SNS Serious Nutrition Solutions Growth Factor XT - 150 Cap

Suggested Use:
As a dietary supplement, either take 5 capsules before bedtime or take 3 capsules before bedtime, and another 2 capsules spaced out 10 to 12 hours apart from the bedtime serving. For best results, take on an empty stomach. No not exceed 60 days of consecutive use without at least a 2 week break.

Warnings:
This product is for healthy adults over 18 years of age. Consult a physician before using this or any dietary supplement. Do not use if you have any pre-existing medical condition or are taking any medication without consulting your physician. Store in a cool, dry place away from children.

* These statements haven’t been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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References
1. Khanam et al. (2013). Safed musli (Chlorophytum borivilianum): a review of its botany, ethnopharmacology and phytochemistry. J Ethnopharmacol. 2013 Nov 25;150(2):421-41. doi: 10.1016/j.jep.2013.08.064.

2. Ray et al. (2013). Bioefficacy of hydromethanolic extract of tuber of Chlorophytum borivilianum (Safed Musli) for the management of male infertility in cyproterone acetate-treated albino rats. Andrologia. 2013 Aug 19. doi: 10.1111/and.12133.

3. Rath, S. K., & Panja, A. K. (2013). Clinical evaluation of root tubers of Shweta Musali (Chlorophytum borivilianum L.) and its effect on semen and testosterone. Ayu, 34(3), 273-5.

4. Bloomer. (2012). A Dietary Supplement Containing Chlorophytum Borivilianum and Velvet Bean Improves Sleep Quality in Men and Women. Integrative Medicine Insights.

5. Bloomer. (2011). A Blend of Chlorophytum Borivilianum and Velvet Bean Increases Serum Growth Hormone in Exercise-Trained Men. Nutrition and Metabolic Insights.

6. Broad EM, Maughan RJ, Galloway SD (2011). Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. International Journal of Sport Nutrition and Exercise Metabolism, 2011, 21:385-397.

7. Ho, J.-Y., Kraemer, W. J., Volek, J. S., Fragala, M. S., Thomas, G. A., Dunn-Lewis, C., Coday, M., et al. (2010). l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism Clinical And Experimental, 59(8):1190-9.

8. Pekala, J., Patkowska-Sokola, B., Bodkowski, R., Jamroz, D., Nowakowski, P., Lochynski, S., & Librowski, T. (2011). L-carnitine - metabolic functions and meaning in humans life. Current Drug Metabolism, 12(7), 667-78.

9. Volek, Jeff S., Kraemer, Wiliam J., et al. (2002). L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physio Endocrinol Metab, 282: E474-E482.

10. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, HatWeld DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. (2006). Androgenic responses to resistance exercise: effcts of feeding and L-carnitine. Med Sci Sports Exerc, 38:1288–1296.

11. Wu, A. H., Spicer, D., Stanczyk, F. Z., Tseng, C.-C., Yang, C. S., & Pike, M. C. (2012). Effect of 2-Month Controlled Green Tea Intervention on Lipoprotein Cholesterol, Glucose, and Hormone Levels in Healthy Postmenopausal Women. Cancer Prevention Research.

12. Stevenson, et al. (2005). Comparison between vitamin C, green tea extracts and olive leaf extracts : Oxygen Radical Absorbance Capacity (ORAC) Report on Olive Leaf Australia's Olive Leaf Extracts, Southern Cross University.

13. Y.S. Zhen, Z.M. Chen, S.J. Cheng & M.L. Chen. (2002). Tea: bioactivity and therapeutic potential, London, UK: New York Taylor & Francis, pp. 121–225.

14. I.T. Johnson & G. Williamson. (2003). Phytochemical functional foods, Cambridge, UK: Woodhead Publishing, pp. 135-145

15. Haramizu, S., Ota, N., Hase, T., & Murase, T. (2013). Catechins suppress muscle inflammation and hasten performance recovery after exercise. Medicine and science in sports and exercise, 45(9), 1694-702.

16. Cavagnini, F., Invitti, C., Pinto, M., Maraschini, C., Di Landro, A., Dubini, A., & Marelli, A. (1980). Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta endocrinologica.

17. Powers, M. E., Yarrow, J. F., McCoy, S. C., & Borst, S. E. (2008). Growth hormone isoform responses to GABA ingestion at rest and after exercise. Medicine and science in sports and exercise.

18. Chihara, K., Kashio, Y., Kita, T., Okimura, Y., Kaji, H., Abe, H., & Fujita, T. (1986). L-dopa stimulates release of hypothalamic growth hormone-releasing hormone in humans. The Journal of clinical endocrinology and metabolism, 62(3), 466-473.

19. Lal S, et al. (1984). Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects. Prog Neuropsychopharmacol Biol Psychiatry.

20. Nagai M, Conney AH, Zhu BT. (2004). Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase. Drug Metab Dispos.

21. Yamada T, et al. (1995). Effect of chronic L-dopa administration on serum luteinizing hormone levels in male rats. Toxicology.

22. Root AW, Russ RD. (1972). Effect of L-dihydroxyphenylalanine upon serum growth hormone concentrations in children and adolescents. J Pediatr.

23. Boden G, Lundy LE, Owen OE. (1972). Influence of levodopa on serum levels of anterior pituitary hormones in man. Neuroendocrinology.
 
24. Shukla, K. K., Mahdi, A. A., Ahmad, M. K., Shankhwar, S. N., Rajender, S., & Jaiswar, S. P. (2009). Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertility and Sterility, 92(6), 1934-1940.

25. Saito, I., Kawabe, H., Hasegawa, C., Iwaida, Y., Yamakawa, H., Saruta, T., Takeshita, E., et al. (1991). Effect of L-dopa in young patients with hypertension. Angiology.

26. Dunn, P. J., Donald, R. A., & Espiner, E. A. (1976). A comparison of the effect of levodopa and somatostatin on the plasma levels of growth hormone, insulin, glucagon and prolactin in acromegaly. Clinical endocrinology, 5(2), 167-174.

27. Unno, K., Tanida, N., Ishii, N., Yamamoto, H., Iguchi, K., Hoshino, M., Takeda, A., et al. (2013). Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary a-amylase activity, trait anxiety and subjective stress. Pharmacology Biochemistry and Behavior, 111, 128-135.

28. Zukhurova, M., Prosvirnina, M., Daineko, A., Simanenkova, A., Petrishchev, N., Sonin, D., Galagudza, M., et al. (2013). L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. Phytother Res, 27(9), 1282-1287. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23097345

29. Tamano, H., Fukura, K., Suzuki, M., Sakamoto, K., Yokogoshi, H., & Takeda, A. (2013). Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory. Brain Research Bulletin, 95, 1-6.

30. Tian, X., Sun, L., Gou, L., Ling, X., Feng, Y., Wang, L., Yin, X., et al. (2013). Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain Research, 1503, 24-32.

31. Siamwala, J. H., Dias, P. M., Majumder, S., Joshi, M. K., Sinkar, V. P., Banerjee, G., & Chatterjee, S. (2013). L-Theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation. Journal of Nutritional Biochemistry, 24(3), 595-605.

32. Yoto, A., Motoki, M., Murao, S., & Yokogoshi, H. (2012). Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. Journal of Physiological Anthropology.

33. Ren, S. G., Ren, S. G., Melmed, S., & Melmed, S. (2006). Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology, 147(8), 3936-3942.
34. Moretti et al. (1982). Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise. N Engl J Med. Aug 12;307(7):444-5.

35. Ren, S. G., Ren, S. G., Melmed, S., & Melmed, S. (2006). Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology, 147(8), 3936-3942.

36. Moretti et al. (1982). Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise. N Engl J Med. Aug 12;307(7):444-5.

37. Delitala, G., & Masala, A. (1977). Dissociation of growth hormone and prolactin response to levodopa during pyridoxine administration. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 27(6), 219-222.

38. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. (2002). "Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4". J. Pharmacol. Exp. Ther. 302 (2): 645–50.

 39 Atal CK, Dubey RK, Singh J. (1985). "Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism". J. Pharmacol. Exp. Ther. 232 (1): 258–62.

 40. Reen RK, Jamwal DS, Taneja SC, et al. (1993). "Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine". Biochem. Pharmacol. 46 (2): 229–38.

 41. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. (1998). "Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers". Planta Med. 64 (4): 353–6.