Nothing is more frustrating than an impinged or injured nerve. Signal reduction triggers a whole landslide of negative effects: Weakness, pain, atrophy. After time, these side effects seem like they will last forever - and sometimes do...until now. Enter Nerve Restore. Nerve Restore is a nerve signal amplifier. In people with impingement or nerve injuries it will help alleiviate discomfort, weakness, and muscular atrophy. The enhanced nerve amplitude and velocity, in healthy people as well, should result in increased strength and quicker reflexes/coordination.
Back in 2013 I researched, formulated, and released a product way ahead of its time. Nerve Restore deals with the function, dysfunction, and optimization of Nerve Signals.
Originally targeting the normalization of nerve functions for those suffering from nerve impingement, from herniated discs and such, my research soon delved deeply into the mountain - but not deeply enough to awaken the Balrog of strength and size.
Since then the more "popular" research has caught up and they are actively looking for ways to thicken myelin (the insulation around nerves. Loss of insulation causes electrical "diffusion" and weaker signals), as well as seeing how we can strengthen the signals themselves. Well, they are coming up behind me on a path I already blazed, so let's revisit and focus on the role of nerve signals in muscle growth, mind/muscle connection, sympathetic/parasympathetic functions, and reaction speed.
Key Terms to Know Nerve Growth Factor (NGF)- A signaling protein crucial for growth, upkeep, and survival of nerves.
Brain Derived Neurotrophic Factor (BDNF)- A neurotrophin active in the brain and periphery, aiding in growth, survival and differentiation of neurons and synapses, and a key player in long term memory.
Neurotrophins- An umbrella of NGFs including BDNF, NT-3 and NT-4/5
Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve.
Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system.
Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon.
Protein Kinase C (PKC)- A family of enzymes that control the function of other proteins through the act of phosphorylation.
Schwann Cells- Cells that provide raw materials for myelination
Ingredients and Function
4-Methylcatechol (4-MC) Where does it come from? Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.
What does it do? 4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.
Thermosensitivity is basically the sensory perception of temperature changes, which is often damaged in nerve dysfunction. 4-MC has been shown to promote reinnervation and normalization of thermosensitivity in neuropathy (1).
Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. Several studies have found a huge benefit and reversal of these symptoms with 4-MC administration. One study showed in increase in NGF of 140% over controls (2), multiple other studies have confirmed the de novo NGF synthesis capability of 4-MC while also demonstrating its ability to significantly increase myelination and nerve blood flow (3–6).
Several studies have given animal models a nerve toxin known as acrylamide monomer (ACR), and examined the potential protective effect of 4-MC. They found similar results as the previously mentioned studies, 4-MC was able to increase MNCV, NGF, and myelination, and researchers noted that it can "accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically" (4,7).
Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF (8,9).
Salidroside Where does it come from? Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties.
What does it do? Several studies have demonstrated salidroside's neuroprotective ability (10–13). Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function (14).
Methylcobalamin Where does it come from? Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function.
What does it do? Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:
- Correct nerve damage done from oxidative damage and impaired neural signaling of PKC (15). - Stimulate proteosynthesis in Schwann cells to facilitate neural regeneration (16,17). - Enhance recovery of myelination, muscle action potentials and motor end plate innervation (17). - Improve nerve regeneration and inhibit degeneration from neuronal damage such as crushed sciatic nerves (18–20).
Palmitoylethanolamide (PEA)
Where does it come from? PEA (not to be confused with the other PEA, phenylethylamine) is a fatty acid amide (formed when a fatty acid combines with an amine). Most of its functions in the body involve the regulation of pain and inflammation.
What does it do? By working through numerous angles to reduce pain and improve nerve signaling, PEA holds large promise. Quite a bit of published data has shown that PEA favorably modulates PPARa, PPARg, CB(1),TRPV1, TNFa, and the mast cells of the immune system to reduce pain, inflammation and discomfort in nerve injuries such as neuropathy, carpal tunnel syndrome and sciatic nerve crushes (21–25).
Chitooligosaccharide (COS)
Where does it come from? COS is a combination of two different types of glucosamine derived from crustacean shells.
What does it do? Several studies have shown COS to have a positive outcome on improvement of nerve dysfunction. One recent study looking at peripheral nerve crush injuries published in the Journal of Microsurgery found that COS significantly improved muscle action potentials, number of regenerated nerve fibers and thickness of myelin sheaths, and even an increase in muscle size of the tibialis posterior (one of the calf muscles) (26).
Other studies have shown COS to promote nerve regeneration and differentiation, functional recovery, and nerve cell adhesion (27,28).
Achyranthes bidentata polypeptides (ABP)
Where does it come from? ABP is a polypeptide derived from the achyranthes plant found in China, Japan, Nepal, and India, known for its anti-inflammatory properties.
What does it do? ABP has been shown repeatedly in research to enhance nerve regeneration and function in sciatic and common peroneal nerve injuries (29–31).
Also of interest, ABP has central as well as peripheral nerve preservation and restoration effects, shown in the Journal of Neuroscience Research to counteract the effect of overstimulated NMDA receptors in the brain by reversing intracellular ROS and mitochondrial damage to the hippocampus (32).
Ginsenoside Rg1 (GRg1)
Where does it come from? The Rg1 group of ginsenoside is a bioactive compound found primarily in the Chinese/Korean Ginesing plant, selected for its specific nerve regeneration properties. The ginsenosides are considered the active compounds in ginesing.
What does it do? Recent research has shown GRg1 can successfully promote nerve regeneration after nerve injuries (33–35). After an oxidative insult from administered hydrogen peroxide, GRg1 increases SOD, CAT and GSH with a concurrent reduction in MDA (34). It has also been shown to increase expression of NGF and BDNF through the PKA pathway in Schwann cells (35).
Pyridoxal-5-Phosphate (P5P)
Where does it come from? P5P is the active form of Vitamin B6 in the body, and is a crucial factor for a laundry list of functions in the body.
What does it do? The most recent research has shown that P5P improves clinical symptoms in carpal tunnel syndrome (a nerve related disorder), which means it likely has farther reaching effects on nerve dysfunction throughout the body, (36).
Dipsaci radix (water extract)
Where does it come from? In Traditional Chinese Medicine (TCM), Dipsaci radix has been used to treat dysfunctions of the liver, kidney, tendons and bones. It comes from the plant Dipsacus asperoides.
What does it do? After nerve injury, muscle atrophy tends to onset fairly quickly. Dipsaci helps improve muscle size and glycogen storage in tissues surrounding a nerve injury (37).
Radix Hedysari
Where does it come from? Also from TCM, Radix Hedysari is an herbal preperation used for nerve regeneration.
What does it do? Radix Hedysari has been shown to be effective at improving peripheral nerve regeneration, MNCV, nerve fiber and axon diameter, number of nerve fibers, and amplification ratio (38–40).
Lion's Mane mushroom extract 4:1 (Hericium erinaceus)
Where does it come from? Lion's Mane Mushroom extract is an edible mushroom found in North America, Europe and Asia.
What does it do? Lion's Mane is considered a neurotrophic agent, as it has been shown in multiple studies to induce NGF synthesis (41,42). Two studies have also shown oral administration of Lion's Mane to regenerate injured peroneal nerves in rats (43,44). Finally, it has been shown to directly regulate myelin genesis in vitro (45).
Earthworm extract (Dilong)
Where does it come from? Exactly what it sounds like, this compound widely used in TCM is an extract from earthworms.
What does it do? Two recent studies have demonstrated Earthworm Extract's ability to increase nerve cell regeneration through Schwann cell activity, stimulating myelination (46,47).
Conclusion Oftentimes, nerve injuries take a massive toll on us mentally and physically. We watch, helpless, as our hard-earned size and strength gains falter and fade away. After many months of research, Evolutionary Muse offers a potential solution. While your physician or therapist should guide you along the road to recovery, and your trainer can advise you how to best prevent future injuries, EvoMuse has brought to you a product that will jumpstart the processes of recovery and help restore, and optimize, nerve function.
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