrition.net\/i\/31055\/gaspari-aminolast-berry-cherry-30-servings.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"22.98","url":"https:\/\/www.dpsnutrition.net\/i\/31055\/gaspari-aminolast-berry-cherry-30-servings.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Gaspari Nutrition SizeOn Max Performance Grape - 24 Serving","sku":"GP126","description":" Gaspari Nutrition SizeOn<\/span><\/p> Max Performance Benefits:<\/span><\/p> Contains the never before seen LOLA, our cutting-edge, amino acid salt L-Ornithine-L-Aspartate that cuts down on ammonia in the body!*<\/span><\/p> Gaspari Nutrition takes sports nutrition to the highest level with SizeOn – The Ultimate Hybrid Intra-Workout Amino Acid & Creatine Formula. The original SizeOn became known as the King of Creatines and by utilizing the latest advances in clinical research, this award-winning formula is better than ever! SizeOn contains high-quality whey protein hydrolysate, which is clinically proven to absorb even faster than free-form amino acids. SizeOn also boasts a premium creatine formula, high-performance carbohydrates, a high dose of L-Leucine (4 g), and many more anabolic-promoting ingredients. SizeOn contains the revolutionary ingredient L-Ornithine-L-aspartate (LOLA), which has been shown to reduce ammonia and improve psychometric function. L-Ornithine-L-aspartate is able to reduce high blood ammonia levels induced either by ammonium chloride or protein ingestion. Furthermore, LOLA decreased protein breakdown and stimulated protein synthesis in muscle.*<\/span><\/p> Gaspari Nutrition has formulated a product that will literally put Size On your body. With its top of the line research driven formula, SizeOn stimulates lean muscle synthesis due to the potent combination of creatine and the high-quality whey hydrolysates.<\/span><\/p> The whey hydrolysate that includes over 50% di and tripeptides as well as a large array of pro-anabolic promoting components such as a high dose of L-LEUCINE (5 grams) to allow for unequaled support in athletic performance, skeletal muscle recuperation, explosiveness and most particularly, nearly instant increases in muscle size. FREQUENTLY ASKED QUESTIONS: The new version of SizeOn contains high amounts of whey protein hydrolysate, leucine, along with more carbohydrates and the insulinotropic powerhouse pterostilbene. All in all, it is a much more advanced product based on cutting-edge research.*<\/span><\/p> Q: Can SizeOn only be used by bodybuilders or can athletes looking to build muscle mass and enhance their recovery use it as well?<\/span><\/p> SizeOn can be utilized by anyone wishing to speed their recovery, build muscle mass, and increase performance whether in the gym or for athletic competition.*<\/span><\/p> *These statements have not been evaluated by the Food and Drug Administration This product is not intended to diagnose, treat, cure or prevent any disease.<\/span><\/p><\/span>","gtin12":"646511005242","image":["https:\/\/siteimgs.com\/10017\/item\/sizeon-2021-grapecooler-6_1628190750-0.jpg"],"brand":"Gaspari Nutrition","url":"https:\/\/www.dpsnutrition.net\/i\/2355\/gaspari-sizeon-max-performance-grape-24-serving.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"42.99","url":"https:\/\/www.dpsnutrition.net\/i\/2355\/gaspari-sizeon-max-performance-grape-24-serving.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"GCode Nutrition JUICE: Intra\/Post Recovery Macho Mango - 30 Servings","sku":"GCN60","description":" “YOU’RE ONLY AS GOOD AS YOU CAN RECOVER.”<\/p>\r\n Your ability to push yourself in the gym and beyond, create new muscle, minimize soreness, gain strength, and to bounce back and do it again. This fundamental cycle determines your progress. So we set out to optimize this process.<\/p>\r\n The result? JUICE. A mouth-wateringly refreshing supplemental solution created to be consumed immediately after (or even during) the most intense training. From strength to endurance to martial arts to conventional athletics, there is no serious athlete who won’t benefit from the postworkout recovery powerhouse that is GCode Nutrition JUICE.<\/p>\r\n Each scoop is all jacked up with creatine monohydrate, essential amino acids (EAA\/BCAA), patented Carb10 carbohydrate fuel, natural fruit extracts, antioxidants, electrolytes and more. Designed to replenish depleted glycogen and flood your muscles with critical nutrients at the precise moment they’re at their most damaged and broken down, triggering the anabolic process, ensuring maximal recovery and new growth.<\/p>\r\n Take your recovery… Your training… Your performance… Your strength… Your physique… To the next level. The advantage over the competition you desperately desire is only a scoop or two away. With JUICE Intra\/Post Recovery, only from GCode Nutrition. Get on it.<\/p>\r\n ENHANCE STRENGTH & STAMINA <\/p>\r\n GLAXON FLIGHT REGENERATE - BUILD & RECOVER<\/p>\r\n Flight is an ultimate recovery formula that utilizes peptide and stem cell-based technologies. By incorporating freeze-dried organ extracts and colostrum, Flight helps facilitate muscle repair by providing bioactive peptides from these tissues. Additionally, we provide a blend of different types of algae, and a new extract of Sea Buckthorn that has been clinically shown to increase stem cell output.<\/p>\r\n Maybe your testosterone levels are at their peak. You’ve got every other aspect covered in your anabolic arsenal, but you’re missing that one extra “X-factor” that can really take your gains to a new level. Flight works on several pathways that facilitate muscle growth by delivering various peptides found in placental tissues that generate new tissue.<\/p>\r\n HOW DOES THIS WORK?<\/p>\r\n Flight works by delivering bioactive peptides to the small intestine via DRcaps®. Targeted delivery of peptides is of utmost importance - mostly because if they were in any other kind of capsule - they would get completely destroyed in the stomach. With DRcaps® delivery, Flight is able to deploy these peptides straight to the small intestine where they can be absorbed. Additionally, we use a combination of marine algae to increase the activity of stem cells that are secreted into circulation to further promote the growth and repair of muscle tissue.<\/p>\r\n HOW MUCH SHOULD I TAKE?<\/p>\r\n Flight is best taken 3 capsules per day either post-workout to work in conjunction with a post workout protein, or 3 capsules before bed to promote growth and regeneration while sleeping.<\/p>\r\n <\/p>\r\n Post JYM BCAAs+ Recovery Matrix Post-Workout Features FULL RECOVERY, FULL RESULTS* Formulated For Complete Recovery* NO PROPRIETARY BLENDS Or CONCENTRATED FORMULAS PRE & POST FOR GREAT GAINS RECOVERY* Break It Down, Build It Back Faster* NO BS, JUST SCIENCE <\/p>\r\n <\/p>\r\n *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.<\/p>","gtin12":"817047021413","image":["https:\/\/siteimgs.com\/10017\/item\/postjym-active-30sv_1668101506-0.jpg"],"brand":"JYM Supplement Science","url":"https:\/\/www.dpsnutrition.net\/i\/32583\/jym-post-jym-bcaas-recovery-matrix-blue-arctic-30.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"44.99","url":"https:\/\/www.dpsnutrition.net\/i\/32583\/jym-post-jym-bcaas-recovery-matrix-blue-arctic-30.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"JYM Post Jym BCAAs + Recovery Matrix Lemon Lime - 30 Servings","sku":"JYM06","description":" Post JYM BCAAs+ Recovery Matrix Post-Workout Features FULL RECOVERY, FULL RESULTS* Formulated For Complete Recovery* NO PROPRIETARY BLENDS Or CONCENTRATED FORMULAS PRE & POST FOR GREAT GAINS RECOVERY* Break It Down, Build It Back Faster* NO BS, JUST SCIENCE <\/p>\r\n <\/p>\r\n *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.<\/p>","gtin12":"817047020270","image":["https:\/\/siteimgs.com\/10017\/item\/postjym-active-30sv_1668101433-0.jpg"],"brand":"JYM Supplement Science","url":"https:\/\/www.dpsnutrition.net\/i\/32584\/jym-post-jym-bcaas-recovery-matrix-lemon-lime-30.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"44.99","url":"https:\/\/www.dpsnutrition.net\/i\/32584\/jym-post-jym-bcaas-recovery-matrix-lemon-lime-30.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"JYM Post Jym BCAAs + Recovery Matrix Mandarin Orange - 30 Servings","sku":"JYM07","description":" Post JYM BCAAs+ Recovery Matrix Post-Workout Features FULL RECOVERY, FULL RESULTS* Formulated For Complete Recovery* NO PROPRIETARY BLENDS Or CONCENTRATED FORMULAS PRE & POST FOR GREAT GAINS RECOVERY* Break It Down, Build It Back Faster* NO BS, JUST SCIENCE <\/p>\r\n <\/p>\r\n *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.<\/p>","gtin12":"817047020072","image":["https:\/\/siteimgs.com\/10017\/item\/postjym-active-30sv_1668101450-0.jpg"],"brand":"JYM Supplement Science","url":"https:\/\/www.dpsnutrition.net\/i\/32585\/jym-post-jym-bcaas-recovery-matrix-mandarin-orang.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"44.99","url":"https:\/\/www.dpsnutrition.net\/i\/32585\/jym-post-jym-bcaas-recovery-matrix-mandarin-orang.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"JYM Post Jym BCAAs + Recovery Matrix Rainbow Sherbet - 30 Servings","sku":"JYM08","gtin12":"817047020171","image":["https:\/\/siteimgs.com\/10017\/item\/postjym-active-30sv_1668101469-0.jpg"],"brand":"JYM Supplement Science","url":"https:\/\/www.dpsnutrition.net\/i\/32586\/jym-post-jym-bcaas-recovery-matrix-rainbow-sherbe.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"44.99","url":"https:\/\/www.dpsnutrition.net\/i\/32586\/jym-post-jym-bcaas-recovery-matrix-rainbow-sherbe.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Kaged Muscle Re-Kaged Iced Lemon Cake - 20 Servings","sku":"KM329","description":" <\/p>\r\n POST-WORKOUT SUPPLEMENT BREAKTHROUGH Although BCAAs are important pre- and intra-workout for muscle energy, post workout is when you need a full spectrum amino acid profile for maximum growth and recovery.<\/span><\/p>\r\n Each serving contains 28 g of non-GMO whey protein isolate, 7 g of glutamine and glutamic acid (4 g naturally occurring from WPI + 3 g of free-form L-glutamine), patented BetaPower (betaine), patented Creatine HCl and the super enzyme ProHydrolase, which breaks down (hydrolyzes) whey protein into smaller particle sizes for enhanced absorption. The difference between hydrolyzed whey and RE-KAGED’s whey protein isolate plus ProHydrolase is that with RE-KAGED the protein is hydrolyzed at the point of consumption versus being chemically treated during the manufacturing process into very small peptides and then dried.<\/span><\/p>\r\n As a matter of fact, if you don’t drink RE-KAGED within 15-20 minutes of mixing you will start to taste the flavor get bitter like hydrolyzed whey protein. This is due to the ability of ProHydrolase to rapidly hydrolyze (break down) the whey protein isolate.<\/span><\/p>\r\n <\/span><\/p>\r\n WHY KAGED MUSCLE RE-KAGED?<\/strong> NOTHING COMES CLOSE<\/span><\/p>\r\n FORMULATING THE UNTHINKABLE 3 PROBLEMS WITH MOST POST-WORKOUT PRODUCTS LET'S TALK ABOUT LOGIC FOR A SECOND Artificial flavors Untested generic ingredients Fast-acting carbs, however, can be effective for triathletes, long-distance runners, cyclists, and events that last more than 3 hours with continuous activity.<\/span><\/p>\r\n WHY RE-KAGED VS. OTHER POST-WORKOUT PRODUCTS KEY INGREDIENTS IN RE-KAGED Micropure Whey Protein Isolate (WPI) is the first of a new generation of dairy ingredients which combine premium nutrition, enhanced functionality, and ultra-clear solubility.<\/span><\/p>\r\n A soluble, easy-to-digest whey protein that is quickly put to work in the body to start rebuilding and repairing lean muscle tissue after training.<\/span><\/p>\r\n
Key Terms to Know <\/strong>
Nerve Growth Factor (NGF)- A signaling protein crucial for growth, upkeep, and survival of nerves.<\/p>\r\n
Where does it come from?
Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.<\/p>\r\n
4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.<\/p>\r\n
Where does it come from?
Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties.<\/p>\r\n
Several studies have demonstrated salidroside's neuroprotective ability (10–13). Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function (14).<\/p>\r\n
Where does it come from?
Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function.<\/p>\r\n
Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:<\/p>\r\n
- Stimulate proteosynthesis in Schwann cells to facilitate neural regeneration (16,17).
- Enhance recovery of myelination, muscle action potentials and motor end plate innervation (17).
- Improve nerve regeneration and inhibit degeneration from neuronal damage such as crushed sciatic nerves (18–20).<\/p>\r\n
PEA (not to be confused with the other PEA, phenylethylamine) is a fatty acid amide (formed when a fatty acid combines with an amine). Most of its functions in the body involve the regulation of pain and inflammation.<\/p>\r\n
By working through numerous angles to reduce pain and improve nerve signaling, PEA holds large promise. Quite a bit of published data has shown that PEA favorably modulates PPARa, PPARg, CB(1),TRPV1, TNFa, and the mast cells of the immune system to reduce pain, inflammation and discomfort in nerve injuries such as neuropathy, carpal tunnel syndrome and sciatic nerve crushes (21–25).<\/p>\r\n
COS is a combination of two different types of glucosamine derived from crustacean shells.<\/p>\r\n
Several studies have shown COS to have a positive outcome on improvement of nerve dysfunction. One recent study looking at peripheral nerve crush injuries published in the Journal of Microsurgery found that COS significantly improved muscle action potentials, number of regenerated nerve fibers and thickness of myelin sheaths, and even an increase in muscle size of the tibialis posterior (one of the calf muscles) (26).<\/p>\r\n
ABP is a polypeptide derived from the achyranthes plant found in China, Japan, Nepal, and India, known for its anti-inflammatory properties.<\/p>\r\n
What does it do?
ABP has been shown repeatedly in research to enhance nerve regeneration and function in sciatic and common peroneal nerve injuries (29–31).<\/p>\r\n
The Rg1 group of ginsenoside is a bioactive compound found primarily in the Chinese\/Korean Ginesing plant, selected for its specific nerve regeneration properties. The ginsenosides are considered the active compounds in ginesing.<\/p>\r\n
Recent research has shown GRg1 can successfully promote nerve regeneration after nerve injuries (33–35). After an oxidative insult from administered hydrogen peroxide, GRg1 increases SOD, CAT and GSH with a concurrent reduction in MDA (34). It has also been shown to increase expression of NGF and BDNF through the PKA pathway in Schwann cells (35).<\/p>\r\n
P5P is the active form of Vitamin B6 in the body, and is a crucial factor for a laundry list of functions in the body.<\/p>\r\n
The most recent research has shown that P5P improves clinical symptoms in carpal tunnel syndrome (a nerve related disorder), which means it likely has farther reaching effects on nerve dysfunction throughout the body, (36).<\/p>\r\n
In Traditional Chinese Medicine (TCM), Dipsaci radix has been used to treat dysfunctions of the liver, kidney, tendons and bones. It comes from the plant Dipsacus asperoides.<\/p>\r\n
After nerve injury, muscle atrophy tends to onset fairly quickly. Dipsaci helps improve muscle size and glycogen storage in tissues surrounding a nerve injury (37).<\/p>\r\n
Also from TCM, Radix Hedysari is an herbal preperation used for nerve regeneration.<\/p>\r\n
Radix Hedysari has been shown to be effective at improving peripheral nerve regeneration, MNCV, nerve fiber and axon diameter, number of nerve fibers, and amplification ratio (38–40).<\/p>\r\n
Lion's Mane Mushroom extract is an edible mushroom found in North America, Europe and Asia.<\/p>\r\n
Lion's Mane is considered a neurotrophic agent, as it has been shown in multiple studies to induce NGF synthesis (41,42). Two studies have also shown oral administration of Lion's Mane to regenerate injured peroneal nerves in rats (43,44). Finally, it has been shown to directly regulate myelin genesis in vitro (45).<\/p>\r\n
Exactly what it sounds like, this compound widely used in TCM is an extract from earthworms.<\/p>\r\n
Two recent studies have demonstrated Earthworm Extract's ability to increase nerve cell regeneration through Schwann cell activity, stimulating myelination (46,47).<\/p>\r\n
Oftentimes, nerve injuries take a massive toll on us mentally and physically. We watch, helpless, as our hard-earned size and strength gains falter and fade away. After many months of research, Evolutionary Muse offers a potential solution. While your physician or therapist should guide you along the road to recovery, and your trainer can advise you how to best prevent future injuries, EvoMuse has brought to you a product that will jumpstart the processes of recovery and help restore, and optimize, nerve function.<\/p>\r\n\r\n Servings Size: 2 Capsules<\/span><\/strong><\/td>\r\n <\/span><\/td>\r\n<\/tr>\r\n \r\n <\/span><\/td>\r\n <\/span><\/td>\r\n<\/tr>\r\n \r\n 4-Methylcatechol<\/span><\/td>\r\n 15mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Rhodiola Rosea (11% Salidroside)<\/span><\/td>\r\n 250mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Methylcobalamin<\/span><\/td>\r\n 2mg<\/span><\/td>\r\n<\/tr>\r\n \r\n PalmitoylEthanolamide<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Chitooligosaccharides<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Achyranthes Bidentata Extract (60% polypeptides\/Polysaccharides)<\/span><\/td>\r\n 125mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Panax Ginseng Berry Extract 10:1<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Pyridoxal-5-Phosphate<\/span><\/td>\r\n 5mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Dipsaci Radix Water Extract 20:1<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Radix Heydsari 20:1<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Lions Mane Mushroom Extract 4:1<\/span><\/td>\r\n 400mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Lumbricus Extract 10:1<\/span><\/td>\r\n 250mg<\/span><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n
2. Hanaoka Y, Ohi T, Furukawa S, Furukawa Y, Hayashi K, Matsukura S. Effect of 4-methylcatechol on sciatic nerve growth factor level and motor nerve conduction velocity in experimental diabetic neuropathic process in rats. Exp. Neurol. [Internet]. 1992 Mar [cited 2013 Dec 28];115(2):292–6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1735473
3. Hanaoka Y, Ohi T, Furukawa S, Furukawa Y, Hayashi K, Matsukura S. The therapeutic effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental diabetic neuropathy in rats. J. Neurol. Sci. [Internet]. 1994 Mar [cited 2013 Dec 28];122(1):28–32. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8195800
4. Saita K, Ohi T, Hanaoka Y, Furukawa S, Furukawa Y, Hayashi K, et al. Effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental acrylamide-induced neuropathy in rats. Neurotoxicology [Internet]. 1995 Jan [cited 2013 Dec 28];16(3):403–12. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8584273
5. Kaechi K, Ikegami R, Nakamura N, Nakajima M, Furukawa Y, Furukawa S. 4-Methylcatechol, an inducer of nerve growth factor synthesis, enhances peripheral nerve regeneration across nerve gaps. J. Pharmacol. Exp. Ther. [Internet]. 1995 Mar [cited 2013 Dec 28];272(3):1300–4. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7891347
6. Sameni H, Panahi M. The Effect of Co-administration of 4-Methylcatechol and Progesterone on Sciatic Nerve Function and Neurohistological Alterations in Streptozotocin-Induced Diabetic Neuropathy in Rats. Cell J. [Internet]. 2011 Jan [cited 2013 Dec 28];13(1):31–8. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3652538&tool=pmcentrez&rendertype=abstract
7. Saita K, Ohi T, Hanaoka Y, Furukawa S, Furukawa Y, Hayashi K, et al. A catechol derivative (4-methylcatechol) accelerates the recovery from experimental acrylamide-induced neuropathy. J. Pharmacol. Exp. Ther. [Internet]. 1996 Jan [cited 2013 Dec 28];276(1):231–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8558436
8. Hsieh Y-L, Chiang H, Tseng T-J, Hsieh S-T. Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy. J. Neuropathol. Exp. Neurol. [Internet]. 2008 Mar [cited 2013 Dec 28];67(2):93–104. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18219259
9. Fukuhara K, Ishikawa K, Yasuda S, Kishi****a Y, Kim H-K, Kakeda T, et al. Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor (BDNF). Cell. Mol. Neurobiol. [Internet]. 2012 Aug [cited 2013 Dec 28];32(6):971–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22198556
10. Zhang S, Chen X, Yang Y, Zhou X, Liu J, Ding F. Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside. Mol. Cell. Biochem. [Internet]. 2011 Aug [cited 2013 Dec 29];354(1-2):161–70. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21499890
11. Yu S, Shen Y, Liu J, Ding F. Involvement of ERK1\/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death. J. Mol. Neurosci. [Internet]. 2010 Mar [cited 2013 Dec 29];40(3):321–31. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19787459
12. Chen X, Zhang Q, Cheng Q, Ding F. Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons. Mol. Cell. Biochem. [Internet]. 2009 Dec [cited 2013 Dec 29];332(1-2):85–93. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19554425
13. Chen X, Liu J, Gu X, Ding F. Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. Brain Res. [Internet]. 2008 Oct 31 [cited 2013 Dec 29];1238:189–98. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18680733
14. Sheng Q-S, Wang Z-J, Zhang J, Zhang Y-G. Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport [Internet]. 2013 Mar 27 [cited 2013 Dec 28];24(5):217–23. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23358450
15. Mizukami H, Ogasawara S, Yamagishi S-I, Takahashi K, Yagihashi S. Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats. Eur. J. Clin. Invest. [Internet]. 2011 Apr [cited 2013 Dec 28];41(4):442–50. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21128935
16. Yamatsu K, Yamanishi Y, Kaneko T, Ohkawa I. [Pharmacological studies on degeneration and regeneration of the peripheral nerves. (2) Effects of methylcobalamin on mitosis of Schwann cells and incorporation of labeled amino acid into protein fractions of crushed sciatic nerve in rats]. Nihon Yakurigaku Zasshi. [Internet]. 1976 Mar [cited 2013 Dec 28];72(2):269–78. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/987971
17. Liao W-C, Chen J-R, Wang Y-J, Tseng G-F. Methylcobalamin, but not methylprednisolone or pleiotrophin, accelerates the recovery of rat biceps after ulnar to musculocutaneous nerve transfer. Neuroscience [Internet]. 2010 Dec 15 [cited 2013 Dec 28];171(3):934–49. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20884334
18. Okada K, Tanaka H, Temporin K, Okamoto M, Kuroda Y, Moritomo H, et al. Methylcobalamin increases Erk1\/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp. Neurol. [Internet]. 2010 Apr;222(2):191–203. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20045411
19. Yamazaki K, Oda K, Endo C, Kikuchi T, Wakabayashi T. Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse. Neurosci. Lett. [Internet]. 1994 Mar 28 [cited 2013 Dec 28];170(1):195–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8041506
20. Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. [Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve]. Nihon Yakurigaku Zasshi. [Internet]. 1976 Mar [cited 2013 Dec 28];72(2):259–68. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/987970
21. Di Cesare Mannelli L, D’Agostino G, Pacini A, Russo R, Zanardelli M, Ghelardini C, et al. Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism. Mediators Inflamm. [Internet]. 2013 Jan [cited 2013 Dec 28];2013:328797. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3596927&tool=pmcentrez&rendertype=abstract
22. Bettoni I, Comelli F, Colombo A, Bonfanti P, Costa B. Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide. CNS Neurol. Disord. Drug Targets [Internet]. 2013 Mar 1 [cited 2013 Dec 28];12(1):34–44. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23394519
23. Conigliaro R, Drago V, Foster PS, Schievano C, Di Marzo V. Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist. Minerva Med. [Internet]. 2011 Apr [cited 2013 Dec 28];102(2):141–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21483401
24. Calabrò RS, Gervasi G, Marino S, Mondo PN, Bramanti P. Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide. Pain Med. [Internet]. 2010 May [cited 2013 Dec 28];11(5):781–4. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20345619
25. Costa B, Comelli F, Bettoni I, Colleoni M, Giagnoni G. The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors. Pain [Internet]. 2008 Oct 31 [cited 2013 Dec 28];139(3):541–50. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18602217
26. Gong Y, Gong L, Gu X, Ding F. Chitooligosaccharides promote peripheral nerve regeneration in a rabbit common peroneal nerve crush injury model. Microsurgery [Internet]. 2009 Jan [cited 2013 Dec 28];29(8):650–6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19653322
27. Jiang M, Zhuge X, Yang Y, Gu X, Ding F. The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model. Neurosci. Lett. [Internet]. 2009 May 1 [cited 2013 Dec 15];454(3):239–43. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19429091
28. Yang Y, Liu M, Gu Y, Lin S, Ding F, Gu X. Effect of chitooligosaccharide on neuronal differentiation of PC-12 cells. Cell Biol. Int. [Internet]. 2009 Mar [cited 2013 Dec 28];33(3):352–6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19272331
29. Cheng Q, Yuan Y, Sun C, Gu X, Cao Z, Ding F. Neurotrophic and neuroprotective actions of Achyranthes bidentata polypeptides on cultured dorsal root ganglia of rats and on crushed common peroneal nerve of rabbits. Neurosci. Lett. [Internet]. 2013 Dec 17 [cited 2013 Dec 28]; Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24361134
30. Wang Y, Shen W, Yang L, Zhao H, Gu W, Yuan Y. The protective effects of Achyranthes bidentata polypeptides on rat sciatic nerve crush injury causes modulation of neurotrophic factors. Neurochem. Res. [Internet]. 2013 Mar [cited 2013 Dec 28];38(3):538–46. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23242788
31. Yuan Y, Shen H, Yao J, Hu N, Ding F, Gu X. The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury. Brain Res. Bull. [Internet]. 2010 Jan 15 [cited 2013 Dec 28];81(1):25–32. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19646511
32. Shen H, Yuan Y, Ding F, Hu N, Liu J, Gu X. Achyranthes bidentata polypeptides confer neuroprotection through inhibition of reactive oxygen species production, Bax expression, and mitochondrial dysfunction induced by overstimulation of N-methyl-D-aspartate receptors. J. Neurosci. Res. [Internet]. 2010 Mar 15 [cited 2013 Dec 28];88(3):669–76. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19774671
33. Ma J, Li W, Tian R, Lei W. Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury. Neurosci. Lett. [Internet]. 2010 Jul 5 [cited 2013 Dec 28];478(2):66–71. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20438804
34. Ma J, Liu J, Wang Q, Yu H, Chen Y, Xiang L. The beneficial effect of ginsenoside Rg1 on Schwann cells subjected to hydrogen peroxide induced oxidative injury. Int. J. Biol. Sci. [Internet]. 2013 Jan [cited 2013 Dec 29];9(6):624–36. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3708042&tool=pmcentrez&rendertype=abstract
35. Liang W, Ge S, Yang L, Yang M, Ye Z, Yan M, et al. Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures. Brain Res. [Internet]. 2010 Oct 21 [cited 2013 Dec 29];1357:19–25. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20682297
36. Talebi M, Andalib S, Bakhti S, Ayromlou H, Aghili A, Talebi A. Effect of vitamin b6 on clinical symptoms and electrodiagnostic results of patients with carpal tunnel syndrome. Adv. Pharm. Bull. [Internet]. 2013 Jan [cited 2013 Dec 28];3(2):283–8. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3848223&tool=pmcentrez&rendertype=abstract
37. Jung H-S, Noh C-K, Ma S-H, Hong EK, Sohn N-W, Kim Y-B, et al. Effect of Dipsaci radix on hind limb muscle atrophy of sciatic nerve transected rats. Am. J. Chin. Med. [Internet]. 2009 Jan [cited 2013 Dec 29];37(6):1069–84. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19938217
38. Wang Z, Zhang P, Kou Y, Yin X, Han N, Jiang B. Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect. PLoS One [Internet]. 2013 Jan [cited 2013 Dec 29];8(7):e67921. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3700897&tool=pmcentrez&rendertype=abstract
39. Wang ZY, Zhang PX, Han N, Kou YH, Yin XF, Jiang BG. Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration. Evid. Based. Complement. Alternat. Med. [Internet]. 2013 Jan [cited 2013 Dec 29];2013:647982. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3595679&tool=pmcentrez&rendertype=abstract
40. Wei S-Y, Zhang P-X, Han N, Dang Y, Zhang H-B, Zhang D-Y, et al. Effects of Hedysari polysaccharides on regeneration and function recovery following peripheral nerve injury in rats. Am. J. Chin. Med. [Internet]. 2009 Jan [cited 2013 Dec 29];37(1):57–67. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19222112
41. Lai P-L, Naidu M, Sabaratnam V, Wong K-H, David RP, Kuppusamy UR, et al. Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int. J. Med. Mushrooms [Internet]. 2013 Jan [cited 2013 Dec 29];15(6):539–54. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378
42. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol. Pharm. Bull. [Internet]. 2008 Sep [cited 2013 Dec 29];31(9):1727–32. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18758067
43. Wong K-H, Naidu M, David RP, Bakar R, Sabaratnam V. Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). Int. J. Med. Mushrooms [Internet]. 2012 Jan [cited 2013 Dec 29];14(5):427–46. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23510212
44. Wong K-H, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 16];2011:580752. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3176599&tool=pmcentrez&rendertype=abstract
45. Kolotushkina E V, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol. Zh. [Internet]. 2003 Jan [cited 2013 Dec 29];49(1):38–45. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12675022
46. Chang Y-M, Shih Y-T, Chen Y-S, Liu C-L, Fang W-K, Tsai C-H, et al. Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2\/9 Mediated through ERK1\/2 and p38. Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 29];2011:395458. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3135425&tool=pmcentrez&rendertype=abstract
47. Chang Y-M, Chi W-Y, Lai T-Y, Chen Y-S, Tsai F-J, Tsai C-H, et al. Dilong: role in peripheral nerve regeneration. Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 29];2011:380809. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3136393&tool=pmcentrez&rendertype=abstract<\/p>","gtin12":"737534363218","image":["https:\/\/siteimgs.com\/10017\/item\/img-7263b_1674073057-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32759\/evomuse-nerve-restore.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"47.99","url":"https:\/\/www.dpsnutrition.net\/i\/32759\/evomuse-nerve-restore.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"EvoMuse Nerve Restore - 2 x 120 Cap Btls TWINPACK","sku":"EM2014","description":"Nerve Restore<\/h4>\r\n
Originally targeting the normalization of nerve functions for those suffering from nerve impingement, from herniated discs and such, my research soon delved deeply into the mountain - but not deeply enough to awaken the Balrog of strength and size.<\/p>\r\n
Well, they are coming up behind me on a path I already blazed, so let's revisit and focus on the role of nerve signals in muscle growth, mind\/muscle connection, sympathetic\/parasympathetic functions, and reaction speed.<\/p>\r\n
Key Terms to Know <\/strong>
Nerve Growth Factor (NGF)- A signaling protein crucial for growth, upkeep, and survival of nerves.<\/p>\r\n
Where does it come from?
Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.<\/p>\r\n
4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.<\/p>\r\n
Where does it come from?
Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties.<\/p>\r\n
Several studies have demonstrated salidroside's neuroprotective ability (10–13). Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function (14).<\/p>\r\n
Where does it come from?
Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function.<\/p>\r\n
Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:<\/p>\r\n
- Stimulate proteosynthesis in Schwann cells to facilitate neural regeneration (16,17).
- Enhance recovery of myelination, muscle action potentials and motor end plate innervation (17).
- Improve nerve regeneration and inhibit degeneration from neuronal damage such as crushed sciatic nerves (18–20).<\/p>\r\n
PEA (not to be confused with the other PEA, phenylethylamine) is a fatty acid amide (formed when a fatty acid combines with an amine). Most of its functions in the body involve the regulation of pain and inflammation.<\/p>\r\n
By working through numerous angles to reduce pain and improve nerve signaling, PEA holds large promise. Quite a bit of published data has shown that PEA favorably modulates PPARa, PPARg, CB(1),TRPV1, TNFa, and the mast cells of the immune system to reduce pain, inflammation and discomfort in nerve injuries such as neuropathy, carpal tunnel syndrome and sciatic nerve crushes (21–25).<\/p>\r\n
COS is a combination of two different types of glucosamine derived from crustacean shells.<\/p>\r\n
Several studies have shown COS to have a positive outcome on improvement of nerve dysfunction. One recent study looking at peripheral nerve crush injuries published in the Journal of Microsurgery found that COS significantly improved muscle action potentials, number of regenerated nerve fibers and thickness of myelin sheaths, and even an increase in muscle size of the tibialis posterior (one of the calf muscles) (26).<\/p>\r\n
ABP is a polypeptide derived from the achyranthes plant found in China, Japan, Nepal, and India, known for its anti-inflammatory properties.<\/p>\r\n
What does it do?
ABP has been shown repeatedly in research to enhance nerve regeneration and function in sciatic and common peroneal nerve injuries (29–31).<\/p>\r\n
The Rg1 group of ginsenoside is a bioactive compound found primarily in the Chinese\/Korean Ginesing plant, selected for its specific nerve regeneration properties. The ginsenosides are considered the active compounds in ginesing.<\/p>\r\n
Recent research has shown GRg1 can successfully promote nerve regeneration after nerve injuries (33–35). After an oxidative insult from administered hydrogen peroxide, GRg1 increases SOD, CAT and GSH with a concurrent reduction in MDA (34). It has also been shown to increase expression of NGF and BDNF through the PKA pathway in Schwann cells (35).<\/p>\r\n
P5P is the active form of Vitamin B6 in the body, and is a crucial factor for a laundry list of functions in the body.<\/p>\r\n
The most recent research has shown that P5P improves clinical symptoms in carpal tunnel syndrome (a nerve related disorder), which means it likely has farther reaching effects on nerve dysfunction throughout the body, (36).<\/p>\r\n
In Traditional Chinese Medicine (TCM), Dipsaci radix has been used to treat dysfunctions of the liver, kidney, tendons and bones. It comes from the plant Dipsacus asperoides.<\/p>\r\n
After nerve injury, muscle atrophy tends to onset fairly quickly. Dipsaci helps improve muscle size and glycogen storage in tissues surrounding a nerve injury (37).<\/p>\r\n
Also from TCM, Radix Hedysari is an herbal preperation used for nerve regeneration.<\/p>\r\n
Radix Hedysari has been shown to be effective at improving peripheral nerve regeneration, MNCV, nerve fiber and axon diameter, number of nerve fibers, and amplification ratio (38–40).<\/p>\r\n
Lion's Mane Mushroom extract is an edible mushroom found in North America, Europe and Asia.<\/p>\r\n
Lion's Mane is considered a neurotrophic agent, as it has been shown in multiple studies to induce NGF synthesis (41,42). Two studies have also shown oral administration of Lion's Mane to regenerate injured peroneal nerves in rats (43,44). Finally, it has been shown to directly regulate myelin genesis in vitro (45).<\/p>\r\n
Exactly what it sounds like, this compound widely used in TCM is an extract from earthworms.<\/p>\r\n
Two recent studies have demonstrated Earthworm Extract's ability to increase nerve cell regeneration through Schwann cell activity, stimulating myelination (46,47).<\/p>\r\n
Oftentimes, nerve injuries take a massive toll on us mentally and physically. We watch, helpless, as our hard-earned size and strength gains falter and fade away. After many months of research, Evolutionary Muse offers a potential solution. While your physician or therapist should guide you along the road to recovery, and your trainer can advise you how to best prevent future injuries, EvoMuse has brought to you a product that will jumpstart the processes of recovery and help restore, and optimize, nerve function.<\/p>\r\n\r\n Servings Size: 2 Capsules<\/span><\/strong><\/td>\r\n <\/span><\/td>\r\n<\/tr>\r\n \r\n <\/span><\/td>\r\n <\/span><\/td>\r\n<\/tr>\r\n \r\n 4-Methylcatechol<\/span><\/td>\r\n 15mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Rhodiola Rosea (11% Salidroside)<\/span><\/td>\r\n 250mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Methylcobalamin<\/span><\/td>\r\n 2mg<\/span><\/td>\r\n<\/tr>\r\n \r\n PalmitoylEthanolamide<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Chitooligosaccharides<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Achyranthes Bidentata Extract (60% polypeptides\/Polysaccharides)<\/span><\/td>\r\n 125mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Panax Ginseng Berry Extract 10:1<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Pyridoxal-5-Phosphate<\/span><\/td>\r\n 5mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Dipsaci Radix Water Extract 20:1<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Radix Heydsari 20:1<\/span><\/td>\r\n 200mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Lions Mane Mushroom Extract 4:1<\/span><\/td>\r\n 400mg<\/span><\/td>\r\n<\/tr>\r\n \r\n Lumbricus Extract 10:1<\/span><\/td>\r\n 250mg<\/span><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n
2. Hanaoka Y, Ohi T, Furukawa S, Furukawa Y, Hayashi K, Matsukura S. Effect of 4-methylcatechol on sciatic nerve growth factor level and motor nerve conduction velocity in experimental diabetic neuropathic process in rats. Exp. Neurol. [Internet]. 1992 Mar [cited 2013 Dec 28];115(2):292–6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1735473
3. Hanaoka Y, Ohi T, Furukawa S, Furukawa Y, Hayashi K, Matsukura S. The therapeutic effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental diabetic neuropathy in rats. J. Neurol. Sci. [Internet]. 1994 Mar [cited 2013 Dec 28];122(1):28–32. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8195800
4. Saita K, Ohi T, Hanaoka Y, Furukawa S, Furukawa Y, Hayashi K, et al. Effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental acrylamide-induced neuropathy in rats. Neurotoxicology [Internet]. 1995 Jan [cited 2013 Dec 28];16(3):403–12. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8584273
5. Kaechi K, Ikegami R, Nakamura N, Nakajima M, Furukawa Y, Furukawa S. 4-Methylcatechol, an inducer of nerve growth factor synthesis, enhances peripheral nerve regeneration across nerve gaps. J. Pharmacol. Exp. Ther. [Internet]. 1995 Mar [cited 2013 Dec 28];272(3):1300–4. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7891347
6. Sameni H, Panahi M. The Effect of Co-administration of 4-Methylcatechol and Progesterone on Sciatic Nerve Function and Neurohistological Alterations in Streptozotocin-Induced Diabetic Neuropathy in Rats. Cell J. [Internet]. 2011 Jan [cited 2013 Dec 28];13(1):31–8. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3652538&tool=pmcentrez&rendertype=abstract
7. Saita K, Ohi T, Hanaoka Y, Furukawa S, Furukawa Y, Hayashi K, et al. A catechol derivative (4-methylcatechol) accelerates the recovery from experimental acrylamide-induced neuropathy. J. Pharmacol. Exp. Ther. [Internet]. 1996 Jan [cited 2013 Dec 28];276(1):231–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8558436
8. Hsieh Y-L, Chiang H, Tseng T-J, Hsieh S-T. Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy. J. Neuropathol. Exp. Neurol. [Internet]. 2008 Mar [cited 2013 Dec 28];67(2):93–104. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18219259
9. Fukuhara K, Ishikawa K, Yasuda S, Kishi****a Y, Kim H-K, Kakeda T, et al. Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor (BDNF). Cell. Mol. Neurobiol. [Internet]. 2012 Aug [cited 2013 Dec 28];32(6):971–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22198556
10. Zhang S, Chen X, Yang Y, Zhou X, Liu J, Ding F. Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside. Mol. Cell. Biochem. [Internet]. 2011 Aug [cited 2013 Dec 29];354(1-2):161–70. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21499890
11. Yu S, Shen Y, Liu J, Ding F. Involvement of ERK1\/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death. J. Mol. Neurosci. [Internet]. 2010 Mar [cited 2013 Dec 29];40(3):321–31. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19787459
12. Chen X, Zhang Q, Cheng Q, Ding F. Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons. Mol. Cell. Biochem. [Internet]. 2009 Dec [cited 2013 Dec 29];332(1-2):85–93. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19554425
13. Chen X, Liu J, Gu X, Ding F. Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. Brain Res. [Internet]. 2008 Oct 31 [cited 2013 Dec 29];1238:189–98. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18680733
14. Sheng Q-S, Wang Z-J, Zhang J, Zhang Y-G. Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport [Internet]. 2013 Mar 27 [cited 2013 Dec 28];24(5):217–23. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23358450
15. Mizukami H, Ogasawara S, Yamagishi S-I, Takahashi K, Yagihashi S. Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats. Eur. J. Clin. Invest. [Internet]. 2011 Apr [cited 2013 Dec 28];41(4):442–50. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21128935
16. Yamatsu K, Yamanishi Y, Kaneko T, Ohkawa I. [Pharmacological studies on degeneration and regeneration of the peripheral nerves. (2) Effects of methylcobalamin on mitosis of Schwann cells and incorporation of labeled amino acid into protein fractions of crushed sciatic nerve in rats]. Nihon Yakurigaku Zasshi. [Internet]. 1976 Mar [cited 2013 Dec 28];72(2):269–78. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/987971
17. Liao W-C, Chen J-R, Wang Y-J, Tseng G-F. Methylcobalamin, but not methylprednisolone or pleiotrophin, accelerates the recovery of rat biceps after ulnar to musculocutaneous nerve transfer. Neuroscience [Internet]. 2010 Dec 15 [cited 2013 Dec 28];171(3):934–49. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20884334
18. Okada K, Tanaka H, Temporin K, Okamoto M, Kuroda Y, Moritomo H, et al. Methylcobalamin increases Erk1\/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp. Neurol. [Internet]. 2010 Apr;222(2):191–203. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20045411
19. Yamazaki K, Oda K, Endo C, Kikuchi T, Wakabayashi T. Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse. Neurosci. Lett. [Internet]. 1994 Mar 28 [cited 2013 Dec 28];170(1):195–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8041506
20. Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. [Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve]. Nihon Yakurigaku Zasshi. [Internet]. 1976 Mar [cited 2013 Dec 28];72(2):259–68. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/987970
21. Di Cesare Mannelli L, D’Agostino G, Pacini A, Russo R, Zanardelli M, Ghelardini C, et al. Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism. Mediators Inflamm. [Internet]. 2013 Jan [cited 2013 Dec 28];2013:328797. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3596927&tool=pmcentrez&rendertype=abstract
22. Bettoni I, Comelli F, Colombo A, Bonfanti P, Costa B. Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide. CNS Neurol. Disord. Drug Targets [Internet]. 2013 Mar 1 [cited 2013 Dec 28];12(1):34–44. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23394519
23. Conigliaro R, Drago V, Foster PS, Schievano C, Di Marzo V. Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist. Minerva Med. [Internet]. 2011 Apr [cited 2013 Dec 28];102(2):141–7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21483401
24. Calabrò RS, Gervasi G, Marino S, Mondo PN, Bramanti P. Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide. Pain Med. [Internet]. 2010 May [cited 2013 Dec 28];11(5):781–4. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20345619
25. Costa B, Comelli F, Bettoni I, Colleoni M, Giagnoni G. The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors. Pain [Internet]. 2008 Oct 31 [cited 2013 Dec 28];139(3):541–50. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18602217
26. Gong Y, Gong L, Gu X, Ding F. Chitooligosaccharides promote peripheral nerve regeneration in a rabbit common peroneal nerve crush injury model. Microsurgery [Internet]. 2009 Jan [cited 2013 Dec 28];29(8):650–6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19653322
27. Jiang M, Zhuge X, Yang Y, Gu X, Ding F. The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model. Neurosci. Lett. [Internet]. 2009 May 1 [cited 2013 Dec 15];454(3):239–43. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19429091
28. Yang Y, Liu M, Gu Y, Lin S, Ding F, Gu X. Effect of chitooligosaccharide on neuronal differentiation of PC-12 cells. Cell Biol. Int. [Internet]. 2009 Mar [cited 2013 Dec 28];33(3):352–6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19272331
29. Cheng Q, Yuan Y, Sun C, Gu X, Cao Z, Ding F. Neurotrophic and neuroprotective actions of Achyranthes bidentata polypeptides on cultured dorsal root ganglia of rats and on crushed common peroneal nerve of rabbits. Neurosci. Lett. [Internet]. 2013 Dec 17 [cited 2013 Dec 28]; Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24361134
30. Wang Y, Shen W, Yang L, Zhao H, Gu W, Yuan Y. The protective effects of Achyranthes bidentata polypeptides on rat sciatic nerve crush injury causes modulation of neurotrophic factors. Neurochem. Res. [Internet]. 2013 Mar [cited 2013 Dec 28];38(3):538–46. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23242788
31. Yuan Y, Shen H, Yao J, Hu N, Ding F, Gu X. The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury. Brain Res. Bull. [Internet]. 2010 Jan 15 [cited 2013 Dec 28];81(1):25–32. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19646511
32. Shen H, Yuan Y, Ding F, Hu N, Liu J, Gu X. Achyranthes bidentata polypeptides confer neuroprotection through inhibition of reactive oxygen species production, Bax expression, and mitochondrial dysfunction induced by overstimulation of N-methyl-D-aspartate receptors. J. Neurosci. Res. [Internet]. 2010 Mar 15 [cited 2013 Dec 28];88(3):669–76. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19774671
33. Ma J, Li W, Tian R, Lei W. Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury. Neurosci. Lett. [Internet]. 2010 Jul 5 [cited 2013 Dec 28];478(2):66–71. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20438804
34. Ma J, Liu J, Wang Q, Yu H, Chen Y, Xiang L. The beneficial effect of ginsenoside Rg1 on Schwann cells subjected to hydrogen peroxide induced oxidative injury. Int. J. Biol. Sci. [Internet]. 2013 Jan [cited 2013 Dec 29];9(6):624–36. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3708042&tool=pmcentrez&rendertype=abstract
35. Liang W, Ge S, Yang L, Yang M, Ye Z, Yan M, et al. Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures. Brain Res. [Internet]. 2010 Oct 21 [cited 2013 Dec 29];1357:19–25. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20682297
36. Talebi M, Andalib S, Bakhti S, Ayromlou H, Aghili A, Talebi A. Effect of vitamin b6 on clinical symptoms and electrodiagnostic results of patients with carpal tunnel syndrome. Adv. Pharm. Bull. [Internet]. 2013 Jan [cited 2013 Dec 28];3(2):283–8. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3848223&tool=pmcentrez&rendertype=abstract
37. Jung H-S, Noh C-K, Ma S-H, Hong EK, Sohn N-W, Kim Y-B, et al. Effect of Dipsaci radix on hind limb muscle atrophy of sciatic nerve transected rats. Am. J. Chin. Med. [Internet]. 2009 Jan [cited 2013 Dec 29];37(6):1069–84. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19938217
38. Wang Z, Zhang P, Kou Y, Yin X, Han N, Jiang B. Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect. PLoS One [Internet]. 2013 Jan [cited 2013 Dec 29];8(7):e67921. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3700897&tool=pmcentrez&rendertype=abstract
39. Wang ZY, Zhang PX, Han N, Kou YH, Yin XF, Jiang BG. Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration. Evid. Based. Complement. Alternat. Med. [Internet]. 2013 Jan [cited 2013 Dec 29];2013:647982. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3595679&tool=pmcentrez&rendertype=abstract
40. Wei S-Y, Zhang P-X, Han N, Dang Y, Zhang H-B, Zhang D-Y, et al. Effects of Hedysari polysaccharides on regeneration and function recovery following peripheral nerve injury in rats. Am. J. Chin. Med. [Internet]. 2009 Jan [cited 2013 Dec 29];37(1):57–67. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19222112
41. Lai P-L, Naidu M, Sabaratnam V, Wong K-H, David RP, Kuppusamy UR, et al. Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int. J. Med. Mushrooms [Internet]. 2013 Jan [cited 2013 Dec 29];15(6):539–54. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378
42. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol. Pharm. Bull. [Internet]. 2008 Sep [cited 2013 Dec 29];31(9):1727–32. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18758067
43. Wong K-H, Naidu M, David RP, Bakar R, Sabaratnam V. Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). Int. J. Med. Mushrooms [Internet]. 2012 Jan [cited 2013 Dec 29];14(5):427–46. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23510212
44. Wong K-H, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 16];2011:580752. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3176599&tool=pmcentrez&rendertype=abstract
45. Kolotushkina E V, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol. Zh. [Internet]. 2003 Jan [cited 2013 Dec 29];49(1):38–45. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12675022
46. Chang Y-M, Shih Y-T, Chen Y-S, Liu C-L, Fang W-K, Tsai C-H, et al. Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2\/9 Mediated through ERK1\/2 and p38. Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 29];2011:395458. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3135425&tool=pmcentrez&rendertype=abstract
47. Chang Y-M, Chi W-Y, Lai T-Y, Chen Y-S, Tsai F-J, Tsai C-H, et al. Dilong: role in peripheral nerve regeneration. Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 29];2011:380809. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3136393&tool=pmcentrez&rendertype=abstract<\/p>","gtin12":"737534363218","image":["https:\/\/siteimgs.com\/10017\/item\/nerve-restore-twinb_1674073122-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32760\/evomuse-nerve-restore.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"79.99","url":"https:\/\/www.dpsnutrition.net\/i\/32760\/evomuse-nerve-restore.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Gaspari Nutrition AminoLast Watermelon Blast - 30 Servings","sku":"GP368","description":"
Whether it’s putting on muscle, increasing endurance, or just trying to look the best you can, it takes persistence. We know this too which is why we spent over 24 months developing AminoLast based on the latest cutting-edge research. We wouldn’t settle for just another \"me too” formulation. You want something different. We’ve created an amino acid product that tastes great, and brings something new to the market to help you reach your goals. Utilizing only the best ingredients without added synthetic colors, we created a superior recovery and endurance BCAA superfuel.<\/span><\/p>
FREQUENTLY ASKED QUESTIONS
Q: What type of results can I expect from AMINOLAST?<\/span><\/p><\/span><\/p>
SizeOn brings these carefully selected ingredients together for unparalleled increases in athletic performance, skeletal muscle recovery, explosiveness and most notably, immediate increases in muscle size WHILE YOU ARE STILL TRAINING.*<\/span><\/p>
SizeOn¨ Maximum Performance promotes both muscle growth and muscle recovery to get you functioning at the highest performance levels.<\/span><\/p>
Q: What is the difference between the new version of SizeOn and the original?<\/span><\/p><\/p>
No matter how hard and consistently you train… Regardless of your specific discipline… Recovery is the bottom line.<\/p>\r\n
CREATINE & ESSENTIAL AMINO ACIDS
15G OF CARB 10 CARBS PER SCOOP
FRUIT JUICE EXTRACTS & ELECTROLYTES<\/p>\r\n<\/p>","gtin12":"855816007640","image":["https:\/\/siteimgs.com\/10017\/item\/juce-mm-front-1500x_1666360566-0.jpg"],"brand":"GCode Nutrition","url":"https:\/\/www.dpsnutrition.net\/i\/32482\/gcode-nutrition-juice-intra-post-recovery-macho.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"39.99","url":"https:\/\/www.dpsnutrition.net\/i\/32482\/gcode-nutrition-juice-intra-post-recovery-macho.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Glaxon Flight Regenerate - 30 Servings (90 Cap) *New formula","sku":"GN038","description":"
WHY WOULD I TAKE IT?<\/p>\r\n<\/p>","gtin12":"850016284037","image":["https:\/\/siteimgs.com\/10017\/item\/flight-front-720x_1687442967-0.jpg"],"brand":"Glaxon","url":"https:\/\/www.dpsnutrition.net\/i\/30398\/glaxon-flight-30-servings-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"54.99","url":"https:\/\/www.dpsnutrition.net\/i\/30398\/glaxon-flight-30-servings-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"JYM Post Jym BCAAs + Recovery Matrix Blue Arctic - 30 Servings","sku":"JYM05","description":"
Powerful Cocktail Designed to Help Refuel, Recover, and Rebuild*<\/p>\r\n
6 grams BCAAs in a 3:1:1 ratio
3 grams Glutamine
2 grams Creatine HCl
2 grams Beta-Alanine
2 grams Carnipure® L-carnitine L-tartrate
1.5 grams Betaine
5 milligrams BioPerine®<\/p>\r\n
Before Post JYM™, there was a huge void in sports nutrition: post-workout supplementation. The so-called “experts” would tell you protein powder, and maybe some BCAAs, was all you needed after a hard training session. But if you want full recovery from intense workouts you need way more than just protein and BCAAs! That’s why Post JYM BCAAs+ Recovery Matrix was created.<\/p>\r\n
The Post JYM BCAAs+ Active Recovery formula consists of 8 hand-picked ingredients to help you bounce back from the brink of exhaustion with key nutrients that your muscles can use to rebuild, refuel and recover so you can do what you do even better next time.* I’ve seen these results both in the lab and in the gym over the past 20+ years.<\/p>\r\n
As with all JYM Supplement Science products, Post JYM never has and never will use proprietary blends or concentrated formulas – two tricks used by some supplement companies to under-dose products without you, the consumer, realizing you’re getting cheated. All 8 ingredients in Post JYM BCAAs+ Recovery Matrix are clearly listed on the label at their exact amounts. Full transparency of ingredients means you can have the confidence that you’re leaving no gains on the table with Post JYM.<\/p>\r\n
You know supplementing pre- and post-exercise can help maximize your results. And if you’re taking Pre JYM, before training, great! But don’t forget the other half of the equation, solid post-workout supplementation. Post JYM BCAAs+ Recovery Matrix and Pre JYM complement each other to help fuel both your training and recovery.*<\/p>\r\n
Intense training breaks down muscle tissue, and it must be built back up via muscle protein synthesis (MPS) to promote recovery.* The ingredients in Post JYM BCAAs+ Recovery Matrix collectively work to help increase muscle protein synthesis and start the repair process immediately.*<\/p>\r\n
Muscles don't repair in the gym, that happens at rest. But resting your body isn't enough. Post JYM BCAAs+ Recovery Matrix gives your body what it needs to help rebuild, refuel, and recover - sooner rather than later.* It's the product your muscles crave, and it just might hold the key to your greatest gains ever.*<\/p>\r\n
I've been studying nutrition and supplement science both in the lab and in the gym for decades. I’ve done the research, and I’ve converted it into real results for thousands of real people just like yourself. I began educating hard-training men and women worldwide through the pages of Muscle & Fitness, FLEX, and Muscle & Fitness Hers magazines before finding a home for my programs, articles, and videos on my own website JimStoppani.com. I developed Post JYM BCAAs+ Recovery Matrix to take recovery* to the next level and provide the perfect complement to Pre JYM.<\/p>\r\n<\/p>\r\n
Always consult with a qualified healthcare professional prior to beginning any diet or exercise program or taking any dietary supplement. The content on this website is for informational and educational purposes only and is not intended as medical advice or to replace a relationship with a qualified healthcare professional.<\/p>\r\n
Powerful Cocktail Designed to Help Refuel, Recover, and Rebuild*<\/p>\r\n
6 grams BCAAs in a 3:1:1 ratio
3 grams Glutamine
2 grams Creatine HCl
2 grams Beta-Alanine
2 grams Carnipure\u00ae L-carnitine L-tartrate
1.5 grams Betaine
5 milligrams BioPerine\u00ae<\/p>\r\n
Before Post JYM\u2122, there was a huge void in sports nutrition: post-workout supplementation. The so-called \u201cexperts\u201d would tell you protein powder, and maybe some BCAAs, was all you needed after a hard training session. But if you want full recovery from intense workouts you need way more than just protein and BCAAs! That\u2019s why Post JYM BCAAs+ Recovery Matrix was created.<\/p>\r\n
The Post JYM BCAAs+ Active Recovery formula consists of 8 hand-picked ingredients to help you bounce back from the brink of exhaustion with key nutrients that your muscles can use to rebuild, refuel and recover so you can do what you do even better next time.* I\u2019ve seen these results both in the lab and in the gym over the past 20+ years.<\/p>\r\n
As with all JYM Supplement Science products, Post JYM never has and never will use proprietary blends or concentrated formulas \u2013 two tricks used by some supplement companies to under-dose products without you, the consumer, realizing you\u2019re getting cheated. All 8 ingredients in Post JYM BCAAs+ Recovery Matrix are clearly listed on the label at their exact amounts. Full transparency of ingredients means you can have the confidence that you\u2019re leaving no gains on the table with Post JYM.<\/p>\r\n
You know supplementing pre- and post-exercise can help maximize your results. And if you\u2019re taking Pre JYM, before training, great! But don\u2019t forget the other half of the equation, solid post-workout supplementation. Post JYM BCAAs+ Recovery Matrix and Pre JYM complement each other to help fuel both your training and recovery.*<\/p>\r\n
Intense training breaks down muscle tissue, and it must be built back up via muscle protein synthesis (MPS) to promote recovery.* The ingredients in Post JYM BCAAs+ Recovery Matrix collectively work to help increase muscle protein synthesis and start the repair process immediately.*<\/p>\r\n
Muscles don't repair in the gym, that happens at rest. But resting your body isn't enough. Post JYM BCAAs+ Recovery Matrix gives your body what it needs to help rebuild, refuel, and recover - sooner rather than later.* It's the product your muscles crave, and it just might hold the key to your greatest gains ever.*<\/p>\r\n
I've been studying nutrition and supplement science both in the lab and in the gym for decades. I\u2019ve done the research, and I\u2019ve converted it into real results for thousands of real people just like yourself. I began educating hard-training men and women worldwide through the pages of Muscle & Fitness, FLEX, and Muscle & Fitness Hers magazines before finding a home for my programs, articles, and videos on my own website JimStoppani.com. I developed Post JYM BCAAs+ Recovery Matrix to take recovery* to the next level and provide the perfect complement to Pre JYM.<\/p>\r\n<\/p>\r\n
Always consult with a qualified healthcare professional prior to beginning any diet or exercise program or taking any dietary supplement. The content on this website is for informational and educational purposes only and is not intended as medical advice or to replace a relationship with a qualified healthcare professional.<\/p>\r\n
Powerful Cocktail Designed to Help Refuel, Recover, and Rebuild*<\/p>\r\n
6 grams BCAAs in a 3:1:1 ratio
3 grams Glutamine
2 grams Creatine HCl
2 grams Beta-Alanine
2 grams Carnipure® L-carnitine L-tartrate
1.5 grams Betaine
5 milligrams BioPerine®<\/p>\r\n
Before Post JYM™, there was a huge void in sports nutrition: post-workout supplementation. The so-called “experts” would tell you protein powder, and maybe some BCAAs, was all you needed after a hard training session. But if you want full recovery from intense workouts you need way more than just protein and BCAAs! That’s why Post JYM BCAAs+ Recovery Matrix was created.<\/p>\r\n
The Post JYM BCAAs+ Active Recovery formula consists of 8 hand-picked ingredients to help you bounce back from the brink of exhaustion with key nutrients that your muscles can use to rebuild, refuel and recover so you can do what you do even better next time.* I’ve seen these results both in the lab and in the gym over the past 20+ years.<\/p>\r\n
As with all JYM Supplement Science products, Post JYM never has and never will use proprietary blends or concentrated formulas – two tricks used by some supplement companies to under-dose products without you, the consumer, realizing you’re getting cheated. All 8 ingredients in Post JYM BCAAs+ Recovery Matrix are clearly listed on the label at their exact amounts. Full transparency of ingredients means you can have the confidence that you’re leaving no gains on the table with Post JYM.<\/p>\r\n
You know supplementing pre- and post-exercise can help maximize your results. And if you’re taking Pre JYM, before training, great! But don’t forget the other half of the equation, solid post-workout supplementation. Post JYM BCAAs+ Recovery Matrix and Pre JYM complement each other to help fuel both your training and recovery.*<\/p>\r\n
Intense training breaks down muscle tissue, and it must be built back up via muscle protein synthesis (MPS) to promote recovery.* The ingredients in Post JYM BCAAs+ Recovery Matrix collectively work to help increase muscle protein synthesis and start the repair process immediately.*<\/p>\r\n
Muscles don't repair in the gym, that happens at rest. But resting your body isn't enough. Post JYM BCAAs+ Recovery Matrix gives your body what it needs to help rebuild, refuel, and recover - sooner rather than later.* It's the product your muscles crave, and it just might hold the key to your greatest gains ever.*<\/p>\r\n
I've been studying nutrition and supplement science both in the lab and in the gym for decades. I’ve done the research, and I’ve converted it into real results for thousands of real people just like yourself. I began educating hard-training men and women worldwide through the pages of Muscle & Fitness, FLEX, and Muscle & Fitness Hers magazines before finding a home for my programs, articles, and videos on my own website JimStoppani.com. I developed Post JYM BCAAs+ Recovery Matrix to take recovery* to the next level and provide the perfect complement to Pre JYM.<\/p>\r\n<\/p>\r\n
Always consult with a qualified healthcare professional prior to beginning any diet or exercise program or taking any dietary supplement. The content on this website is for informational and educational purposes only and is not intended as medical advice or to replace a relationship with a qualified healthcare professional.<\/p>\r\n
RE-KAGED is a game-changing anabolic protein that you can’t beat if you are serious about adding size and strength. Supercharge your muscles with our lightning fast delivery of BCAAs, EAAs, CAAs, and NAAs from non-GMO whey protein isolate for maximum anabolic results and post-workout recovery support.
Our bodies need all of the nine essential amino acids (EAAs) in order to build muscle. Don’t shortchange your results during this important anabolic window by using a post-workout product that only contains BCAAs.<\/span><\/p>\r\n
Whey protein isolate from non-GMO whey
No soy
Patented BetaPower
Patented Creatine HCl
ProHydrolase digestive enzyme technology
Mixes instantly
No artificial colors
No artificial flavors
Tastes amazing!<\/span><\/p>\r\n
If you are looking for another product to compare RE-KAGED with, you are wasting your time! Nothing on the market even comes close or has the same ingredients. Many of the ingredients we use are unique and exclusive to Kaged Muscle, which means you will only get them from Kaged Muscle.<\/span><\/p>\r\n
Most brands are serving you a glass that is only 30% full by offering you a BCAA only product at a critical time when your body craves a full spectrum amino acid profile that has all nine essential amino acids in order to support muscle building.
New research on individuals who train with weights shows that during a 1.5 – 2 hour workout the human body does not burn enough glycogen to justify supplementing with fast-acting carbs post workout for the majority of us.
They are loaded with artificial flavors, colors, and low-quality ingredients.<\/span><\/p>\r\n
You train to failure and eat clean all day - why then drink a \"bodybuilding supplement\" loaded with:<\/span><\/p>\r\n
Artificial colors (Red 40, Yellow 6)
Soy lecithin
Cookie pieces
High-fructose corn syrup<\/span><\/p>\r\n
LET'S TALK REAL,
MODERN-DAY SCIENCE
Most bodybuilders and fitness enthusiasts work out for less than 2 hours each day. During workouts there are several rests between sets so the actual workload does not burn enough glycogen to justify supplementing with fast-acting carbs for the majority of us.<\/span><\/p>\r\n
The answer is simple – all of our ingredients are third-party tested for purity and quality! In return for a premium price, Kaged Muscle vendors and manufacturers commit to strict ethical, quality, and testing standards, ensuring our ingredients are manufactured with care.<\/span><\/p>\r\n
Whey protein isolate is compared to gold by many bodybuilders and athletes.<\/span><\/p>\r\n