Performax Labs HyperMax EXTREME Orange Mango - 40 Servings

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Pre-workout supplements play an essential role in a person’s exercise and diet regimen. They must deliver on many fronts: energy, focus, blood flow, and performance, just to name a few. In order to properly prepare the mind and body for the hard work ahead, a precise blend of ingredients working together synergistically must be achieved. That is why Performax Labs is proud to present HyperMax Extreme: a fine-tuned formulation of clinically-backed, efficaciously-dosed ingredients for optimal performance. Our blend of vasodilators, adrenaline boosters, and sports performance enhancers will keep your brain humming and your body pushing through, no matter what you throw at it.

Citrulline – The precursor to arginine that works better than arginine to boost blood flow to skeletal muscle.
VASO6 – Studies show VASO6 leads to 50% vasodilation at a 300mg dose, the exact dose found in 2 scoops of Hypermax Extreme

Beta-alanine – One of the most trusted and well-studied ingredients available, this precursor to carnosine helps to buffer acid buildup for increased exercise performance and lean mass with reduced muscle soreness.

Betaine – A tripeptide that improves workout volume and hydration
B-phenylethylamine HCl – A trace amine that can increase the action of noradrenaline to vastly improve focus and cognition.

Hordenine HCL – This natural source of hordenine acts as a noradrenaline reuptake inhibitor to enhance its effects and enable it to last longer.

Caffeine Anhydrous– At 325 mg, this popular stimulant will deliver powerful enhancement of exercise performance, whether aerobic or anerobic.

In HyperMax Extreme, we have combined clinically-researched vasodilators and performance boosters with the best neuroenhancers available. By pairing B-phenylethylamine HCl with whole plant Eria jarensis extract, we are able to provide a full spectrum of phenethylamines, which maximizes their potency and cognitive effectiveness. Before your next workout, maximize your performance with HyperMax Extreme.

L-Citrulline

Citrulline is a precursor to arginine, and increases blood arginine more reliably and for a longer period of time than supplemental arginine. Citrulline is an amino acid that doesn’t build proteins, so the liver does not metabolize any of it. Therefore, more citrulline will be delivered into the bloodstream.

Ochiai et al. (2012) showed that supplementation with 5.6g of citrulline for 7 days increased blood arginine, nitric oxide production, and blood flow.

Regarding performance, Perez-Guisado and colleagues (2010) demonstrated that citrulline consumption increased training volume, lowered fatigue, and reduced muscle soreness.
 VASO6

VASO6 increases nitric oxide production. More nitric oxide in the blood stream results in endothelial-dependent relaxation (EDR). This is valuable for delivering more oxygen to muscle for greater ATP production and power, as well as nutrient delivery

Schlaich 2000 Reference U.S. Patent No 6,706,756 BI, Fig.7 † Grape seed extract fractions were separated and bioassayed for EDR activity using the rat aorta preparation. The compounds that exhibited the most EDR activity are contained in VASO6 at levels shown to induce 50% relaxation in the rat aorta.
Beta-Alanine

One of the best studied supplements for sports nutrition, beta-alanine is a precursor to carnosine – the main acid buffer for skeletal muscle. Exercise produces acid buildup, which can lead to soreness and decreased performance. Beta-alanine supplementation improves the body’s buffering ability, which leads to decreased muscle soreness and increased performance.

Eight weeks of beta-alanine consumption increased lean mass in both collegiate wrestlers and football players (Kern et al. 2011).
Smith et al. (2009) showed that beta-alanine improved total work performed, time to exhaustion, and VO2MAX, as well as lean mass, in young, healthy men.
 Betaine Anhydrous

Betaine, or trimethylglycine, is a tripeptide that can benefit athletes in multiple ways. As an osmolyte, it will improve whole body and intracellular hydration. It can also support anabolic hormones to keep you building muscle throughout the workout.

Trepanowski and colleagues (2011) observed an increase in training volume and oxygenation of the muscle.
Agmatine Sulfate

Agmatine bestows multiple benefits that improve exercise. Not only can agmatine improve glucose uptake to muscles, but it also increases blood flow.

Gao et al. (1995) demonstrated agmatine’s potent vasodilatory properties.
 

B-phenylethylamine HC
B-phenylethylamine is a powerful nootropic that acts on trace amine receptors in the brain and body. Via these mechanisms, it is able to affect multiple neurotransmitters to improve energy, focus and mood, including catecholamines such as adrenaline and noradrenaline.

Borowsky et al. (2001) showed that trace amine receptors can be found in specific brain areas where B-pheylethylamine has demonstrated catecholaminergic activity.
Paterson (1993) observed that phenylethylamine activated noradrenaline receptors in a sympathomimetic fashion, independent of noradrenaline.
 

N,N-dimethylphenylethylamine

N,N-dimethylphenylethylamine pairs remarkably with B-phenylethylamine for vastly enhanced efficacy, potency, and long-lasting effect.

N,N-dimethylphenylethylamine has shown improvements in focus and mood by affecting both noradrenaline and dopamine, respectively.
 

Hordenine HCL

Hordenine HCL is a naturally-occurring source of hordenine, an adrenergic-like compound that improves energy and focus. Through its action as a noradrenaline reuptake inhibitor, it enhances the bioavailability, action, and long-lasting effect of noradrenaline.

Barwell et al. (1989) observed the effects of hordenine on noradrenaline and its reuptake, suggesting that it would be effective when combined with other enhancers of noradrenaline release.
 

L-Tyrosine

Tyrosine is a precursor to serotonin, an important neurotransmitter regarding mood and energy.

In military cadets, tyrosine improved cognitive performance after a week of combat training, specifically regarding memory and cognitive task performance (Deijen et al., 1999).
Banderet and colleagues (1989) demonstrated that tyrosine improved mood and cognitive function during stressful conditions (cold and altitude).
 

Caffeine Anhydrous

Caffeine is the most commonly used stimulant in the world. Its effectiveness doesn’t stop at adrenaline and focus – it also improves power output, aerobic, and anerobic exercise.

In trained athletes, Schneiker et al. (2006) observed that caffeine induced an increase in peak power of 7% and an increase in total work of 8.5%.
In rugby players, caffeine increased power output and testosterone by 21% (Beaven et al., 2008).
Glaister et al. (2012) found that caffeine improved sprinting time by 1.4% during a multiple sprint running test.
 

Synephrine HCL

Synephrine HCL, or bitter orange, is a natural source of p-synephrine – a trace amine with structural similarities to ephedrine and noradrenaline. Known for its metabolism-boosting properties, p-synephrine has demonstrated beta-adrenergic agonism, similar to noradrenaline.

Seifert et al. (2011) demonstrated a synergistic benefit when caffeine was combined with Synephrine HCL, specifically regarding substrate utilization.
 

Rauwolfia Vomitoria

Rauwolfia is a natural source of rawolscine, a stereoisomer of yohimbine. It acts similarly to yohimbine as an alpha-2 adrenergic antagonist and as an agonist for serotonin receptors. As such, it stimulates the central nervous system to elevate mood, energy, and affect body composition via improved substrate utilization.
 

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L-Citrulline

Ochiai, M., et al., Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. Int J Cardiol, 2012. 155(2): p. 257-61.
Perez-Guisado, J. and P.M. Jakeman, Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res, 2010. 24(5): p. 1215-22.
Bendahan, D., et al., Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med, 2002. 36(4): p. 282-9.
Hickner, R.C., et al., L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sports Exerc, 2006. 38(4): p. 660-6.
Moinard, C., et al., Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. Br J Nutr, 2008. 99(4): p. 855-62.
 

Beta-Alanine

Walter, A.A., et al., Six weeks of high-intensity interval training with and without beta-alanine supplementation for improving cardiovascular fitness in women. J Strength Cond Res, 2010. 24(5): p. 1199-207.
Kern, B.D. and T.L. Robinson, Effects of beta-alanine supplementation on performance and body composition in collegiate wrestlers and football players. J Strength Cond Res, 2011. 25(7): p. 1804-15.
Smith, A.E., et al., Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial. J Int Soc Sports Nutr, 2009. 6: p. 5.
Hoffman, J.R., et al., Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutr Res, 2008. 28(1): p. 31-5.
Stout, J.R., et al., Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids, 2007. 32(3): p. 381-6.
Stout, J.R., et al., The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study. J Int Soc Sports Nutr, 2008. 5: p. 21.
 

Agmatine Sulfate

Lortie, M.J., et al., Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. J Clin Invest, 1996. 97(2): p. 413-20.
Gao, Y., et al., Agmatine: a novel endogenous vasodilator substance. Life Sci, 1995. 57(8): p. PL83-6.
Ishikawa, T., et al., N omega-hydroxyagmatine: a novel substance causing endothelium-dependent vasorelaxation. Biochem Biophys Res Commun, 1995. 214(1): p. 145-51.
Chang, C.H., et al., Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats. Neurosci Lett, 2010. 468(3): p. 297-9.
Hwang, S.L., et al., Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats. Diabetologia, 2005. 48(4): p. 767-75.
Khan, S., et al., Beta-endorphin decreases fatigue and increases glucose uptake independently in normal and dystrophic mice. Muscle Nerve, 2005. 31(4): p. 481-6.
Cheng, J.T., et al., Plasma glucose-lowering effect of beta-endorphin in streptozotocin-induced diabetic rats. Horm Metab Res, 2002. 34(10): p. 570-6.
Evans, A.A., S. Khan, and M.E. Smith, Evidence for a hormonal action of beta-endorphin to increase glucose uptake in resting and contracting skeletal muscle. J Endocrinol, 1997. 155(2): p. 387-92.
 

B-phenylethylamine HCl
Borowsky, B., et al., Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A, 2001. 98(16): p. 8966-71.
Astrup, A., L. Breum, and S. Toubro, Pharmacological and clinical studies of ephedrine and other thermogenic agonists. Obes Res, 1995. 3 Suppl 4: p. 537S-540S.
Kato, M., et al., ß-Phenylethylamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D 2 receptor mechanism. European journal of pharmacology, 2001. 418(1): p. 65-71.
Shannon, H.E., E.J. Cone, and D. Yousefnejad, Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. J Pharmacol Exp Ther, 1982. 223(1): p. 190-6.
Paterson, I., The potentiation of cortical neuron responses to noradrenaline by 2-phenylethylamine is independent of endogenous noradrenaline. Neurochemical research, 1993. 18(12): p. 1329-1336.
 

N,N-dimethylphenylethylamine

Kato, M., et al., ß-Phenylethylamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D 2 receptor mechanism. European journal of pharmacology, 2001. 418(1): p. 65-71.
Narang, D., et al., Trace amines and their relevance to psychiatry and neurology: a brief overview. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2011. 21(1): p. 73-79.
Paterson, I., The potentiation of cortical neuron responses to noradrenaline by 2-phenylethylamine is independent of endogenous noradrenaline. Neurochemical research, 1993. 18(12): p. 1329-1336.
Shannon, H.E., E.J. Cone, and D. Yousefnejad, Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. J Pharmacol Exp Ther, 1982. 223(1): p. 190-6.
Ono, H., H. Ito, and H. Fukuda, 2-Phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers. The Japanese Journal of Pharmacology, 1991. 55(3): p. 359-366.
 

Hordenine HCL

Barwell, C.J., et al., Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. J Pharm Pharmacol, 1989. 41(6): p. 421-3.
Nedergaard, O.A. and E. Westermann, Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig. Br J Pharmacol, 1968. 34(3): p. 475-83.
Frank, M., et al., Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse. Equine Vet J, 1990. 22(6): p. 437-41.
Hapke, H.J. and W. Strathmann, [Pharmacological effects of hordenine]. Dtsch Tierarztl Wochenschr, 1995. 102(6): p. 228-32.
Pellati, F. and S. Benvenuti, Chromatographic and electrophoretic methods for the analysis of phenethylamine [corrected] alkaloids in Citrus aurantium. J Chromatogr A, 2007. 1161(1-2): p. 71-88.
Servillo, L., et al., Tyramine Pathways in Citrus Plant Defense: Glycoconjugates of Tyramine and Its N-Methylated Derivatives. J Agric Food Chem, 2017. 65(4): p. 892-899.
Konczol, A., et al., Blood-brain barrier specific permeability assay reveals N-methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba. J Pharm Biomed Anal, 2016. 131: p. 167-174.
 

L-Tyrosine

Deijen, J.B., et al., Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull, 1999. 48(2): p. 203-9.
Banderet, L.E. and H.R. Lieberman, Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull, 1989. 22(4): p. 759-62.
Neri, D.F., et al., The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med, 1995. 66(4): p. 313-9.
Fernstrom, J.D. and M.H. Fernstrom, Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr, 2007. 137(6 Suppl 1): p. 1539S-1547S; discussion 1548S.
Lehnert, H. and R.J. Wurtman, Amino acid control of neurotransmitter synthesis and release: physiological and clinical implications. Psychother Psychosom, 1993. 60(1): p. 18-32.
 

Caffeine Anhydrous

Glaister, M., et al., Caffeine supplementation and multiple sprint running performance. Med Sci Sports Exerc, 2008. 40(10): p. 1835-40.
Schneiker, K.T., et al., Effects of caffeine on prolonged intermittent-sprint ability in team-sport athletes. Med Sci Sports Exerc, 2006. 38(3): p. 578-85.
Beaven, C.M., et al., Dose effect of caffeine on testosterone and cortisol responses to resistance exercise. Int J Sport Nutr Exerc Metab, 2008. 18(2): p. 131-41.
Astrup, A., et al., Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition, 1990. 51(5): p. 759-767.
Anderson, D.E. and M.S. Hickey, Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Med Sci Sports Exerc, 1994. 26(4): p. 453-8.
Harpaz, E., et al., The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol, 2017. 28(1): p. 1-10.
Gurley, B.J., S.C. Steelman, and S.L. Thomas, Multi-ingredient, caffeine-containing dietary supplements: history, safety, and efficacy. Clin Ther, 2015. 37(2): p. 275-301.
Goldstein, E.R., et al., International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr, 2010. 7(1): p. 5.
Spriet, L.L., Caffeine and performance. Int J Sport Nutr, 1995. 5 Suppl: p. S84-99.
 

Synephrine HCL

Stohs, S.J., et al., Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. Int J Med Sci, 2011. 8(4): p. 295-301.
Stohs, S.J., H.G. Preuss, and M. Shara, A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine. International Journal of Medical Sciences, 2012. 9(7): p. 527-538.
Jordan, R., et al., Beta-adrenergic activities of octopamine and synephrine stereoisomers on guinea-pig atria and trachea. J Pharm Pharmacol, 1987. 39(9): p. 752-4.
Arch, J.R., beta(3)-Adrenoceptor agonists: potential, pitfalls and progress. Eur J Pharmacol, 2002. 440(2-3): p. 99-107.
Seifert, J.G., et al., Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. Int J Med Sci, 2011. 8(3): p. 192-7.
Pellati, F. and S. Benvenuti, Chromatographic and electrophoretic methods for the analysis of phenethylamine [corrected] alkaloids in Citrus aurantium. J Chromatogr A, 2007. 1161(1-2): p. 71-88.
Servillo, L., et al., Tyramine Pathways in Citrus Plant Defense: Glycoconjugates of Tyramine and Its N-Methylated Derivatives. J Agric Food Chem, 2017. 65(4): p. 892-899.
 

Rauwolfia Vomitoria

Perry, B.D. and D.C. U’Prichard, [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol, 1981. 76(4): p. 461-4.
Rockhold, R.W. and F. Gross, Yohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the rat. Naunyn Schmiedebergs Arch Pharmacol, 1981. 315(3): p. 227-31.
Arthur, J.M., S.J. Casanas, and J.R. Raymond, Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem Pharmacol, 1993. 45(11): p. 2337-41.
Wainscott, D.B., et al., [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol, 1998. 357(1): p. 17-24.
Kohli, J.D. and N.N. De, Pharmacological action of rauwolscine. Nature, 1956. 177(4521): p. 1182
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