Every now and then, a supplement comes along that defies the odds. In other words, it actually works the way its advertisers claim, and at the dosages recommended on the bottle. This is far from the norm though. The only clear-cut, non-steroidal anabolic agent and ergogenic aid to come out of the 90’s was Creatine.
5a-Hydroxy Laxogenin was discovered in 1996 and was shown to have an anabolic/androgenic ratio similar to the best anabolics, but without the side effects of liver toxicity or testing positive for steroidal therapy. Athletes claim to have seen strength increases in 3-5 days, and muscle mass increases in 3-4 weeks. Laboratory tests showed that protein synthesis increased by over 200%, the key to lean muscle growth and accelerated repair. In testing, 5a-Hydroxy Laxogenin has balanced cortisol response, which is the major cornerstone to healthy recovery and reduction of muscle wasting.
"The best (published) study can be found in the journal Phytochemistry, 1971, vol. 10, pp 1339-1346. Again in 1989, same journal vol. 28, no. 9 pp 2509-2511 (laxogenin acetate). There is reference going back to 1965 in Chem. Pharm. Bull. 13(5), pp. 545-550 (laxogenin).
It was Dr. Syrov's paper of 1976 though, appearing in Farmakol, Toksikol that really caused Hi-Tech researchers to begin looking into making this compound in 1994. The paper is entitled, "An Experimental Study on the Anabolic Activities of 6-keto Derivatives of some natural sapogenins". It details the 4 sapogenins (referred to as compounds 1-4 in the Soviet Union) and gives source material, results of the classic steroid model and mentions. 5a-Hydroxy Laxogenin appears to be Compound 2, the most desirable of these steroidal saponins.
A double-blind study of laxogenin and 5a-Hydroxy Laxogenin on athletic performance is shown below. One hundred healthy male bodybuilders volunteered for the 4-week double-blind study during an intensive training period. The subjects were randomly divided into three groups and assigned to receive 5a-Hydroxy Laxogenin, laxogenin and placebo (isomaltulose) everyday, respectively. The daily training schedule included barbell bench press, barbell bicep curls, seated leg press and seated leg press at 65% of the maximum exercise. Meanwhile, upper arm circumference, bust and thigh circumference were measured weekly. During the period, nobody was allowed to try a new supplement or drug. Daily food was not changed suddenly, and protein intake remained constant.
As compared to placebo, 5a-Hydroxy Laxogenin supplementation had a significant effect on increased strength and endurance, broader arms, legs and shoulders. It is believe that 5a-Hydroxy Laxogenin can help you to build a stronger and healthier body. The results appeared as shown below.
5a-Hydroxy Laxogenin is an ingredient Hi-Tech utilized while other compounds sold illegal prohormones and we perfected our synthesis process better than anyone in the industry given our 23 year history with it. Hi-Tech's founder used every 5a-Hydroxy Laxogenin going back to the original Mesobolin, put out by Amino Discounters in the early 1990’s. All the studies show in order for 5a-Hydroxy Laxogenin to exert its full effects, an optimal androgen level is needed. For example, one of Dr. Syrov’s papers details Laxogenin and how it works. From "An Experimental Study On The Anabolic Activities of 6-Keto Derivatives Of Some Natural Sapogenins”, and Syrov stated "Castratration of the rats resulted in 26% less growth vs. intact rats of the same age”. In a companion paper, "Novel, Natural and Non Hormonal Anabolic Agents Derived From Plants”, this point is again hammered home, "Castration of the animals weakens the anabolic effects of Laxogenin”. This tells us that some level of Testosterone/androgen must be present to exert its full effects. Hi-Tech recommends if you are a male athlete that you combine Laxogenin 100™ with our Superdrol, Dianabol, 1-Testosterone or other prohormone products as a stack. For females Laxogenin 100™ can be taken by itself and not cause androgenic side effects.