Yohimbine has been one of the most popular supplements for years. It’s typically used as a fat loss and appetite suppression aid as well as an aphrodisiac and sexual performance supplement.* What is Yohimbine?
Yohimbine is a naturally occurring alkaloid found within the bark of the yohimbe tree (Pausinystalia yohimbe) indigenous to central and western Africa.
What is Yohimbine Typically Used For?
Fat Loss* Appetite Control* Improved Sex Drive* Greater Libido* What Does Yohimbine Do?
Yohimbine acts as a central nervous stimulant, activating the body’s "fight or flight” response, causing an increase in levels of two catecholamines -- noradrenaline and adrenaline.
Catecholamines can bind to the adrenergic receptors on fat cells and either kick start fat burning or shut it off.
You see, fat cells have two types of adrenergic receptors:
Alpha receptors -- suppress fat burning Beta receptors -- support fat burning
When these catecholamines bind to the alpha receptors, fat burning is stunted. However, when they bind to beta receptors, the adipocyte "unlocks” (in a manner of speaking), unloading its stored fatty acids into the bloodstream where they can then be picked up and burned for energy.*
The problem is that we don’t really get to choose to which receptors our catecholamines bind. And, on top of that, some regions of fat on the body tend to have a greater density of alpha receptors than beta receptors. FYI, these are usually the areas referred to as "stubborn fat.”
Seeing that yohimbine has a high affinity for alpha-2 adrenergic receptors, it can bind to them, thereby allowing more catecholamines available to bind to beta receptors and encourage fat burning.
In other words, yohimbine helps stop fat cells from resisting fat burning.
Supports Fat Loss
Yohimbine’s ability to antagonize (inhibit) alpha-2 adrenergic receptors should support fat loss, and, indeed, there are several studies noting that supplementation with yohimbine does help reduce body fat.*
Specifically, a study in 20 top-level male soccer players showed that daily yohimbine supplementation reduced body fat levels from 9.3 to 7.1%.*
Another study in obese women noted that those who supplemented with yohimbine lost significantly more weight than those taking a placebo — 7.8 pounds vs. 4.9 pounds, respectively.*
Older research found that yohimbine supplementation may help increase resting energy expenditure and exercise-induced energy expenditure in both lean and obese women.*
Finally, it’s also worth noting that It yohimbine may help reduce body fat without affecting lean mass.*
Supports Exercise Performance
Beyond its pro-fat loss properties, additional studies indicate that yohimbine supplementation may also improve exercise performance by reducing the onset of fatigue.*
The longer an individual can exercise without succumbing to fatigue, the more calories they may burn, further supporting weight loss.*
Supports Sexual Health
Additional studies suggest yohimbine may be beneficial for those who struggle to stand strong in the bed room.*[7,8,9]
A 1998 meta-analysis of seven studies found that supplementation with yohimbine was more effective than placebo for the treatment of erectile dysfunction.
Researchers concluded their review of the literature by stating:
"Therefore, yohimbine is believed to be a reasonable therapeutic option for erectile dysfunction that should be considered as initial pharmacological intervention.”
Additional studies indicate that yohimbine may also enhance the release of nitric oxide (NO) from cavernosal endothelial cells, improving blood flow and sexual performance.*
What Can I Stack with Yohimbine?
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
McCarty, M. F. (2002). Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Medical Hypotheses, 58(6), 491–495. Millan, M. J., Newman-Tancredi, A., Audinot, V., Cussac, D., Lejeune, F., Nicolas, J. P., Gobert, A. (2000). Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse (New York, N.Y.), 35(2), 79–95. Ostojic, S. M. (2006). Yohimbine: the effects on body composition and exercise performance in soccer players. Research in Sports Medicine (Print), 14(4), 289–299. https://doi.org/10.1080/15438620600987106Kucio, C., Jonderko, K., & Piskorska, D. (1991). Does yohimbine act as a slimming drug? Israel Journal of Medical Sciences, 27(10), 550–556. Zahorska-Markiewicz, B., Kucio, C., & Piskorska, D. (1986). Adrenergic control of lipolysis and metabolic responses in obesity. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme, 18(10), 693—697. https://doi.org/10.1055/s-2007-1012409Al-kuraishy, H., Abood, H., & Al-Gareeb, A. (2015). Ergogenic Effects of Yohimbine: Standardized Cycling… Ergogenic Effects of Yohimbine: Standardized Cycling Clinical Study. Karbala J. Med.(Vol. 7). Ernst E, Pittler MH. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. Journal of Urology. 1998;159(2):433–436 Pittler, M. H. (1998). [Yohimbine in therapy of erectile dysfunction]. Fortschritte der Medizin, 116(1–2), 32–33. Corazza O, Martinotti G, Santacroce R, et al. Sexual enhancement products for sale online: raising awareness of the psychoactive effects of yohimbine, maca, horny goat weed, and Ginkgo biloba. Biomed Res Int. 2014;2014:841798. doi:10.1155/2014/841798