EvoMuse SlinTensity

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Slintensity Redux Write-Up
Designed to help drive more nutrients into the muscle cells and away from fat, the idea behind Slintensity Redux is to make every meal more anabolic. Whether you are on a low, medium or high carbohydrate nutrition plan, Slintensity Redux has a place in the arsenal. Here are some thoughts on each:

Low Carb Eater
Typically low carb eaters lean towards a higher fat intake, hence the term "LCHF” for low carb/high fat. The higher fat intake can lead to a degree of insulin resistance and elevated fasting blood glucose in some people (but certainly not all). This is typically not a problem if carbs are continuously kept low, as insulin is less of a player on a LCHF diet, and insulin resistance doesn’t really matter if you’re not using much endogenous insulin.

However, many LCHF eaters still like to have a higher carbohydrate post workout meal to replenish muscle glycogen, and this would be the perfect time to use Slintensity Redux to allow improved insulin sensitivity and insurance of the extra carbohydrate load going where it is wanted. It could also be used before a cheat meal on a ketogenic diet to reduce the time needed to get back into ketosis.

Moderate Carb Eater
For the moderate carb eater, Slintensity Redux is perfect to take before any carb containing meals to help maximally encourage muscle building while minimizing fat storage. You will likely find that you can get away with a higher carb intake than usual, if so desired.

High Carb Eater
For those on a gaining phase, or those that just eat high carbs year round, you will likely notice a much easier time building muscle and losing fat with the addition of Slintensity Redux. If you are the type that is prone to crashing/fogginess/fatigue after meals, you will also likely start to notice feeling quite a bit better once the improved nutrient partitioning takes effect. You may either be able to reduce your carb intake while still enjoying the same rate of muscle growth, or maintain/increase your high carb intake with a lower level of fat spillover and even more muscle growth.

How does Slintensity Redux work?
Improved GLUT4 translocation
Improved insulin sensitivity, production and signaling
Increased nutrient disposal into muscle
Decreased nutrient disposal into fat cells
And much more…see below

Let’s take a look at each of the ingredients and how they work.
Banaba blend (Corosolic Acid/mixed elaggitannins)
Coming from the banaba leaf, this extract is standardized for a high concentration of corosolic acid and mixed elaggitannins. The first published study dates all the way back to 1940, and is commonly used in folk medicine for diabetes.

Banaba has several powerful effects, the most important ones for our purposes relate to its interaction with blood sugar. It has been shown in numerous studies to decrease serum blood sugar after carbohydrate ingestion by enhancing glucose uptake at the muscle cell (1–8).

Banaba appears to carry out its effects through favorable signaling modulation of PPARa, PPARy, MAPK, and NF-kb, while significantly increasing insulin sensitivity and translocation of GLUT4 receptors to the outside of the cell membrane, giving insulin more places to dock and let the glucose in (1–3,7,9,10). It also appears to be an insulin mimetic, albeit acting in a different way than insulin itself (11).

Multiple studies have also elucidated banaba’s ability to either decrease or inhibit gluconeogenesis, which is the basically the conversion of protein into glucose (1,2,12). This means less protein being wasted, and more available for muscle building.

Good news for blood lipids and other general health markers as well, take a look at these benefits:

Antihyperlipidemic (reduces elevated blood lipids) (1,2)
Reduces serum Triglycerides, FFA’s, and hepatic lipid content (1,2,7,10,13,14)
Decreases blood pressure, oxidative stress, and inflammatory markers like CRP-hs (13)
Reduces HbA1c (which is typically thought of as a window into your last three months of blood sugar levels, however it is also an indicator of the level of Advanced Glycation End Products {AGE’s} in the body) (7).
Increases adiponectin (10).

One group of researchers took genetically obese mice and fed them a fattening diet, and found that the addition of corosolic acid reduced fat gain by 15% over controls (10). And remember, this is in an obese model, where everything related to a functional metabolism is a disaster.

Finally, one last cool thing about banaba; it has been shown to suppress adipocyte differentiation, preventing stem cells from becoming mature fat cells (15).
4OH-Ile (4-hydroxyisoleucine)
4OH-Ile is an atypical branched-chain amino acid derived from fenugreek. Unlike banaba which has insulin like effects without stimulating extra insulin production, 4OH-Ile appears to directly stimulate glucose-induced insulin release from the pancreas. This effect is seen when blood glucose starts to rise above about 118mg/dL, which would be well above a fasting glucose for a healthy person but a pretty easily achieved post-prandial level for even a moderate carbohydrate meal. Also, the more blood glucose rises, the more insulin 4OH-Ile triggers, in a biphasic fashion (16).
Similar to banaba, 4OH-Ile has been shown to increase insulin sensitivity and glucose uptake in muscle cells, doing so by triggering translocation of GLUT4 receptors through the PI3-kinase/AKT pathway (17–21). However, even though 4OH-Ile stimulates insulin production in response to elevated blood sugar (i.e., carb intake), it also tends to lower fasting insulin levels (17,21).

Once cells become insulin resistant, a cascade of bad things starts to happen in the body. 4OH-Ile has demonstrated the ability to reverse many of these problems. Namely, reducing total cholesterol, LDL, triglycerides, TNFa, liver enzymes AST and ALT, and HbA1c, while elevating HDL (15,18,19,21,22).

So basically 4OH-Ile is going to crank up insulin production when it’s beneficial to get more glucose and amino acids into the muscle cells, support normal levels while fasting, and help optimize blood lipids and inflammatory cytokines.
Momordin is a titerpenoid saponin extracted from the bitter melon fruit. It is the third ingredient in the Slintensity formula shown to increase GLUT4 translocation in skeletal muscle cells, thereby encouraging better insulin sensitivity and higher glucose uptake (23). Momordin works, at least in part, through PI3K/MAPK dependent PPAR signaling (24,25). It has also been shown to increase AMPK phosphorylation and reduce the expression of PEPCK. One study looking at overfed mice showed that the addition of momordin caused less visceral fat gain and reduced glucose levels, triglycerides and fatty acid synthase (FAS) (26).

Momordin has also been shown to have a three-pronged attack on preventing fat gain in human fat cells by inhibiting its storage, increasing lipolysis, and inhibiting adipocyte differentiation (27). Finally, it also appears to slow gastric emptying which improves glucose metabolism and insulin signaling (28).
FMOC-L-Leu is a derivative of the Amino Acid Leucine, with some highly unique effects. It acts as a ligand for PPARy, binding in a particular way that causes it to only activate the beneficial signaling pathways that we want. Specifically, it potently increases insulin sensitivity without increasing adipogenesis (often when insulin sensitivity is increased, it happens at both muscle and fat cells encouraging heightened uptake at both places, which is not ideal in a non-pathological state) (29). 
Phellodendri Cortex 20:1
Extracted from the bark of the Phellodendron tree, Phellodendri Cortex contains two major compounds relevant to Slintensity, obacunone and berberine (30).

Obacunone does several beneficial things, let’s take a look.

Arginase Inhibition
Nitric Oxide Synthase (NOS) competes with arginase for available L-arginine. Too much arginase, and the L-arginine substrate pool becomes depleted, leaving little left over for NOS to produce NO with. More NO allows us to take advantage of post meal vasodilation, encouraging enhanced delivery of nutrients to the cells. Obacunone has been demonstrated to be an arginase inhibitor, and subsequently boost NO production. It was even able to attenuate the effect of a vasoconstrictor (31).

TRG5 agonism
This is a protein that serves as a cell surface bile acid receptor. The activation of this receptor triggers intracellular cAMP production and MAPk signaling, demonstrating involvement in energy homeostasis. Interestingly, when this receptor is agonized it activates enzymes that convert the minimally active thyroid hormone T4 into the potent hormone T3. The ineffective conversion of T4 to T3 is quite common in people with suboptimal thyroid function, which can throw a wrench into fat loss and muscle gain, among other things.

TRG5 agonism, which obacunone has demonstrated capability for, has been shown to prevent elevated blood sugar and obesity in mice overfed a high fat diet (32,33).

P-gp (P-glycoprotein) inhibition
This glycoprotein carries several things through intra and extra-cellular membranes, and it can reduce the bioavailability of many pharmaceuticals and supplements. The intestinal barrier cells use P-gp to resist absorption of berberine, which likely accounts for reports of GI distress when users consume high doses of the compound. Obacunone has demonstrated significant P-gp inhibition capabilities, allowing for better bioavailability of berberine and other ingredients (30).

In addition to the above, obacunone also acts as an anti-aromatase, reduces inflammatory markers like NF-kB & COX2, activates the p38/MAPK pathway, and prevents glutamate induced neurotoxicity (34,35).

As for Berberine, a ton of research has been done on this compound assessing its beneficial effect on blood sugar, insulin and diabetes management, so we will avoid going through all of that for the sake of brevity and just look at a few interesting points.

In a recent randomized double blind placebo study, 24 subjects with metabolic syndrome participated; half were given berberine three times per day before meals. Those that received berberine compared to controls, saw reduced blood pressure, triglycerides, reduced AUC for glucose and insulin, increased insulin sensitivity, and an improvement in the Matsuda index (an index looking at the response to an oral glucose tolerance test) (36).

Berberine has also been shown to donwregulate lipogenetic genes and upregulate energy expenditure genes in adipose and muscle cells (37). It also appears to increase insulin sensitivity in a novel way, by having a somewhat dichotomous effect on mitochondria. It activates AMPK, then inhibits mitochondrial function, then when the berberine clears the extra AMPK enhances mitochondrial function, and the end result is enhanced glucose and FFA oxidation with improved insulin sensitivity (38).

Berberine also inhibits preadipocyte differentiation, and encourages the gut microbiota to shift towards the type that produce the extremely beneficial Short Chain Fatty Acids (SCFA’s) (39,40).
Green Curry Leaf Extract
GCLE is exactly what it sounds like, also known as Murraya Koenigii. GCLE has been shown in numerous studies to have a glucose lowering effect, fasting and in response to a meal. It appears to do so by the familiar mechanism of increasing GLUT4 translocation causing enhanced glucose uptake at the muscle cell, as well as being another ingredient that actually stimulates insulin synthesis and secretion (41–46).

In addition, GLCE has also been shown to lower total cholesterol, triglycerides, reduce oxidative stress and pancreatic cell damage, inhibit glycation, and boost glutathione (41,43,46–49).

As you can see, we have combined several potent and exciting ingredients into Slintensity Redux that should have a profound effect on muscle gain and fat loss. Optimal dosing will take experimenting depending on your carbohydrate intake, so start with label directions and go from there.

1.  Miura T, Takagi S, Ishida T. Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid. Evid Based Complement Alternat Med [Internet]. 2012 Jan [cited 2014 Jul 29];2012:871495. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3468018&tool=pmcentrez&rendertype=abstract
2.  Stohs SJ, Miller H, Kaats GR. A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid. Phytother Res [Internet]. 2012 Mar [cited 2014 Jul 29];26(3):317–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22095937
3.  Yang MH, Vasquez Y, Ali Z, Khan IA, Khan SI. Constituents from Terminalia species increase PPAR? and PPAR? levels and stimulate glucose uptake without enhancing adipocyte differentiation. J Ethnopharmacol [Internet]. 2013 Sep 16 [cited 2014 Jul 29];149(2):490–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23850833
4.  Shi L, Zhang W, Zhou Y-Y, Zhang Y-N, Li J-Y, Hu L-H, et al. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. Eur J Pharmacol [Internet]. 2008 Apr 14 [cited 2014 Sep 27];584(1):21–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18348886
5.  Minamino K, Yanaga Y, Ohtsuru M. Bioactive substance from Grifola frondosa (maitake) mushroom inhibits CCAAT enhancer binding protein beta and delta expression on C3H10T1/2 B2C1 adipocyte cells. J Nutr Sci Vitaminol (Tokyo) [Internet]. 2008 Jun [cited 2013 Oct 9];54(3):250–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18635913
6.  Fukushima M, Matsuyama F, Ueda N, Egawa K, Takemoto J, Kajimoto Y, et al. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res Clin Pract [Internet]. 2006 Aug [cited 2014 Sep 27];73(2):174–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16549220
7.  Park M-Y, Lee K-S, Sung M-K. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life Sci [Internet]. 2005 Nov 12 [cited 2014 Sep 27];77(26):3344–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15979095
8.  Judy W V, Hari SP, Stogsdill WW, Judy JS, Naguib YMA, Passwater R. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol [Internet]. 2003 Jul [cited 2014 Sep 27];87(1):115–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12787964
9.  De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab [Internet]. 2004 Jun [cited 2014 Apr 7];14(3):298–307. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15256690
10.  Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, et al. Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biol Pharm Bull [Internet]. 2008 Apr [cited 2014 Sep 27];31(4):651–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18379057
11.  Hattori K, Sukenobu N, Sasaki T, Takasuga S, Hayashi T, Kasai R, et al. Activation of insulin receptors by lagerstroemin. J Pharmacol Sci [Internet]. 2003 Sep [cited 2014 Sep 27];93(1):69–73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14501154
12.  Yamada K, Hosokawa M, Fujimoto S, Fujiwara H, Fujita Y, Harada N, et al. Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Res Clin Pract [Internet]. 2008 Apr [cited 2014 Sep 27];80(1):48–55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18177973
13.  Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci [Internet]. 2006 Nov 25 [cited 2014 Sep 27];79(26):2474–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16959274
14.  Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) [Internet]. 1999 Dec [cited 2014 Sep 27];45(6):791–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10737232
15.  Xue W-L, Li X-S, Zhang J, Liu Y-H, Wang Z-L, Zhang R-J. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pac J Clin Nutr [Internet]. 2007 Jan [cited 2014 Jul 29];16 Suppl 1:422–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17392143
16.  Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, et al. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes [Internet]. 1998 Feb [cited 2014 Sep 19];47(2):206–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9519714
17.  Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, et al. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol [Internet]. 1999 Oct [cited 2014 Sep 19];277(4 Pt 1):E617–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10516120
18.  Jetté L, Harvey L, Eugeni K, Levens N. 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome. Curr Opin Investig Drugs [Internet]. 2009 Apr [cited 2014 Sep 19];10(4):353–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19337956
19.  Yu H, Wu M, Lu F-R, Xie J, Zheng N, Qin Y, et al. [Effect of trigonella foenum-graecum 4-hydroxyisoleucine on high-glucose induced insulin resistance in 3T3-L1 adipocytes of mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi [Internet]. 2013 Oct [cited 2014 Jul 29];33(10):1394–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24432687
20.  Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya P, Srivastava AK, Narender T, et al. 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway. Eur J Nutr [Internet]. 2012 Oct [cited 2014 Jul 29];51(7):893–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22610671
21.  Singh AB, Tamarkar AK, Narender T, Srivastava AK. Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice. Nat Prod Res [Internet]. 2010 Mar [cited 2014 Jul 29];24(3):258–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20140804
22.  Haeri MR, Izaddoost M, Ardekani MRS, Nobar MR, White KN. The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats. Phytother Res [Internet]. 2009 Jan [cited 2014 Jul 29];23(1):61–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18680121
23.  Wang ZQ, Zhang XH, Yu Y, Poulev A, Ribnicky D, Floyd ZE, et al. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. J Nutr Biochem [Internet]. 2011 Jan [cited 2011 Feb 3]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21277185
24.  Sasa M, Inoue I, Shinoda Y, Takahashi S, Seo M, Komoda T, et al. Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta. J Atheroscler Thromb [Internet]. 2009 Jan [cited 2010 Jul 1];16(6):888–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20032574
25.  Wang J, Yuan L, Xiao H, Wang C, Xiao C, Wang Y, et al. A novel mechanism for momordin Ic-induced HepG2 apoptosis: involvement of PI3K- and MAPK-dependent PPAR? activation. Food Funct [Internet]. 2014 May [cited 2014 Jul 29];5(5):859–68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24584198
26.  Shih C-C, Shlau M-T, Lin C-H, Wu J-B. Momordica charantia ameliorates insulin resistance and dyslipidemia with altered hepatic glucose production and fatty acid synthesis and AMPK phosphorylation in high-fat-fed mice. Phytother Res [Internet]. 2014 Mar [cited 2014 Jul 29];28(3):363–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23610006
27.  Nerurkar P V, Lee YK, Nerurkar VR. Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes. BMC Complement Altern Med [Internet]. 2010 Jun [cited 2010 Jul 1];10(1):34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20587058
28.  Matsuda H, Li Y, Yamahara J, Yoshikawa M. Inhibition of gastric emptying by triterpene saponin, momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves, and central nervous system. J Pharmacol Exp Ther [Internet]. 1999 May [cited 2013 May 25];289(2):729–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10215646
29.  Rocchi S, Picard F, Vamecq J, Gelman L, Potier N, Zeyer D, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell [Internet]. 2001 Oct [cited 2014 Jul 29];8(4):737–47. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11684010
30.  Min YD, Kwon HC, Yang MC, Lee KH, Choi SU, Lee KR. Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity. Arch Pharm Res [Internet]. 2007 Jan [cited 2014 Sep 28];30(1):58–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17328243
31.  Yoon J, Park M, Lee J hyung, Min BS, Ryoo S. Endothelial nitric oxide synthase activation through obacunone-dependent arginase inhibition restored impaired endothelial function in ApoE-null mice. Vascul Pharmacol [Internet]. 2014 Mar [cited 2014 Jul 29];60(3):102–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24509132
32.  Ono E, Inoue J, Hashidume T, Shimizu M, Sato R. Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet. Biochem Biophys Res Commun [Internet]. 2011 Jul 8 [cited 2014 Jul 29];410(3):677–81. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21693102
33.  Kim H-J, Kong M-K, Kim Y-C. Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats. BMB Rep [Internet]. 2008 Oct 31 [cited 2014 Sep 28];41(10):710–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18959817
34.  Kim J, Jayaprakasha GK, Patil BS. Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. Biochimie [Internet]. 2014 Jun 11 [cited 2014 Jul 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24927687
35.  Yoon JS, Yang H, Kim SH, Sung SH, Kim YC. Limonoids from Dictamnus dasycarpus protect against glutamate-induced toxicity in primary cultured rat cortical cells. J Mol Neurosci [Internet]. 2010 Sep [cited 2014 Jul 16];42(1):9–16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20155333
36.  Pérez-Rubio KG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Espinel-Bermúdez MC. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab Syndr Relat Disord [Internet]. 2013 Oct [cited 2014 Sep 28];11(5):366–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23808999
37.  Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes [Internet]. 2006 Aug [cited 2014 Sep 15];55(8):2256–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16873688
38.  Zhang Y, Ye J. Mitochondrial inhibitor as a new class of insulin sensitizer. Acta Pharm Sin B [Internet]. 2012 Aug [cited 2014 Sep 28];2(4):341–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3660979&tool=pmcentrez&rendertype=abstract
39.  Yang J, Yin J, Gao H, Xu L, Wang Y, Xu L, et al. Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evid Based Complement Alternat Med [Internet]. 2012 Jan [cited 2014 Sep 28];2012:363845. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3310165&tool=pmcentrez&rendertype=abstract
40.  Zhang X, Zhao Y, Zhang M, Pang X, Xu J, Kang C, et al. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS One [Internet]. 2012 Jan [cited 2014 Sep 28];7(8):e42529. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3411811&tool=pmcentrez&rendertype=abstract
41.  Xie J-T, Chang W-T, Wang C-Z, Mehendale SR, Li J, Ambihaipahar R, et al. Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice. Am J Chin Med [Internet]. 2006 Jan [cited 2014 Jul 29];34(2):279–84. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16552838
42.  Lawal HA, Atiku MK, Khelpai DG, Wannang NN. Hypoglycaemic and hypolipidaemic effect of aqueous leaf extract of Murraya koenigii in normal and alloxan-diabetic rats. Niger J Physiol Sci [Internet]. [cited 2014 Sep 24];23(1-2):37–40. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19434212
43.  Kesari AN, Kesari S, Singh SK, Gupta RK, Watal G. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J Ethnopharmacol [Internet]. 2007 Jun 13 [cited 2014 Sep 24];112(2):305–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17467937
44.  Vinuthan MK, Girish Kumar V, Ravindra JP, Jayaprakash, Narayana K. Effect of extracts of Murraya koenigii leaves on the levels of blood glucose and plasma insulin in alloxan-induced diabetic rats. Indian J Physiol Pharmacol [Internet]. 2004 Jul [cited 2014 Sep 24];48(3):348–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15648408
45.  Pandey J, Maurya R, Raykhera R, Srivastava MN, Yadav PP, Tamrakar AK. Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity. J Sci Food Agric [Internet]. 2014 Aug [cited 2014 Sep 24];94(11):2282–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24395372
46.  El-Amin M, Virk P, Elobeid MAR, Almarhoon ZM, Hassan ZK, Omer SA, et al. Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats. Pak J Pharm Sci [Internet]. 2013 Mar [cited 2014 Sep 24];26(2):359–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23455208
47.  Paul S, Bandyopadhyay TK, Bhattacharyya A. Immunomodulatory effect of leaf extract of Murraya koenigii in diabetic mice. Immunopharmacol Immunotoxicol [Internet]. 2011 Dec [cited 2014 Sep 24];33(4):691–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21401386
48.  Arulselvan P, Subramanian SP. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats. Chem Biol Interact [Internet]. 2007 Jan 30 [cited 2014 Sep 24];165(2):155–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17188670
49.  Ramkissoon JS, Mahomoodally MF, Ahmed N, Subratty AH. Antioxidant and anti-glycation activities correlates with phenolic composition of tropical medicinal herbs. Asian Pac J Trop Med [Internet]. 2013 Jul [cited 2014 Sep 23];6(7):561–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23768830


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