Cissus Quadrangularis (std. for 2.5% ketosteroids):<\/strong> <\/span>Cissus quadrangularis has been used in traditional Eastern medicine for hundreds of years to treat many ailments such as obesity and even as a natural anabolic, but specifically what caught my attention was its use for accelerating bone fracture healing rates and pain relief properties. Cissus quadrangularis is loaded with antioxidants, ascorbic acid, calcium, carotene\/carotenoids, resveratrol and triterpinoids. Many studies show that the main healing bioactives in cissus quadrangularis were its ketosteroid content found in the stem: onocer -7-ene-3α, 21-β-diol and onocer -7-ene-3β, 21α-diol. However, newer research shows that it seems to be more of a cumulative effect from influencing early regeneration and faster uptake of minerals in bone cells. The ketosteroids still play a major part in healing, but it’s more like the “entourage effect.” A 2010 study showed a week faster healing period vs the placebo. This was attributed to the faster stimulation of fibroblasts(synthesizes collagen), chondroblasts(helps grow collagen) and bone cells. One study showed that collagen synthesis increased by 86%! I truly believe this is an extremely undervalued ingredient when it comes to joint and collagen supplementation. We used a whopping 750mg per serving!<\/p>\r\n
Pamlmitoylethanolamide:<\/strong> <\/span>Palmitoylethanolamide (PEA, a mouthful) is your body’s main naturally produced anti-inflammatory agent. PEA is one of many fatty acids that have the enthanolamide functional group attached to it. Its origins go back to an obscure study in the 1940s showing that PEA derived from purified egg yolks exhibited anti-inflammatory and anti-allergic properties. In 1964, it was first isolated in mammalian tissues and has over 350 studies since. PEA binds to the nuclear receptor, where it then elicits a variety of biological activities including fighting inflammation and pain. PEA has been extensively studied, including a 1970 study showing similar pain relief and joint improvement to aspirin. As far as managing pain and inflammation, PEA seems to have multiple mechanisms of action. One such mechanism is the inhibition pro-inflammatory compounds like TNF-alpha and histamine, as well as reducing cyclooxygenase-2(COX-2), which is how most over-the-counter NSAIDs(ibuprofen) work. In 1993, the Nobel Prize was given out to Lvei-Montalcini, who worked for almost 40 years trying to explain how PEA and inflammation were connected, by showing its positive role on NGF(nerve growth factor) and how mast cells(immune cells) could be modulated by PEA. In 1990, it was shown that PEA’s mechanism could also be explained by its high affinity for peroxisome proliferator-activated receptor alpha(PPAR-a). In 2017, a meta-analysis involving 10 studies and 786 participants showed that subjects given PEA had significantly reduced pain levels. Daily doses ranged from 300-1200mg, with an average of 600mg.<\/p>\r\n
Tamarind Seed Extract (10:1 Tamarindus indica):<\/strong> <\/span>Tamarind seed extract is a more recently studied compound for helping with joint pain, movement and overall antiarthritic properties. Originally thought to solely work based on its high antioxidant content, newer research has shown that tamarind seed extract can lower levels of pro-inflammatory cytokines like interleukin-1B(IL-1B), TNF-a, IL-6, and COX-2. After running an High performance liquid chromatography(HPLC) on the seed extract, the main components were found to be Threo-Isocitric acid, Galactosyl glycerol, Procyanidin B2, Areccatannin B1, Catechin, Rutin and Embelin. In a 2015 study, arthritic rats given tamarind seed extract showed significantly improvement. Appendage swelling was dramatically down(comparable to rats given ibuprofen). Not only that, but metalloproteinases(MMPs) which are responsible for degradation of cartilage activity was significantly lowered in arthritic rats receiving tamarind seed extract, similar to pre-arthritic state. Oxidative stress levels were significantly lowered, not to mention glutathione(GSH), the body’s main antioxidant levels decline during levels of high oxidative stress. Tamarind seed extract was able to reverse the decline of GSH by 91%! This wonder seed is exactly what you need for lowering inflammation by multiple pathways.
CurcuWIN (Curcuma longa L. 20%):<\/strong> <\/span>Curcumin is one of the main curcuminoids found in turmeric. There have been hundreds of studies on curcumin and its positive effects on inflammation and joint improvement, not to mention antioxidant properties, heart health and overall health. Curcumin interacts with multiple inflammation pathways, specifically negating the action of IkB Kinase and nuclear factor-kappa B(NF-kB). It has the ability to help with both acute and chronic inflammation, via constantly inhibiting pro-inflammatory cytokines and downregulation of inflammatory enzymes like COX-2 and leukotrienes. It’s polyphenolic molecular shape allows it to be an excellent antioxidant and free radical scavenger. Curcumin has actually been shown to increase endogenous levels of antioxidants. Sounds amazing right? The downfall to curcumin and curcuminoids is their poor bioavailability. CurcuWIN\uf0d2 solves this problem using a proprietary delivery system called UltraSOL, which has been shown to increase the bioavailability of curcumin by 46X! Essentially, UltraSOL converts oil-soluble compounds(like curcumin) into more water dispersible compounds by using a polymer known as N-vinylpyrrolidone(NVP). NVP helps encase and disperse the curcuminoids to help them be more hydrophilic(water soluble). This allows your body to utilize much more of the active curcuminoids.<\/p>\r\n
Curcucmin<\/strong> AprèsFlex Boswellia serrata gum resin std. for 20% AKBA:<\/strong> <\/span>The gum resin from Boswellia serrata has been used for centuries because its rich in terpene and triterpenic acids, known as boswellic acids that have anti-inflammatory enzyme properties. The most potent of them being 11-keto-\uf062-boswellic acid and 3-O-acetly-11-keto-\uf062-boswellic acid(AKBA). This compound specifically has a very strong ability to inhibit the enzyme 5-lipoxygenase(5-LOX), which is very proinflammatory. 5-LOX generates leukotrienes which can promote free radical damage and the migration of these compounds to inflamed areas. Another key benefit for boswellic acids in general is that they do not disrupt the synthesis of glycosaminoglycans like hyaluronic acid, chondroitin, heparin, keratin, ect, which can help with wound repair. Most over-the-counter NSAIDs do disrupt this and can actually hurt you in the long run and impair damage control. AprèsFlex\uf0d2 is standardized to 20% pure AKBA to get maximum results from the strongest component in the gum resin. Studies show that taking 1 serving of AprèsFlex\uf0d2 begins to work in as little as 5 days! No more taking big chalky pills for 30days to help.<\/p>\r\n
UC-II Standardized Chicken Cartilage(Providing 10mg Total Cartilage, Including Undenatured Type II Collagen):<\/strong> <\/span>Undenatured type-II collagen or UC-II has been extensively studies in humans to show improvements in almost all metrics used in testing(pain, flareups, joint mobility, ect). The key term here is UNDENATURED. This means the protein of the collagen is exactly has it is inside the body and includes all the necessary components like proteoglycans, glucosamine hyaluronic acid, and chondroitin sulfate. These make up the very basics of cartiliage and synovial fluid- the viscous, non-Newtonian fluid between your joints to reduce friction. Many human studies have all come to the same conclusion: supplementing with UC-II can significantly lower levels of inflammatory cytokines that have been linked to severity and incidence of signs of arthritic tendencies. Specifically, UC-II has been shown to lower TNF-alpha, IL-1Beta, and IL-6, all of which are prone to causing inflammation. But, helping increase\/preserve synovial fluid, that is something that can help your joints fight discomfort and keep them lubricated for either lifting weight in the gym or doing cardiovascular exercise.
Tetrahydrocurcumin:<\/strong> <\/span>We have already spoken about curcumin and its many benefits, we all as pitfalls. One major pitfall we spoke about was oral bioavailability, which I rectified using an highly-bioavailable form known as CurcuWin. However, we have yet to speak about one of the main metabolites of curcumin known as tetrahydrocurucmin. The “tetrahydro” means that there is a reduction in 2 double bonds on the molecule where 4 hydrogens are added in place. This dramatically improves the oral bioavailability of curcumin, especially in the intestinal tract. But, that’s not all. Tetrahydrocurcumin has been shown to have much higher antioxidant properties. Studies have shown it can lower cell damage via lipid peroxidation(damage from free radicals\/ROS). Tetrahydrocurcumin can also help to lower blood sugar levels and LDL(good cholesterol). In fact, in 2015, a meta-analysis was published comparing curcumin to tetrahydrocurcumin that included over 50 studies, both in vitro and in vivo. But perhaps more importantly, has been shown to hit different molecular targets than regular curcumin, which may have added benefits of its own. For example, vasoprotection seems to be a property of tetrahydrocurcumin vs curcumin, which as you guessed may be linked to helping control blood pressure.<\/p>\r\n
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References:<\/strong>
1. Stohs, Sidney J., and Sidhartha D. Ray. \"A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts.\" Phytotherapy research 27.8 (2013): 1107-1114. 2. Jadhav, Atul N., et al. \"Ketosteroid standardized Cissus quadrangularis L. extract and its anabolic activity: Time to look beyond ketosteroid?.\" Pharmacognosy magazine 12.Suppl 2 (2016): S213. 3. Ghouse, Mr Mohammed Shakir. \"A pharmacognostical review on cissus quadrangularis linn.\" International Journal of Research 28 (2015). 4. Oben, Julius E., et al. \"The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress.\" Lipids in Health and Disease 6.1 (2007): 1-8. 5. Solorzano, Carlos, et al. \"Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.\" Proceedings of the National Academy of Sciences 106.49 (2009): 20966-20971. 6. Artukoglu, Bekir Berker, et al. \"Efficacy of palmitoylethanolamide for pain: a meta-analysis.\" Pain Physician 20.5 (2017): 353-362. 7. M Keppel Hesselink, Jan. \"New targets in pain, non-neuronal cells, and the role of palmitoylethanolamide.\" The Open Pain Journal 5.1 (2012). 8. Gabrielsson, Linda, Sofia Mattsson, and Christopher J. Fowler. \"Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy.\" British journal of clinical pharmacology 82.4 (2016): 932-942. 9. Sundaram, Mahalingam S., et al. \"Tamarind seed (Tamarindus indica) extract ameliorates adjuvant-induced arthritis via regulating the mediators of cartilage\/bone degeneration, inflammation and oxidative stress.\" Scientific reports 5.1 (2015): 1-13. 10. Oliver, Jonathan Michael, et al. \"Novel form of curcumin attenuates performance decrements following muscle damaging exercise.\" The FASEB Journal 31 (2017): lb415-lb415. 11. Juturu, Vijaya, et al. \"Antioxidant Properties and Safety Evaluation of Curcumin (CurcuWINTM).\" The FASEB Journal 29 (2015): 924-5. 12. Jäger, Ralf, et al. \"Curcumin reduces muscle damage and soreness following muscle\u2010damaging exercise.\" The Faseb Journal 31 (2017): lb766-lb766. 13. Kanwar, Jagat R., et al. \"Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling.\" Drug design, development and therapy 9 (2015): 2927. 14. Lugo, James P., et al. \"Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers.\" Journal of the International Society of Sports Nutrition 10.1 (2013): 1-12. 15. Crowley, David C., et al. \"Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.\" International journal of medical sciences 6.6 (2009): 312. 16. Bagchi, D., et al. \"Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration.\" International journal of clinical pharmacology research 22.3-4 (2002): 101-110. 17. Aggarwal, Bharat B et al; “Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.”; Molecules (Basel, Switzerland); vol. 20,1; 185-205; 24 Dec. 2014; 18. Sandur, Santosh K., et al. \"Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.\" Carcinogenesis 28.8 (2007): 1765-1773. 19. Sugiyama, Yosunori, Shunro Kawakishi, and Toshihiko Osawa. \"Involvement of the β-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin.\" Biochemical pharmacology 52.4 (1996): 519-525. 20. Zhang, Zhen-Biao, et al. \"Curcumin’s metabolites, tetrahydrocurcumin and octahydrocurcumin, possess superior anti-inflammatory effects in vivo through suppression of TAK1-NF-κB pathway.\" Frontiers in pharmacology 9 (2018): 1181.<\/p>","gtin12":"860003220467","image":["https:\/\/siteimgs.com\/10017\/item\/57f3826c-cf8d-4f40-984b-e_1620664215-0.jpg"],"brand":"Chemix","url":"https:\/\/www.dpsnutrition.net\/i\/30908\/chemix-joint-90-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"41.98","url":"https:\/\/www.dpsnutrition.net\/i\/30908\/chemix-joint-90-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"InnovaPharm Superior Cissus - 180 Cap","sku":"INV29","description":"
Superior Cissus contains a highly dosed engineered extract of Cissus Quadrangularis known as QuadraFlex. This unique herbal extract has been shown to support bone, joint and connective tissue health. Whether you are a competitive bodybuilider, powerlifter, collegiate athlete or weekend warrior, Superior Cissus can provide a multitude of benefits to the active male and female.<\/span><\/p>\r\n
Support Joint, Tendon, Ligament, & Cartilage Health*<\/SPAN><\/DIV>
Cissus XT can be used to help support joint, tendon, ligament, and cartilage health. It can also be used to help support healthy weight management.<\/SPAN><\/P>
The Goals of the Serious Nutrition Solutions Baseline Series are simple ones \u2013 to provide top quality products at the most cost effective prices, and to provide a straight forward approach to the consumer about what the products are, and what they are used for.<\/SPAN><\/P>
Serious Nutrition Solutions \u2013 Baseline Series Straight Forward, Top Quality, Cost Effective Sports Nutrition<\/SPAN><\/DIV>
<\/SPAN> <\/DIV>
<\/SPAN><\/DIV>
<\/SPAN> <\/DIV>
Directions:<\/SPAN><\/P>
As a dietary supplement, take 2 capsules 30 minutes prior to a meal in the morning and 1 to 2 caosules 30 minutes prior to a mean 8 to 12 hours later.<\/SPAN><\/P>
Warnings:<\/SPAN><\/P>
This product is intended for healthy adults over 18 years of age. Consult a physician before using this or any dietary supplement. Do not use if you have any pre-existing medical condition or if you are taking any medication without consulting your physician. Store in a cool, dry place away from children.<\/SPAN><\/P>","gtin12":"899773000955","image":["https:\/\/siteimgs.com\/10017\/item\/sns-serious-nutrition-sol_716-0.jpg"],"brand":"SNS Serious Nutrition Solutions","url":"https:\/\/www.dpsnutrition.net\/i\/15510\/serious-nutrition-solutions-cissus-xt-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"15.92","url":"https:\/\/www.dpsnutrition.net\/i\/15510\/serious-nutrition-solutions-cissus-xt-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"SNS Serious Nutrition Solutions Cissus XT - 120 Servings (120 Grams)","sku":"SN264","description":"
1,000 Mg. (1 Gram) Per Serving\/120 Servings Per Container<\/h4>\r\n
<\/p>\r\n
SNS Cissus XT powder provides 1,000 mg. per serving of Cissus Quadrangularis, a popular herb that is commonly used to help support joint, tendon, ligament, and cartilage health and comfort, as well as supporting healthy weight management.<\/p>\r\n
There are several different standardizations of Cissus available and Cissus XT uses Cissus Quadrangularis extracted to 5% ketosterones; the standardization that is regarded by many as being the most effective for joint, tendon, ligament, and cartilage support.<\/p>\r\n
SNS Cissus XT is available in both capsule and powder forms.<\/p>\r\n
Stacking & Synergy:<\/h3>\r\n
SNS Cissus XT can be stacked with SNS Joint Support XT, Elite Curcumin, Inflammation Assist XT, or a wide variety of other SNS products for improved synergistic results.<\/p>\r\n
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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.<\/p>\r\n
<\/p>\r\n<\/div>\r\n<\/div>","gtin12":"850008039195","image":["https:\/\/siteimgs.com\/10017\/item\/cissus-xt-powder-renderin_1614706583-0.jpg"],"brand":"SNS Serious Nutrition Solutions","url":"https:\/\/www.dpsnutrition.net\/i\/30643\/sns-serious-nutrition-solutions-cissus-xt-120.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"18.74","url":"https:\/\/www.dpsnutrition.net\/i\/30643\/sns-serious-nutrition-solutions-cissus-xt-120.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"SNS Serious Nutrition Solutions Cissus XT - 240 Cap (2 x 120 Cap Btls) TWINPACK","sku":"SN2084","description":"
<\/SPAN><\/DIV>
<\/SPAN> <\/DIV>
<\/SPAN> <\/DIV>
Support Joint, Tendon, Ligament, & Cartilage Health*<\/SPAN><\/DIV>
Cissus XT can be used to help support joint, tendon, ligament, and cartilage health. It can also be used to help support healthy weight management.<\/SPAN><\/P>
The Goals of the Serious Nutrition Solutions Baseline Series are simple ones \u2013 to provide top quality products at the most cost effective prices, and to provide a straight forward approach to the consumer about what the products are, and what they are used for.<\/SPAN><\/P>
Serious Nutrition Solutions \u2013 Baseline Series Straight Forward, Top Quality, Cost Effective Sports Nutrition<\/SPAN><\/DIV>
<\/SPAN> <\/DIV>
<\/SPAN><\/DIV>
<\/SPAN> <\/DIV>
Directions:<\/SPAN><\/P>
As a dietary supplement, take 2 capsules 30 minutes prior to a meal in the morning and 1 to 2 caosules 30 minutes prior to a mean 8 to 12 hours later.<\/SPAN><\/P>
Warnings:<\/SPAN><\/P>
This product is intended for healthy adults over 18 years of age. Consult a physician before using this or any dietary supplement. Do not use if you have any pre-existing medical condition or if you are taking any medication without consulting your physician. Store in a cool, dry place away from children.<\/SPAN><\/P>","gtin12":"899773000955","image":["https:\/\/siteimgs.com\/10017\/item\/cissus-tw_1674743555-0.jpg"],"brand":"SNS Serious Nutrition Solutions","url":"https:\/\/www.dpsnutrition.net\/i\/32807\/serious-nutrition-solutions-cissus-xt-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"29.91","url":"https:\/\/www.dpsnutrition.net\/i\/32807\/serious-nutrition-solutions-cissus-xt-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Usp Labs Super Cissus - 150 Cap *Paypal can't be used for this product","sku":"US008","description":"
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Promotes Bone, Muscle and Tendon Health*<\/li>\r\n
Increases Joint Flexibility*<\/li>\r\n
Provides Nutrients for Healthy Joints*<\/li>\r\n<\/ul>\r\n
The Original patented Cissus Quandrangularis joint product. Super Cissus™<\/strong> <\/span>has earned numerous \"Joint Product of the Year\" awards since its inception. Do not accept inferior imitations - demand the best, Super Cissus™<\/strong>. This contains the most potent extract of Cissus Quadrangularis out of any joint support product and can be successfully incorporated into a healthy lifestyle to help reduce pain and preserve joint mobility. The Key Ingredients in Super Cissus™<\/strong>, Cissus Quadrangularis contains compounds that may work to promote tendon and ligament health. More importantly it is shellfish-free and supported by centuries of use in Ayurvedic Medicinal System. Promotes overall joint health & longevity! Through much trial and error... not to mention costs... our research team has perfected the extraction process. This is crucial to getting results you expect.<\/p>\r\n
Take better care of your body by using USPLabs™ Super Cissus™<\/strong> <\/span>joint support supplement. Whether you're an athlete or an individual of advanced age, it's important to take care of your joints. Strenuous exercise and time are the two most common causes of joint pain in adults due to everyday exertion. USPLabs™ Super Cissus™<\/strong> <\/span>is designed to help joint mobility by providing the body with the nutrition it needs to heal and protect the joints. The revolutionary new formula is quickly becoming one of the most popular joint support supplements on the market. The capsulated supplement is made of high-quality ingredients and can be taken with other joint supporting products such as glucosamine, chondroitin and MSM or the omega-3 fatty acids DHA and EPA.<\/p>\r\n