Core BURN is setting a new standard for fat-burning effectiveness! For years, many supplement companies have been hyping their products for reducing fat by seizing on one or two improperly dosed active ingredients and producing a "kitchen-sink,” proprietary blend formula. These formulas might in theory have some limited effectiveness, but they often don't work because of the improper doses of their active ingredients.
Core BURN is changing the game by carefully combining ten potent compounds—in the correct, clinically demonstrated doses—to create a powerful, balanced product for destroying fat. Core BURN is designed to target the precise primary and secondary metabolic pathways for incinerating fat while preserving muscle! Like all Core Nutritionals' products, the ingredient amounts are clearly labeled. We don't hide behind "proprietary blends.” With our products, you know exactly what you are getting.
Every week, there is a new story about a "breakthrough” or "miracle” substance that will obliterate fat. Some of these claims may actually have some merit. But the truth is that the biochemical processes of lipolysis (fat burning) are very complex and tightly regulated by the endocrine system and other biochemical pathways. Navigating this maze to effectively shrink or eliminate adipose tissue doesn't work with just one "miracle” compound. It involves numerous agents that activate different metabolic functions, while suppressing others. No single "magic” compound can do the job alone.
Core BURN takes tried-and-true fat burning compounds, such as caffeine and green tea extract, and then adds the most potent new discoveries of modern clinical research – like forskolin, rauwolscine, and higenamine – to deliver a product that obliterates adipocyte cells before they can even settle in as fatty deposits.
To understand how Core BURN works, it's necessary to take a look at how the lipolytic process works. Fat cells have receptors—sort of like windows in the cell membrane—that allow hormones and other signaling agents to tell the cell what to do. Fat cells (and also muscle cells) have a special type of these, called adrenergic receptors or adrenoreceptors (they "receive” adrenaline). Type alpha (a) are activated to create and store fat, while the type beta (ß)-adrenergic receptors are in charge of breaking down the fat. Some chemical compounds activate one or the other of these adrenoreceptors (they are called agonists) and others suppress them (called antagonists).
When the body goes into "fight or flight” mode it activates the sympathetic nervous system and releases the catecholamine hormones, epinephrine and adrenaline. These interact with the adrenoreceptors on the fat cells and begin a complex cascade of reactions that ends with elevated levels of something called cyclic adenosine monophosphate (cAMP), which ultimately causes the fat cell to be broken down into free fatty acid (for energy) and glycerol.
So, to burn fat, you just suppress the a-adrenoreceptors, activate the ß-adrenoreceptors and increase levels of cAMP. Simple, right? Hardly. Because the process is so complex, and because some attempts to increase fat burning can backfire (adrenergic receptors can become desensitized from excessive stimulation), it takes a multi-pronged approach, with numerous different compounds that interact in specific ways and with specific doses. That is the secret to Core BURN'S effectiveness.
K J Acheson, B Zahorska-Markiewicz, P Pittet, K Anantharaman, and E Jéquier, Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals, Am J Clin Nutr May 1980 vol. 33 no. 5 989-997.Allen, D.O. et al. (1986) Relationships between cyclic AMP levels and lipolysis in fat cells after isoproterenol and forskohlin stimulation. The Journal of Pharmacology and Experimental Therapeutics. 238(2): 659-664.Al-Qarawi AA, Al-Damegh MA, ElMougy SA., Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Phytother Res. 2002 May;16(3):286-7.P. J. Arciero, A. W. Gardner, J. Calles-Escandon, N. L. Benowitz, and E. T. Poehlman, Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men, American Journal of Physiology – Endocrinology and Metabolism, June 1, 1995 vol. 268 no. 6 E1192-E1198Anon, "Rauvolfia L.”. Germplasm Resources Information Network.United States Department of Agriculture. 2003-03-14.Bai G, et al. Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1. Acta Pharmacol Sin. (2008)Berlan M, Le Verge R, Galitzky J, et al. Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine. Br J Pharmacol. 1993 Apr;108(4):927-932D. Bracco, J. M. Ferrarra, M. J. Arnaud, E. Jequier, and Y. Schutz, Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women, AJP - Endo October 1, 1995 vol. 269 no. 4 E671-E678.Castan I, Valet P, Quideau N, et al. Antilipolytic effects of a 2-adrenergic agonists, neuropeptide Y, adenosine, and PGE1 in mammal adipocytes. Am J Physiol 1994; 266:R1141.Chang KC, Lim JK and Park CW (1986) Synthesis of higenamine and its cardiovascular effects in rabbit: Evidence for b-adrenoceptor agonist. Kor J Pharmacol 22:96 –104Costill DL, Dalsky GP, Fink WJ, Effects of caffeine ingestion on metabolism and exercise performance, Medicine and Science in Sports [1978, 10(3):155-158]Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R77-85Doherty M, Smith PM, Effects of caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004 Dec;14(6):626-46.Dorofeev BF, Kholodov LE (1991). "[Pikamilon pharmacokinetics in animals]" (in Russian). Farmakologiia i toksikologiia 54 (2): 66–9. PMID 1884802.Dullo AG, Geissler CA, Horton T, et al. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989 Jan;49(1):44-50M. Doherty, P. M. Smith, Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scandinavian Journal of Medicine & Science in Sports, Volume 15, Issue 2, pages 69–78, April 2005
Flechtner-Mors M, Jenkinson CP, Alt A, et al. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. 2002 Apr;301(1):229-233Gang BAI, Yang YANG, Qian SHI, Ze LIU, Qi ZHANG, Yuan-yuan ZHU, Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist. Acta Pharmacol Sin 2008 Oct; 29 (10): 1187–1194.Godard, M.P., Johnson, B.A., & Richmond, S.R. (2005). Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obesity Research, 13, 1335-1343.Haye, B. et al. (1985) Chronic and acute effects of forskohlin on isolated thyroid cell metabolism. Molecular and Cellular Endocrinology. 43:41-50.Henderson S, Magu B, Rasmussen C, Lancaster S, Kerksick C, Smith P, Melton C, Cowan P, Greenwood M, Earnest C, Almada A, Milnor P, Magrans T, Bowden R, Ounpraseuth S, Thomas A, Kreider RB. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. Journal of the International Society of Sports Nutrition. 2(2):54-62, 2005Horst Hemmerle, Hans-Joerg Burger, Peter Below, Gerrit Schubert, Robert Rippel, Peter W. Schindler, Erich Paulus, and Andreas W. Herling., Chlorogenic Acid and Synthetic Chlorogenic Acid Derivatives:? Novel Inhibitors of Hepatic Glucose-6-phosphate Translocase. J. Med. Chem., 1997, 40 (2), pp 137–145Hsu CL, Huang SL, Yen GC. Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity. J Agric Food Chem. (2006)Kaplan GB, Greenblatt DJ, Ehrenberg BL, et al. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997 Aug;37(8):693-703Kar A, Panda S, & Bharti S. (2002). Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. Journal of Ethnopharmacology. 81(2), 281-5Kimura I, et al. Inotropic effects of (+/-)-higenamine and its chemically related components, (+)-R-coclaurine and (+)-S-reticuline, contained in the traditional sino-Japanese medicines "bushi" and "shin-i" in isolated guinea pig papillary muscle. Jpn J Pharmacol. (1989)Kimura I, et al. Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria. Jpn J Pharmacol. (1994)Kohli JD, DE NN (June 1956). "Pharmacological action of rauwolscine”. Nature 177 (4521): 1182Langin D, Tavernier G, Lafontan M. Regulation of beta 3-adrenceptor expression in white fat cells. Fundam Clin Pharmacol 1995; 9:97.Limbard LE, MacMillan LB, Keefer JR. Specificity in a2-adrenoceptor signal transduction: receptor subtypes coupling to distinct signal transduction pathways and localization to discrete subdomains in target cells. p. 139-145. In: Adrenoceptors: Structure, Function, and Pharmacology, Ruffolo, RR ed. 1995. Harwood Academic Publishers.Liu W, et al. Effects of higenamine on regulation of ion transport in guinea pig distal colon. Jpn J Pharmacol. (2000)Carol Minassian, Sandrine Tarpin,Gilles Mithieux, Role of Glucose-6 Phosphatase, Glucokinase, and Glucose-6 Phosphate in Liver Insulin Resistance and Its Correction by Metformin. Biochemical Pharmacology Volume 55, Issue 8, 15 April 1998, Pages 1213–1219.Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H., Anti-obese action of raspberry ketone. Life Sci. 2005 May 27;77(2):194-204. Epub 2005 Feb 25.Must, A. (1996) Morbidity and mortality associated with elevated body weight in children and adolescents. Am. J. Clin. Nutr. 63(3 Suppl):445S-4447SNam Su Kim,Chang Yee Hong,Chan Woong Pak,Jung Kyoo Lim, An Experimental Study on Adrenergic Effect of Higenamine in Rabbit Cardiovascular System. Korean Circ J 1986;16:1-18Nehlig A, Debry G, Caffeine and sports activity: a review. Int J Sports Med. 1994 Jul;15(5):215-23.Yuriko Oi-Kano, Teruo Kawada, Tatsuo Watanabe, Fumihiro Koyama, Kenichi Watanabe, Reijirou Senbongi, Kazuo Iwai, Oleuropein, a Phenolic Compound in Extra Virgin Olive Oil, Increases Uncoupling Protein 1 Content in Brown Adipose Tissue and Enhances Noradrenaline and Adrenaline Secretions in Rats. Journal of Nutritional Science and Vitaminology Vol. 54 (2008) No. 5 P 363-370Margreet R. Olthof, Peter C. H. Hollman, and Martijn B. Katan, Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans. J. Nutr. January 1, 2001 vol. 131 no. 1 66-71Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther. (1984)Park JB. N-coumaroyldopamine and N-caffeoyldopamine increase cAMP via beta 2-adrenoceptors in myelocytic U937 cells. FASEB J. 2005 Apr;19(6):497-502Park KS, Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med. 2010 Oct;76(15):1654-8. doi: 10.1055/s-0030-1249860. Epub 2010 Apr 27.Perez-Castillo A, Hernandez A, Pipaon C, Santos A, Obregon MJ. Multiple regulation of S14 gene expression during brown fat differentiation. Endocrinology. 1993 Aug;133 (2):545-52.Perry BD, U'Prichard DC (December 1981). "[3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors”. European Journal of Pharmacology 76 (4): 461–4.Poudyal H, Campbell F, Brown L., Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr. 2010 May;140(5):946-53. Epub 2010 Mar 24.Rai D, Bhatia G, Palit G, Pal R, Singh S, & Singh HK. (2003). Adaptogenic effect of Bacopa monniera (Brahmi). Pharmacology, Biochemistry, and Behavior. 75(4), 823-30.Seamon, K.B., Padgett, W., & Daly, J.W. (1981). Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proceedings of the National Academy of Sciences, 78, 3363-3367Shephard RA (June 1987). "Behavioral effects of GABA agonists in relation to anxiety and benzodiazepine action". Life Sci. 40 (25): 2429–36. doi:10.1016/0024-3205(87)90758-2. PMID 2884549.Stevens, J. et al. (1998), The body mass index-mortality relationship in white and African American women. Obes. Res., 6(4):268-77.Thom, E., The Effect of Chlorogenic Acid Enriched Coffee on Glucose Absorption in Healthy Volunteers and Its Effect on Body Mass When Used Long-term in Overweight and Obese People. The Journal of International Medical Research, Volume 35, Number 6, November 2007 , pp. 900-908(9).Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL (January 1998). "3HRauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor". Naunyn-Schmiedeberg's Archives of Pharmacology 357 (1): 17–24.Xiang Rong. Yi Ningyu. Xia Zongqin, A study on the mechanism of the yang-tonic effect of higenamine. Pharmacology and Clinics of Chinese Materia Medica. 1994-06Yajima H. et al (1999) cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets. Diabetes 48(5):1006-12Zahorska-Markiewicz B, Kucio C, et al. Adrenergic control of lipolysis and metabolic responses in obesity. Horm Metab Res. 1986 Oct;18(10):693-697