Primavar is a premium quality all-natural supplement designed to support muscle growth and recovery. Each serving contains Dioscorea zingiberensis Root Extract, supplying 125 mg Laxogenin. Laxogenin is a dietary supplement steroidal sapogenin found in a number of plants. Limited inconclusive research reports steroidal saponins are considered principal bioactive compounds responsible for the plant's pharmacological effects.*
Laxogenin is a naturally occurring steroidal sapogenin belonging to the brassinosteroid family. It is found in a number of plants, including Dioscorea zingiberensis.*
Brassinosteroids are a family of plant sterols and steroid hormones identified as the sixth class of plant hormones. First discovered over 40 years ago, brassinosteroids are responsible for a wide range of normal activity in plants including : cell elongation (i.e. growth), cell division, root growth, photo-morphogenesis ,stomatal and vascular differentiation, seed germination, immune function, reproduction, governing a plant’s response to stress (heat, cold.*
While research is limited and inconclusive, it’s believed Laxogenin may support enhancing muscle protein synthesis as well as help reduce muscle breakdown during exercise*. Increased protein synthesis and less muscle breakdown leads to less soreness, faster recovery, and more efficient muscle growth.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
SUGGESTED USESuggested Use
Consume 1 capsule twice daily delivering a total of 250 mg Laxogenin to support muscle size, strength, performance, and recovery!*
REFERENCESReferenceshttp://www.jbc.org/content/198/2/533.full.pdfKubo S, Mimaki Y, Sashida Y, Nikaido T, Ohmoto T. Steroidal saponins from the rhi- zomes of Smilax sieboldii. Phytochemistry. 1992;31(7):2445-2450. https:// www.ncbi.nlm.nih.gov/pubmed/1369386Syrov, V. N., & Kurmukov, A. G. (1975). [Experimental study of the anabolic activity of 6-keto derivatives of certain natural sapogenins]. Farmakologiya i toksikologija, 39(5), 631-635. https://www.ncbi.nlm.nih.gov/pubmed/1028596Fasciola, Andre Armel; "Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals”; US Patent & Trademark Office; September 18, 2014; http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sec- t2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/ srchnum.html&r=1&f=G&l=50&s1=20140274978.PGNR.Fasciola, Andre Armel; "Phytosterol spirostane and spirostane derivatives having a wide variety of utilities in humans and other animals”; Google Patents; September 18, 2014; https://www.google.com/patents/US20140274978McNurlan, M. A., et al. (1996). "Protein synthesis rates of skeletal muscle, lympho- cytes, and albumin with stress hormone infusion in healthy man." Metabolism 45.11:1388-1394.Kyle, L. H., Ball, M. F., & Doolan, P. D. (1966). Effect of thyroid hormone on body composition in myxedema and obesity. New England Journal of Medicine, 275(1), 12-17Zhang, X., Jin, M., Tadesse, N., Dang, J., Zhou, T., Zhang, H., … Ito, Y.(2018). Dioscorea zingiberensis C. H. Wright: An overview on its traditional use, phy- tochemistry, pharmacology, clinical applications, quality control, and toxicity. Journal of Ethnopharmacology, 220, 283–293.doi:10.1016/j.jep.2018.03.017Qin, Y., Wu, X., Huang, W., Gong, G., Li, D., He, Y., & Zhao, Y. (2009). Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents. Journal of Ethnopharmacology, 126(3), 543–550.doi:10.1016/ j.jep.2009.08.047