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BMP2 plays a major role in bone and cartilage formation, as well as osteoblast differentiation. Differentiation is an important point here, as will be discussed below. BMP2 is the secondary, but no less important, target of this formula, with BMP7 being the primary target.<\/p>\r\n
BMP4<\/p>\r\n
BMP4, while still important, is comparatively our lowest priority of the three for targeting muscle growth. Like the other BMPs it is involved in bone and cartilage development, although more specifically for teeth and limbs, as well as being a key player during embryonic development.<\/p>\r\n
BMP7
BMP7 is our priority target for muscle growth. It is a major player in osteoblast differentiation as well as the induction of SMAD 1\/5\/8 (see below).<\/p>\r\n
Now, going back to MyoStatin since it is most familiar to most of you (you’ve all seen the bulls and dogs with the deleted Myostatin gene and how huge and muscular they are), we also throw in Activins and Atrogin-1, the primary catabolic signals. These signals all seem to converge on SMADs.<\/p>\r\n
SMADs are the molecules that actually communicate the signals deep into the nucleus to trigger our desireable (and undesireable) effects. SMAD 1\/5\/8, activated by BMP 2, 4, and 7, meet up with SMAD4, which is an escort molecule, to travel to the nucleus. Myostatin, and other catabolic proteins, activate SMAD2\/3 which ALSO require SMAD4, and thereby compete with SMAD 1\/5\/8 for dominance. While the SMADs activated by BMP 2, 4, and 7 usually dominate, the nature of the competition (and partiular environment – like starvation and sleep) can sometimes give the checkered flag to SMAD2\/3.<\/p>\r\n
So what we have so far:<\/p>\r\n
•BMP signaling is the fundamental signal for hypertrophy<\/p>\r\n
•Inhibiting BMP signaling causes atrophy, abolishes Myostatin deficient mice from gaining the enormous amount of muscle they normally do, and increases the negative effect from fasting<\/p>\r\n
•BMP plays a critical role in adult muscle growth<\/p>\r\n
Before getting into the meat of the product, let’s do 2 things. Cover SMAD7 quickly, and do a summary.<\/p>\r\n
SMAD7 used to be thought of as a suppressive SMAD, and some studies still indicate functionality there – but it appears to both suppress MyoStatin as well as undesirable inflammatory cytokines. But SMAD7 is also becoming one of the main inducers of new muscle cell differentiation (cellular division of muscle cells rather than drawing from stem cells). This elusive process is highly sought after in terms of muscle strength and size. So what are we doing here with BMP, as a product?<\/p>\r\n
We are increasing expression of BMP 2\/4\/7 to trigger stem cell differentiation into new bone, connective tissue, and muscle, denying (closing off) their differentiation into destructive cell types or even plain old ugly adipose.<\/p>\r\n
We are increasing expression of SMAD7 to cause muscle cell division and differentiation, making the muscles bigger and stronger.<\/p>\r\n
We are suppressing SMAD2\/3 (basically short circuiting Myostatin and Activins at their final step) thus not only blocking catabolism, but enhancing the availability of SMAD4 to complex with SMAD 1\/5\/8 to amplify the effects. This is the major upgrade to this version.<\/p>\r\n
Let’s get to those ingredients, if you’re still awake.<\/p>\r\n
Kaempferol Cyclodextrin<\/p>\r\n
Kaempferol is a flavanol found in a variety of plants. The Hydroxypropyl-Beta-Cyclodextrin has been added to increase bioavailability due to poor water solubility. In the past Kaempferol has been shown to increase cellular energy expenditure and enhance thyroid function which has landed it a spot in several fat burning formulas, however it has been included in this formula for an entirely different reason.<\/p>\r\n
Kaempferol appears to have quite a strong effect on bone anabolism, and has been called a “promising agent for the prevention or treatment of bone loss”. A 2013 in vitro study demonstrated that Kaempferol enhanced the expression of chondrogenic marker genes, and greatly increased expression of BMP2. In addition to increasing BMP2, it has also been shown to increase the number of BMP2 receptors in animals. More BMP and more places to dock, that’s a solid combo.<\/p>\r\n
Kaempferol also potently activates our BMP7, leading to increased muscle (an important addition here is prevention of fibrosis). Fibrosis (think scar tissue) is the process of converting healthy, functioning tissue into slabs of dysfunctional useless tissue. This is particularly insidious in organs like the kidneys, and in the spongy tissue of the penis, causing major (and previously thought to be permanent) erectile dysfunction.<\/p>\r\n
https:\/\/pubmed.ncbi.nlm.nih.gov\/32115512<\/p>\r\n
Phytic Acid<\/p>\r\n
This was a controversial addition to the last version that had people asking questions. A component of seeds, nuts, and grains, PA can interfere with the absorption of some minerals. However, it has an astounding absorption boosting property for Kaempferol (and Quercetin...see below) and was well worth the inclusion.<\/p>\r\n
Salidroside<\/p>\r\n
Salidroside is an extremely interesting glucoside found in Rhodiola Rosea, which boasts numerous studies demonstrating a wide range of health benefits. Two very recent studies looked at the effect of Salidroside on bone anabolism. In the first study, they found that Salidroside increased the mRNA level of genes controlling the BMP pathway. It elevated BMP2 and BMP7 as well as SMAD 1\/5\/8 (SMAD 6\/7 are the inhibitory ones we don’t want to activate).<\/p>\r\n
The second study, carried out by different researchers, confirmed the increased phosphorylation and expression of SMAD 1\/5\/8. Then to be sure this was mediated by BMP, they added in a BMP antagonist to block the signaling pathway. As suspected, this attenuated the effect, demonstrating that BMP was indeed the target of Salidroside.<\/p>\r\n
For the new BMP formula, you might have noticed that we slightly reduced the dosage of Salidroside over the old version, finding that we can still get the same benefit with a lower dose and therefore allowing the addition of new ingredients while still making the formula just as cost-effective for the user.<\/p>\r\n
Osthole Cyclodextrin<\/p>\r\n
Found in Cnidium monnieri and a few other plants, Osthole is classified as a coumarin. It has been used in supplement form for liver health, cognitive enhancement and vasodilation. Research shows it can activate AMPK and ACC, regulate blood glucose and GLUT4 activity, and decrease liver fat. One study even demonstrated that in mice a high dose of Osthole had an androgenic effect and boosted LH and testosterone levels.<\/p>\r\n
All these things are nice, but what about BMP? Fear not, Osthole has been shown to activate Wnt\/beta-catenin signaling, increase BMP2 expression, and stimulate mesenchymal stem cells differentiation (MSC) to osteoblasts. Early phase differentiation involves BMP2, SMAD 1\/5\/8, RUNX2, and p38, whereas later phase differentiation involves ERK 1\/2. Osthole has been shown to enhance both phases, it sticks around until the job is done.<\/p>\r\n
Ligusticum Wallichii Extract (98% ligustrazine)<\/p>\r\n
Isolated from the fermented food Natto, LWE is an interesting compound with well-known anti-inflammatory and nootropic properties. More importantly, however, LWE has recently been shown to significantly elevate BMP7. LWE also favorably works the anabolic bone and muscle signaling pathway by activating something called the SERCA pump, which brings extracellular calcium back into the cell so it can be reused.<\/p>\r\n
To determine the anabolic and\/or anti-catabolic ability of a compound, scientists will often use methods such as denervation (cutting off or inhibiting nerve supply to a muscle), or suspension of a muscle (making it weightless). These methods basically make the brain forget these muscles exist, so they tend to atrophy quite rapidly. In multiple studies, when comparing Ligustrazine supplementation to control groups, in which both groups had been subjected to either denervation or muscle suspension, the Ligustrazine groups lost significantly less muscle over controls, both short term (one week) and longer term (one month).<\/p>\r\n
Ligustrazine has also been shown to selectively increase glucose uptake in muscle cells, protect against oxidative damage from high fat and high glucose, block vasoconstriction, and even upregulate mitochondrial biogenesis.<\/p>\r\n
Ligustrazine has also been found, recently, to preserve intervertebral disc integrity and prevent breakdown.<\/p>\r\n
https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1529943013014630<\/p>\r\n
Paeoniflorin<\/p>\r\n
Paeoniflorin is a compound isolated from any number of herbs. Working through multiple mechanisms, Paeoniflorin has a direct stimulatory effect on bone formation signaling. The current research on this compound has looked mainly at the potential beneficial effects in certain bone related disease states, which we can use to make some reasonable assumptions in how it might behave in healthy individuals. Renal fibrosis involves the accumulation of excess fibrous material in the extracellular matrix of kidney cells.<\/p>\r\n
Renal (kidney) fibrosis is the principal process underlying the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). In this condition, BMP7 expression and SMAD activation tends to become quite disrupted, and Paeoniflorin has been shown to normalize this signaling. This could very well translate to increased BMP7 expression in healthy individuals.<\/p>\r\n
In Rheumatoid Arthritis (RA), the body attacks the joints through an inflammatory cascade, causing pain, joint swelling, bone erosion and cartilage breakdown. Paeoniflorin supplementation has been shown to reverse or severely diminish all of these problems, largely through controlling the inflammatory factors prostaglandin E2, leukotriene B4, ROS, and cytokines IL-1B and TNF-a.<\/p>\r\n
Again with regard to disease state models, we have some data regarding the effect of Paeoniflorin on periodontitis, which is an inflammatory condition that causes shrinking of the gums and bone loss in the teeth. In periodontic subjects supplementing with Paeoniflorin, alveolar bone loss and soft tissue destruction were significantly prevented and the compound exhibited anti-inflammatory and immunoregulatory effects.<\/p>\r\n
Finally, as a bonus point, we’ve got a cool interaction with Heat Shock Proteins (HSPs). When the body undergoes heat stress (like during exercise), the muscle cells have to control potential damage with HSPs. Often referred to as intracellular “chaperones”, they’re basically molecules that act as a clean up crew to facilitate protein transport, prevent mishaps during protein folding, and protect against protein denaturation. They have also been shown to improve insulin sensitivity, reduce oxidative stress, inhibit inflammatory pathways and enhance the metabolic characteristics of muscle cells.<\/p>\r\n
Anything that increases specific HSPs will likely speed up recovery and hypertrophy, and as you may have guessed by now, Paeoniflorin does just that. Scientists looked at the effect of Glycyrrhizin (the active component of licorice) and Paeoniflorin on HSPs. They found that Paeoniflorin was able to induce HSP expression and also enhance the function of the elevated HSPs, whereas Glycyrrhizin was only able to enhance their function.<\/p>\r\n
Hwanggeumchal Sorghum Extract<\/p>\r\n
Another Superstar of the formula, Sorghum refers to a genus of grasses, typically used in livestock feed. As you can probably assume by now, we didn’t just throw some grass clippings in this advanced formula. We have found a very specific extract of Sorghum that boasts some cool properties. HSE works, for our purposes, in a unique way that should synergize with the other ingredients in the formula.<\/p>\r\n
In addition to being an incredibly powerful BMP7 inducer, it also amplifies the GH\/IGF-1 pathway (mo’ muscle, mo’ muscle).<\/p>\r\n
Growth Hormone (GH) is a well-known regulator of bone growth. When GH is elevated, it triggers something called the Jak\/STAT pathway, which regulates IGF-1, a major player in bone and muscle growth. HSE has been shown to act almost exactly like GH in activating this Jak\/STAT pathway, which then increases the expression of GH related proteins, (one of which, STAT5b, triggers BMP7), the GH receptor itself, IGF-1, the IGF-1 receptor, and BMP7. The science nerds might have noticed something particularly intriguing about that. When we trigger more BMP7, we trigger more MSC differentiation towards osteoblasts, giving the (now also elevated by HSE) anabolic IGF-1 more beneficial places to exert its effects.<\/p>\r\n
And for the bonus round, HSE has been shown to reduce plasma total cholesterol and triglycerides when given to obese rats on a high fat diet.<\/p>\r\n
Houttuynia Cordata<\/p>\r\n
HC (I am NOT typing that over and over) is a flowering plant from China, studied for its positive effects on kidney fibrosis. As analyses progressed, it was found to be an extremely potent inducer of BMP7. As a side bonus, it was also found to increase expression of Adiponectin, which is released by adipocytes to help regulate insulin sensitivity, glucose levels, and control inflammatory cytokines.<\/p>\r\n
https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0254627212600326<\/p>\r\n
Quercetin Dihydrate<\/p>\r\n
Quercetin is a very common and useful component of most edible plants. It also turns out to not just increase expression of BMP2, but enhance BMP signaling overall. It also works as an extremely potent escort molecule to get zinc into cells.<\/p>\r\n
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5875037<\/p>\r\n
Boron Citrate<\/p>\r\n
Boron is added to the formula to enhance BMP2 expression, as well as reducing the urinary excretion of calcium and magnesium.<\/p>\r\n
https:\/\/pubmed.ncbi.nlm.nih.gov\/32676937<\/p>\r\n
Now that we’ve traveled through our BMP 2\/4\/7 ingredients (to activate SMAD 1\/5\/8) to trigger anabolism and muscle cell division\/differentiation, as well as stronger bones and joints, let's get to the juicy new additions. While finishing the research on the new MyoSynergy formula (coming soon) it occurred to me that, since Myostatin and the other catabolic signaling proteins converge and cause activation of SMAD2\/3 (again, not only very undesirable but competing for SMAD4 escort into the nucleus), we might as well pull the specialized ingredients over to BMP and make it unbeatable for effectiveness. So let’s hit it…<\/p>\r\n
We are going to include the first two sort of together, since that is how they were most studied.<\/p>\r\n
Astragalus Membranaceus-HPBCD Complex<\/p>\r\n
I have been using Astragalus in my formulas (see earlier version of MyoSynergy) for a while, and it has since become a popular ingredient. I always have, and likely always will, use a custom extraction to better be able to control the concentrated compounds. We are using a 50:1 ethanol extract to maximize potency.<\/p>\r\n
AM (combined with SM, see below) has an incredibly potent inhibitory effect on not only SMAD2\/3 phosphorylation, but seems to cripple their ability to complex with SMAD4.<\/p>\r\n
https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378874108002110<\/p>\r\n
https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/jgh.12490<\/p>\r\n
Salvia Miltiorrhiza<\/p>\r\n
If you’ve been following my work for a while, you will recognize this way back in the first version of DCP. In addition to the inhibition of SMAD2\/3, SM also acts as a potent DGAT inhibitor. The fatty acids stored in fat cells is in the form of Tri(acyl)Glycerides, which means 3 acyl esters attached to a glycerol backbone. This is the only way they are stored. DGAT (Diacylglycerol Acyl Transferase) pushed that third acyl group onto diglycerides allowing them to be restored. By blocking DGAT, we cause the fatty acids to remain in circulation longer, allowing extra time for them to be burned as fuel. Side bonus there.<\/p>\r\n
There are 2 main components to SM we are looking for, and luckily they have the same solubilities – which means we can use the same solvent to extract them – Tanshinones and Salvianolic acid.<\/p>\r\n
Oleuropein<\/p>\r\n
Extracted from Olive Leaves, I'm beginning to suspect that Oleuropein is one of the key players (along with Anthocyanins\/Cyanidins) in the health effects seen from the Mediterranean Diet. Oleuropein has a very, very potent effect inhibiting SMAD2 (the more potent of the two, between 2 and 3).<\/p>\r\n
https:\/\/www.mdpi.com\/2076-3921\/12\/6\/1140\/<\/p>\r\n
It, along with the other two also inhibit something called PAI-1. This gets messy, so be patient. Blood clotting is a complicated process, that is usually tightly controlled with multiple, redundant pathways – one being Plasminogen. Plasminogen helps to break up clots quickly, but also triggers release of PAI-1 (Plasminogen Activated Inhibitor) to make sure clotting doesn’t get out of hand. Now, several pathological states that I prefer not to cover for...reasons...can cause a hyperactivation of PAI-1, resulting in extreme and uncontrolled clotting by oversuppression of Plasminogen. Oleuropein acts as a PAI-1 inhibitor (yes, it inhibits an inhibitor), normalizing clotting functions.<\/p>\r\n
https:\/\/link.springer.com\/article\/10.1007\/s10549-020-06054-x\/<\/p>\r\n
Sinomenine<\/p>\r\n
Sinomenine is an alkaloid extracted from certain vines. It is also getting more expensive and harder to source.<\/p>\r\n
Sinomenine acts as a very potent substrate for the P-Glycoprotein efflux pump – one of the active hurdles to ingredient absorption. As ingredients try to enter the bloodstream, the P-gp pump dumps them back in to the gut for elimination. What a waste. By acting as substrate, it keeps the P-gp pump busy while the rest of the formula freely enters circulation.<\/p>\r\n
Interestingly, Sinomenine has also been found to alleviate peripheral diabetic neuropathy, CNS disorders, and some pain (oddly enough, when combined with Ligustrazine it is extremely effective at blunting acute, non-inflammatory pain).<\/p>\r\n
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7900506\/<\/p>\r\n
Things to Avoid\/Monitor When Taking BMP<\/p>\r\n
•Synthetic Vitamin E
The synthetic form of Vitamin E (dl-alpha-tocopherol) lowers gamma tocopherol, which potentially interferes with anabolic bone signaling. If you are taking Vitamin E for a medical reason, please consult with your doctor before cessation.<\/p>\r\n
•Nicotine
Nicotine has been shown to interfere with bone formation. The addition of mixed tocopherols to the BMP formula could help counteract this, but it would still be a good idea to limit use of nicotine while using this product to prevent negative interactions with the BMP signaling cascade.<\/p>\r\n
Things to stack with BMP.<\/p>\r\n
While certainly not necessary, these should provide a synergistic effect:<\/p>\r\n
•MyoSynergy Elite
•X-Factor
•Any anabolic\/androgenic steroid or prohormone that you’re currently taking<\/p>\r\n
So here we are. In conclusion, my BMP research was inspired by a passing thought, a flash of inspiration, and has become a labor of love, yielding an absolute powerhouse of a product. All natural, Hormone-Free, safe for women and natties, this new iteration of BMP is easily the most potent natural product for building muscle, bone, and strong joints available in supplement form.<\/p>\r\n
While nature wants to limit us within starkly defined physical parameters, a special breed of man (and woman) exists to break out of those limitations and become BEAST.<\/p>\r\n
EvoMuse: Inspire to Evolve.<\/p>\r\n
BMP > Body Modify: Phenotype<\/strong><\/span> \"Nature...uh...finds a way.\" ~ Ian Malcolm Dinosaurs. Massive eating machines. Strong. Savage. And Extinct.<\/p> Though we still don't know exactly what happened, generally we can zero in on a major factor. When you are a huge, muscled beast you require a LOT of resources just to maintain, not to mention grow. Remove or reduce the resources and suddenly that gigantic physique becomes a liability.<\/p> And what survived? What came to dominate next? Initially it was the scurrying, furry little mammals. Small, quick, and able to maintain on very little. Though again they started to trend massive, culminating with mammoths, giant cave bears, huge prehistoric rhinos, and saber-toothed cats - they eventually also disappeared.<\/p> By my speculation, Nature is pretty badass at controlling for efficiency, and has developed biological mechanisms to both grow and restrict that growth. The bigger you are, the more resources you consume - so let's put a governing mechanism on how big you can get.<\/p> In humans, and other mammals, we have multiple pathways to trigger growth. As well, we have multiple pathways to restrict, and even reverse, that same growth. Think of it like a biological Overton Window.<\/p> Quite a while back I was walking through downtown Columbus and watching the erection of some tallish buildings, the hardened steel structure resembling a skeleton - everything else built upon that. It got me thinking about the human body. Bone, once thought to be nothing but a stiff dead mineral structure, began to reveal itself as a dynamic organ system, sending and receiving signals from the environment and changing accordingly. Endocrine signals coming and going, making sure our bodies were dialed in to efficient survival. That is where my research began, and what I eventually found confirmed I was in the right place.<\/p> The TGF-b1 superfamily of signaling molecules expands as Transforming Growth Factor, and that is what most of this class does \u2013 Transforms. Stem cells or satellite cells into fully differentiated cells like Muscle, Bone and Adipose. Then can also transform into destructive type cells like osteoclasts, which leech calcium from bones and dump it into the bloodstream.<\/p> As well, Myostatin and the Activins function to limit, and sometimes reverse, tissue growth \u2013 reverting our beloved anabolism into catabolism. In some tissues, like the heart, this is essential to maintaining health by making sure the heart doesn\u2019t enlarge, but it certainly does frustrate our desire to be muscular beasts.<\/p> BMP, for the sake of our new groundbreaking formula, stands for Body Modify: Phenotype.<\/p> For the sake of the physiology it happens to be targeting, it stands for Bone Morphogenetic Protein. Thought initially to simply affect bone turnover, within the last 15 years or so it has been traced to be one of the major master control pathways that control other things - like muscle mass and joint health. There are quite a few BMPs, some of which we still know very little about, but for our updated formula you should be familiar with the 3 types.<\/p> BMP 2, 4, and 7<\/p> BMP2 plays a major role in bone and cartilage formation, as well as osteoblast differentiation. Differentiation is an important point here, as will be discussed below. BMP2 is the secondary, but no less important, target of this formula, with BMP7 being the primary target.<\/p> BMP4, while still important, is comparatively our lowest priority of the three for targeting muscle growth. Like the other BMPs it is involved in bone and cartilage development, although more specifically for teeth and limbs, as well as being a key player during embryonic development.<\/p> BMP7 is our priority target for muscle growth. It is a major player in osteoblast differentiation as well as the induction of SMAD 1\/5\/8 (see below).<\/p> Now, going back to MyoStatin since it is most familiar to most of you (you\u2019ve all seen the bulls and dogs with the deleted Myostatin gene and how huge and muscular they are), we also throw in Activins and Atrogin-1, the primary catabolic signals. These signals all seem to converge on SMADs.<\/p> SMADs are the molecules that actually communicate the signals deep into the nucleus to trigger our desirable (and undesirable) effects. SMAD 1\/5\/8, activated by BMP 2, 4, and 7, meet up with SMAD4, which is an escort molecule, to travel to the nucleus. Myostatin, and other catabolic proteins, activate SMAD2\/3 which ALSO require SMAD4, and thereby compete with SMAD 1\/5\/8 for dominance. While the SMADs activated by BMP 2, 4, and 7 usually dominate, the nature of the competition (and particular environment \u2013 like starvation and sleep) can sometimes give the checkered flag to SMAD2\/3.<\/p> So what do we have so far:<\/p> Kaempferol is a flavanol found in a variety of plants. The Hydroxypropyl-Beta-Cyclodextrin has been added to increase bioavailability due to poor water solubility. In the past Kaempferol has been shown to increase cellular energy expenditure and enhance thyroid function which has landed it a spot in several fat-burning formulas, however, it has been included in this formula for an entirely different reason.<\/p> Kaempferol appears to have quite a strong effect on bone anabolism, and has been called a \u201cpromising agent for the prevention or treatment of bone loss\u201d. A 2013 in vitro study demonstrated that Kaempferol enhanced the expression of chondrogenic marker genes, and greatly increased expression of BMP2. In addition to increasing BMP2, it has also been shown to increase the number of BMP2 receptors in animals. More BMP and more places to dock, that\u2019s a solid combo.<\/p> Kaempferol also potently activates our BMP7, leading to increased muscle (an important addition here is the prevention of fibrosis). Fibrosis (think scar tissue) is the process of converting healthy, functioning tissue into slabs of dysfunctional useless tissue. This is particularly insidious in organs like the kidneys and in the spongy tissue of the penis, causing major (and previously thought to be permanent) erectile dysfunction.<\/p> This was a controversial addition to the last version that had people asking questions. A component of seeds, nuts, and grains, PA can interfere with the absorption of some minerals. However, it has an astounding absorption-boosting property for Kaempferol (and Quercetin...see below) and was well worth the inclusion.<\/p> Salidroside is an extremely interesting glucoside found in Rhodiola Rosea, which boasts numerous studies demonstrating a wide range of health benefits. Two very recent studies looked at the effect of Salidroside on bone anabolism. In the first study, they found that Salidroside increased the mRNA level of genes controlling the BMP pathway. It elevated BMP2 and BMP7 as well as SMAD 1\/5\/8 (SMAD 6\/7 are the inhibitory ones we don\u2019t want to activate).<\/p> The second study, carried out by different researchers, confirmed the increased phosphorylation and expression of SMAD 1\/5\/8. Then to be sure this was mediated by BMP, they added in a BMP antagonist to block the signaling pathway. As suspected, this attenuated the effect, demonstrating that BMP was indeed the target of Salidroside.<\/p> For the new BMP formula, you might have noticed that we slightly reduced the dosage of Salidroside over the old version, finding that we can still get the same benefit with a lower dose and therefore allowing the addition of new ingredients while still making the formula just as cost-effective for the user.<\/p> Found in Cnidium monnieri and a few other plants, Osthole is classified as a coumarin. It has been used in supplement form for liver health, cognitive enhancement, and vasodilation. Research shows it can activate AMPK and ACC, regulate blood-glucose and GLUT4 activity, and decrease liver fat. One study even demonstrated that in mice a high dose of Osthole had an androgenic effect and boosted LH and testosterone levels.<\/p> All these things are nice, but what about BMP? Fear not, Osthole has been shown to activate Wnt\/beta-catenin signaling, increase BMP2 expression, and stimulate mesenchymal stem cell differentiation (MSC) to osteoblasts. Early phase differentiation involves BMP2, SMAD 1\/5\/8, RUNX2, and p38, whereas later phase differentiation involves ERK1\/2. Osthole has been shown to enhance both phases; it sticks around until the job is done.<\/p> Isolated from the fermented food Natto, LWE is an interesting compound with well-known anti-inflammatory and nootropic properties. More importantly, however, LWE has recently been shown to significantly elevate BMP7. LWE also favorably works the anabolic bone and muscle signaling pathway by activating something called the SERCA pump, which brings extracellular calcium back into the cell so it can be reused.<\/p> To determine the anabolic and\/or anti-catabolic ability of a compound, scientists will often use methods such as denervation (cutting off or inhibiting nerve supply to a muscle), or suspension of a muscle (making it weightless). These methods basically make the brain forget these muscles exist, so they tend to atrophy quite rapidly. In multiple studies, when comparing Ligustrazine supplementation to control groups, in which both groups had been subjected to either denervation or muscle suspension, the Ligustrazine groups lost significantly less muscle over controls, both short term (one week) and longer term (one month).<\/p> Ligustrazine has also been shown to selectively increase glucose uptake in muscle cells, protect against oxidative damage from high fat and high glucose, block vasoconstriction, and even upregulate mitochondrial biogenesis.<\/p> Ligustrazine has also been found, recently, to preserve intervertebral disc integrity and prevent breakdown.<\/p> Paeoniflorin is a compound isolated from any number of herbs. Working through multiple mechanisms, Paeoniflorin has a direct stimulatory effect on bone formation signaling. The current research on this compound has looked mainly at the potential beneficial effects in certain bone-related disease states, which we can use to make some reasonable assumptions in how it might behave in healthy individuals. Renal fibrosis involves the accumulation of excess fibrous material in the extracellular matrix of kidney cells.<\/p> Renal (kidney) fibrosis is the principal process underlying the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). In this condition, BMP7 expression and SMAD activation tends to become quite disrupted, and Paeoniflorin has been shown to normalize this signaling. This could very well translate to increased BMP7 expression in healthy individuals.<\/p> In Rheumatoid Arthritis (RA), the body attacks the joints through an inflammatory cascade, causing pain, joint swelling, bone erosion, and cartilage breakdown. Paeoniflorin supplementation has been shown to reverse or severely diminish all of these problems, largely through controlling the inflammatory factors prostaglandin E2, leukotriene B4, ROS, and cytokines IL-1B and TNF-a.<\/p> Again with regard to disease state models, we have some data regarding the effect of Paeoniflorin on periodontitis, which is an inflammatory condition that causes shrinking of the gums and bone loss in the teeth. In periodontic subjects supplementing with Paeoniflorin, alveolar bone loss and soft tissue destruction were significantly prevented and the compound exhibited anti-inflammatory and immunoregulatory effects.<\/p> Finally, as a bonus point, we\u2019ve got a cool interaction with Heat Shock Proteins (HSPs). When the body undergoes heat stress (like during exercise), the muscle cells have to control potential damage with HSPs. Often referred to as intracellular \u201cchaperones\u201d, they\u2019re basically molecules that act as a clean-up crew to facilitate protein transport, prevent mishaps during protein folding, and protect against protein denaturation. They have also been shown to improve insulin sensitivity, reduce oxidative stress, inhibit inflammatory pathways, and enhance the metabolic characteristics of muscle cells.<\/p> Anything that increases specific HSPs will likely speed up recovery and hypertrophy, and as you may have guessed by now, Paeoniflorin does just that. Scientists looked at the effect of Glycyrrhizin (the active component of licorice) and Paeoniflorin on HSPs. They found that Paeoniflorin was able to induce HSP expression and also enhance the function of the elevated HSPs, whereas Glycyrrhizin was only able to enhance their function.<\/p> Another Superstar of the formula, Sorghum refers to a genus of grasses, typically used in livestock feed. As you can probably assume by now, we didn\u2019t just throw some grass clippings in this advanced formula. We have found a very specific extract of Sorghum that boasts some cool properties. HSE works, for our purposes, in a unique way that should synergize with the other ingredients in the formula.<\/p> In addition to being an incredibly powerful BMP7 inducer, it also amplifies the GH\/IGF-1 pathway (mo\u2019 muscle, mo\u2019 muscle).<\/p> Growth Hormone (GH) is a well-known regulator of bone growth. When GH is elevated, it triggers something called the Jak\/STAT pathway, which regulates IGF-1, a major player in bone and muscle growth. HSE has been shown to act almost exactly like GH in activating this Jak\/STAT pathway, which then increases the expression of GH-related proteins, (one of which, STAT5b, triggers BMP7), the GH receptor itself, IGF-1, the IGF-1 receptor, and BMP7. The science nerds might have noticed something particularly intriguing about that. When we trigger more BMP7, we trigger more MSC differentiation towards osteoblasts, giving the (now also elevated by HSE) anabolic IGF-1 more beneficial places to exert its effects.<\/p> And for the bonus round, HSE has been shown to reduce plasma total cholesterol and triglycerides when given to obese rats on a high-fat diet.<\/p> HC (I am NOT typing that over and over) is a flowering plant from China, studied for its positive effects on kidney fibrosis. As analyses progressed, it was found to be an extremely potent inducer of BMP7. As a side bonus, it was also found to increase expression of Adiponectin, which is released by adipocytes to help regulate insulin sensitivity, glucose levels, and control inflammatory cytokines.<\/p> Quercetin is a very common and useful component of most edible plants. It also turns out to not just increase expression of BMP2, but enhance BMP signaling overall. It also works as an extremely potent escort molecule to get zinc into cells.<\/p> Boron is added to the formula to enhance BMP2 expression, as well as reducing the urinary excretion of calcium and magnesium.<\/p> While certainly not necessary, these should provide a synergistic effect:<\/p> So here we are. In conclusion, my BMP research was inspired by a passing thought, a flash of inspiration, and has become a labor of love, yielding an absolute powerhouse of a product. All natural, Hormone-Free, safe for women and natties, this new iteration of BMP is easily the most potent natural product for building muscle, bone, and strong joints available in supplement form.<\/p> While nature wants to limit us within starkly defined physical parameters, a special breed of man (and woman) exists to break out of those limitations and become BEAST. EvoMuse: Inspire to Evolve.<\/p>","gtin12":"744271399691","image":["https:\/\/siteimgs.com\/10017\/item\/bmp-twin_1694286662-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/33427\/evomuse-bmp-enhanced-formula-2-x-120-cap-btls.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"99.99","url":"https:\/\/www.dpsnutrition.net\/i\/33427\/evomuse-bmp-enhanced-formula-2-x-120-cap-btls.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"EvoMuse Brite Capsules - 180 Cap *New Formula","sku":"EM036","description":" BRITE | Adipocyte Conversion Formula<\/p>\r\n \"A cold, starving animal doesn't care about a 6-pack.\"<\/p>\r\n Perspective is a complex thing. From the perspective of an undisciplined modern human, life is surrounded by plenty and our worries can consist of trying to reach our most aesthetically pleasing selves. However, perspective for most of the creatures on the planet is harsh, difficult, and a never-ending quest for precious resources.<\/p>\r\n Heat is one of the most precious resources, as the universe contends with \"hot spots\" in its quest to finally attain perfect order and energy distribution – namely heat death.<\/p>\r\n Nature, on the other hand – if it can be separated from the Universe – seems obsessed with continuing bright hot spots of life, without caring about individuals. The mechanistic viewpoint of our bodies, which still reigns supreme, follows laws of thermodynamics and thus life and heat can almost be interchangeable.<\/p>\r\n As we have covered countless times, humans, in our dominant but highly artificial state, are an aberration from the general rules. Nature drives numerous animals into dormancy when resources become scarce and more energy would be spent finding calories (heat, fuel) than could be replenished. Hibernation is the name of the game for Winter. Hibernation must be prepared for, which is why hibernating animals begin gorging and getting fat during Fall. Those fat stores are our point of interest, as much of it is stored in specialized cells.<\/p>\r\n The key to thermogenesis is adrenergic signaling (meaning related to adrenaline and noradrenaline). While humans have come to rely more on B2 (and A2) signaling for active lipolysis resulting in ATP formation with increases in heat a secondary effect (to fuel activity), the animals that hibernate during cold weather rely on different receptors (B3, A1) to generate heat via thermogenesis to go along with a more passive release of adrenaline\/noradrenaline, since for the most part they aren't moving much.<\/p>\r\n Human B3 receptors have lost importance, which means the first step is to increase activity here…<\/p>\r\n …but before we do that, let's take a quick step back for all those who are new to this here do-si-do.<\/p>\r\n A full decade ago, Evolutionary Muse released a first-in-kind product designed to facilitate the browning of white fat. Aptly named BRITE™, it shares the same name as those adipocytes which are named for being BROWN-IN-WHITE cells – white adipocytes which behave like brown adipocytes. Brown adipocytes are metabolically active cells which use their fat stores to generate body heat...the life hack of all life hacks, if you will. But there was one glaring problem – modern living was all but making this phenomenon a thing of the past. No problem, we should just reject modernity and embrace tradition. Right?<\/p>\r\n Wrong.<\/p>\r\n Evolutionary Muse: Inspire to Evolve. (Translation: We take a pill for that now.)<\/p>\r\n DIFFERENCE BETWEEN WAT AND BAT<\/p>\r\n BAT works quite differently, if not opposite, to White Adipose Tissue (WAT). BAT is dense in mitochondria and considered a highly thermogenic fat cell, responsible for creating heat through a process called “non-shivering thermogenesis”. This process burns calories through a futile cycle of shuttling protons to the mitochondria to generate heat. WAT, however, is what we all think of when we hear the term “body fat”. It stores calories so they can be used later during periods of hunger or famine, and secretes various adipokines.<\/p>\r\n Even more recently, we have discovered another player in the adipocyte story – Brown-in-White cells, or “BRITE”. At a microscopic level, these cells display a color between brown and white, and behave in a similar thermogenic fashion to BAT cells. While we don’t know yet if reduced thermogenic activity is a cause or consequence of obesity, we do know that an increase in BAT and\/or brite cells improves glucose tolerance and insulin sensitivity.<\/p>\r\n Two distinct pathways exist towards increasing brite cells in adult humans, (1) triggering precursor cells into becoming brite cells, and (2) turning mature WAT cells into brite cells. We want to target these pathways directly so that we can increase the ratio of brite cells to WAT cells, allowing your body to constantly burn more calories. So, let’s dive into some of the known methods of brite cell creation and activation.<\/p>\r\n COLD THERAPY, B3 ADRENERGIC ACTIVATORS<\/p>\r\n Cold exposure triggers macrophages in BAT to produce catecholamines like norepinephrine. Norepinephrine agonizes b-adrenergic receptors on fat cells. Cold also activates beige cell development and function. The effect can be mimicked with B3 adrenergic activators, which also trigger PGC-1a and brite cell development. It can also be mimicked with TRPM, or cold-sensor activators.<\/p>\r\n IRISIN AND PGC-1 ALPHA<\/p>\r\n Exercise causes increased expression in muscle of PPARg coactivator 1-alpha (PGC-1a), which downstream results in a hormone\/myokine called irisin. This irisin contributes to a browning of WAT cells. So not only does exercise burn calories directly, but also secondarily through triggering the browning process with irisin. Fortunately, this is an exploitable angle independent of exercise by triggering the PPARg cascade.<\/p>\r\n PRDM16, BMP-7<\/p>\r\n Prdm16 is a transcriptional cofactor, substantially enriched in human BAT compared to adjacent WAT. It acts by binding to and modulating other factors like C\/EBPb, PPARy, PPARa, and the aforementioned PGC-1a. Knocking out Prdm16 negates the thermogenic effect of brown cells, and increases WAT. Considered a key driver of brown fat cell fate, this cofactor is quite important. Bone Morphogenetic Protein-7 (BMP-7) increases expression of Prdm16 in precursor cells, and is essential for brown fat development. BMP-7 is fortunately something we can target with supplementation.<\/p>\r\n ADENYLYL CYCLASE AND ALPHA-1 ADRENERGIC ACTIVATION<\/p>\r\n Adenylyl cyclase is an enzyme that catalyzes the conversion of ATP to cyclic AMP. We mentioned beta-adrenergic receptor agonism, but it turns out this is greatly enhanced with simultaneous adenylyl cyclase upregulation and alpha-1 activation. So, targeting adenylyl cyclase, alpha-1, and beta-adrenergic agonism together causes enhanced brite cell creation.<\/p>\r\n UCP1<\/p>\r\n BAT mitochondria respond to something called UCP1 (uncoupling protein 1) to burn fat and generate heat, while brite cells seem to express lower levels of UCP1. However, brite cells potentially burn fat independently of UCP1 signaling, and furthermore, with the proper triggers, brite fat can actually turn on high levels of UCP1. Multiple ingredients in the BRITE formula will encourage WAT cells to upregulate UCP1 levels. Some of you may be familiar with a somewhat popular drug in the bodybuilding community years ago called DNP (which actually has roots in the 1930s as a weight loss drug). DNP was meant to mimic activated UCP1, which drastically elevated thermogenesis. While extremely effective, unregulated uncoupling can (and did) cause hyperthermia and death. Fortunately, we now have effective ways of targeting UCP1 safely.<\/p>\r\n PHOSPHODIESTERASES<\/p>\r\n Phosphodiesterases (or PDEs from here on out) are a family of enzymes that catalyze the inactivity (and therefore homeostasis) of the cAMP and\/or cGMP systems. An example we should all be familiar with is PDE5, which reduces cGMP in the erectile tissues, suppressing erectile response. Viagra, Cialis, etc., all inhibit the PDE5 enzyme, which leads to accumulation of cGMP, relaxation of penile tissues, dilation of blood vessels and eventually an erection.<\/p>\r\n The cAMP and cGMP systems are tightly controlled by physiological signals in order to maximally preserve resources. The cAMP system, for example, is related to energy states using Adenosine as a backbone (think highly depleted ATP – Adenosine Triphosphate). Elevation of cAMP leads to lipolysis, the freeing of fatty acids for transport to metabolically active tissue for either conversion to ATP or, in our case, thermogenesis.<\/p>\r\n There are two members of the PDE family that are of interest to us. One is PDE3b, the enzyme form activated by insulin to suppress lipolysis, allowing for the opposite to occur (storage of fat\/carbs). By suppressing PDE3b, we preserve a state of lipolysis and fat continues to be \"burned\" even after eating. Inhibition of PDE3b also removes the barriers of induction of UCP1, which causes non-shivering thermogenesis (the use of fatty acids to generate heat).<\/p>\r\n The other member is a newer player, PDE4D. Working hand-in-hand with PDE3b inhibition, PDE4D inhibition amplifies adrenergic signaling, UCP1 expression, lipolysis, and amplification of thermogenesis – especially basal (baseline) levels which means the rate of lipolysis without additional stimulation. The higher the basal rate, the more fat burned\/heat generated.<\/p>\r\n At the end of this inhibition, we go back to that Adenylyl Cyclase (and in the case of cGMP, Guanylyl Cyclase) creating the energy usage and replenishment cycle.<\/p>\r\n INGREDIENTS AND FUNCTION<\/p>\r\n Butcher’s Broom 50:1 Extract<\/p>\r\n Butcher’s Broom is a herb also known as Ruscus aculeatus. It gets its name from the practice of butchers using it for its supposed antibacterial properties to clean their cutting boards. It has been used in traditional medicine for its vasoconstrictive and anti-inflammatory actions (reducing swelling, preventing hemorrhoids, etc.).<\/p>\r\n The plant contains a variety of saponins, which have been shown to activate alpha-1 adrenergic receptors and stimulate the release of norepinephrine. It also has a protective effect on capillaries, strengthens blood vessels, and helps maintain healthy circulation.<\/p>\r\n As discussed previously, this alpha-1 activation is important and has been shown to shift preadipocytes to beige cells as opposed to white adipose tissue. As well, recent research shows that when hibernating, animals’ thermosensitive mechanisms will detect ambient and body temperatures and, if falling under threshold, the SNS will release norepinephrine to activate BAT in order to maintain viable body temperatures.<\/p>\r\n Gypenosides (75%)<\/p>\r\n Gypenosides are saponins found in the jiaogulan plant. This ingredient targets both WAT and BAT. With it we get WAT browning and an increase in fat oxidation genes in both WAT and BAT. Obesogenic diet mice treated with Gypenosides had a significantly reduced bodyweight vs. control, with lower cholesterol and insulin resistance. Gypenosides potently activate AMPk, which is tied directly to the cGMP\/cAMP systems and sympathetic\/parasympathetic nervous systems (metabolic autopilots), and amplify the lipolytic\/thermogenic effects on brite cells.<\/p>\r\n Menthol Crystals<\/p>\r\n Aside from B3 adrenergic receptor activation, the other most important way to start the browning process of WAT browning, as previously discussed, is through cold exposure. By exposing the body to cold temperatures long-term, it activates the TRPM8 receptor, which triggers browning in order to more effectively use WAT to create body warmth.<\/p>\r\n TRPM8 activation also enhances the thermogenic function of brown adipocytes through UCP1 and the b-adrenergic pathway.<\/p>\r\n So Menthol mimics long-term cold exposure by activating the TRPM8 channel, which has been shown to induce WAT browning as well as an upregulation in BAT thermogenesis. This has been shown to increase core temperature, reduce body fat and improve glucose metabolism.<\/p>\r\n Vanillin<\/p>\r\n An ingredient used in fake vanilla extracts for baking, Vanillin (and its metabolite Vanillic Acid) are metabolic derivatives from Anthocyanins. In addition to favorably reducing the ratio of Firmicutes to Bacteroides, resulting in a favorable gut environment for fat loss, Vanillin potently induces both browning of white fat and expression of UCP1.<\/p>\r\n Vanillin also increases glucose uptake in muscle tissue as well as regulating redox imbalances and inflammation.<\/p>\r\n Black Pepper Extract (20% Piperine)<\/p>\r\n TRPV1 is a capsaicin and vanilloid receptor in the body that is responsible for detection and regulation of body temperature and pain. More recently this receptor has been identified as a major player in obesity and body fat regulation. Stimulation of TRPV1 has been shown to upregulate BAT and increase fat oxidation and energy expenditure. TRPA1 is a similar receptor that functions to recognize cold and pain. Piperine, as well as several other compounds in black pepper, have been shown to be TRPV1 and TRPA1 agonists, with an even greater efficacy than capsaicin.<\/p>\r\n Trans-Cinnamaldehyde<\/p>\r\n Trans-Cinnamaldehyde is a pungent compound from cinnamon or dried cassia bark. It has been shown to increase UCP1 in both WAT and BAT, inducing browning of WAT cells. It also activates the cold receptor TRPA1. Back to those rodents fed obesogenic diets, Trans-Cinnamaldehyde inhibited hypertrophy of adipose cells, decreased body fat (including visceral fat), decreased voluntary food intake, and improved insulin sensitivity.<\/p>\r\n Salvia Miltiorrhiza 20:1 (Ethanol Extract)<\/p>\r\n Salvia Miltiorrhiza is a fascinating plant containing potent compounds that inhibit an enzyme called DGAT (diacylglycerol acyltransferase). Salvia Miltiorrhiza is able to prevent the final step in esterifying lipids into the form that WAT need them in – namely triacylglycerides (triglycerides). This keeps the lipids circulating in the bloodstream to be picked up and used by peroxisomes and mitochondria, and thrown off as heat.<\/p>\r\n Salvia Miltiorrhiza also inhibits SMAD2\/3 expression (see the BMP writeup), which suppresses myostatin activity and preserves muscle mass.<\/p>\r\n Salvia Miltiorrhiza has a dramatic effect on mitochondrial function in brite cells, basically turbocharging their activity by amplifying UCP1 activity.<\/p>\r\n Rutaecarpine<\/p>\r\n Contained in large quantities in the evodia fruit, it was first thought the Evodiamine was the compound responsible for the increase in non-shivering thermogenesis. Evodiamine turned out to be a huge disappointment, because it turns out the Rutaecarpine was what we were looking for.<\/p>\r\n Potently activating both AMPk and PGC-1a, Rutaecarpine also very strongly increases thermogenesis as well as mitochondrial biogenesis in brite cells. The more mitochondria, the more uncoupling and thus more thermogenesis and more fat burned.<\/p>\r\n Rutaecarpine also inhibits adipogenesis and lipogenesis, preventing lipid accumulation in WAT. Remember lipids in WAT have to be removed through a process of lipolysis before they can be transferred to metabolically active tissue and organelles (peroxisomes, mitochondria). By preventing WAT from accumulating lipids as well as crippling the body’s ability to simply make more white fat cells, all while shutting the lipids into the metabolically active brown\/brite fat cells, the process of thermogenesis becomes more efficient.<\/p>\r\n Sesamol<\/p>\r\n Sesamol is a phenol derivative of sesame oil with antioxidant and anti-inflammatory properties. This is another ingredient in the formula with the aforementioned two-pronged attack. It downregulates adipogenic differentiation factors (C\/EBPa, PPARy, SREBP-1) and decreases fat accumulating enzymes like fatty acid synthase (FAS), while upregulating fat oxidizing enzymes like HSL, LPL and AMPk. In mice on an obesogenic diet, it decreased fat mass and adipocyte size in both WAT and BAT by increasing UCP1 and PCG-1a.<\/p>\r\n Borneol<\/p>\r\n Borneol is a very potent P-glycoprotein efflux pump inhibitor. While “distracting” the P-gp pump, the ingredients of BRITE are able to enter the body unhindered by this physiochemical saboteur. As an additional benefit, Borneol also activates the TRPM8 cold receptor.<\/p>\r\n Myricetin-Nicotinamide Crystalline Complex<\/p>\r\n The primary superstar of the new formula, Myricetin is an incredibly diverse and hugely potent ingredient.<\/p>\r\n Let’s do a quick functional run through.<\/p>\r\n GLP-1 agonist – GLP-1 agonists are all the rage for weight loss right now. GLP-1 stands for Glucagon-like Peptide 1. Initially targeted to reverse type 2 diabetes, GLP-1 agonists soon manifested an interesting secondary effect – massive and rapid fat loss. As research gains traction, several explanations are emerging. A potent appetite suppression pathway, GLP-1 appears to be extremely active in the brain, activating brain-specific AMPk (hypothalamus, etc.) and stimulating central activation of brown\/brite fat thermogenesis. They also are highly active in increasing muscle-specific glucose uptake, and are effective at improving cardiac function. GLP-1 agonists are inactivated by something called dipeptidyl peptidase-4 (DPP-4). Interestingly enough, Myricetin inhibits DPP-4, thus amplifying and prolonging its own effect.<\/p>\r\n Myricetin has also been shown to be incredibly potent at inducing brite cell conversion, activating non-shivering thermogenesis, and dramatically increasing mitochondrial biogenesis (formation of new mitochondria).<\/p>\r\n GSK3b – Touched on briefly in the TopMuscle writeup, Glycogen Synthase Kinase 3b functions to inhibit a ton of growth associated positive effects in the body. This includes muscle growth, glycogen formation, and most importantly, brown\/brite fat thermogenesis. In fact, its potency at shutting down non-shivering thermogenesis is stunning. As luck (or design) would have it, Myricetin is the most potent GSK3b inhibitor so far found in natural form, with an IC50 of 900 nanomoles – incredibly potent.<\/p>\r\n PDE3b – as mentioned elsewhere, in order for BAT\/BRITE thermogenesis to be maximized, both PDE3b and PDE4D need to be inhibited. As if Myricetin hasn’t already shown to be badass, it also inhibits PDE3b.<\/p>\r\n Myricetin sounds great – let’s toss that in. Well, being a flavonoid, Myricetin has one of the worst oral absorption profiles I’ve ever seen, at very low single digit %. Other absorption enhancing methods (cyclodextrin, etc.) also turned out to be disappointing. However, I worked out a crystallization process with Nicotinamide that yielded some absolutely gorgeous, and highly absorbable, crystals – enabling us to include this spectacular ingredient in the formula.<\/p>\r\n The best part? Nicotinamide is also a highly potent brown fat activating ingredient, by both amplifying adrenergic signaling at the B3 receptor and by triggering mitochondrial biogenesis, as well as increasing expression of PPARa and PGC-1a.<\/p>\r\n Fucoxanthin 40%<\/p>\r\n Fucoxanthin is a simple ingredient. It dramatically increases expression of UCP1, which should be clear by now.<\/p>\r\n Ginger-6 Specialized Extract (std for 6-Paradol, 6-Shogaol, 6-Gingerol)<\/p>\r\n Ginger is absolutely one of the most popular plants for digestion, soothing a dysfunctional stomach, and tossing back after sushi and wasabi. It is also popular for fat loss, though in previous usages sort of haphazardly tossed in. I’m sure you’ve also seen something called Grains of Paradise (6-Paradol) used in competing formulas, though with highly mixed, often disappointing results. Turns out, if you know the correct solvents to use and in what order, you can extract the 3 main “browning” compounds from Ginger in high concentrations.<\/p>\r\n 6-Paradol – As mentioned it has become a commonly used ingredient. Another compound used to increase WAT browning, 6-Paradol also increases expression of PCG-1a and UCP1, resulting in increased thermogenesis with measurable temperature increases in brite\/brown adipose. However, of the three it appears to be the weakest.<\/p>\r\n 6-Shogaol – The immediate precursor of 6-Paradol, 6-Shogaol shows extreme promise as a thermogenic and browning agent, both in mature and preadipocytes. Increasing expression of the usual suspects (PCG-1a, UCP1), 6-Shogaol also increases mitochondrial turnover and biogenesis, increases the binding energy of ligands in the essential B3 adrenoreceptors (amplified signaling), and provides for a dramatic upregulation of beige markers, indicating significant browning of WAT.<\/p>\r\n 6-Gingerol – Along with 6-Shogaol, the most dominant compound in ginger – and the most potent. Sharing functionality with 6-Shogaol (all pathways similarly, but more potently, activated), 6-Gingerol also inhibits lipogenesis. 6-Gingerol also shows an extremely potent ability to break the giant lipid droplet which characterizes WAT into smaller, multiple droplets – enabling the shift to classical brite characteristics more easily.<\/p>\r\n Humulus Japonicus Extract 50:1 (Water)<\/p>\r\n Humulus Japonicus Extract is a new and exciting addition to the formula. In addition to inducing browning of WAT, it exerts potent antioxidant effects and increases expression of both AMPk and UCP1, as well as being a decent PPAR-delta agonist. The difference in hibernating animals using more PPARa to provide mitochondrial substrate in the liver is that they generally spend the winter dormant, whereas humans have the added benefit of physical motion, thus adding PPAR-delta, which is dominant in skeletal muscle, to the mix.<\/p>\r\n Quercetin-Theobromine Crystalline Complex<\/p>\r\n An absolute thermonuclear addition to the new formula is an ingredient combination I’ve been trying to fit for years, and this is an incredibly fortuitous (that means lucky) addition. Though they are grown together into a crystalline complex, which mostly enhances absorption by several fold, we will take each ingredient separately.<\/p>\r\n Quercetin – The Big Q is an extremely common compound in most plants. In addition to acting as a potent zinc ionophore (escort molecule into the cells), it is quite the potent antioxidant. But let’s get to the good stuff…<\/p>\r\n A 2021 study showed Quercetin to do a whole host of things related to BAT\/brite activation. It increases expression of PGC-1a (necessary for brite conversion) and UCP1, reduces plasma cholesterol, increases expression of the elusive (in humans) B3 adrenoreceptor (which is a key in the whole package), and as well induces mitochondrial transcription factors. Best of all? It was also discovered to be a very potent PDE4D inhibitor (see the section on phosphodiesterases\/cAMP) and, less potently, a PDE3b inhibitor. Recall that both PDE3b inhibition and PDE4D inhibition are required for both browning and optimized non-shivering thermogenesis.<\/p>\r\n As a side note, Quercetin decreases Firmicutes (starts with F for Fatty) to Bacteroides ratio in the gut, thus leading to a leaner phenotype expression.<\/p>\r\n Now Quercetin, while relatively inexpensive, has horrible solubility in water and dismal oral absorption. The crystallization with Theobromine increases oral absorption substantially.<\/p>\r\n Theobromine – Starting where we left off with Quercetin, Theobromine is ALSO quite a potent PDE4D inhibitor, the combination pretty much providing everything we need to preserve SNS cAMP signaling and optimized thermogenesis. But wait...there’s more!<\/p>\r\n Theobromine is a major component of cocoa. It has been toyed with, mostly unsuccessfully, in fat burning formulas for decades. Knowing what we know now about mechanisms, it makes sense why it didn’t deliver as promised.<\/p>\r\n Theobromine increases non-shivering thermogenesis, increases expression of PGC-1a, UCP1, other brite specific markers (we won’t be delving into those here quite yet) as well as increasing transport molecules like CPT1, which escorts shortened fatty acids from peroxisomes into the mitochondria for further beta-oxidation (and in our case, uncoupling\/heat production rather than ATP yield). In addition, Theobromine activates both B3 adrenoreceptors and AMPk, with the end result being a backblast of thermogenesis. As well, Theobromine suppresses preadipocyte differentiation, lipogenesis, and extends the browning effect to sub-mature adipocytes.<\/p>\r\n Oleuropein 50%<\/p>\r\n Oleuropein, contained in the olive plant, appears to be one of the main compounds contributing to the healthiness of the Mediterranean Diet. A unique compound, Oleuropein both dramatically increases UCP1 expression, and increases adrenaline\/noradrenaline secretion (absolutely essential for any kind of lipolysis, and therefore thermogenesis). Adrenaline\/noradrenaline acts as a ligand at the B3 adrenoreceptor (which, if you have been following has had both quantity increased as well as binding increased and signal amplified), the end result being hyperactivation of non-shivering thermogenesis.<\/p>\r\n We mentioned BMP7 also being essential to brown\/brite thermogenesis. While we are using a 50% oleuropein extract here, the other polyphenols in Olive (the “other” 50%) have been demonstrated to increase expression of BMP7, thus completing the perfection of our formula.<\/p>\r\n CONCLUSION<\/p>\r\n As you can see, we have exhaustively targeted all of the known pathways of creating and activating brite cells in the body through either recruiting precursor cells or converting mature white cells. Regular supplementation should encourage fat loss and mimicking of a lean phenotype acutely, and even more so when taken chronically – as brite cells don’t immediately revert back to white adipose upon cessation of the product. BRITE is a long-term solution to an ongoing, serious problem plaguing modern society.<\/p>\r\n <\/p>\r\n BRITE | Adipocyte Conversion Formula<\/p>\r\n \"A cold, starving animal doesn't care about a 6-pack.\"<\/p>\r\n Perspective is a complex thing. From the perspective of an undisciplined modern human, life is surrounded by plenty and our worries can consist of trying to reach our most aesthetically pleasing selves. However, perspective for most of the creatures on the planet is harsh, difficult, and a never-ending quest for precious resources.<\/p>\r\n Heat is one of the most precious resources, as the universe contends with \"hot spots\" in its quest to finally attain perfect order and energy distribution – namely heat death.<\/p>\r\n Nature, on the other hand – if it can be separated from the Universe – seems obsessed with continuing bright hot spots of life, without caring about individuals. The mechanistic viewpoint of our bodies, which still reigns supreme, follows laws of thermodynamics and thus life and heat can almost be interchangeable.<\/p>\r\n As we have covered countless times, humans, in our dominant but highly artificial state, are an aberration from the general rules. Nature drives numerous animals into dormancy when resources become scarce and more energy would be spent finding calories (heat, fuel) than could be replenished. Hibernation is the name of the game for Winter. Hibernation must be prepared for, which is why hibernating animals begin gorging and getting fat during Fall. Those fat stores are our point of interest, as much of it is stored in specialized cells.<\/p>\r\n The key to thermogenesis is adrenergic signaling (meaning related to adrenaline and noradrenaline). While humans have come to rely more on B2 (and A2) signaling for active lipolysis resulting in ATP formation with increases in heat a secondary effect (to fuel activity), the animals that hibernate during cold weather rely on different receptors (B3, A1) to generate heat via thermogenesis to go along with a more passive release of adrenaline\/noradrenaline, since for the most part they aren't moving much.<\/p>\r\n Human B3 receptors have lost importance, which means the first step is to increase activity here…<\/p>\r\n …but before we do that, let's take a quick step back for all those who are new to this here do-si-do.<\/p>\r\n A full decade ago, Evolutionary Muse released a first-in-kind product designed to facilitate the browning of white fat. Aptly named BRITE™, it shares the same name as those adipocytes which are named for being BROWN-IN-WHITE cells – white adipocytes which behave like brown adipocytes. Brown adipocytes are metabolically active cells which use their fat stores to generate body heat...the life hack of all life hacks, if you will. But there was one glaring problem – modern living was all but making this phenomenon a thing of the past. No problem, we should just reject modernity and embrace tradition. Right?<\/p>\r\n Wrong.<\/p>\r\n Evolutionary Muse: Inspire to Evolve. (Translation: We take a pill for that now.)<\/p>\r\n DIFFERENCE BETWEEN WAT AND BAT<\/p>\r\n BAT works quite differently, if not opposite, to White Adipose Tissue (WAT). BAT is dense in mitochondria and considered a highly thermogenic fat cell, responsible for creating heat through a process called “non-shivering thermogenesis”. This process burns calories through a futile cycle of shuttling protons to the mitochondria to generate heat. WAT, however, is what we all think of when we hear the term “body fat”. It stores calories so they can be used later during periods of hunger or famine, and secretes various adipokines.<\/p>\r\n Even more recently, we have discovered another player in the adipocyte story – Brown-in-White cells, or “BRITE”. At a microscopic level, these cells display a color between brown and white, and behave in a similar thermogenic fashion to BAT cells. While we don’t know yet if reduced thermogenic activity is a cause or consequence of obesity, we do know that an increase in BAT and\/or brite cells improves glucose tolerance and insulin sensitivity.<\/p>\r\n Two distinct pathways exist towards increasing brite cells in adult humans, (1) triggering precursor cells into becoming brite cells, and (2) turning mature WAT cells into brite cells. We want to target these pathways directly so that we can increase the ratio of brite cells to WAT cells, allowing your body to constantly burn more calories. So, let’s dive into some of the known methods of brite cell creation and activation.<\/p>\r\n COLD THERAPY, B3 ADRENERGIC ACTIVATORS<\/p>\r\n Cold exposure triggers macrophages in BAT to produce catecholamines like norepinephrine. Norepinephrine agonizes b-adrenergic receptors on fat cells. Cold also activates beige cell development and function. The effect can be mimicked with B3 adrenergic activators, which also trigger PGC-1a and brite cell development. It can also be mimicked with TRPM, or cold-sensor activators.<\/p>\r\n IRISIN AND PGC-1 ALPHA<\/p>\r\n Exercise causes increased expression in muscle of PPARg coactivator 1-alpha (PGC-1a), which downstream results in a hormone\/myokine called irisin. This irisin contributes to a browning of WAT cells. So not only does exercise burn calories directly, but also secondarily through triggering the browning process with irisin. Fortunately, this is an exploitable angle independent of exercise by triggering the PPARg cascade.<\/p>\r\n PRDM16, BMP-7<\/p>\r\n Prdm16 is a transcriptional cofactor, substantially enriched in human BAT compared to adjacent WAT. It acts by binding to and modulating other factors like C\/EBPb, PPARy, PPARa, and the aforementioned PGC-1a. Knocking out Prdm16 negates the thermogenic effect of brown cells, and increases WAT. Considered a key driver of brown fat cell fate, this cofactor is quite important. Bone Morphogenetic Protein-7 (BMP-7) increases expression of Prdm16 in precursor cells, and is essential for brown fat development. BMP-7 is fortunately something we can target with supplementation.<\/p>\r\n ADENYLYL CYCLASE AND ALPHA-1 ADRENERGIC ACTIVATION<\/p>\r\n Adenylyl cyclase is an enzyme that catalyzes the conversion of ATP to cyclic AMP. We mentioned beta-adrenergic receptor agonism, but it turns out this is greatly enhanced with simultaneous adenylyl cyclase upregulation and alpha-1 activation. So, targeting adenylyl cyclase, alpha-1, and beta-adrenergic agonism together causes enhanced brite cell creation.<\/p>\r\n UCP1<\/p>\r\n BAT mitochondria respond to something called UCP1 (uncoupling protein 1) to burn fat and generate heat, while brite cells seem to express lower levels of UCP1. However, brite cells potentially burn fat independently of UCP1 signaling, and furthermore, with the proper triggers, brite fat can actually turn on high levels of UCP1. Multiple ingredients in the BRITE formula will encourage WAT cells to upregulate UCP1 levels. Some of you may be familiar with a somewhat popular drug in the bodybuilding community years ago called DNP (which actually has roots in the 1930s as a weight loss drug). DNP was meant to mimic activated UCP1, which drastically elevated thermogenesis. While extremely effective, unregulated uncoupling can (and did) cause hyperthermia and death. Fortunately, we now have effective ways of targeting UCP1 safely.<\/p>\r\n PHOSPHODIESTERASES<\/p>\r\n Phosphodiesterases (or PDEs from here on out) are a family of enzymes that catalyze the inactivity (and therefore homeostasis) of the cAMP and\/or cGMP systems. An example we should all be familiar with is PDE5, which reduces cGMP in the erectile tissues, suppressing erectile response. Viagra, Cialis, etc., all inhibit the PDE5 enzyme, which leads to accumulation of cGMP, relaxation of penile tissues, dilation of blood vessels and eventually an erection.<\/p>\r\n The cAMP and cGMP systems are tightly controlled by physiological signals in order to maximally preserve resources. The cAMP system, for example, is related to energy states using Adenosine as a backbone (think highly depleted ATP – Adenosine Triphosphate). Elevation of cAMP leads to lipolysis, the freeing of fatty acids for transport to metabolically active tissue for either conversion to ATP or, in our case, thermogenesis.<\/p>\r\n There are two members of the PDE family that are of interest to us. One is PDE3b, the enzyme form activated by insulin to suppress lipolysis, allowing for the opposite to occur (storage of fat\/carbs). By suppressing PDE3b, we preserve a state of lipolysis and fat continues to be \"burned\" even after eating. Inhibition of PDE3b also removes the barriers of induction of UCP1, which causes non-shivering thermogenesis (the use of fatty acids to generate heat).<\/p>\r\n The other member is a newer player, PDE4D. Working hand-in-hand with PDE3b inhibition, PDE4D inhibition amplifies adrenergic signaling, UCP1 expression, lipolysis, and amplification of thermogenesis – especially basal (baseline) levels which means the rate of lipolysis without additional stimulation. The higher the basal rate, the more fat burned\/heat generated.<\/p>\r\n At the end of this inhibition, we go back to that Adenylyl Cyclase (and in the case of cGMP, Guanylyl Cyclase) creating the energy usage and replenishment cycle.<\/p>\r\n INGREDIENTS AND FUNCTION<\/p>\r\n Butcher’s Broom 50:1 Extract<\/p>\r\n Butcher’s Broom is a herb also known as Ruscus aculeatus. It gets its name from the practice of butchers using it for its supposed antibacterial properties to clean their cutting boards. It has been used in traditional medicine for its vasoconstrictive and anti-inflammatory actions (reducing swelling, preventing hemorrhoids, etc.).<\/p>\r\n The plant contains a variety of saponins, which have been shown to activate alpha-1 adrenergic receptors and stimulate the release of norepinephrine. It also has a protective effect on capillaries, strengthens blood vessels, and helps maintain healthy circulation.<\/p>\r\n As discussed previously, this alpha-1 activation is important and has been shown to shift preadipocytes to beige cells as opposed to white adipose tissue. As well, recent research shows that when hibernating, animals’ thermosensitive mechanisms will detect ambient and body temperatures and, if falling under threshold, the SNS will release norepinephrine to activate BAT in order to maintain viable body temperatures.<\/p>\r\n Gypenosides (75%)<\/p>\r\n Gypenosides are saponins found in the jiaogulan plant. This ingredient targets both WAT and BAT. With it we get WAT browning and an increase in fat oxidation genes in both WAT and BAT. Obesogenic diet mice treated with Gypenosides had a significantly reduced bodyweight vs. control, with lower cholesterol and insulin resistance. Gypenosides potently activate AMPk, which is tied directly to the cGMP\/cAMP systems and sympathetic\/parasympathetic nervous systems (metabolic autopilots), and amplify the lipolytic\/thermogenic effects on brite cells.<\/p>\r\n Menthol Crystals<\/p>\r\n Aside from B3 adrenergic receptor activation, the other most important way to start the browning process of WAT browning, as previously discussed, is through cold exposure. By exposing the body to cold temperatures long-term, it activates the TRPM8 receptor, which triggers browning in order to more effectively use WAT to create body warmth.<\/p>\r\n TRPM8 activation also enhances the thermogenic function of brown adipocytes through UCP1 and the b-adrenergic pathway.<\/p>\r\n So Menthol mimics long-term cold exposure by activating the TRPM8 channel, which has been shown to induce WAT browning as well as an upregulation in BAT thermogenesis. This has been shown to increase core temperature, reduce body fat and improve glucose metabolism.<\/p>\r\n Vanillin<\/p>\r\n An ingredient used in fake vanilla extracts for baking, Vanillin (and its metabolite Vanillic Acid) are metabolic derivatives from Anthocyanins. In addition to favorably reducing the ratio of Firmicutes to Bacteroides, resulting in a favorable gut environment for fat loss, Vanillin potently induces both browning of white fat and expression of UCP1.<\/p>\r\n Vanillin also increases glucose uptake in muscle tissue as well as regulating redox imbalances and inflammation.<\/p>\r\n Black Pepper Extract (20% Piperine)<\/p>\r\n TRPV1 is a capsaicin and vanilloid receptor in the body that is responsible for detection and regulation of body temperature and pain. More recently this receptor has been identified as a major player in obesity and body fat regulation. Stimulation of TRPV1 has been shown to upregulate BAT and increase fat oxidation and energy expenditure. TRPA1 is a similar receptor that functions to recognize cold and pain. Piperine, as well as several other compounds in black pepper, have been shown to be TRPV1 and TRPA1 agonists, with an even greater efficacy than capsaicin.<\/p>\r\n Trans-Cinnamaldehyde<\/p>\r\n Trans-Cinnamaldehyde is a pungent compound from cinnamon or dried cassia bark. It has been shown to increase UCP1 in both WAT and BAT, inducing browning of WAT cells. It also activates the cold receptor TRPA1. Back to those rodents fed obesogenic diets, Trans-Cinnamaldehyde inhibited hypertrophy of adipose cells, decreased body fat (including visceral fat), decreased voluntary food intake, and improved insulin sensitivity.<\/p>\r\n Salvia Miltiorrhiza 20:1 (Ethanol Extract)<\/p>\r\n Salvia Miltiorrhiza is a fascinating plant containing potent compounds that inhibit an enzyme called DGAT (diacylglycerol acyltransferase). Salvia Miltiorrhiza is able to prevent the final step in esterifying lipids into the form that WAT need them in – namely triacylglycerides (triglycerides). This keeps the lipids circulating in the bloodstream to be picked up and used by peroxisomes and mitochondria, and thrown off as heat.<\/p>\r\n Salvia Miltiorrhiza also inhibits SMAD2\/3 expression (see the BMP writeup), which suppresses myostatin activity and preserves muscle mass.<\/p>\r\n Salvia Miltiorrhiza has a dramatic effect on mitochondrial function in brite cells, basically turbocharging their activity by amplifying UCP1 activity.<\/p>\r\n Rutaecarpine<\/p>\r\n Contained in large quantities in the evodia fruit, it was first thought the Evodiamine was the compound responsible for the increase in non-shivering thermogenesis. Evodiamine turned out to be a huge disappointment, because it turns out the Rutaecarpine was what we were looking for.<\/p>\r\n Potently activating both AMPk and PGC-1a, Rutaecarpine also very strongly increases thermogenesis as well as mitochondrial biogenesis in brite cells. The more mitochondria, the more uncoupling and thus more thermogenesis and more fat burned.<\/p>\r\n Rutaecarpine also inhibits adipogenesis and lipogenesis, preventing lipid accumulation in WAT. Remember lipids in WAT have to be removed through a process of lipolysis before they can be transferred to metabolically active tissue and organelles (peroxisomes, mitochondria). By preventing WAT from accumulating lipids as well as crippling the body’s ability to simply make more white fat cells, all while shutting the lipids into the metabolically active brown\/brite fat cells, the process of thermogenesis becomes more efficient.<\/p>\r\n Sesamol<\/p>\r\n Sesamol is a phenol derivative of sesame oil with antioxidant and anti-inflammatory properties. This is another ingredient in the formula with the aforementioned two-pronged attack. It downregulates adipogenic differentiation factors (C\/EBPa, PPARy, SREBP-1) and decreases fat accumulating enzymes like fatty acid synthase (FAS), while upregulating fat oxidizing enzymes like HSL, LPL and AMPk. In mice on an obesogenic diet, it decreased fat mass and adipocyte size in both WAT and BAT by increasing UCP1 and PCG-1a.<\/p>\r\n Borneol<\/p>\r\n Borneol is a very potent P-glycoprotein efflux pump inhibitor. While “distracting” the P-gp pump, the ingredients of BRITE are able to enter the body unhindered by this physiochemical saboteur. As an additional benefit, Borneol also activates the TRPM8 cold receptor.<\/p>\r\n Myricetin-Nicotinamide Crystalline Complex<\/p>\r\n The primary superstar of the new formula, Myricetin is an incredibly diverse and hugely potent ingredient.<\/p>\r\n Let’s do a quick functional run through.<\/p>\r\n GLP-1 agonist – GLP-1 agonists are all the rage for weight loss right now. GLP-1 stands for Glucagon-like Peptide 1. Initially targeted to reverse type 2 diabetes, GLP-1 agonists soon manifested an interesting secondary effect – massive and rapid fat loss. As research gains traction, several explanations are emerging. A potent appetite suppression pathway, GLP-1 appears to be extremely active in the brain, activating brain-specific AMPk (hypothalamus, etc.) and stimulating central activation of brown\/brite fat thermogenesis. They also are highly active in increasing muscle-specific glucose uptake, and are effective at improving cardiac function. GLP-1 agonists are inactivated by something called dipeptidyl peptidase-4 (DPP-4). Interestingly enough, Myricetin inhibits DPP-4, thus amplifying and prolonging its own effect.<\/p>\r\n Myricetin has also been shown to be incredibly potent at inducing brite cell conversion, activating non-shivering thermogenesis, and dramatically increasing mitochondrial biogenesis (formation of new mitochondria).<\/p>\r\n GSK3b – Touched on briefly in the TopMuscle writeup, Glycogen Synthase Kinase 3b functions to inhibit a ton of growth associated positive effects in the body. This includes muscle growth, glycogen formation, and most importantly, brown\/brite fat thermogenesis. In fact, its potency at shutting down non-shivering thermogenesis is stunning. As luck (or design) would have it, Myricetin is the most potent GSK3b inhibitor so far found in natural form, with an IC50 of 900 nanomoles – incredibly potent.<\/p>\r\n PDE3b – as mentioned elsewhere, in order for BAT\/BRITE thermogenesis to be maximized, both PDE3b and PDE4D need to be inhibited. As if Myricetin hasn’t already shown to be badass, it also inhibits PDE3b.<\/p>\r\n Myricetin sounds great – let’s toss that in. Well, being a flavonoid, Myricetin has one of the worst oral absorption profiles I’ve ever seen, at very low single digit %. Other absorption enhancing methods (cyclodextrin, etc.) also turned out to be disappointing. However, I worked out a crystallization process with Nicotinamide that yielded some absolutely gorgeous, and highly absorbable, crystals – enabling us to include this spectacular ingredient in the formula.<\/p>\r\n The best part? Nicotinamide is also a highly potent brown fat activating ingredient, by both amplifying adrenergic signaling at the B3 receptor and by triggering mitochondrial biogenesis, as well as increasing expression of PPARa and PGC-1a.<\/p>\r\n Fucoxanthin 40%<\/p>\r\n Fucoxanthin is a simple ingredient. It dramatically increases expression of UCP1, which should be clear by now.<\/p>\r\n Ginger-6 Specialized Extract (std for 6-Paradol, 6-Shogaol, 6-Gingerol)<\/p>\r\n Ginger is absolutely one of the most popular plants for digestion, soothing a dysfunctional stomach, and tossing back after sushi and wasabi. It is also popular for fat loss, though in previous usages sort of haphazardly tossed in. I’m sure you’ve also seen something called Grains of Paradise (6-Paradol) used in competing formulas, though with highly mixed, often disappointing results. Turns out, if you know the correct solvents to use and in what order, you can extract the 3 main “browning” compounds from Ginger in high concentrations.<\/p>\r\n 6-Paradol – As mentioned it has become a commonly used ingredient. Another compound used to increase WAT browning, 6-Paradol also increases expression of PCG-1a and UCP1, resulting in increased thermogenesis with measurable temperature increases in brite\/brown adipose. However, of the three it appears to be the weakest.<\/p>\r\n 6-Shogaol – The immediate precursor of 6-Paradol, 6-Shogaol shows extreme promise as a thermogenic and browning agent, both in mature and preadipocytes. Increasing expression of the usual suspects (PCG-1a, UCP1), 6-Shogaol also increases mitochondrial turnover and biogenesis, increases the binding energy of ligands in the essential B3 adrenoreceptors (amplified signaling), and provides for a dramatic upregulation of beige markers, indicating significant browning of WAT.<\/p>\r\n 6-Gingerol – Along with 6-Shogaol, the most dominant compound in ginger – and the most potent. Sharing functionality with 6-Shogaol (all pathways similarly, but more potently, activated), 6-Gingerol also inhibits lipogenesis. 6-Gingerol also shows an extremely potent ability to break the giant lipid droplet which characterizes WAT into smaller, multiple droplets – enabling the shift to classical brite characteristics more easily.<\/p>\r\n Humulus Japonicus Extract 50:1 (Water)<\/p>\r\n Humulus Japonicus Extract is a new and exciting addition to the formula. In addition to inducing browning of WAT, it exerts potent antioxidant effects and increases expression of both AMPk and UCP1, as well as being a decent PPAR-delta agonist. The difference in hibernating animals using more PPARa to provide mitochondrial substrate in the liver is that they generally spend the winter dormant, whereas humans have the added benefit of physical motion, thus adding PPAR-delta, which is dominant in skeletal muscle, to the mix.<\/p>\r\n Quercetin-Theobromine Crystalline Complex<\/p>\r\n An absolute thermonuclear addition to the new formula is an ingredient combination I’ve been trying to fit for years, and this is an incredibly fortuitous (that means lucky) addition. Though they are grown together into a crystalline complex, which mostly enhances absorption by several fold, we will take each ingredient separately.<\/p>\r\n Quercetin – The Big Q is an extremely common compound in most plants. In addition to acting as a potent zinc ionophore (escort molecule into the cells), it is quite the potent antioxidant. But let’s get to the good stuff…<\/p>\r\n A 2021 study showed Quercetin to do a whole host of things related to BAT\/brite activation. It increases expression of PGC-1a (necessary for brite conversion) and UCP1, reduces plasma cholesterol, increases expression of the elusive (in humans) B3 adrenoreceptor (which is a key in the whole package), and as well induces mitochondrial transcription factors. Best of all? It was also discovered to be a very potent PDE4D inhibitor (see the section on phosphodiesterases\/cAMP) and, less potently, a PDE3b inhibitor. Recall that both PDE3b inhibition and PDE4D inhibition are required for both browning and optimized non-shivering thermogenesis.<\/p>\r\n As a side note, Quercetin decreases Firmicutes (starts with F for Fatty) to Bacteroides ratio in the gut, thus leading to a leaner phenotype expression.<\/p>\r\n Now Quercetin, while relatively inexpensive, has horrible solubility in water and dismal oral absorption. The crystallization with Theobromine increases oral absorption substantially.<\/p>\r\n Theobromine – Starting where we left off with Quercetin, Theobromine is ALSO quite a potent PDE4D inhibitor, the combination pretty much providing everything we need to preserve SNS cAMP signaling and optimized thermogenesis. But wait...there’s more!<\/p>\r\n Theobromine is a major component of cocoa. It has been toyed with, mostly unsuccessfully, in fat burning formulas for decades. Knowing what we know now about mechanisms, it makes sense why it didn’t deliver as promised.<\/p>\r\n Theobromine increases non-shivering thermogenesis, increases expression of PGC-1a, UCP1, other brite specific markers (we won’t be delving into those here quite yet) as well as increasing transport molecules like CPT1, which escorts shortened fatty acids from peroxisomes into the mitochondria for further beta-oxidation (and in our case, uncoupling\/heat production rather than ATP yield). In addition, Theobromine activates both B3 adrenoreceptors and AMPk, with the end result being a backblast of thermogenesis. As well, Theobromine suppresses preadipocyte differentiation, lipogenesis, and extends the browning effect to sub-mature adipocytes.<\/p>\r\n Oleuropein 50%<\/p>\r\n Oleuropein, contained in the olive plant, appears to be one of the main compounds contributing to the healthiness of the Mediterranean Diet. A unique compound, Oleuropein both dramatically increases UCP1 expression, and increases adrenaline\/noradrenaline secretion (absolutely essential for any kind of lipolysis, and therefore thermogenesis). Adrenaline\/noradrenaline acts as a ligand at the B3 adrenoreceptor (which, if you have been following has had both quantity increased as well as binding increased and signal amplified), the end result being hyperactivation of non-shivering thermogenesis.<\/p>\r\n We mentioned BMP7 also being essential to brown\/brite thermogenesis. While we are using a 50% oleuropein extract here, the other polyphenols in Olive (the “other” 50%) have been demonstrated to increase expression of BMP7, thus completing the perfection of our formula.<\/p>\r\n CONCLUSION<\/p>\r\n As you can see, we have exhaustively targeted all of the known pathways of creating and activating brite cells in the body through either recruiting precursor cells or converting mature white cells. Regular supplementation should encourage fat loss and mimicking of a lean phenotype acutely, and even more so when taken chronically – as brite cells don’t immediately revert back to white adipose upon cessation of the product. BRITE is a long-term solution to an ongoing, serious problem plaguing modern society.<\/p>\r\n <\/p>\r\n The Cutting-Edge Cognitive Enhancer REMINDER: Daily use of 3-4 caps, rather than full 4 caps x2 is usually sufficient, making this a 2 month supply. Cost has risen dramatically for this product.<\/p> Clear Edge\u2122 is a highly potent creativity and intelligence support supplement that maximizes brain efficiency and interneuronal communication, enabling the user to effortlessly tap into a higher potential level. Clear Edge quickens thought response and reaction speed, allowing for faster access to memories and a quicker formation of new memories, i.e., learning. While boosting short-term memory via hippocampal activation and enhancing reward centers to make you associate learning and performance as a pleasant experience, Clear Edge also accelerates the transition from short-term memory to long-term memory, increasing informational recall. Clear Edge will help in verbal fluency and articulation, so whether your job is technical or more people-oriented you will find yourself always on top of your game.<\/p> Clear Edge\nNeuron Optimization Formula\n240 Capsules<\/p>","gtin13":"0737534363225","image":["https:\/\/siteimgs.com\/10017\/item\/img-5406_1711042194-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32799\/evomuse-clearedge-240-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"64.95","url":"https:\/\/www.dpsnutrition.net\/i\/32799\/evomuse-clearedge-240-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Evomuse Clear Edge Nootropic - 2 x 240 Cap Btls TWINPACK","sku":"EM2032","description":" Neuron Optimization Formula 240 Capsules<\/p> The Cutting-Edge Cognitive Enhancer<\/p> REMINDER: Daily use of 3-4 caps, rather than full 4 caps x2 is usually sufficient, making this a 2 month supply.<\/p> Cost has risen dramatically for this product.<\/p> Clear Edge\u2122 is a highly potent creativity and intelligence support supplement that maximizes brain efficiency and interneuronal communication, enabling the user to effortlessly tap into a higher potential level. Clear Edge quickens thought response and reaction speed, allowing for faster access to memories and a quicker formation of new memories, i.e., learning. While boosting short-term memory via hippocampal activation and enhancing reward centers to make you associate learning and performance as a pleasant experience, Clear Edge also accelerates the transition from short-term memory to long-term memory, increasing informational recall. Clear Edge will help in verbal fluency and articulation, so whether your job is technical or more people-oriented you will find yourself always on top of your game.<\/p> Clear Edge Neuron Optimization Formula 240 Capsules<\/p>","gtin13":"0737534363225","image":["https:\/\/siteimgs.com\/10017\/item\/clearedge-2_1711042214-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/33660\/evomuse-clearedge-240-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"119.99","url":"https:\/\/www.dpsnutrition.net\/i\/33660\/evomuse-clearedge-240-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"EvoMuse DCP Ultra - 180 Cap","sku":"EM051","description":" Epitome is a brand new, cutting-edge development in fat loss. It works in ways we've only previously been able to fantasize about. Epitome helps control appetite and accelerates fat burning by manipulation of the leptin pathway. By increasing leptin sensitivity and keeping leptin levels within normal range, the brain and body self-adjust to drive your physique where it should be: Lean. Leptin signals will tell your body that it's not hungry while at the same time telling your brain to burn that fat!<\/p> With the addition of Gypenosides we boost AMPk signals, literally causing the body to react as if you are smack dab in the middle of a heavy demanding workout, causing additional acceleration of fat loss. Epitome is exactly what it promises \u2014 the epitome of fat loss.<\/p> Epitome Fat Loss Amplifier 120 Capsules<\/p> Serving size: 2 caps<\/p> We have moved to a MUCH upgraded formula, while trying to keep the price close to the same. Upgrades are:<\/p> *Magnolol - potent Magnolia compound which suppresses Cortisol induced visceral fat accumulation (belly fat), inhibits aromatase, as well as inhibiting PTP-1b (same as BA)<\/p> *Semen Cassiae - is an ingredient that boosts lipolytic function. Working with the rest of the formula, SC accelerates release of fatty acids from fat cells to be burned, as well as boosting fat burning pathways.<\/p>","gtin12":"780742996846","image":["https:\/\/siteimgs.com\/10017\/item\/epitome-rendering-300dpi_1694551512-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/17988\/evomuse-epitome-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"38.99","url":"https:\/\/www.dpsnutrition.net\/i\/17988\/evomuse-epitome-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"EvoMuse Eviscerate Smolder - 180 ml","sku":"EM002","description":" A Kinder, Gentler Fat Loss Topical Where You Don't Have to Sacrifice Results The King of Fat Loss topicals now has a milder cousin. Slightly reduced capsaicin content makes it more bearable, while extra ingredients have been added to tighten up the skin. SMOLDER will produce rapid fat loss around the abdominal region and, especially for women, in the hip\/butt\/thigh region. Directions: Apply 3-4 pumps over entire ab area or other stubborn areas.<\/p> Ingredients: Water, Isopropyl Alcohol, Benzyl Alcohol, Cetearyl Isononanoate, Ceteareth-20, Cetearyl Alcohol, Glycerin, Ceteareth-12, Cetyl Palmitate, Triglyceride Complex, N-Methyl-2-Pyrrolidone, Raspberry Ketones, Yohimbine HCl, Theophylline, 18-B Glycyrrhetinic Acid, Caffeine Anhydrous, 50% Chlorogenic Acid Green Coffee Bean Extract, Aloe Extract, Bergenin, Ginger Extract, Cucumber Extract, Beta-Escin, Benzyl Nicotinate, Dandelion Extract, L-Carnitine, Elagic Acid 98%, Banaba Leaf Extract, Hydroxyethyl Acrylate \/ Sodium Acryloyldimethyl Taurate Copolymer, L-Menthol, Capsaicin 98%.<\/p>","gtin12":"700112961359","image":["https:\/\/siteimgs.com\/10017\/item\/smolder_1659796326-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/15644\/evomuse-eviscerate-smolder-5-oz.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"43.99","url":"https:\/\/www.dpsnutrition.net\/i\/15644\/evomuse-eviscerate-smolder-5-oz.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"EvoMuse Gut Health - 75 Cap","sku":"EM004","description":" Gut Health NOW HAS ADDITIONAL INGREDIENTS TO BOLSTER MUCOUS MEMBRANE BARRIER FUNCTION IN THE INTESTINES, PREVENTING PATHOGENIC BACTERIA FROM ENTERING THE BLOODSTREAM, AS WELL AS APPLE PEEL POLYPHENOL EXTRACT TO GREATLY REDUCE INFLAMMATION.<\/p> AS WELL, THE PROBIOTIC COUNT HAS BEEN DOUBLED TO 12 BILLION CFU PER CAPSULE.<\/p> Gut Health is the newly updated formula originally released in 2006. Representing the latest in probiotic technology, Gut Health contains a specialized force of complementary probiotic strains. Gut Health helps contribute to optimized nutrient absorption, protection against foodborne\/environmental pathogens, prevention of bowel irritation\/inflammation, support for a powerful immune system and reduction of GI stress caused by modern diet. Encased in Entericap technology, Gut Health provides the base of success in your health and fitness goals.<\/p> In an age where we view our body as our temple, we\u2018re constantly looking for ways to improve the function and capacity of our inner machine. All of the nutrients that we take in on a daily basis through food consumption are utilized by our body in different ways. However, far too often many of the intended benefits of those nutrients are never fully translated into improved health and vitality. Here\u2019s why\u2026<\/p> Our body\u2018s digestive tract is literally a microbial battlefield, and unless you have the right troops to lead into battle on a daily basis, you\u2018re going to continue to fight an uphill war. This is severely limiting your inner machines natural robust potential of nutrient absorption, nutrient delivery, and resilient immune function. Imagine a dietary probiotic supplement that can help provide those vital and essential troops on a daily basis leading to improved terminal and systemic functions of the natural digestive process.<\/p> EvoMuse is proud to present a newly updated formula of the original 2006 released product, Gut Health. The original probiotic product designed for the fitness enthusiast just got better!<\/p> Representing the latest in probiotic technology, Gut Health contains a specialized force of complementary probiotic strains that have been assembled to maximize and improve your overall health, fitness goals, and overall well-being.<\/p> The new and improved Gut Health contains 12 billion CFU each of the following synergistic and beneficial probiotic strains along with their evinced associated benefits: Bacillus Coagulens: has been shown to decrease abdominal pain and bloating that\u2018s associated with a high protein diet in the normal digestive process. Bacillus Subtilis: has been shown to stimulate and improve innate immune function improving overall systemic function. Lactobacillus Casei: has been shown to reduce lactose intolerance, enhance nutrient digestion and absorption, and reduce GI inflammatory factors. Streptococcus Thermophilae: has been shown to reduce GI inflammatory factors and have potent immunomodulatory and anticarcinogenic effects. Lactobacillus Plantarum: has been shown to promote protein absorption\/ utilization and reduce GI inflammatory factors.<\/p> Bifidobacterium Breve: has been shown to alleviate gas symptoms typical with high protein ingestion, reduce bloating, and have powerful immunomodulary effects. This is evinced by potent competitive exclusion properties of harmful bacteria such as E coli that can typically cause GI related distress and disease.<\/p> To ensure superior delivery of our product, we\u2018ve utilized our innovative entericap technology in Gut Health that will shuttle these super strains of good bacteria past the acidic environment of the stomach and introduce them directly into the intestinal system; where these strains will flourish, multiply, and ultimately boost our performance by leveling the microbial battlefield.<\/p> It\u2018s time to go to war with our \"Gut\u201d and fight back against inadequate nutrient uptake and compromised immune function. EvoMuse has carefully assembled a complete probiotic formulation that has been specifically designed to dramatically improve your fitness related goals, overall health, and vitality.<\/p> Let Gut Health Lead The Way! These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.<\/p> Directions: Take 2 Entericaps for 5 days, then 1 Entericap daily thereafter.<\/p>","gtin12":"752423448227","image":["https:\/\/siteimgs.com\/10017\/item\/guthealth_1618507609-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/15842\/evomuse-gut-health-75-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"24.95","url":"https:\/\/www.dpsnutrition.net\/i\/15842\/evomuse-gut-health-75-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"EvoMuse Gut Health - 2 x 75 Cap Btls TWINPACK","sku":"EM2004","description":" Gut Health NOW HAS ADDITIONAL INGREDIENTS TO BOLSTER MUCOUS MEMBRANE BARRIER FUNCTION IN THE INTESTINES, PREVENTING PATHOGENIC BACTERIA FROM ENTERING THE BLOODSTREAM, AS WELL AS APPLE PEEL POLYPHENOL EXTRACT TO GREATLY REDUCE INFLAMMATION.<\/p> AS WELL, THE PROBIOTIC COUNT HAS BEEN DOUBLED TO 12 BILLION CFU PER CAPSULE.<\/p> Gut Health is the newly updated formula originally released in 2006. Representing the latest in probiotic technology, Gut Health contains a specialized force of complementary probiotic strains. Gut Health helps contribute to optimized nutrient absorption, protection against foodborne\/environmental pathogens, prevention of bowel irritation\/inflammation, support for a powerful immune system and reduction of GI stress caused by modern diet. Encased in Entericap technology, Gut Health provides the base of success in your health and fitness goals.<\/p> In an age where we view our body as our temple, we\u2018re constantly looking for ways to improve the function and capacity of our inner machine. All of the nutrients that we take in on a daily basis through food consumption are utilized by our body in different ways. However, far too often many of the intended benefits of those nutrients are never fully translated into improved health and vitality. Here\u2018s why\u2026<\/p> Our body\u2018s digestive tract is literally a microbial battlefield, and unless you have the right troops to lead into battle on a daily basis, you\u2018re going to continue to fight an uphill war. This is severely limiting your inner machine's natural robust potential of nutrient absorption, nutrient delivery, and resilient immune function. Imagine a dietary probiotic supplement that can help provide those vital and essential troops on a daily basis leading to improved terminal and systemic functions of the natural digestive process.<\/p> EvoMuse is proud to present a newly updated formula of the original 2006 released product, Gut Health. The original probiotic product designed for the fitness enthusiast just got better!<\/p> Representing the latest in probiotic technology, Gut Health contains a specialized force of complementary probiotic strains that have been assembled to maximize and improve your overall health, fitness goals, and overall well-being.<\/p> Some of These Notable Improvements Include:<\/p> Bacillus Coagulens: has been shown to decrease abdominal pain and bloating that's associated with a high-protein diet in the normal digestive process. Bacillus Subtilis: has been shown to stimulate and improve innate immune function improving overall systemic function. Lactobacillus Casei: has been shown to reduce lactose intolerance, enhance nutrient digestion and absorption, and reduce GI inflammatory factors. Streptococcus Thermophilae: has been shown to reduce GI inflammatory factors and have potent immunomodulatory and anticarcinogenic effects. Lactobacillus Plantarum: has been shown to promote protein absorption\/utilization and reduce GI inflammatory factors.<\/p> Bifidobacterium Breve: has been shown to alleviate gas symptoms typical with high protein ingestion, reduce bloating, and have powerful immunomodulatory effects. This is evinced by potent competitive exclusion properties of harmful bacteria such as E. coli that can typically cause GI related distress and disease.<\/p> To ensure superior delivery of our product, we've utilized our innovative entericap technology in Gut Health that will shuttle these super strains of good bacteria past the acidic environment of the stomach and introduce them directly into the intestinal system; where these strains will flourish, multiply, and ultimately boost our performance by leveling the microbial battlefield.<\/p> It\u2018s time to go to war with our \"Gut\u201d and fight back against inadequate nutrient uptake and compromised immune function. EvoMuse has carefully assembled a complete probiotic formulation that has been specifically designed to dramatically improve your fitness related goals, overall health, and vitality.<\/p> Let Gut Health Lead The Way! These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.<\/p> Servings per bottle: 75<\/p> Take 2 Entericaps for 5 days, then 1 Entericap daily thereafter.<\/p>","gtin12":"752423448227","image":["https:\/\/siteimgs.com\/10017\/item\/gut-twin_1675725327-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32827\/evomuse-gut-health-75-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"46.96","url":"https:\/\/www.dpsnutrition.net\/i\/32827\/evomuse-gut-health-75-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"EvoMuse MyoSynergy - 180 Cap","sku":"EM037","description":" MyoSynergy is a brand new, unique formula designed to potently trigger multiple pathways of muscle building at the cellular level. In addition, it will also aid in preventing muscle breakdown, boosting strength levels, and encouraging mitochondrial biogenesis.<\/p> To better understand the inclusion of the specific ingredients in the formula, it is important to have a little bit of background on the ways the body upregulates muscle growth. We don't just grow or shrink unless we have the proper signals to do so. The primary growth signal, and the main anabolic focus of MyoSynergy, is the PI3K\/AKT\/mTOR pathway.<\/p> To trigger anabolism, the body primarily engages in the following sequence of events:<\/p> Insulin Like Growth Factor 1 (IGF1) activates Phosphoinositide 3-Kinase (PI3K), which activates Protein Kinase B (Akt), which then activates the Mechanistic Target of Rapamycin (MTOR, also known as the mammalian Target of Rapamycin). Considered the master regulator of protein synthesis in muscle, MTOR is the key player in this cascade.<\/p> IGF1>PI3K>Akt>MTOR<\/p> Although it was previously thought that Myostatin generated a cellular signal to kickstart muscle breakdown, it has now been shown to instead block the above anabolic pathway. So inhibition of myostatin allows for accelerated anabolism.<\/p> Now with this background out of the way, let's get into how MyoSynergy will favorably manipulate these pathways to greatly augment your ability to gain muscle!<\/p> While Astragalus Membranaceus (AM) has numerous potential benefits, here we are focused on a few specific ones, namely IGF1 boosting, Myostatin inhibition, glucose and insulin signaling, and exercise performance.<\/p> AM has been shown to upregulate IGF1 production, which, as noted above, kickstarts the entire anabolic cascade. Researchers later conducted a study to re-test this, and found that it did in fact increase IGF1 while also stimulating bone growth in rats, and suggested that AM 'may be helpful in stimulating growth in children with short stature', which it is actually used for in traditional Korean medicine. In fully-grown adults, IGF1 is no longer responsible for bone growth, as it shifts its focus to other duties like muscle growth. So, sorry, MyoSynergy will not make you taller, you'll just have to distract people with your bigger muscles.<\/p> As you recall from earlier, IGF1 activation is going to indirectly decrease Myostatin levels. In addition to that, another study showed that AM was able to reduce Myostatin more directly by inhibiting the NF-kappaB pathway.<\/p> Aside from boosting IGF1 to enhance anabolism, AM also appears to have a pronounced effect on the way the body handles glucose and insulin. In one study, when researchers tried to fatten rats up and give them diabetes, AM was able to ameliorate 'glucose toxicity', improve insulin sensitivity, and increase glucose uptake in the muscle cells. This boost in insulin sensitivity and increased muscle glycogen storage has been corroborated by other studies as well. Better skeletal muscle insulin sensitivity and more glucose uptake = bigger muscles. Nice.<\/p> AM has also been shown to enhance exercise performance by reducing the accumulation of metabolic waste products.<\/p> AKT. Now, I consider my customers to be pretty savvy. We should all be well aware of what the mTOR pathway is in relation to Muscle Protein Synthesis. The primary trigger of mTOR is several key amino acids, notable the Branched Chain (L-Leucine, especially). What is less well known is the AKT pathway. AKT works hand in hand with mTOR to increase muscle Hypertrophy as well as block atrophy, in particular, trigger an increase in fiber size.<\/p> Several compounds have been shown to increase AKT signaling at physiological doses, notably in the Angelica family. We are using a potent Angelica Sinensis extract.<\/p> For you older lifters (like myself) or those that will be combining MyoSynergy with BMP, recent research demonstrates synergy between BMP7 signaling and AKT signaling in hypertrophy. Notably, as we get older increases in BMP7 levels are counteracted by reduction in AKT signaling. The combination of BMP and MyoSynergy should therefore be essential inclusions in the older lifters arsenal.<\/p> Interesting side fact \u2013 MyoStatin dramatically reduces AKT signaling.<\/p> Shilajit is one of those mythical substances touted for centuries as a wonder, which was largely dismissed initially by modern science. A substance \u201csecreted\u201d at the base of the Himalayan Mountains, Shilajit is complex indeed. Almost serendipitously, Shilajit aids in muscle adaptation to demanding exercise as well as providing amazing anti-fatigue properties. Seems handy if you live in the mountains. Shilajit has also been indicated as a compound that assists in the absorption of other compounds.<\/p> (-)Epicatechin is an exciting ingredient with potential to stimulate muscle growth through multiple avenues. EvoMuse was the first product to include Epicatechin, specific for muscle growth, but that wasn\u2019t enough. Finding that the results in real world applications weren\u2019t mindblowing, some companies began jacking up dosage to ridiculous levels. Biding my time, and spending thousands of hours researching, it was determined that several road blocks were in the way. Most obvious was absorption. We will get into this as the writeup continues, as the solution lie in an innovative new approach designed exclusively by EvoMuse, with patents filed.<\/p> As we age, Myostatin increases while its inhibitors like follistatin and myogenin\/MyoD (the latter two are responsible for regulating muscle cell differentiation) tend to decrease. This sets the stage for increased muscle loss. (-)Epicatechin has been shown to reverse this, decreasing Myostatin and improving the follistatin\/myostatin ratio and increasing strength after only seven days of intake. As well, MyoStatin expression is one of the major limiting factors in muscle growth for people of all ages. Inhibition of MyoStatin by MyoSynergy should result in increased muscle growth rates for all users. As well, see below for Broccoli Sprout\/Myrosinase.<\/p> (-)Epicatechin has also been shown in multiple studies to increase muscle capillarity and biogenesis of mitochondria, which persists even with cessation of use. More blood flow and mitochondria paves the road to enhanced hypertrophic capability and improved performance. In addition, (-)epicatechin has recently been shown to favorably regulate the function of specific proteins in control of muscular contraction.<\/p> Nicotinamide aka Niacinamide is a potent water soluble amide form of B3. It forms a core compound that is absolutely essential in the body, A cofactor known as Nicotinamide Adenine Dinucleotide (in several forms including NADH, NADP). Malfunction has been implicated in aging and resultant malfunctioning of the body, including muscle weakness and wasting. Nicotinamide can be combined with Tryptophan to form these essential cofactors, or it can also be recycled through several pathways. NAD is crucial for proper function of the body.<\/p> Several studies involving muscle wasting and mitochondrial dysfunction identified NAD+ deficiency as the main culprit, and researchers were able to reverse these with proper supplementation. Unfortunately, like most critical nutrients, modern diets tend to be poor sources of most B vitamins.<\/p> Nicotinamide is included for the above reasons, as well as the fact that it is an incredible coformer in the structural formation of cocrystals and, in our case, my special tricrystal lattice.<\/p> Once in a while something comes along that looks so amazing on paper, and we just cannot get it to pan out. In TopMuscle, we used a topical delivery with decent results, but everyone really just wants a capsule they can swallow. Unfortunately, UA has such dismal chemical properties that oral dosing is worthless. By taking advantage of the painstaking process I worked out, we are able to make a layered crystalline lattice using Epicatechin\/Nicotinamide and Ursolic acid, which allows major doses of each ingredient to be absorbed. For functionality, I will use my previous section on UA:<\/p> UA is in the MyoSynergy formula based on its ability to further target two of the previously mentioned pathways, as well as a third pathway that will be a common theme with some of the upcoming ingredients (so pay attention).<\/p> For starters, UA favorably triggers that sweet, sweet IGF-1 pathway. Additionally, UA allows us to reduce the myostatin governor of muscle growth.<\/p> The third pathway involves something called irisin. Irisin is a myokine triggered by exercise, which favorably modulates several pathways involving inhibition of fat gain, adipocyte browning, and muscle growth. In a study involving 16 healthy males, adding UA to a resistance training protocol for 8 weeks resulted in significantly decreased body fat percentage, elevated IGF-1 and irisin, as well as boosting strength levels (all vs. placebo pill combined with resistance training).<\/p> In summary, combined research shows UA supports an increase in muscle fiber size, strength, exercise capacity, adipocyte browning, IGF-1, irisin, and protein synthesis. It also promotes a suppression of myostatin, inflammatory cytokines, and body fat accumulation.<\/p> Broccoli Sprout is a source of sulforaphane, which has numerous beneficial effects on general health, such as acting as a histone deacetylase inhibitor. It also acts as an antioxidant, and more specifically, modulates the redox environment in muscle cells to control exercise induced muscle damage.<\/p> The main reason for inclusion of Broccoli Sprout, however, is the interaction with Myostatin. A recent study in the journal Epigenetics showed that sulforaphane significantly suppresses Myostatin, while also suppressing the negative feedback inhibitors of the Myostatin pathway.<\/p> Broccoli Sprout Extract, which contains Sulphoraphane (above) also contains major amounts of its immediate precursor, glucoraphanin. By combining Broccoli Sprout with Brown Mustard, extracted specifically for the enzyme Myrosinase, we boost the conversion to Sulphoraphane and wind up with quite a potent dose. In addition, this process itself is dynamic, and results in a 4x increase in bioavailability.<\/p> You will recall one of my projects for the last couple of years has been absorption enhancement. As detailed in the BMP writeup, one of the biggest hurdles is called the p-Glycoprotein efflux pump. Efflux is a word that means the opposite of Influx. Quite simply, compounds trying to enter the bloodstream via intestinal cells are actively \u201cpumped\u201d back out again. Not helpful, and a huge waste. Borneol has a high affinity for the pGP pump. It busies this mechanism like that superstar student that would get the attention of the hall monitor while everyone else would sneak by. Not that I misbehaved in school\u2026.at all. You hear that mom? Anyway, Borneol inhibits that pGP pump, allowing everything else that might get tossed back out to absorb.<\/p> In summary, MyoSynergy is designed to potently upregulate the body's main anabolic signals, inhibit catabolic pathways, and promote increases in strength and exercise performance. This state of the art formula is the most potent inhibitor of MyoStatin available, and should allow you to Mack Truck your way through previous physiological limitations, adding more muscle than ever though possible. The specific combination and dosages of these novel ingredients should allow users to tap into a previously unattainable level of muscle growth.<\/p>","gtin12":"780742996839","image":["https:\/\/siteimgs.com\/10017\/item\/myosynergy-btl_1618506974-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/30829\/180-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"55.99","url":"https:\/\/www.dpsnutrition.net\/i\/30829\/180-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"EvoMuse Nerve Restore - 120 Cap","sku":"EM014","description":" Nothing is more frustrating than an impinged or injured nerve. Signal reduction triggers a whole landslide of negative effects: Weakness, pain, atrophy. After time, these side effects seem like they will last forever - and sometimes do...until now. Enter Nerve Restore. Nerve Restore is a nerve signal amplifier. In people with impingement or nerve injuries it will help alleviate discomfort, weakness, and muscular atrophy. The enhanced nerve amplitude and velocity, in healthy people as well, should result in increased strength and quicker reflexes\/coordination.<\/p> Back in 2013 I researched, formulated, and released a product way ahead of its time. Nerve Restore deals with the function, dysfunction, and optimization of Nerve Signals.<\/p> Originally targeting the normalization of nerve functions for those suffering from nerve impingement, from herniated discs and such, my research soon delved deeply into the mountain - but not deeply enough to awaken the Balrog of strength and size.<\/p> Since then the more \"popular\" research has caught up and they are actively looking for ways to thicken myelin (the insulation around nerves. Loss of insulation causes electrical \"diffusion\" and weaker signals), as well as seeing how we can strengthen the signals themselves.<\/p> Well, they are coming up behind me on a path I already blazed, so let's revisit and focus on the role of nerve signals in muscle growth, mind\/muscle connection, sympathetic\/parasympathetic functions, and reaction speed.<\/p> Where does it come from?<\/p> Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.<\/p> What does it do?<\/p> 4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.<\/p> Thermosensitivity is basically the sensory perception of temperature changes, which is often damaged in nerve dysfunction. 4-MC has been shown to promote reinnervation and normalization of thermosensitivity in neuropathy.<\/p> Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. Several studies have found a huge benefit and reversal of these symptoms with 4-MC administration. One study showed an increase in NGF of 140% over controls, multiple other studies have confirmed the de novo NGF synthesis capability of 4-MC while also demonstrating its ability to significantly increase myelination and nerve blood flow.<\/p> Several studies have given animal models a nerve toxin known as acrylamide monomer (ACR), and examined the potential protective effect of 4-MC. They found similar results as the previously mentioned studies, 4-MC was able to increase MNCV, NGF, and myelination, and researchers noted that it can \"accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically\".<\/p> Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF.<\/p> Where does it come from? Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties. What does it do?<\/p> Several studies have demonstrated salidroside's neuroprotective ability. Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function.<\/p> Where does it come from? Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function. What does it do? Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:<\/p> Where does it come from?<\/p> PEA (not to be confused with the other PEA, phenylethylamine) is a fatty acid amide (formed when a fatty acid combines with an amine). Most of its functions in the body involve the regulation of pain and inflammation.<\/p> What does it do?<\/p> By working through numerous angles to reduce pain and improve nerve signaling, PEA holds large promise. Quite a bit of published data has shown that PEA favorably modulates PPARa, PPARg, CB(1),TRPV1, TNFa, and the mast cells of the immune system to reduce pain, inflammation and discomfort in nerve injuries such as neuropathy, carpal tunnel syndrome and sciatic nerve crushes.<\/p> Where does it come from? COS is a combination of two different types of glucosamine derived from crustacean shells. What does it do?<\/p> Several studies have shown COS to have a positive outcome on improvement of nerve dysfunction. One recent study looking at peripheral nerve crush injuries published in the Journal of Microsurgery found that COS significantly improved muscle action potentials, number of regenerated nerve fibers and thickness of myelin sheaths, and even an increase in muscle size of the tibialis posterior (one of the calf muscles).<\/p> Other studies have shown COS to promote nerve regeneration and differentiation, functional recovery, and nerve cell adhesion.<\/p> Where does it come from? ABP is a polypeptide derived from the achyranthes plant found in China, Japan, Nepal, and India, known for its anti-inflammatory properties. What does it do? ABP has been shown repeatedly in research to enhance nerve regeneration and function in sciatic and common peroneal nerve injuries.<\/p> Where does it come from?<\/p> The Rg1 group of ginsenoside is a bioactive compound found primarily in the Chinese\/Korean Ginseng plant, selected for its specific nerve regeneration properties. The ginsenosides are considered the active compounds in ginseng.<\/p> What does it do?<\/p> Recent research has shown GRg1 can successfully promote nerve regeneration after nerve injuries. After an oxidative insult from administered hydrogen peroxide, GRg1 increases SOD, CAT and GSH with a concurrent reduction in MDA. It has also been shown to increase expression of NGF and BDNF through the PKA pathway in Schwann cells.<\/p> Where does it come from? P5P is the active form of Vitamin B6 in the body, and is a crucial factor for a laundry list of functions in the body. What does it do?<\/p> The most recent research has shown that P5P improves clinical symptoms in carpal tunnel syndrome (a nerve related disorder), which means it likely has farther reaching effects on nerve dysfunction throughout the body.<\/p> Where does it come from? In Traditional Chinese Medicine (TCM), Dipsaci radix has been used to treat dysfunctions of the liver, kidney, tendons and bones. It comes from the plant Dipsacus asperoides. What does it do? After nerve injury, muscle atrophy tends to onset fairly quickly. Dipsaci helps improve muscle size and glycogen storage in tissues surrounding a nerve injury.<\/p> Where does it come from? Also from TCM, Radix Hedysari is an herbal preparation used for nerve regeneration. What does it do? Radix Hedysari has been shown to be effective at improving peripheral nerve regeneration, MNCV, nerve fiber and axon diameter, number of nerve fibers, and amplification ratio.<\/p> Where does it come from? Lion's Mane Mushroom extract is an edible mushroom found in North America, Europe and Asia. What does it do?<\/p> Lion's Mane is considered a neurotrophic agent, as it has been shown in multiple studies to induce NGF synthesis. Two studies have also shown oral administration of Lion's Mane to regenerate injured peroneal nerves in rats. Finally, it has been shown to directly regulate myelin genesis in vitro.<\/p> Where does it come from? Exactly what it sounds like, this compound widely used in TCM is an extract from earthworms. What does it do? Two recent studies have demonstrated Earthworm Extract's ability to increase nerve cell regeneration through Schwann cell activity, stimulating myelination.<\/p> Conclusion<\/p> Oftentimes, nerve injuries take a massive toll on us mentally and physically. We watch, helpless, as our hard-earned size and strength gains falter and fade away. After many months of research, Evolutionary Muse offers a potential solution. While your physician or therapist should guide you along the road to recovery, and your trainer can advise you how to best prevent future injuries, EvoMuse has brought to you a product that will jumpstart the processes of recovery and help restore, and optimize, nerve function.<\/p> Nerve Restore...fire away.<\/p>","gtin12":"737534363218","image":["https:\/\/siteimgs.com\/10017\/item\/img-7263b_1674073057-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32759\/evomuse-nerve-restore.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"47.99","url":"https:\/\/www.dpsnutrition.net\/i\/32759\/evomuse-nerve-restore.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"EvoMuse Nerve Restore - 2 x 120 Cap Btls TWINPACK","sku":"EM2014","description":" Nothing is more frustrating than an impinged or injured nerve. Signal reduction triggers a whole landslide of negative effects: Weakness, pain, atrophy. After time, these side effects seem like they will last forever - and sometimes do...until now. Enter Nerve Restore. Nerve Restore is a nerve signal amplifier. In people with impingement or nerve injuries it will help alleviate discomfort, weakness, and muscular atrophy. The enhanced nerve amplitude and velocity, in healthy people as well, should result in increased strength and quicker reflexes\/coordination.<\/p> Back in 2013 I researched, formulated, and released a product way ahead of its time. Nerve Restore deals with the function, dysfunction, and optimization of Nerve Signals.<\/p> Originally targeting the normalization of nerve functions for those suffering from nerve impingement, from herniated discs and such, my research soon delved deeply into the mountain - but not deeply enough to awaken the Balrog of strength and size.<\/p> Since then the more \"popular\" research has caught up and they are actively looking for ways to thicken myelin (the insulation around nerves. Loss of insulation causes electrical \"diffusion\" and weaker signals), as well as seeing how we can strengthen the signals themselves. Well, they are coming up behind me on a path I already blazed, so let's revisit and focus on the role of nerve signals in muscle growth, mind\/muscle connection, sympathetic\/parasympathetic functions, and reaction speed.<\/p> Nerve Growth Factor (NGF)- A signaling protein crucial for growth, upkeep, and survival of nerves.<\/p> Brain Derived Neurotrophic Factor (BDNF)- A neurotrophin active in the brain and periphery, aiding in growth, survival and differentiation of neurons and synapses, and a key player in long term memory.<\/p> Neurotrophins- An umbrella of NGFs including BDNF, NT-3 and NT-4\/5 Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve. Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system. Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon. Protein Kinase C (PKC)- A family of enzymes that control the function of other proteins through the act of phosphorylation. Schwann Cells- Cells that provide raw materials for myelination<\/p> Where does it come from? Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.<\/p> What does it do? 4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.<\/p> Where does it come from? Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties.<\/p> What does it do? Several studies have demonstrated salidroside's neuroprotective ability (10\u201313). Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function (14).<\/p> Where does it come from? Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function. What does it do? Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:<\/p> Where does it come from? PEA (not to be confused with the other PEA, phenylethylamine) is a fatty acid amide (formed when a fatty acid combines with an amine). Most of its functions in the body involve the regulation of pain and inflammation.<\/p> What does it do? By working through numerous angles to reduce pain and improve nerve signaling, PEA holds large promise. Quite a bit of published data has shown that PEA favorably modulates PPARa, PPARg, CB(1), TRPV1, TNFa, and the mast cells of the immune system to reduce pain, inflammation and discomfort in nerve injuries such as neuropathy, carpal tunnel syndrome and sciatic nerve crushes (21\u201325).<\/p> Where does it come from? COS is a combination of two different types of glucosamine derived from crustacean shells.<\/p> What does it do? Several studies have shown COS to have a positive outcome on improvement of nerve dysfunction. One recent study looking at peripheral nerve crush injuries published in the Journal of Microsurgery found that COS significantly improved muscle action potentials, number of regenerated nerve fibers and thickness of myelin sheaths, and even an increase in muscle size of the tibialis posterior (one of the calf muscles) (26).<\/p> Other studies have shown COS to promote nerve regeneration and differentiation, functional recovery, and nerve cell adhesion (27,28).<\/p> Where does it come from? ABP is a polypeptide derived from the achyranthes plant found in China, Japan, Nepal, and India, known for its anti-inflammatory properties. What does it do? ABP has been shown repeatedly in research to enhance nerve regeneration and function in sciatic and common peroneal nerve injuries (29\u201331).<\/p> Also of interest, ABP has central as well as peripheral nerve preservation and restoration effects, shown in the Journal of Neuroscience Research to counteract the effect of overstimulated NMDA receptors in the brain by reversing intracellular ROS and mitochondrial damage to the hippocampus (32).<\/p> Where does it come from? The Rg1 group of ginsenoside is a bioactive compound found primarily in the Chinese\/Korean Ginesing plant, selected for its specific nerve regeneration properties. The ginsenosides are considered the active compounds in ginesing.<\/p> What does it do? Recent research has shown GRg1 can successfully promote nerve regeneration after nerve injuries (33\u201335). After an oxidative insult from administered hydrogen peroxide, GRg1 increases SOD, CAT and GSH with a concurrent reduction in MDA (34). It has also been shown to increase expression of NGF and BDNF through the PKA pathway in Schwann cells (35).<\/p> Where does it come from? P5P is the active form of Vitamin B6 in the body, and is a crucial factor for a laundry list of functions in the body.<\/p> What does it do? The most recent research has shown that P5P improves clinical symptoms in carpal tunnel syndrome (a nerve related disorder), which means it likely has farther reaching effects on nerve dysfunction throughout the body (36).<\/p> Where does it come from? In Traditional Chinese Medicine (TCM), Dipsaci radix has been used to treat dysfunctions of the liver, kidney, tendons and bones. It comes from the plant Dipsacus asperoides. What does it do? After nerve injury, muscle atrophy tends to onset fairly quickly. Dipsaci helps improve muscle size and glycogen storage in tissues surrounding a nerve injury (37).<\/p> Where does it come from? Also from TCM, Radix Hedysari is an herbal preparation used for nerve regeneration.<\/p> What does it do? Radix Hedysari has been shown to be effective at improving peripheral nerve regeneration, MNCV, nerve fiber and axon diameter, number of nerve fibers, and amplification ratio (38\u201340).<\/p> Where does it come from? Lion's Mane Mushroom extract is an edible mushroom found in North America, Europe and Asia.<\/p> What does it do? Lion's Mane is considered a neurotrophic agent, as it has been shown in multiple studies to induce NGF synthesis (41,42). Two studies have also shown oral administration of Lion's Mane to regenerate injured peroneal nerves in rats (43,44). Finally, it has been shown to directly regulate myelin genesis in vitro (45).<\/p> Where does it come from? Exactly what it sounds like, this compound widely used in TCM is an extract from earthworms. What does it do? Two recent studies have demonstrated Earthworm Extract's ability to increase nerve cell regeneration through Schwann cell activity, stimulating myelination (46,47).<\/p> Oftentimes, nerve injuries take a massive toll on us mentally and physically. We watch, helpless, as our hard-earned size and strength gains falter and fade away. After many months of research, Evolutionary Muse offers a potential solution. While your physician or therapist should guide you along the road to recovery, and your trainer can advise you how to best prevent future injuries, EvoMuse has brought to you a product that will jumpstart the processes of recovery and help restore, and optimize, nerve function.<\/p> Nerve Restore...fire away.<\/p>","gtin12":"737534363218","image":["https:\/\/siteimgs.com\/10017\/item\/nerve-restore-twinb_1674073122-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32760\/evomuse-nerve-restore.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"79.99","url":"https:\/\/www.dpsnutrition.net\/i\/32760\/evomuse-nerve-restore.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"EvoMuse Slintensity - 90 Cap *New Updated Formula","sku":"EM021","description":" \u201cIt\u2019s a Tiger!! TIGER!!!!\u201d<\/p> Chef had the right idea when he ran and said \u201cNever get out of the boat\u201d. A hungry Tiger is the ultimate Apex Predator. Lean, fully muscled, and powerful. So beyond the obvious of genetics and species, how does an apex predator like a tiger build, maintain, and even increase his muscle and power?<\/p> One of the main secrets is what happens when the hunt is successful. The Feast.<\/p> Hunting, at least from an animal perspective, is one of the most demanding things you can engage in. Since nature didn\u2019t see fit to equip a tiger with a bright orange vest and scoped .30-06, it uses what it DOES have. Stealth and powerful muscle.<\/p> When a kill occurs, the tiger is driven uncontrollably to gorge on flesh and blood until it is satiated. That feast not only trigger its body to rebuild the muscle that was damaged during the hunt, but to build even more. To give it a boost up to the next level of efficient killing machine. Nature rewards success.<\/p> But alas, we are too successful for our own good, sometimes. A trip to the fridge or the drive-thru is hardly a triumph of raw primitive instict. Look around you and you will see what happens to those that gorge without putting in the work. But we? We are a different breed. We who battle gravity and sloth. We who suffer and scream our barbaric yawp surrounded by spandex (hey...HEY...don\u2019t get distracted) and iron, and who do so willingly because we understand the Machina of our bodies.<\/p> But the analogy works, somewhat. While we aren\u2019t pure carnivores, so pathways are different from a tiger \u2013 utilizing these things called Carbs as well as the pure-bloody proteins (unless you eat chicken, then cook that sh*t all the way) \u2013 to trigger adaptation, repair, and most importantly GROWTH.<\/p> POWER!!! UNLIMITED POWER!!! Take it easy, Palpatine...you actually have to work for this, you scabby flabby wrinkled old man. Anyway, let\u2019s get to this \u2013 I know you are anxious to hear about the exciting upgrade-redesign for Slintensity.<\/p> As mentioned at the beginning, the Tiger analogy breaks down a bit, since we are not pure carnivores. We bring a significant number of carbs into the game \u2013 or at least you should be if you\u2019re trying to maximize growth. Carbs tie in to insulin which, I\u2019m sure you\u2019ve heard, is an extremely anabolic hormone. But insulin is also something to be feared, as shuttling nutrients into our muscle also comes with the caveat of your hungry, hungry hippo...err, fat cells trying to greedily suck up nutrients as well. Here we use an inducible receptor \u2013 which means it isn\u2019t bound to the membrane necessarily but must be signaled to emerge from deep inside the cell out to the membrane to interact with, mostly, glucose. This receptor is called a GLUT4 receptor (side note, we will touch briefly on the GLUT1 receptor, also a glucose transporter, but we know a bit less about it)<\/p> GLUT4 \u2013 Berberine cause dramatic increases in expression of the GLUT4 transporter, and the effects seems to be dominant in muscle cells rather than fat cells.<\/p> By increasing GLUT4 activity in muscle cells, especially when timed after some glycogen depletion and a hearty carb intake post workout, we can stuff dem dere muscle cells right back up to full, creating an environment ripe for muscle growth. Remember, when the body is given ample nutrients, it interprets this as you are evolutionarily successful, and will be rewarded with \u201caccess\u201d to more resources (muscle, strength, stamina...and downstream from that \u2013 better choice of mates (giggity).<\/p> Berberine sounds amazing! Why not just load up? Well, grasshopper, berberine has some drawbacks. For one, it has absolutely dismal oral absorption. And if you try to make up for that by taking more, well make sure you stay close to a bathroom. Intestinal irritation comes with high doses. Instead what I have done is dialed in a Berberine-Nicotinamide (more in a second) Cocrystal. Recall that cocrystals can be formed by dissolving 2 or more compounds in a commonly effective solvent, applying some initial heat, and then allowing the solvent to evaporate. As the fluid volume decreases, our compounds are forced together where physics does its thing \u2013 and they form a crystalline lattice, which changes the physical properties such as solubility and absorption. In this case, the crystals are beautiful and very effective.<\/p> Berberine has also been shown to inhibit the Devil Incarnate of bodybuilding\u2026.MYOSTATIN (boo, boo, hiss). It also inhibits expression of SMAD 2\/3. See the BMP writeup, but SMAD 2\/3 are the bad ones for muscle building. Using Slintensity in conjunction with BMP will amplify the effects. Yes way.<\/p> Berberine also has the unfortunate property of increasing expression of Atrogin-1, a highly catabolic\/atrophic pathway. So while you are waiting like Christmas Eve for Santa to bring you muscle, Krampus shows up to undo it. So what did I do about that? Good questions<\/p> Puerarin comes from the a few plants, but luckily for your wallet it can be easily extracted from Kudzu. Anyone who has spent time in the South knows that Kudzu is in incredibly hearty INVASIVE species that grows insanely long and as yet has been laughing off attempts to control it. So come on, the more Slintensity you buy the more Kudzu we can eliminate. Do the right thing!<\/p> Anyway, Puerarin has a wonderful property here, namely inhibiting expression of Atrogin-1<\/p> Please, please hold your applause until the end because it doesn\u2019t end there. Puerarin also enhances GLUT4 translocation, increased PPAR-a expression and, to a lesser extent PPAR-gamma while also suppressing gluconeogenesis in the liver, while at the same time increasing fatty acid oxidation, and triggering mitochondrial biogenesis. Finally, Puerarin inhibits PTP-1b (see the Epitome writeup) leading to enhanced insulin sensitivity and vascular restoration.<\/p> Finally, additive to the Berberine, Puerarin inhibits the anti-anabolic SMAD2 pathway, while increasing several ROS scavenging pathways.<\/p> How could this possibly get any cooler? Because, based on an obscure study, I was able to posit the fact the Berberine and Puerarin were excellent candidates to join together into a single crystalline lattice \u2013 which proved to be just the case. Since Puerarin, along with Berberine, both have really low oral absorption separately, by combining them we deliver both ingredients in an efficient and effective form.<\/p> FMOC-L-Leucine is a very unique amino acid derivative. As a partial PPAR-gamma agonist, it does wonders for insulin sensitivity, while at the same time only weakly contributing to adipogenesis. This makes it far superior to other full PPAR-g agonists for keeping your muscle cells highly responsive to insulin.<\/p> 4OH is a really cool compound that I have been a fan of for 20 years. By potentiating insulin release per unit of glucose, 4OH allows for a bigger insulin spike, which speeds up the process of nutrient entry, before allowing insulin levels to fall back to baseline. Basically like hitting the nitrous for a quick burst, then shutting it down before engine damage occurs. In our approach to this new product, the Glucose Disposal angle needs to be hard and fast \u2013 contributing its part in mTORc1 activation- then backing off to watch from the sidelines as Muscle Protein Synthesis goes wild. More of a tactical nuke.<\/p> Piperine is included as a p-GP efflux pump inhibitor and absorption enhancer<\/p> Corosolic Acid? From Banaba? YAWN...I thought you were innovative. Well, hang on. In the previous version of Slintensity, we first address the role of the TGR5 Bile Acid receptor using Obacunone. Obacunone was co-extracted with Berberine from the Phellodendron Cortex plant. Unfortunately, as I moved on with my experiments using purified Berberine cocrystals, my engineers were unable to separate the two, which means Obacunone was no longer an option. Having moved through several other compound, each with steep absorption problems and an even steeper price tag, I wound up finding an obscure study comparing TGR5 activators. The most potent in the study was none other than Corosolic Acid. But, at much higher dosage than was being used. This took a ton of work to get made, and still isn\u2019t cheap, but fortunately CA has excellent absorption.<\/p> TGR5 \u2013 lets revisit our Tiger Analogy. Remember, without receptors and other sensors the body is blind and stupid. Nutrient sensors in particular signal to the body WHAT and HOW MUCH you are eating. There are carb and protein sensors, but what macronutrient is left behind? Yep\u2026.fat. One of the ways the body is able to digest fat is using bile acids. What does that have to do with our Tiger you might ask? Well, when a successful kill is made our tiger begins his feast \u2013 and it ain\u2019t frosted flakes he\u2019s eating. Flesh, blood, muscle \u2013 protein, and quite a bit of fat. Nature in it\u2019s brilliance uses a TGR5 receptor to detect the bile response to fatty acid intake, and with a strong enough signal, indicating a successful hunt, again Nature LOVES a winner. More resources, in this case again MUSCLE. The TGR5 receptor activation, especially when combined with or after strenuous exercise, triggers not only muscle protein synthesis leading to muscle hypertrophy, but actually causes new muscle cells to differentiate. This increases not only current size and strength, but increases the pool of muscle cells that we can grow.<\/p> So, corosolic acid. We needed a target range of 40-50mg for ideal activation of TGR5. Since the most common CA Banaba extract is 1%, there was no way to make it viable. That is why I used a 10%. I\u2019m working on an even more potent custom extraction for the future.<\/p> To wrap it up, the combination of post-workout protein and carbohydrate ingestion (the omnivore version of a post-kill feast) creates a highly anabolic environment with little to no drawback. By keeping muscle cells highly sensitized to insulin signaling, we can take advantage of that metabolic flux and replenish any glycogen used to fuel our workouts. Ingesting excess fat during this window has drawbacks, including slowing down absorption of those carbs and blunting the response, so by using purified Corosolic Acid as a TGR5 agonist, we enter a new realm where hyper response to nutrients can cause dramatic muscle gain.<\/p> Take 1 serving with post workout meal of at least 50 grams of protein and 100 grams of carbohydrates on workout days.<\/p> Serving size: 2 Capsules Berberine-Puerarin Cocrystals 400mg FMOC-L-Leucine 200mg 4-OH Isoleucine 100mg Banaba Extract (std for 10% Corosolic Acid) 425mg Piperine 8mg<\/p>","gtin12":"715786013877","image":["https:\/\/siteimgs.com\/10017\/item\/img-8185_1683817899-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/33035\/evomuse-slintensity-90-cap-new-updated-formula.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"39.99","url":"https:\/\/www.dpsnutrition.net\/i\/33035\/evomuse-slintensity-90-cap-new-updated-formula.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@context":"https:\/\/schema.org","@type":"WebSite","name":"DPS Nutrition","image":"https:\/\/siteimgs.com\/10017\/imgs\/04\/dpslogo_1595279419-0.jpg","url":"https:\/\/www.dpsnutrition.net\/","potentialAction":{"@type":"SearchAction","target":"https:\/\/www.dpsnutrition.net\/search?q={search_term_string}","query-input":"required name=search_term_string"},"sameAs":["https:\/\/www.facebook.com\/DPSNutrition","https:\/\/twitter.com\/DpsNutrition","https:\/\/instagram.com\/dpsnutrition"]},{"@context":"https:\/\/schema.org","@type":"Organization","url":"https:\/\/www.dpsnutrition.net\/","logo":"https:\/\/siteimgs.com\/10017\/imgs\/04\/dpslogo_1595279419-0.jpg","image":"https:\/\/siteimgs.com\/10017\/imgs\/04\/dpslogo_1595279419-0.jpg","name":"DPS Nutrition","legalName":"DPS Nutrition","telephone":"1-800-697-4969","address":{"@type":"PostalAddress","addressLocality":"Taylor","addressRegion":"PA","postalCode":"18517","streetAddress":"29 Stauffer Industrial Park"}}]}
Bone and Muscle Growth Stimulator<\/strong><\/span>
120 Capsules<\/strong><\/span><\/p>\r\n\r\n Cyclodextrin-Kaempferol Complex<\/strong><\/span><\/td>\r\n 100 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Cyclodextrin-Osthole Complex<\/strong><\/span><\/td>\r\n 100 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Rhodiola Rosea (8% Salidroside)<\/strong><\/span><\/td>\r\n 240 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Ligusticum Wallichii Extract (std for 98% Ligustrazine)<\/strong><\/span><\/td>\r\n 100 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Hwanggeumchal Sorghum 100:1<\/strong><\/span><\/td>\r\n 200 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Paeoniflorin<\/strong><\/span><\/td>\r\n 100 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Sinomenine<\/strong><\/span><\/td>\r\n 75 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Quercetin<\/strong><\/span><\/td>\r\n 200 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Phytic Acid\/IP6<\/strong><\/span><\/td>\r\n 250 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Houttuynia Cordata 20:1<\/strong><\/span><\/td>\r\n 75 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Boron Citrate<\/strong><\/span><\/td>\r\n 2 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Astragalus Membranaceus 50:1 Ethanol - HPBCD Complex<\/strong><\/span><\/td>\r\n 400 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Salvia Miltiorrhiza 20:1 Water Extract<\/strong><\/span><\/td>\r\n 200 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Olive Leaf Extract (50% Oleuropein)<\/strong><\/span><\/td>\r\n 150 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n \r\n Chitosan<\/strong><\/span><\/td>\r\n 50 mg<\/strong><\/span><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n BMP 2023 | Body Modify: Phenotype<\/h5>
BMP\/TGF-b1\/SMAD<\/h5>
BMP<\/h5>
BMP2<\/h6>
BMP4<\/h6>
BMP7<\/h6>
Kaempferol Cyclodextrin<\/h5>
Phytic Acid<\/h5>
Salidroside<\/h5>
Osthole Cyclodextrin<\/h5>
Ligusticum Wallichii Extract (98% ligustrazine)<\/h5>
Paeoniflorin<\/h5>
Hwanggeumchal Sorghum Extract<\/h5>
Houttuynia Cordata<\/h5>
Quercetin Dihydrate<\/h5>
Boron Citrate<\/h5>
Things to Avoid\/Monitor When Taking BMP<\/h5>
Things to stack with BMP.<\/h5>
<\/p>","gtin13":"0758381476494","image":["https:\/\/siteimgs.com\/10017\/item\/brite-rendering_1703084216-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/28735\/evomuse-brite-capsules-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"59.99","url":"https:\/\/www.dpsnutrition.net\/i\/28735\/evomuse-brite-capsules-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"EvoMuse Brite Capsules - 360 Cap (2 x 180 Cap Btls) TWINPACK *New Formula","sku":"EM2036","description":"
<\/p>","gtin13":"0758381476494","image":["https:\/\/siteimgs.com\/10017\/item\/2brite_1703091174-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/33659\/evomuse-brite-capsules-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"99.98","url":"https:\/\/www.dpsnutrition.net\/i\/33659\/evomuse-brite-capsules-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"Evomuse Clear Edge Nootropic - 240 Cap","sku":"EM032","description":"
Clear Edge\nNeuron Optimization Formula\n240 Capsules<\/h5>
Clear Edge<\/h5>
","image":["https:\/\/siteimgs.com\/10017\/item\/dcp_1655572491-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32043\/evomuse-dcp-ultra-180-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"56.99","url":"https:\/\/www.dpsnutrition.net\/i\/32043\/evomuse-dcp-ultra-180-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"EvoMuse DCP Ultra - 2 x 180 Cap TWINPACK","sku":"EM22051","image":["https:\/\/siteimgs.com\/10017\/item\/dcp-tw_1655572629-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/32125\/evomuse-dcp-ultra-180-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"99.99","url":"https:\/\/www.dpsnutrition.net\/i\/32125\/evomuse-dcp-ultra-180-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"EvoMuse Epitome - 120 Cap","sku":"EM023","description":"
The Epitome of Fat Loss<\/h5>
Quick update<\/h5>
Eviscerate SMOLDER<\/h5>
Some of These Notable Improvements Include:<\/h5>
The new and improved Gut Health contains 12 billion CFU each of the following synergistic and beneficial probiotic strains along with their evinced associated benefits:<\/h6>
Serving size: 1 Entericap*<\/h5>
Directions:<\/h5>
MyoSynergy<\/h5>
Anabolic\/Catabolic Signaling<\/h6>
Astragalus Membranaceus 20:1<\/h5>
Angelica Sinensis<\/h5>
Shilajit<\/h5>
(-)Epicatechin\/Nicotinamide\/Ursolic Acid Tricrystal<\/h5>
Nicotinamide<\/h5>
Ursolic Acid<\/h5>
Broccoli Sprout<\/h5>
Myrosinase\/Brown Mustard<\/h5>
Borneol<\/h5>
Nerve Restore<\/h5>
Ingredients and Function<\/h5>
4-Methylcatechol (4-MC)<\/h6>
Salidroside<\/h6>
Methylcobalamin<\/h6>
Palmitoylethanolamide (PEA)<\/h6>
Chitooligosaccharide (COS)<\/h6>
Achyranthes bidentata polypeptides (ABP)<\/h6>
Ginsenoside Rg1 (GRg1)<\/h6>
Pyridoxal-5-Phosphate (P5P)<\/h6>
Dipsaci radix (water extract)<\/h6>
Radix Hedysari<\/h6>
Lion's Mane mushroom extract 4:1 (Hericium erinaceus)<\/h6>
Earthworm extract (Dilong)<\/h6>
Nerve Restore<\/h5>
Key Terms to Know<\/h5>
Ingredients and Function<\/h5>
4-Methylcatechol (4-MC)<\/h6>
Salidroside<\/h6>
Methylcobalamin<\/h6>
Palmitoylethanolamide (PEA)<\/h6>
Chitooligosaccharide (COS)<\/h6>
Achyranthes bidentata polypeptides (ABP)<\/h6>
Ginsenoside Rg1 (GRg1)<\/h6>
Pyridoxal-5-Phosphate (P5P)<\/h6>
Dipsaci radix (water extract)<\/h6>
Radix Hedysari<\/h6>
Lion's Mane mushroom extract 4:1 (Hericium erinaceus)<\/h6>
Earthworm extract (Dilong)<\/h6>
Slintensity<\/h5>
CLEVER PATHWAY SUMMARY<\/h5>
Puerarin<\/h6>
FMOC-L-Leucine<\/h6>
4OH-Isoleucine<\/h6>
Piperine<\/h6>
TGR-5\/Corosolic Acid<\/h6>
Directions<\/h5>
Ingredients<\/h5>