What if I told you that your gut was the most important endocrine organ in your body, controlling everything from metabolism to body composition to your health and mood? What if I told you that it was governed by trillions of bacteria, called the "microbiota”, who have long ago invaded and colonized it? What if I told you that this is as bad as it sounds? They are not all friendly – there is a war going on inside your body -- and, the bad guys are winning!
Well, that is what I am telling you. It is time for YOU to fight back! Neobium is your trusted ally, bringing the big guns and space lasers and nukes at your shit. We bring you three products, three weapons -- Shock Therapy, Suprabiotic, and Primer -- working together, by land, by air, by sea to conquer this terrible adversary.
SupraBiotic The Slimming Probiotic Beyond the cutting edge of probiotic research and development, SupraBiotic™ combines 6 probiotic strains, 100 billion colony forming units, with an unrivalled auxillary formula, optimized to turn the bacterial milieu of your gut into a mean, lean body machine. It does not stop at fat loss, though, fighting and fixing inflammatory pathways that wreak havoc on insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin.
SupraBiotic™ The Slimming Probiotic™
Gut Feelings There are trillions of bacteria, living and breeding inside your body, right now. The gut and its microbiome are essentially a massive endocrine organ, controlling and influencing basically your entire body and brain. You need some of them to survive, but many of them hate you. For most people, due to genetics and/or diet, the evil ones have gotten the upper hand, attacking you with not only fat gain, but whole body inflammation accompanied by damage to insulin sensitivity, cardiovascular and digestive health, the immune system, and even your skin and brain. And, given that all of these trillions of bacteria that call your gut "home” originally came from outside your body – and entered without your permission – it is by far the most important organ in which we can take steps to manipulate and regain control. SupraBiotic™ combines 6 probiotic strains, over 80 billion colony forming units, with an unrivalled auxiliary formula, optimized to turn the bacterial milieu of your gut into a mean, lean body machine. You have sought out and destroyed these invaders with Shock Therapy™, freeing the kingdom of your gut. Now, repopulate it with loyal, benevolent bacterial citizens with SupraBiotic™ Deus Vult!
The Gut-Wrenching Truth
The Western lifestyle (including diet, lack of exercise, and alcohol use) leads to an imbalance of the bacterial composition of the gut. This results in the excess production of inflammatory signals, such as Lipopolysaccharide (LPS), which escape the gut and enter the rest of your body. This leads to general digestive issues and inflammatory bowel syndromes like IBS. While fixing digestive disorders will come along for the ride, our primary focus is going to be on body composition and metabolic health. In other words, we want to make you leaner, protect against diabetes, and help keep you from having a heart attack or stroke. LPS causes an increase in digestion speed, which leads to less nutrient absorption and feedback signals that tell the brain that it is time to stop eating. But, in the colon, speed is decreased which results in a greater total utilization of caloric energy from your food. In other words, your brain tells you to keep eating and this leads to excessive fat accumulation from harvesting more calories. This aggravates the cycle further, as overeating and increased adiposity are inflammatory. So, what you have is more inflammation, more dysfunction, greater food intake, greater extraction of food, more fat accumulation, and REPEAT! The carnage does not end here. Along with this inflammatory state is a disruption in the intestinal barrier. Intestinal permeability is increased and these inflammatory agents spill out. This is often called a "leaky gut”. The biggest culprit here is, once again, LPS. This goes in conjunction with decrease in activity of brake signals such as short chain fatty acids (SCFAs), PPAR-alpha, and AMPK that act as anti-inflammatories and protect intestinal barrier function. Once LPS escapes, it is active in the body and brain, just as in the intestine. In the fat tissue, this leads to fat storage. In the brain, it increases appetite, hunger, and food intake. It does so by decreasing both insulin and leptin insensitivity, peripherally and centrally, via Toll-like Receptor-4 (TLR4). At this point, your body fat thermostat is wrecked, your ability to control food intake is gone, and you are a fat storing machine. It is important to note, this low-level but constant systemic inflammation, PRECEDES insulin/leptin resistance and obesity. Elevated LPS levels, which occur during a Western-style and high-fat diet, initiate all of this. More bad news: atherosclerosis, heart disease, and stroke are promoted by these same inflammatory pathways. Combined with the increased body fat and insulin resistance, you officially have the perfect ingredients for the dreaded Metabolic Syndrome. Obviously, this is not what you want your body doing to itself. It is not what you want it doing to you. It is not what you want it doing to your life. And, it is just a bunch of microscopic bacteria causing all of this devastation. They need to go.
Probiotically Speaking The most well-known, commercial probiotics are Lactobacillus and Bifidobacterium. They are also among the most common in the body, along with several other really interesting ones which are not commercially available, but we can manipulate with supplementation as you will soon learn. Unfortunately, Lactobacillus belong to the Firmicutes phylum which is associated with weight gain and obesity. Just a 20% increase in Firmicutes with an equal decrease in Bacteroides results in an increased energy harvest of 150 calories per day in humans. That is equal to 15lbs of fat per year! Modern food processing and the Western style diet promote these negative changes in microbial proportions. Thus, one can plainly see why it can be so difficult to get lean, as well as how easily obesity has become an epidemic.
In addition, probiotic treatment with several Lactobacillus species are directly associated with weight gain, body mass index, obesity, and Type-2 diabetes. They don’t tell you that on the label. More powerful evidence of the profound effect of the microbiota on body weight and metabolism come from studies on fecal transfer. And, yes, that is exactly what it sounds like – transferring poop from one subject’s intestine to another’s. In twins, transfer of an obese microbiota to lean mice was accompanied by an increase in fat cell formation, fat storage, bodyweight, fat mass, feelings of hunger, food consumption, and a dysbiotic alteration of the Firmicutes:Bacteroides ratio to reflect that of the obese model. On the other side of the coin, transferring the intestinal microbiota from lean donors to obese does the opposite – it fixes all of these things. Obviously, while it highlights the science, doing a fecal transfer is not terribly practical, appetizing, or readily available. Fortunately, there is good news. While several species and strains of lactobacillus have been found to promote weight gain, several have also been found to protect against it. And, of course, we only used the good ones. Furthermore, Bifidobacterium have shown only positive effects to a remarkable extent.
SupraBiotic Ingredients You may have noticed that almost no probiotic formulas contain just a single species of bacteria, nowadays. And, if you did not, I will just say that it is for a good reason. They work better in combination. Microbial diversity is good. Essentially, a diverse gut is a healthy gut.
However, you do not want to just throw every single commercially available species and strain into a product as so many companies do. They need to be rationally combined. If not, they can interfere with each other’s actions and compete for space and resources.
But, the most interesting benefit of probiotic combinations is through cross-feeding. This is when one bacterial strain produces metabolites the others use for fuel, as we will discuss in a bit.
Right now, let’s get to the SupraBiotic probiotic combination.
Bifidobacterium breve Suppresses the accumulation of body weight and fat mass Improves lipid metabolism and insulin/leptin sensitivity Combats LPS induced inflammation and leaky gut
Inhibits enemy of leptin/insulin sensitivity Toll-like Receptor-4 (TLR-4) activity
Reinforces intestinal epithelial cells and mucosa, improving the physical barrier of the intestine
Bifidobacterium animalis subsp. lactis Increases short chain fatty acid (SCFA) production to distal parts of the colon, meaning it has a long acting mechanism of action Shifts the microbiota toward that of a lean phenotype Negatively associated with body mass index and obesity Reduces hunger, weight gain, fat mass accumulation and preserves glucose tolerance Reverses inflammation induced insulin resistance Improved the efficacy of AMPK agonist metformin, suggesting potentiation with this pathway Reduces LPS and inflammation, preserving gut barrier function and recovery in response to stress
Lactobacillis Plantarum Higher in lean subjects Inhibits weight gain, fat storage, fat cell formation, adipose cell size, and adipose tissue mass Reduces plasma glucose, insulin, triglycerides, and oxidative stress levels Increases fatty acid oxidation Improves insulin and leptin sensitivity against an obesity promoting diet via up-regulation of PPAR-alpha Increases in leptin levels even during weight loss Preferentially directs calories toward lean tissue Synergistic with other probiotics as well as with polyphenols Increases levels of the genus Bacteroides while reducing the Firmicutes:Bacteroides ratio Potent anti-inflammatory, attenuating signaling of LPS and TLR-4 Increased tight junction protein formation and improved intestinal barrier function
Lactobacillis gasseri Mitigates bodyweight and fat mass increases in obesity promoting diets Decreases both visceral and subcutaneous adipose tissue Increases insulin and leptin sensitivity via adiponectin (which activates AMPK) Elevates total energy expenditure
Increases tight-junction protein expression and improves intestinal barrier function Inhibits LPS production, intestinal permeability, and adipose tissue inflammation
Lactobacillis Rhamnosum Reduces weight gain, fat mass, and fat synthesis Increases Bacteroides and improves the obesity associated Firmicutes:Bacteroides ratio Increases insulin and leptin sensitizing peptide adiponectin (which activates AMPK) Raises leptin levels even with weight loss Enhances fatty acid oxidation and insulin sensitivity via activation of AMPK in both adipose and skeletal muscle tissue Upregulates thermogenesis Decreases LPS and LPS induced systemic inflammatory markers, as well as TLR-4 expression Protective of microbial composition, inflammation, tight junction proteins, and gut barrier function against a high fructose diet as well as alcohol Anxiolytic in response to stress
Bifidobacterium adolescentis Higher in lean than obese populations and levels predict leanness, in general Reduces bodyweight, visceral adipose tissue, and fat mass, while improving insulin resistance Synergistic with polyphenols Most important as THE archetypal cross-feeder of several of the most important and impressive strains of bacteria
Produces acetate and oligosaccharides which are then consumed by acetate utilizing, butyrate and propionate producing bacteria -- the ones that are not commercially available
The Best Probiotics That Money Can’t Buy
Unfortunately, several species of bacteria with some of the very best data are not available commercially, due to regulatory issues and well as practical challenges that will not soon be resolved. Fortunately, there are a myriad of ways to specifically target and increase these strains using methods that ARE available. And, that is exactly what we have done. So, let’s take a look at these novel wonder-bacteria.
Genus Bacteroides Bacteroides are butyrate and propionate producing. Levels were 6-fold higher in lean vs. obese subjects. It has a negative correlation with fat mass, waist circumference, and energy intake. Bacteroides levels in Type-2 diabetes were only half that of those with normal glucose tolerance. The Firmicutes:Bacteroides ratio was also significantly worse in obese patients, even in comparison with the merely overweight . Various species in the Bacteroides genus reduced bodyweight and fat gain, triglycerides, and adipocyte volume while improving insulin and leptin sensitivity. It also lowered LPS and other inflammatory signals, while increasing fatty acid oxidation via PPAR-alpha.
Faecalibacterium prausnitzii Faecalibacterium prausnitzii is butyrate producing and is considered a physiological sensor and marker of human health. It really does not get much more important than that. It is lower in the obese and type-2 diabetics, as well as higher in normal glucose tolerance vs. prediabetic subjects. It reduces inflammatory markers, improves intestinal barrier function, and is sharply decreased in various inflammatory bowel diseases.
Akkermansia muciniphilia Akkermansia muciniphilia is mucin consuming and butyrate producing. Levels are higher in lean subjects than the general population and decreased in obesity and type-2 diabetes. This species is also inversely correlated to fasting glucose, waist-to-hip ratio, subcutaneous adipocyte diameter, plasma triglyceride levels, visceral adipose tissue mass, and insulin resistance. Its administration reduced fat mass, adipose tissue inflammation, and enhanced insulin sensitivity. Akkermansia levels are higher in normal glucose tolerance vs. pre-diabetic subjects. It increases intestinal endocannabinoid levels, decreasing inflammatory cytokine production and protecting intestinal barrier function.
Roseburia Species Roseburia species are butyrate producing. Increased levels are associated with decreased body weight, fat mass, insulin sensitivity, and triglycerides -- independent of calorie intake. Higher Roseburia counts are correlated with reduced body weight, improved profile of lipid and obesity related gene expression, along with a normalized inflammatory status. It is also lower in type-2 diabetes and atherosclerosis.
Bifidobacterium adolescentis as Cross-Feeder
As mentioned, the most important contribution of B. adolescentis is to feed other bacteria, specifically the really good but unavailable ones above.
B. adolescentis is superior to other potential cross-feeding Bifidobacterium in that it provides a slow, steady degradation of oligosaccharides for a long, continuous release of substrate for these various bacteria to feed on. It is essentially time-released, allowing acetate feeding, butyrate producing bacteria to grow and thrive throughout the entire length of the gut.
Faecalibacterium prausnitzii is almost fully dependent on acetate, which B. adolescentis supplies. F. prausnitzii converts it to butyrate with 85% efficiency, and its growth is enhanced by co-culture with B. adolescentis. Roseburia also generally requires acetate for growth. B. adolescentis also increases Roseburia and F. prausnitzii via partial breakdown of prebiotic oligosaccharides and carbohydrates, which they can then feed on.
Short Chain Fatty Acids (SCFAs) One of the primary ways that probiotic bacteria work their magic is by fermenting prebiotics and producing SCFAs (primarily acetate, butyrate, and propionate). Low carbohydrate diets can result in less fermentable material, thus lower SCFA levels, if you do not make a point to get adequate fiber. SCFAs primarily work by activating free fatty acid receptors, FFAR2 and FFRA3 and by decreasing inflammation and permeability in the gut. Induction of FFA2/3 protects against obesity and insulin resistance by decreasing hunger and food intake, increasing energy expenditure, and improving glucose and lipid metabolism. Butyrate is also the preferred energy source, along with Glutamine, for maintenance and repair of epithelial cells in the colon. It increases tight junction assembly, thus improving barrier function, specifically through AMPK.
AMPK is basically the airbrakes on the runaway train of inflammation and "leaky gut” induced metabolic dysfunction caused by modern food processing, the Western diet, and microbial dysbiosis. In addition to its involvement in barrier function, AMPK activation is extremely positive for the great bacteria that we can’t get commercially. Its activation increases Akkermansia and Bacteroides levels, at least partially by elevating production of mucin, one of their favorite foods.
Pomegranate Extract Extremely rich source of polyphenols Polyphenols are generally prebiotic for good bacteria (Bifidobacterium, Akkermansia, Bacteroides, and Roseburia), and antibacterial for less favorable and pathogenic ones Fruit/berry based polyphenols are particularly favorable toward Bacteroides, the Firmicutes:Bacteroides ratio, and Akkermansia Akkermansia is increased 10 to 30-fold by various fruit polyphenols and by 33 to 47-fold with Pomegranate Extract Reduces weight gain, fat storage, visceral and subcutaneous fat, as well as insulin resistance Activates AMPK at 2 times the potency of metformin Inhibits LPS and inflammation, enhancing tight junction protein integrity and intestinal barrier function Lowers blood glucose output
Fermented Herbs Fermentation of herbs results in much higher concentrations of active compounds compared to unfermented. This same fermentation is done in the body, but it is highly dependent upon the microbial make-up of the individual’s gut, so it can vary widely from person to person.
Fermented Kudzu Polyphenol rich Reduces body weight, body mass index, visceral and subcutaneous fat mass, and lipogenesis Stimulates lipolysis, fatty acid oxidation, and thermogenesis Potent anti-inflammatory, inhibits LPS and TLR-4, improving insulin sensitivity Reduces intestinal permeability and improves intestinal barrier function
Fermented Ginseng Decreases bodyweight, fat mass, adipocyte size, and food efficiency Improves glucose uptake, as well as insulin and leptin sensitivity All of these effects are superior with fermented vs. regular Ginseng Decreases inflammatory cytokines and protects the intestinal barrier Increases mucins (Akkermansia and Bacteroides food) by 50% Strong prebiotic specificity toward Bifidobacterium and Bacteroides Synergistic with prebiotics
Mulberry Extract SupraBiotic contains an industry-best Mulberry Extract, standardized to over 5% 1-Deoxynojirimycin (1-DNJ) and containing relevant amounts of d-Fagomine, as well. Like all berries, it also has high polyphenol content, the benefits of which we have already talked about. 1-DNJ Significantly lowers body weight, blood glucose, and serum insulin levels Increases the insulin and leptin sensitizing peptide adiponectin (which activates AMPK) Reduces visceral adipose tissue, adipose tissue mass, triglycerides, and lipid accumulation Remarkably potent, elevating adiponectin, GLUT4, and AMPK with 1000 times the potency of metformin Increased fatty acid oxidation, while improving mitochondrial function and lipid metabolism Reduces glucose and insulin output
D-fagomine Reduces weight gain, plasma triglycerides, and glucose Attenuates fat gain on obesity promoting diet Enhances leptin and insulin sensitivity Lowers post-meal glucose levels
Selenium Synergistic with probiotics, increasing microbial diversity Enhances prebiotic fermentation activity by gut bacteria Results in better probiotic bacterial growth as well as output of SCFAs
Queen’s Bee Acid (10-hydroxy-2-decenoic acid) 25 times as potent at AMPK as metformin Increases GLUT4, glucose uptake, and insulin sensitivity
Inhibits LPS induced cytokine production Enhances intestinal barrier function and tight junction assembly via AMPK Improves LPS induced blood-brain-barrier disruption much as it does with the intestinal barrier Improves central insulin and leptin signaling, keeping your body fat thermostat functioning properly
Palmitoylethanolamide (PEA) Increase satiety via PPAR-alpha, reducing food intake and body weight Decreases intestinal transit rate, prolonging its own activity on satiety Increases endocannabinoid and PPAR-alpha levels, keeping LPS inflammation and obesity promoting activity in check Selective inhibits insulin and leptin desensitizer TLR-4 Protects against Western style and high-fat diet induced disruptions of endocannabinoid control of gut-brain axis regulation of food intake and fat storage Cannabinoid normalization increased Akkermansia by 4-fold, and improved the Firmicutes:Bacteroides ratio by 6-fold Particularly useful with high-fat diets, including low carb
Activates PPAR-alpha, as well as AMPK, with 5 times the potency of metformin Increases tight junction proteins and protects barrier integrity against inflammatory assault Suppress colitis via anti-inflammatory and anti-oxidant activity Enhances the survival and proliferation of intestinal epithelial cells Reduces spasms of smooth muscle in the digestive tract Increases uptake of Calcium (100+%) and Glutamic acid (60%), both of which protect intestinal barrier function
CONCLUSION As you can see, SupraBiotic takes the concept of probiotic far beyond where anyone has previously taken it before. It starts with bacterial species carefully and purposefully selected to protect against dysfunction of the gut and microbiota to promote better health, better appetite control, better metabolism, and better fat loss. On top of this, SupraBiotic addresses and supports novel probiotic bacterial species that you cannot attain, anywhere, and does so in a way that no other product is even close to doing. Finally, its supporting ingredients crush inflammation and repair your leaky gut, leaving your body functioning in the optimal way it is intended to.
SupraBiotic is a one of a kind product that fits perfectly with and enhances any diet and exercise program, any supplement regimen, any lifestyle.