\/p>\r\n
<\/strong><\/p>\r\n SLIMAGLUTIDE®—REVOLUTIONARY GLP-1 WEIGHT LOSS AGONIST and Blood Sugar Metabolism Support!<\/strong><\/p>\r\n Hi-Tech Pharmaceuticals is proud to announce the launch of its latest product, Slimaglutide®. This groundbreaking weight loss aid supplement utilizes the power of Cyclosome® Berberine along with 10 other Glucagon-like Peptide-1 (GLP-1) Receptor agonist and secretagogues to provide a natural and effective solution for blood sugar metabolism support, healthy weight management and at an affordable cost.* Hi-Tech’s Research and Development Team spent over a year researching the active ingredients and compounds that make Slimaglutide®, a Novel and Revolutionary weight loss aid that will help millions of people lose weight and feel great!<\/p>\r\n Hi-Tech Pharmaceuticals is a leader in Phellodendron and Berberine research with its Nexrutine® series of berberine extracts, which have more than two decades of studies and real-world results in many of Hi-Tech’s branded products. Slimaglutide® utilizes a 97% pure Nexrutine XS® extract naturally derived from Phellodendron bark. Slimaglutide® also uses a high-grade extract called YGDPure® that has been shown to work via the GLP-1 pathway, among other pathways, and in multiple clinical trials. Specifically, it has been shown that in a 45-day trial, those taking YGD lost an average of 11.2lbs whereas those taking placebo lost just 0.7lb. This is just one of the amazing GLP-1 compounds found in Slimaglutide®.<\/p>\r\n The berberine utilized in Slimaglutide® utilized a Berberine Pharmacokinetic study that showed improved berberine bioavailability (AUC) by over 10 times on molar basis and with observed dose linearity. Our berberine increased retention time from about 30-45 minutes to over 10 hours! The uniqueness of Nexrutine XS® Berberine derives directly from one of berberine’s main limits: bioavailability. The raw extract has extremely poor oral bioavailability and bio absorption profile. Nexrutine XS® Berberine groundbreaking supplement harnesses the power of berberine to provide a natural and effective solution for blood sugar metabolism support and healthy weight management. Slimaglutide® effectively supports metabolic health, favorably modulating insulin response, improving the blood sugar profile, leveling both blood glycemic and insulin, having a positive effect on body composition and inducing the redistribution of adipose tissue.<\/p>\r\n Consumer interest in berberine, an herbal compound extracted from various plants, has skyrocketed in popularity due to increased chatter over social media platforms, such as TikTok. Hi-Tech utilizes a proprietary and clinically studied form of berberine called Nexrutine® XS Cyclosome®, which applies cutting-edge, ultra-absorption liposome and cyclodextrin technologies to address these challenges. For Slimaglutide® we also incorporate sodium caprate (C10, a medium-chain triglyceride) to promote optimal absorption and maintenance of gastrointestinal comfort during berberine supplementation.<\/p>\r\n TwinCretin®<\/strong><\/p>\r\n The second pathway Hi-Tech researchers found effective compounds are from Glucose Dependent Insulinotropic Polypeptide (GIP). Hi-Tech developed a proprietary extract called TwinCretin® from the Fagonia Cretia, which stimulated both GLP-1 and GIP secretion, increased cellular hormone content and upregulated gene expression of proglucagon, GIP and prohormone convertase. The main benefit of TwinCretin® was the effect of GLP-1 on appetite and weight loss. The release of GLP-1 and related effects delay gastric emptying and bowel motility, and in addition, exerts pressure on the hypothalamus to alter satiety; thereby, reducing appetite and assisting in weight control. Slimaglutide® is the only omni-faceted nutraceutical on the market to attack both GLP-1 and GIP secretion and is extremely potent when it comes to weight loss.<\/p>\r\n As a society, our expanding waistlines have only increased our pre-existing concerns regarding our blood sugar and cholesterol levels. Slimaglutide® provides an effective, natural means of supporting our efforts toward more balanced blood sugar and weight management. Slimaglutide® is a truly remarkable weight management benefits of GLP-1 receptor agonists and the power of a one-of-a kind- GIP Nutraceutical. This Novel and Revolutionary weight loss aid will turn the Diet Industry on its head!<\/p>\r\n <\/p>\r\n <\/p>","gtin12":"811836027013","image":["https:\/\/siteimgs.com\/10017\/item\/slimaglutide-180ct-bottle_1704317483-0.jpg"],"brand":"Hi Tech Pharmaceuticals","url":"https:\/\/www.dpsnutrition.net\/i\/33684\/hi-tech-pharmaceuticals-slimaglutide-180-tab.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"129.95","url":"https:\/\/www.dpsnutrition.net\/i\/33684\/hi-tech-pharmaceuticals-slimaglutide-180-tab.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"-Hi Tech Pharmaceuticals Slimaglutide - 360 Tab (2 x 180 Tab Btls) TWINPACK **Free Shipping","sku":"HT2301","description":" <\/p>\r\n <\/strong><\/p> \r\n SLIMAGLUTIDE®—REVOLUTIONARY GLP-1 WEIGHT LOSS AGONIST and Blood Sugar Metabolism Support!<\/strong><\/p>\r\n Hi-Tech Pharmaceuticals is proud to announce the launch of its latest product, Slimaglutide®. This groundbreaking weight loss aid supplement utilizes the power of Cyclosome® Berberine along with 10 other Glucagon-like Peptide-1 (GLP-1) Receptor agonist and secretagogues to provide a natural and effective solution for blood sugar metabolism support, healthy weight management and at an affordable cost.* Hi-Tech’s Research and Development Team spent over a year researching the active ingredients and compounds that make Slimaglutide®, a Novel and Revolutionary weight loss aid that will help millions of people lose weight and feel great!<\/p>\r\n Hi-Tech Pharmaceuticals is a leader in Phellodendron and Berberine research with its Nexrutine® series of berberine extracts, which have more than two decades of studies and real-world results in many of Hi-Tech’s branded products. Slimaglutide® utilizes a 97% pure Nexrutine XS® extract naturally derived from Phellodendron bark. Slimaglutide® also uses a high-grade extract called YGDPure® that has been shown to work via the GLP-1 pathway, among other pathways, and in multiple clinical trials. Specifically, it has been shown that in a 45-day trial, those taking YGD lost an average of 11.2lbs whereas those taking placebo lost just 0.7lb. This is just one of the amazing GLP-1 compounds found in Slimaglutide®.<\/p>\r\n The berberine utilized in Slimaglutide® utilized a Berberine Pharmacokinetic study that showed improved berberine bioavailability (AUC) by over 10 times on molar basis and with observed dose linearity. Our berberine increased retention time from about 30-45 minutes to over 10 hours! The uniqueness of Nexrutine XS® Berberine derives directly from one of berberine’s main limits: bioavailability. The raw extract has extremely poor oral bioavailability and bio absorption profile. Nexrutine XS® Berberine groundbreaking supplement harnesses the power of berberine to provide a natural and effective solution for blood sugar metabolism support and healthy weight management. Slimaglutide® effectively supports metabolic health, favorably modulating insulin response, improving the blood sugar profile, leveling both blood glycemic and insulin, having a positive effect on body composition and inducing the redistribution of adipose tissue.<\/p>\r\n Consumer interest in berberine, an herbal compound extracted from various plants, has skyrocketed in popularity due to increased chatter over social media platforms, such as TikTok. Hi-Tech utilizes a proprietary and clinically studied form of berberine called Nexrutine® XS Cyclosome®, which applies cutting-edge, ultra-absorption liposome and cyclodextrin technologies to address these challenges. For Slimaglutide® we also incorporate sodium caprate (C10, a medium-chain triglyceride) to promote optimal absorption and maintenance of gastrointestinal comfort during berberine supplementation.<\/p>\r\n TwinCretin®<\/strong><\/p>\r\n The second pathway Hi-Tech researchers found effective compounds are from Glucose Dependent Insulinotropic Polypeptide (GIP). Hi-Tech developed a proprietary extract called TwinCretin® from the Fagonia Cretia, which stimulated both GLP-1 and GIP secretion, increased cellular hormone content and upregulated gene expression of proglucagon, GIP and prohormone convertase. The main benefit of TwinCretin® was the effect of GLP-1 on appetite and weight loss. The release of GLP-1 and related effects delay gastric emptying and bowel motility, and in addition, exerts pressure on the hypothalamus to alter satiety; thereby, reducing appetite and assisting in weight control. Slimaglutide® is the only omni-faceted nutraceutical on the market to attack both GLP-1 and GIP secretion and is extremely potent when it comes to weight loss.<\/p>\r\n As a society, our expanding waistlines have only increased our pre-existing concerns regarding our blood sugar and cholesterol levels. Slimaglutide® provides an effective, natural means of supporting our efforts toward more balanced blood sugar and weight management. Slimaglutide® is a truly remarkable weight management benefits of GLP-1 receptor agonists and the power of a one-of-a kind- GIP Nutraceutical. This Novel and Revolutionary weight loss aid will turn the Diet Industry on its head!<\/p>\r\n <\/p>\r\n <\/p>","image":["https:\/\/siteimgs.com\/10017\/item\/slima-twin_1704836651-0.jpg"],"brand":"Hi Tech Pharmaceuticals","url":"https:\/\/www.dpsnutrition.net\/i\/33706\/hi-tech-pharmaceuticals-slimaglutide-180-tab.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"239.95","url":"https:\/\/www.dpsnutrition.net\/i\/33706\/hi-tech-pharmaceuticals-slimaglutide-180-tab.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"5% Nutrition Freak Show - 180 Caps","sku":"5P009","description":" <\/p>\r\n Rich Piana 5% Nutrition's Freak Show <\/strong><\/p>\r\n Leave it to 5% Nutrition to create an innovative formula that mimics the power of insulin without the downside - introducing Freak Show! You know 5% Nutrition - of course, you can expect epic dosing using only effective ingredients designed to make those extra carbs do what you want them to.<\/p>\r\n Ingredients That Work<\/strong> Gymnema Sylvestre 1,000 mg – This powerful insulin-enhancing herb originates in India and helps keep levels of blood sugar stable as well as drive carbs into your muscle cells which also pulls in lots of water for insane muscle fullness and it has the research to back it up.(2)<\/p>\r\n We’ve given you a huge 1g dose – we wouldn’t have it any other way!<\/p>\r\n Banaba Powder 500 mg – This is one of the most potent herbs available when it comes to insulin mimickers because it can enhance the delivery of glucose to your muscles, which means more energy to power you through your most brutal training sessions.(3) It will also enhance your body’s sensitivity to insulin.<\/p>\r\n When it came to the dose, we didn’t mess around – we wanted dosages that will get the job done!<\/p>\r\n Berberine 350 mg – This powerful herb has earned quite a reputation for being extremely effective at reducing blood glucose and enhancing glucose absorption in your muscle cells.(4) This is a serious glucose regulator meant for carb-heavy meals, so you can eat those pre-workout carbs and get them where they need to be – your muscles!<\/p>\r\n Cinnamon Extract 300 mg – This popular spice is not only a great addition to countless recipes and foods, it also has been clinically shown to lower levels of blood glucose.(5)<\/p>\r\n Bitter Melon (4:1) 300 mg – This is an age-old remedy used for respiratory problems. Clinical studies have shown that Bitter Melon can lower levels of blood glucose in the body, as well as increased serum levels of protein.(6)<\/p>\r\n Na-R[+]-Alpha Lipoic Acid 200 mg – Alpha Lipoic Acid is a fatty acid that occurs in the mitochondria of every cell in your body. It plays a primary part in energy metabolism and is also well-known as a potent antioxidant.(7) This form attaches ALA to a sodium salt which makes it extremely soluble and much more bioavailable than regular ALA. Leave it to 5% to use the best ingredients available – after all, it’s your results we’re talking about!<\/p>\r\n Chromium 400 mcg – Chromium is an essential trace mineral that plays a key role in insulin metabolism, in fact, it is absolutely required for insulin to function properly.<\/p>\r\n Fenugreek 100 mg – Wait isn't that usually an ingredient found in test boosters? Yes, however, Fenugreek has also been shown to help lower levels of blood glucose so it's a natural fit for Freak Show.(8)<\/p>\r\n WARNING: Not intended for persons under the age of 18. Do not use if pregnant or nursing. Consult a health care professional prior to consumption if you have any pre-existing medical conditions including but not limited to: diabetes, high or low blood pressure, heart, liver or kidney disease, cardiac arrhythmia, stroke or are taking any prescription medication. Store in a cool, dry place away from sunlight and with lid tightly secured.<\/p>\r\n PRODUCT WARNINGS Berberine is a naturally-occurring plant extract that helps enhance glycogen stores and supports healthy digestion. Allmax’s Berberine contains the most researched form – Berberine HCL.*<\/p>\r\n Clinical studies have shown Berberine HCL supplementation [1,2,3,4,5]:<\/p>\r\n Promotes healthy blood sugar metabolism and insulin sensitivity* Serving Size 1 Capsule<\/p>\r\n Servings Per Container 30<\/p>\r\n<\/header>\r\n † Daily Value not established.<\/p>\r\n<\/section>\r\n GLUCOSE DISPOSAL AGENT <\/strong>Perfecting the balancing act of carb utilization and storage depends largely on insulin sensitivity and the effectiveness with which sugars are metabolized. With the rich assortment of ingredients found in the GLUCO FX formula, the body is primed to properly absorb and store carbohydrate-rich foods. The result? Excess glucose is eliminated and the glucose that does make it into circulation can be properly stored and utilized for energy purposes; not spilled over and converted to body fat. No matter how you consume your carbs, GLUCO FX glucose disposal agent (GDA) puts glucose in its place.<\/p>\r\n How does GLUCO FX work to produce its unparalleled advantages and what can it’s combined ingredients do for you? Let’s take a look at what this innovative new product does and its science-supported ingredients.<\/p>\r\n Super Berberine<\/strong><\/p>\r\n <\/strong>It’s called super for a reason. Super Berberine (Berberine Cyclodextrin) is an alkaloid extracted from various plants. It has been tested in numerous studies and found to be ultra-effective as a glucose disposal agent. Among its many benefits is its ability to decrease insulin resistance, increase glycolysis (the breakdown of sugar in cells for energy), decrease sugar production in the liver, increase beneficial gut bacteria and slow the breakdown of carbohydrates in the small intestine. <\/span>4, 12, 18 <\/span><\/sup>One 12-week study found that obese individuals who took the recommended dose of Super Berberine three times daily lost an average of five pounds, including a 3.6% reduction in body fat! <\/span>5<\/sup><\/p>\r\n Chromium<\/strong><\/p>\r\n <\/strong>Chromium helps the body break down and absorb carbohydrates, fats and protein. Chromium supplements are sometimes used to help control blood sugar, provide relief from metabolic syndrome, control body weight and enhance muscle mass.<\/p>\r\n Maqui Berry<\/strong><\/p>\r\n <\/strong>An additional ingredient in GLUCO FX, the potent antioxidant and inflammation-fighter Maqui Berry, also enhances the way in which carbs are used for energy, with one clinical study suggesting that Maqui Berry may help lower blood sugar in people with pre-diabetes. <\/span>1, 10 <\/span><\/sup>Furthermore, a large population study showed that diets high in compounds called anthocyanins (found in large numbers in Maqui Berries) were linked to a significantly reduced risk of type 2 diabetes. <\/span>20<\/sup><\/p>\r\n Pomegranate<\/strong><\/p>\r\n <\/strong>GLUCO FX also features a potent dose of pomegranate, which is known to some as the antidiabetic fruit. Pomegranate is not only very high in antioxidants, but has also been shown to aid blood sugar management by correcting insulin resistance to reduce circulating blood sugar levels. 2<\/p>\r\n Banaba Leaf Extract<\/strong><\/p>\r\n <\/strong>With over 40 beneficial compounds, including corosolic acid, banaba leaf extract greatly assists this process by helping to keep blood sugar levels in check – notably by shuttling glucose into muscle cells (and away from fat cells), where the sugars can be used to power intensive weight training sessions. <\/span>17<\/sup> <\/span>It does this by activating insulin receptors on muscle tissue, a mechanism that automatically lowers blood glucose levels. 6, 7, 13, 14, 15<\/sup><\/p>\r\n Banaba inhibits fat cell production resulting from caloric overconsumption. Important for bodybuilders who want full, round muscle bellies and ample training energy is Banaba’s ability to increase the expression and activation of GLUT-4, a transporter protein that allows glucose to be absorbed into the cells of the body. <\/span>3, 11<\/sup><\/p>\r\n Loquat Extract<\/strong><\/p>\r\n <\/strong>GLUCO FX also features the extensively-researched and nutrient-dense Loquat Extract (Standardized for Maslinic Acid), a plant-compound-packed fruit that has been shown to improve metabolic health by reducing blood triglycerides, blood sugar and excess insulin. <\/span>19 <\/span><\/sup>Used traditionally to treat high blood sugar, Loquat Extract has shown great promise as a natural alternative to improving metabolic conditions such as diabetes. <\/span>9, 16<\/sup><\/p>\r\n Gymnema Sylvestre <\/span><\/em>(75% Gymnemic Shrubs)<\/strong><\/p>\r\n <\/strong>Gymnema Sylvestre<\/em> <\/span>effectively soaks up excess glucose and shuttles it where it belongs. One of its primary active components, gymnemic acid, is known for suppressing cravings for sweet foods by blocking the sugar receptors on the taste buds. <\/span>8<\/sup> <\/span>Indeed, study subjects who received <\/span>Gymnema Sylvestre<\/em> <\/span>were found to have less appetite for sweet foods at subsequent meals and were more likely to limit their food intake. <\/span>2<\/sup><\/p>\r\n <\/strong>As mentioned earlier, GLUCO FX assists fat burning and muscle building in various ways. For muscle building specifically, GLUCO FX renders the body more insulin sensitive. This increases the uptake of vital amino acids into muscle cells to fully induce muscle protein synthesis, the real key to unlocking massive gains and fuelling muscle growth.<\/p>\r\n <\/strong>In addition to consuming GLUCO FX with proven muscle builders such as ISOFLEX and CARBION+, GLUCO FX can also be perfectly paired with superior amino acid products, such as MUSCLEAA and AMINOCORE. Stacking AMINOCORE and MUSCLEAA with GLUCO FX will fully maximize muscle protein synthesis, optimizing the many benefits of GLUCO FX. <\/span>21, 22, 23<\/sup><\/p>\r\n <\/strong>While there are many GDA supplement on the market, GLUCO FX is scientifically proven to achieve results. GLUCO FX is the only fuel your body needs to manage blood sugar levels enabling you to build a ripped, shredded physique.<\/p>\r\n <\/em><\/p>\r\n *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.<\/sup><\/em><\/p>\r\n <\/p>\r\n GAINS CANDY™ GLUCOVANTAGE<\/p>\r\n Turn Carbs From Foe to Friend.† Eat Carbs With Confidence w\/ This “Super Berberine” for Fat Loss & Muscle Building!† Helps Maintain Healthy Insulin Response†<\/p>\r\n Helps Support Healthy Glucose Metabolism†<\/p>\r\n Helps Convert Fat Storage into Energy†<\/p>\r\n No Proprietary Blends (aka full transparency) Turn carbs from foe to friend with GlucoVantage® — the industry’s first Dihydroberberine (DHB) known for its ability to help promote healthy insulin response and healthy glucose metabolism.†<\/p>\r\n STORE CARBS IN MUSCLE AS GLYCOGEN INSTEAD OF FAT† This means less guilt and more gains!<\/p>\r\n HELPS SUPPORT HEALTHY GLUCOSE METABOLISM† Make the carbs you eat work with you — not against you — and more efficiently to achieve your fitness goals.†<\/p>\r\n ANCIENT TRADITION MEETS MODERN SCIENCE† Known for its unmatched ability to inhibit fat cell growth and support healthy carbohydrate utilization.†<\/p>\r\n <\/p>\r\n <\/p>\r\n †THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.<\/p>","gtin12":"810037992229","image":["https:\/\/siteimgs.com\/10017\/item\/img-7281_1674506060-0.jpg"],"brand":"Alpha Lion","url":"https:\/\/www.dpsnutrition.net\/i\/32009\/alpha-lion-gains-candy-glucovantage-60-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"39.99","url":"https:\/\/www.dpsnutrition.net\/i\/32009\/alpha-lion-gains-candy-glucovantage-60-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Apollon Nutrition GlucoVantage (Dihydroberberine) - 90 Cap","sku":"APN112","description":" Berberine has been used for centuries in Ayurvedic and Traditional Chinese practices to support cardiometabolic health. Research notes that, in addition to supporting healthy blood sugar and lipid levels, berberine may also impart antioxidant and anti-inflammatory benefits, too. <\/p>\r\n","gtin12":"850042072547","image":["https:\/\/siteimgs.com\/10017\/item\/apollon-nutrition-gluco-v_1691158292-0.jpg"],"brand":"Apollon Nutrition","url":"https:\/\/www.dpsnutrition.net\/i\/33358\/apollon-nutrition-glucovantage-dihydroberberine-9.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"33.98","url":"https:\/\/www.dpsnutrition.net\/i\/33358\/apollon-nutrition-glucovantage-dihydroberberine-9.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Axis Labs Berberine - 180 Cap","sku":"AX087","description":" <\/p>\r\n <\/p>","image":["https:\/\/siteimgs.com\/10017\/item\/berb-btl_1708012721-0.jpg"],"brand":"Axis Labs","url":"https:\/\/www.dpsnutrition.net\/i\/33795\/axis-labs-berberine-180-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"23.99","url":"https:\/\/www.dpsnutrition.net\/i\/33795\/axis-labs-berberine-180-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"Chemix GDA - 180 Cap","sku":"CMX11","description":" Chemix GDA is an ultra-premium Glucose Disposal Agent designed to improve insulin sensitivity, shuttles carbohydrates into your cells for maximum nutrient partitioning, aids in maintaining healthy glucose levels, and increases glycogen storage to unseen levels. <\/span><\/p> The advanced formula combines research-backed ingredients at clinical and efficacious doses to provide the most potent insulin mimetic available on the market today.<\/span><\/p> Here is a complete breakdown for this extremely powerful formula:<\/span><\/p> Chemix® GDA is a premium, multi-faceted glucose disposal agent product designed to help increase carbohydrate assimilation and metabolism, insulin sensitivity, and maintain healthy blood glucose levels. GDA allows your body to utilize the hormone insulin more efficiently, which can lead to gains in lean mass via increased glucose and amino acid uptake into your cells!<\/span><\/p> Whether you’re trying to gain 10lbs of muscle or lose 10lbs of fat, one key hormone can make or break your success: insulin. Insulin is a protein made up of 110 amino acids, and is secreted from the beta cells in the pancreas upon the intake of carbohydrates. Being a storage hormone, many consider insulin a double-edged sword. Insulin is the most anabolic hormone in the body as it’s responsible for the uptake of glucose and amino acids to from glycogen and skeletal muscle tissue. Bodybuilders have put on slabs of lean muscle tissue by manipulating insulin, and it’s speculated to be the reason why bodybuilders can compete heavier than ever before. But insulin also has a dark side- it can cause to the body to store large amounts of body fat, as well.<\/span><\/p> Macronutrients are of the utmost importance when it comes to building muscle and burning fat, however if your body isn’t utilizing them properly and efficiently you will fail at both. Inefficient nutrient partitioning normally results from the body not using insulin effectively. Here are some of the actions for which insulin is responsible: All dietary carbohydrates are broken down into the monomer glucose in the small intestine, which then is absorbed into the bloodstream. Once in the blood, glucose signals the pancreas to secrete insulin. Insulin will then bind to the insulin receptor (IR), where it triggers a series of reactions that ultimately <\/span><\/p> leads to uptake of glucose and amino acids into the cell, glycogen synthesis, increased muscle protein synthesis, and glucose disposal (glycolysis), usually through the insulin receptor substrate\/phosphoinositide 3-kinase (IRS\/PI3K) pathway. GLUT4, a transporter needed to allow glucose to enter the cell, is translocated to the cell membrane via activation of the IR, and IRS pathway. Different pathways lead to different actions elicited by insulin, and herein lies how one can maximize the use of endogenous insulin to increase lean body mass or lose body fat.<\/span><\/p> <\/span> <\/p> Bitter Melon Extract(standardized to 10% bitters): Known as \"vegetable insulin,” bitter melon is used to treat diabetes in many parts of the world, and in some places it’s the only form of treatment. Bitter melon contains a variety of hypoglycemic herbs such as triterpenes, anthroquinones, and glucosinolates. The 3 most profound ones are charantin, polypeptide-p, and vicine. Studies have shown extracts from bitter melon to stimulate insulin release, increase skeletal muscle glucose uptake and utilization, suppress gluconeogenic enzymes, and preserve and regenerate beta cells(the cells that release insulin in the pancreas). There is even research on these compounds activating AMPK and PPARx, both of which help regulate energy expenditure in the body. <\/span><\/p> Banaba leaf Extract(standardized to 25% tannins): Lagerstromemin speciosa , commonly known as banaba leaf, contains many compounds that can naturally help with blood sugar control. Most people assume it’s the work of corsolic acid, for which most banaba supps are standardized. However, it’s actually the gallotannins that are responsible the most for insulin memetic function. Specifically, Penta- O-galloyl-glucopyranose(PGG) was determined to have the strongest effect of the group. PGG was shown to significantly increase glucose transport into cells, both in vitro and in vivo. It also was shown to have an anti-adipogenic(inhibit fat cell production) effect, which many other glucose disposal agents do not possess(remember, insulin is adipogenic). Lagerstromemin was also identified to activate the insulin <\/span><\/p> receptor(IR), one mechanism for lowering blood glucose. One of the other major mechanisms of action for banaba leaf is increasing expression and activation of GLUT-4, the transporter protein that allows glucose to be absorbed into cells. Interestingly, removing tannins from banaba extract eliminated all glucose transport activity(GLUT4), which also suggests that the tannins, not corsolic acid is responsible for the anti-diabetic effects. Another study showed that Lagerstromemin was about 54% as strong as insulin for glucose transport activity, which is pretty remarkable.<\/span><\/p> <\/span> <\/p> Alpha Lipoic Acid(yielding 150mg of R-ALA): Alpha Lipoic acid is a mitochondrial fatty acid with really interesting properties. It's been extensively studied for a multitude of benefits, but perhaps the most applicable are its use as an anti-oxidant and a tool to manage blood glucose levels and increase insulin sensitivity. ALA has been shown to reduce general biomarkers for oxidation, inflammatory cytosine and lipid peroxidation(generation of free radicals that can damage your cells). In a meta-analysis, ALA was shown to have a remarkable effect on blood glucose levels. It can increase expression of GLUT-4, the transport protein than shuttles glucose into your cells. It can also decrease the activity of phosphotyrosine phosphatase 1B(PTP1B), a negative regulator insulin response, as well as potentiating the insulin receptor substrate-1. All of these mechanisms can result in more carbohydrates going into your muscles instead of being stored as fat. R-ALA is one of the most important ingredients in GDA and works synergistically with the other ingredients to reduce blood glucose levels and increase glucose uptake in muscle cells. <\/span><\/p> Gymnema Sylvestre Extract(standardized to 75% Gymnemic acids): Gymnema sylvestre(GS) is a natural antidiabetic herb that has been used to treat blood sugar ailments for centuries. GS contains triterpenoid saponins called gymnemic acids that stimulate the release of insulin from the pancreas, as well as increase glucose uptake in cells. GS extract has also been shown to lower LDL and vLDL(bad cholesterol), as well as increase HDL(good cholesterol). In addition, gymnema sylvestre extract has been shown to regenerate islet cells in your pancreas, which allows your body to regulate healthy insulin secretion and function. <\/span><\/p> Super Berberine®(Berberine-Cyclodextrin complex): Berberine is one of the only supplements that has human data that shows efficacy on par with pharmaceuticals. It's main properties are activation of 5' adenosine monophosphate-activated protein kinase(AMPK), which leads to fatty acid oxidation, inhibition of cholesterol synthesis and lipogenesis, increases in muscle glucose uptake and insulin secretion(amongst other things). Focusing on muscle glucose uptake and insulin secretion, berberine was shown to very effective as a glucose disposal agent in serval studies. Berberine may increase glucose-stimulated insulin secretion and inhibit a-glucosidase activities, as well as promoting glucose uptake in cells. It works by increasing phosphorylation of the insulin receptor, insulin receptor substrate- 1, and protein kinase B. Berberine also inhibits the enzyme PTP1B, an enzyme that down regulates the insulin pathway which can also lead to insulin resistance. The main problem with Berberine is it has terrible bioavailability. Super Berberine is Berberine encased in beta-cyclodextrin, which has been shown to increase solubility by over double of free berberine in a simulated gastric environment. Super Berberine also contains sodium caprate, a fatty acid that increases diffusion of berberine through the epithelial cells in the intestine. <\/span><\/p> Cinnulin PF®: Cinnulin PF® is a patented version of a 20:1 extract of Cinnamomum burmanni that contains high levels of water soluble double-linked procyanidin type-A polymers of flavanoids. Research shows that these polymers can increase autophosphorlyation of the insulin receptor-ß, insulin receptor substrate-1, and phosphatidylinositol 3-kinase, all of which activates the receptors and increases the ability for insulin to bind, as well as inhibits the enzyme phosphotyrosine phosphatase(PTP1B), which dephosphorlyates(inactivates) the insulin receptor.<\/span><\/p> <\/span> <\/p> By potentiating the insulin receptor, your body can use less insulin to absorb the same amount of glucose, thus increasing your insulin sensitivity. The polymers in Cinnulin PF® hav ealso been shown to increase GLUT-4 expression, the transporter molecule that brings glucose into cells. <\/span><\/p> Chromium(III) polynicotinate: Although it has been known that chromium(III) (Cr) has positive effects on blood glucose control, the mechanism by which it does this has not been fully elucidated until <\/span><\/p> recently. It was shown that insulin binds to the insulin receptor(IR) and then Cr binds in a second binding pocket, which increases IR activity anywhere from 3.5-8 fold, which has a downstream effect on multiple insulin-dependent pathways. Essentially, Chromium allows your body to use insulin more effectively due toits 2 binding sites on the IR. The polyniconinate chelate of Chromium has been found to be more bioavailable than other versions.<\/span><\/p> <\/span> <\/p> Chemix® GDA is a premium insulin memetic formula that combines 7 of the most well-studied and effective ingredients for maximizing the power of the anabolic hormone insulin! These carefully selected ingredients work with different mechanisms to allow your body to increase lean body mass by shuttling more glucose and amino acids into your cells, priming the perfect anabolic environment for growth. GDA can also help lower blood sugar levels, as well as increase insulin sensitivity, which may aid in fat loss! <\/span><\/p> - The Guerrilla Chemist<\/span><\/p> References: <\/span><\/p> Klein G, Kim J, Himmeldirk K, Cao Y, Chen X. Antidiabetes and anti-obesity activity of Lagerstroemia human islets in vivo and in vitro.\" Phytotherapy Research 24.9 (2010): 1370-1376. <\/span><\/p> Vincent, John B. \"Quest for the molecular mechanism of chromium action and its relationship to Shay, Kate Petersen, et al. \"Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.\" Biochimica et Biophysica Acta (BBA)-General Subjects 1790.10 (2009): 1149-1160. Joseph, Baby, and D. Jini. \"Antidiabetic effects of Momordica charantia (bitter melon) and its Imparl-Radosevich, Jennifer, et al. \"Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling.\" Hormone Research in Paediatrics 50.3 (1998): 177-182. Leach, Matthew J. \"Gymnema sylvestre for diabetes mellitus: a systematic review.\" The Journal Akedo, Hitoshi, and Halvor N. Christensen. \"Nature of insulin action on amino acid uptake by the Zhang Y, Cui Y-L, Gao L-N, Jiang H-L. Effects of ß-cyclodextrin on the intestinal absorption of Zhang M, Lv X, Li J, Meng Z, Wang Q, Chang W, et al. Sodium caprate augments the Ziegenfuss, Tim N., et al. \"Effects of a water-soluble cinnamon extract on body composition and with high cholesterol diet.\" Int J Pharmacol 6.2 (2010): 138-141.<\/span><\/p>\r\n
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Thiamine (B1) 100 mg – A member of the B Complex family of vitamins, Thiamine is essential for the metabolism of carbohydrates as well as BCAAs.(1) One of the functions of Thiamine is to bind with ATP to form thiamine diphosphate, which is a coenzyme involved in carbohydrate metabolism. Additionally, this coenzyme plays a role in the utilization of pentose in the hexose monophosphate shunt, which is an alternative glucose oxidation pathway.<\/p>\r\n
It couldn't be more clear: there's no other insulin mimicker to compare with what Freak Show provides. Effective dosing of ingredients clinically researched to perform. Freak Show is a powerful formula that can take your gains to new heights!<\/div>\r\n
REFERENCES
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1375232\/<\/a>
Ulbricht, Catherine & Rae Abrams, Tracee & Basch, Ethan & Davies-Heerema, Theresa & Foppa, Ivo & Hammerness, Paul & Rusie, Erica & Tanguay-Colucci, Shaina & Taylor, Sarah & Varghese, Minney & Weissner, Wendy & Woods, Jen. (2011). An Evidence-Based Systematic Review of Gymnema ( Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration. Journal of dietary supplements. 8. 311-30. 10.3109\/19390211.2011.597977.
Fukushima, M., Matsuyama, F., Ueda, N., Egawa, K., Takemoto, J., Kajimoto, Y., . . . Seino, Y. (2006, August). Effect of corosolic acid on postchallenge plasma glucose levels. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16549220<\/a>
https:\/\/examine.com\/supplements\/berberine\/<\/a>
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5067830\/<\/a>
https:\/\/www.diabetes.co.uk\/natural-therapies\/bitter-melon.html<\/a>
Shay, K. P., Moreau, R. F., Smith, E. J., Smith, A. R., & Hagen, T. M. (2009, October). Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2756298\/<\/a>
https:\/\/www.healthline.com\/health\/type-2-diabetes\/fenugreek-blood-sugar#fenugreek-and-diabetes<\/a><\/p>\r\n
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.<\/p>","gtin12":"850029555179","image":["https:\/\/siteimgs.com\/10017\/item\/freak-show_1711059121-0.jpg"],"brand":"5% Nutrition","url":"https:\/\/www.dpsnutrition.net\/i\/29016\/5-nutrition-freak-show-180-caps.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"37.79","url":"https:\/\/www.dpsnutrition.net\/i\/29016\/5-nutrition-freak-show-180-caps.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"AllMax Nutrition Berberine HCL - 30 Cap","sku":"AMX178","description":"
Can contribute to maintaining a healthy weight*
Supports immune function and the maintenance of healthy respiratory tract mucus membranes*
Aids in maintaining beneficial bacterial balance in the gut and a healthy microbiome*
Helps maintain healthy cholesterol levels*<\/p>\r\nSUPPLEMENT FACTS<\/h2>\r\n
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\r\n AMOUNT PER SERVING<\/b><\/th>\r\n % DAILY VALUE<\/b><\/th>\r\n<\/tr>\r\n<\/thead>\r\n\r\n \r\n Berberine HCL
(Berberis aristata<\/i>, bark) (90% Active Berberine)<\/th>\r\n500 mg<\/b><\/th>\r\n †<\/th>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n
GLUCO FX<\/p>\r\nPUT GLUCOSE WHERE IT BELONGS…IN THE MUSCLE!<\/h4>\r\n
THE INSULIN ADVANTAGE<\/h4>\r\n
HOW TO STACK GLUCO FX<\/h4>\r\n
THE GLUCO FX DIFFERENCE<\/h4>\r\n
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Helps Promote Improved Carbohydrate Utilization†
Helps Maintain Healthy Insulin Response†
Helps Support Healthy Glucose Metabolism†
Helps Convert Fat Storage Into Energy†
Helps Inhibit Adipocyte (Fat Cell) Growth†<\/p>\r\n
Helps Promote Improved Carbohydrate Utilization†<\/p>\r\n
Fully Disclosed Formula. Premium Trademarked Ingredients.
Backed by Research for Maximum Effectiveness!
We take pride in our Full Label Disclosure, so you see the exact amount of EVERY active ingredient used inside, which means:<\/p>\r\n
Scientifically-studied premium ingredients
And most importantly… No excuses!<\/p>\r\n
GlucoVantage® helps promote the shuttling of the carbs you eat to be stored in the muscle as glycogen and used as energy\/fuel by the body instead of being stored as fat.†<\/p>\r\n
What good are carbs if you can’t utilize them properly? GlucoVantage® helps support the process that breaks down those tasty carbs you ingest into the powerful currency that fuels your training and muscle growth.†<\/p>\r\n
GlucoVantage® is the industry's first implementation of Dihydroberberine (DHB) — a derivative of berberine, an ingredient used in Eastern tradition for decades...<\/p>\r\n
However, as great as berberine is, it requires a large dose (1500mg) spread across multiple dosings per day (usually 2-3x per day). On top of that, many individuals report adverse GI effects from larger doses of berberine.
GlucoVantage (dihydroberberine) offers a superior alternative.<\/p>\r\n
It is a natural metabolite of berberine that offers the same benefits as berberine but at a much
lower dose and without the unwanted (unexpected) GI upset. In other words, GlucoVantage is berberine advanced.<\/p>\r\n
JUST THE FACTS<\/strong><\/p>\r\n
<\/span><\/p>
The following is a mini crash course in how insulin works in the body: <\/span><\/p>
speciosa. Evidence-Based Complementary and Alternative Medicine. 2007;4(4):401-7. 2. Al-Romaiyan, A., et al. \"A novel Gymnema sylvestre extract stimulates insulin secretion from <\/span><\/p>
diabetes.\" Nutrition reviews 58.3 (2000): 67-72. <\/span><\/p>
Kamenova, Petya. \"Improvement of insulin sensitivity in patients with type 2 diabetes mellitus
after oral administration of alpha-lipoic acid.\" HORMONES-ATHENS- 5.4 (2006): 251. <\/span><\/p>
medicinal potency.\" Asian Pacific Journal of Tropical Disease3.2 (2013): 93-102. <\/span><\/p>
Yina, Jun, Huili Xing, and Jianping Yeb. \"Efficacy of Berberine in Patients with Type 2 Diabetes.\"
Metabolism 57.5 (2008): 712-717. <\/span><\/p>
of Alternative and Complementary Medicine 13.9 (2007): 977-983. <\/span><\/p>
isolated diaphragm.\" Journal of Biological Chemistry 237.1 (1962): 118-122. <\/span><\/p>
berberinehydrochloride, a P-glycoprotein substrate. International Journal of Biological Macromolecules. 2013 Aug;59:363–71. <\/span><\/p>
hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Mol Cell Endocrinol. 2012 Nov 5;363(1-2):122–30. <\/span><\/p>
features of the metabolic syndrome in pre-diabetic men and women.\" Journal of the International Society of Sports Nutrition 3.2 (2006): 45. 14. Rachh, P. R., et al. \"Antihyperlipidemic activity of Gymenma sylvestre R. Br. leaf extract on rats fed <\/span><\/p>