Primeval Labs Pyretic Black TWINPACK - 2 x 120 Cap

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What is Pyretic Black?

Pyretic Black is a once-a-day weight loss support supplement that not only supports fat burning but can also double as an energy and focus-boosting pre-workout.*

Pyretic Black has been scientifically-formulated to address fat loss from multiple angles, including appetite suppression, fat mobilization, blood sugar stabilization, and metabolism support. *

Unlike conventional fat burners that only load you up on a bunch of caffeine and harsh stimulants, Pyretic Black has been meticulously crafted to supply smooth, long-lasting energy and focus along with added appetite suppression all in the effort to help make weight loss easier than ever.*

*** Due to the potency of Pyretic Black, we recommend starting with 2 caps for your initial dosing and assessing tolerance before proceeding to consume one full serving.

Pyretic Black Ingredients
Green Tea Extract
Green Tea (Camellia sinensis) is one of the most widely consumed beverages on the planet due to its high antioxidant content and smooth, subtle energy boost.*

The leaves of Camellia sinensis are rich in potent polyphenols, catechins, and flavonoids, which help combat inflammation and oxidative stress in the body.*

Primeval Labs uses a green tea extract standardized for 50% EGCG and 98% polyphenols.*

The research on Green Tea Extract, as well as EGCG, is rather extensive, particularly in regards to weight loss. Studies have shown that it can increase fat oxidation and energy expenditure both at rest and during exercise. It may also boost athletic performance, too!*[1,2,3]

Additional studies have noted that green tea extract supplementation led resulted in decreased starch digestion and absorption as well as decreased body fat and waist circumference.*[4]

Rich in polyphenols, catechins, and antioxidants*
Studies demonstrate green tea extract supplementation may enhance fat oxidation and energy expenditure*
May support increased athletic performance*
Gymnema Sylvestre 4:1
Gymnema Sylvestre is held in high regard for its anti-diabetic properties as numerous studies demonstrate that with consistent use Gymnema lowers serum glucose levels and HbA1c.[5,8] The potent compounds inside the plant responsible for its blood sugar-regulating properties is a group of acids known as gymnemic acids.*

Studies have demonstrated that Gymnema enhances insulin function. Better insulin function supports better nutrient partitioning, maintains stable blood sugar levels, and helps avoid the energy highs and lows that can accompany high-carb meals.*

A comprehensive review of Gymnema Sylvestre noted that in addition to supporting the utilization of glucose, supplementation with it also led to improvements in leptin levels, body weight and even BMI (body mass index).*[7]

In addition to its anti-diabetic properties, the powerful herb also possesses antimicrobial, antihypercholesterolemic, and hepatoprotective properties.*[6]

Noted in research to help lower blood glucose and HbA1c*
Supports healthy insulin function*
May support weight loss*
Olive Leaf Extract (6% Oleuropein)
Olives are a staple of Mediterranean cuisine and the Mediterranean diet.*

Olives, their oil, and the leaves of the olive tree are rich in numerous phenolic compounds, including oleuropein, which has been noted to offer a wide range of benefits, including[9]: *

Antioxidant
Anti-inflammatory
Anti-atherogenic
Antimicrobial activity
Antiviral activity
Hypolipidemic (improve lipid profiles)
hypoglycemic effect (lower blood sugar)
Together these abilities make olive leaf one of the most appealing supplements not only for weight loss but general health as well.*

But there’s more!

Additional studies indicate that olive leaf extract may enhance insulin sensitivity and offer protection against LDL ("bad”) cholesterol oxidation.*[10]

And, to top it off, olive leaf extract also supports thyroid function.*[11]

A properly functioning thyroid is essential to a healthy metabolism.*

Rich in antioxidants*
Supports thyroid function*
May promote insulin sensitivity*
Caffeine
Caffeine is a staple fat-burning, thermogenic supplement. It’s incredibly well studied and proven to boost metabolism, increase calorie burning, and enhance lipolysis (the "freeing” of stored fatty acids).*[12,13] 

Caffeine further supports weight loss by acting as a mild appetite suppressant, helping individuals to stay on track with their diet and avoid mindless snacking.

As you’ve experienced for yourself, caffeine is particularly good at increasing energy and heightening mood. This is in part due to caffeine’s ability to stimulate dopamine release in the brain, which increases mood, motivation, and focus -- all things that tend to decline when dieting for fat loss.*[14]

But there’s more, dopamine increases thermogenesis in brown adipose tissue, further ramping up calorie burning.*[15]

Pyretic Black contains 260mg caffeine from a combination of caffeine anhydrous and Infinergy Dicaffeine malate. Using both immediate- and delayed-release caffeine sources helps Pyretic Black supply smooth energy that lasts for hours on end. This combination also helps offset the unpleasant jitters, edginess, and crash of many other weight loss supplements that just load users up on a ton of caffeine.*

Pyretic supplies 260mg caffeine per 4 capsule serving
Supports increased energy and focus*
May help reduce appetite*
Promotes fat burning and increased energy expenditure*
L-Theanine
Theanine is an amino acid prevalently found in green tea leaves that have become a staple in fat burners, nootropics, and even pre workouts, for its ability to promote a sense of calm, controlled focus and heightened productivity, especially when taken alongside caffeine as it is here in Pyretic Black.*

Theanine readily crosses the blood-brain barrier where it can bind to glutamate receptors, inhibiting glutamate reuptake while simultaneously increasing GABA levels in the brain.*[16]

Additional studies have shown that Theanine also boosts dopamine in the striatum and support long-term potentiation and an increase in brain-derived neurotrophic factor with prolonged use.*[17]

Including theanine in Pyretic Black helps smooth out the stimulating qualities of caffeine, providing sustained, controlled energy, focus, and mood, avoiding the harsh "punch” that conventional thermogenic fat burners are known for.*

amino acid prevalent in green tea that crosses the blood-brain barrier*
increases levels of GABA, promoting feelings of calm*
Boosts dopamine concentration*
Synergizes with caffeine to promote focus and attention*
Rhodiola Rosea
Dieting can be extremely stressful from both a psychologically and physiologically standpoint. As stress rises, so too does cortisol, and with greater cortisol comes greater difficulty in burning stubborn belly fat.*

Rhodiola is an adaptogenic herb that reduces stress, decreases cortisol, and combats mental fatigue. A staple herb of Ayurveda, rhodiola is renowned for its ability to naturally boost energy levels, improve cognitive performance, and promote a sense of well-being when the stressors of life seem overwhelming.*[18]

In addition to its anti-stress, anti-fatigue properties, rhodiola also has been noted to increase athletic performance and enhance glucose uptake by skeletal muscle.*[19,20]

Ayurvedic herb noted for its ability to help reduce stress and improve cognitive performance*
May help alleviate mental fatigue*
TeaCrine®
TeaCrine is best described as the slower-acting, longer-lasting cousin of caffeine. Similar to its energy-boosting relative, TeaCrine also binds to adenosine receptors, preventing adenosine from binding, which reduces fatigue and heightens feelings of wakefulness and alertness.*

TeaCrine also increases mood, focus, subjective feelings of energy, all without the jitters, crash or habituation of caffeine. In fact, studies have shown that even after months of daily use, TeaCrine® does not lose its effectiveness or lead to dependency, the same of which can’t be said for caffeine.*

It’s also important to note that co-administration of TeaCrine® with caffeine may help prevent tolerance to caffeine.*

In short, the combination of TeaCrine + Caffeine supports smoother, longer-lasting energy and no crash!*

Supplies long-lasting, jitter-free energy*
Synergistic with caffeine*
Inhibits adenosine via allosteric modulation*
Cayenne Pepper
Cayenne pepper is packed with capsaicin, a fiery little alkaloid that’s responsible for the chile’s tongue-numbing heat. Studies show that in addition to amping up the flavor of culinary fare, capsaicin may also be a valuable stimulant-free weight loss supplement, too.*[24,25]

Capsaicin has been documented to decrease appetite and increase satiety by increasing glucagon-like peptide 1 (GLP-1) and decrease ghrelin (the hunger hormone).[24] Additional research demonstrates that capsaicin can activate brown fat thermogenesis leading to greater fat burning.[25]

Capsaicin may further reduce appetite and calorie intake, due to its binding and activation of transient receptor potential vanilloid-1 (TRPV1) in the mouth, stomach, and small intestine.*[26]

Activation of TRPV1 receptor stimulates the release of noradrenaline and dopamine, which has been noted to support weight loss and exercise performance.*

Noted in research to reduce appetite and increase satiety*
Stimulates thermogenesis*
Activates TRPV1 receptors which increase dopamine and noradrenaline*
Paradoxine™
Pyretic Black further stokes the body's thermogenic engine with the inclusion of Paradoxine, a patented extract of Grains of Paradise (Aframomum Melegueta) standardized to 12.5% 6-paradol.*

Grains of Paradise is a pungent spice that has earned a reputation as one of the most intriguing stimulant-free fat loss supplements on the market.*

What makes Paradoxine such as standout ingredient is some research that indicates it has the ability to increase energy expenditure and mobilize fat from brown adipose tissue (BAT).*[27,28,29]

Mobilization and activation of this fat support greater calorie burning and weight loss.*

stimulant-free ingredient*
noted in research to enhance energy expenditure*
stimulates brown fat thermogenesis*

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Suggested Use:
Due to the potency of Pyretic Black, we recommend starting with 2 caps for your initial dosing and assessing tolerance before proceeding to consume one full serving.

Disclaimer:

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease

References
Boschmann M, Thielecke F. The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr. 2007;26(4):389S-395S.
Auvichayapat P, Prapochanung M, Tongkumnerd Thai O, et al. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav. 2008;93(3):486-491. doi:http://dx.doi.org/10.1016/j.physbeh.2007.10.009.
Hodgson AB, Randell RK, Jeukendrup AE. The Effect of Green Tea Extract on Fat Oxidation at Rest and during Exercise: Evidence of Efficacy and Proposed Mechanisms. Advances in Nutrition. 2013;4(2):129-140. doi:10.3945/an.112.003269.
Lochocka K, Bajerska J, Glapa A, et al. Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study. Scientific Reports. 2015;5:12015. doi:10.1038/srep12015.
Ulbricht, Catherine, et al. "An Evidence-Based Systematic Review of Gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration." Journal of Dietary Supplements, vol. 8, no. 3, 2011, pp. 311-330.
Kanetkar P, Singhal R, Kamat M. Gymnema sylvestre: A Memoir. J Clin Biochem Nutr. 2007;41(2):77-81.
Zuñiga, Laura Y., et al. "Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion." Journal of Medicinal Food, vol. 20, no. 8, 2017, pp. 750-754.
Baskaran, K., et al. "Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients." Journal of Ethnopharmacology, vol. 30, no. 3, 1990, pp. 295-305.
Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010;78(2):133-54.
De Bock M, Derraik JGB, Brennan CM, et al. Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial. Nerurkar PV, ed. PLoS ONE. 2013;8(3):e57622. doi:10.1371/journal.pone.0057622.
Al-Qarawi AA, Al-Damegh MA, ElMougy SA Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Phytother Res. (2002)
Nehlig A. Is caffeine a cognitive enhancer? J Alzheimers Dis 2010;20 Suppl 1, S85-94. Habowski SM, Sandrock J, et al.
Lieberman, H. R., Wurtman, R. J., Emde, G. G., Roberts, C., & Coviella, I. L. (1987). The effects of low doses of caffeine on human performance and mood.Psychopharmacology, 92(3), 308–312.
Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A., & Miller, D. S. (1989). Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American Journal of Clinical Nutrition, 49(1), 44–50.
https://doi.org/10.1093/ajcn/49.1.44
Kohlie, R., Perwitz, N., Resch, J., Schmid, S. M., Lehnert, H., Klein, J., & Iwen, K. A. (2017). Dopamine directly increases mitochondrial mass and thermogenesis in brown adipocytes. Journal of Molecular Endocrinology, 58(2), 57–66. https://doi.org/10.1530/JME-16-0159
White DJ, de Klerk S, Woods W, Gondalia S, Noonan C, Scholey AB. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients. 2016;8(1):53. Published 2016 Jan 19. doi:10.3390/nu8010053
Tamano H., Fukura K., Suzuki M., Sakamoto K., Yokogoshi H., Takeda A. Advantageous effect of theanine intake on cognition. Nutr. Neurosci. 2014;17:279–283. doi: 10.1179/1476830513Y.0000000094.
Khanum F., et. al.; Comprehensive Reviews in Food Science and Food Safety; "Rhodiola rosea: A versatile Adaptogen;” 2005
De Bock K. et al. Acute Rhodiola rosea intake can improve endurance exercise performance. International Journal of Sport Nutrition & Exercise Metabolism 14 (3), 298–307.  2004. 
Li HB et al. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol. 2008 Jul 7;588(2-3):165-9. doi: 10.1016/j.ejphar.2008.04.036. Epub 2008 Apr 20.
He H, Ma D, Crone LB, et al. Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans. J Caffeine Res. 2017;7(3):95-102.
Kuhman DJ, Joyner KJ, Bloomer RJ. Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women. Nutrients. 2015;7(11):9618-32. Published 2015 Nov 19. doi:10.3390/nu7115484
Feduccia, A A, et al; "Locomotor Activation by Theacrine, a Purine Alkaloid Structurally Similar to Caffeine: Involvement of Adenosine and Dopamine Receptors.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Aug. 2012
Smeets AJ and Westerterp-Plantenga MS. The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. European Journal of Nutrition. 2009;48(4):229-234. doi:10.1007/s00394-009-0006-1.
Whiting S, et al. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite 2012;59(2): p.341-8.
Ludy MJ, et al. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 2012: 37(2) p. 103-21.
Sugita, J., Yoneshiro, T., et al; "Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738;
Sugita J, Yoneshiro T, et al; "Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27
Momoe Iwami, Fatma A. Mahmoud, et al; "Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats”; Autonomic Neuroscience: Basic and Clinical; 161 (2011); 63–67

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