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vasoXplode -- Pre-workout Performance, Nitric Oxide, and Energy Booster

Your Final Pre-Workout Solution

Scivation has already made Workout Nutrition a household phrase. In fact, many people wouldn't even think of training without their Xtend and Substance WPI keeping them anabolic and anticatabolic during a grueling training session.

What more could you ask for? Well, Scivation has made pre-workout supplementation a thoughtless endeavor as well. Imagine if you could take the scientifically-proven, synergistic ingredients to guarantee you have all bases covered and to assure that you get the skin-bursting pumps, mind-blowing energy and unbelievable endurance to help you attack the weights like a beast. If you're like anyone here at Team Scivation, this is a dream come true. Time to stop dreaming.

We have formulated vasoXplode around ingredients that are scientifically proven to increase performance and muscle growth. vasoXplode contains synergistic ingredients that work together to take the results you will see to the next level and beyond.

Creatine + Citrulline Malate

Synergistically increases performance

Creatine + Beta-Alanine

Synergistically increases performance and lean mass gains

Citrulline Malate + Arginine

Increases blood flow and amino acid deliver to skeletal muscle, leading to increased protein synthesis (muscle growth)

Tyrosine + ALCAR + Caffeine

Increases energy and mental focus while delaying fatigue, allowing you to workout harder and longer.

Let's take a more indepth look at VasoXplode's ingredients.

CreaSci Blend

(Creatine Monohydrate, Di Creatine Malate)

Creatine is used in the high-energy phosphate or ATP-PCr system to regenerate ATP. ATP, the body's main source of energy, is a molecule of adenosine (adenine + the sugar ribose) linked to three phosphate molecules by high-energy bonds. Breaking of the two outer bonds results in the release of energy.

When the most outer bond is broken, the energy is released and ADP and Pi are left behind. Creatine, which is bonded to a phosphate ion, transfers energy to the ADP and Pi molecule by breaking its own bond. This regenerates the ATP molecule, which means one now has more energy to use. Skeletal muscle has a limited storage of creatine. Therefore supplementing with creatine increases your ability to form ATP and therefore increases the available energy for exercise (Casey et al. 1996 & 2000). Creatine has been shown to:

Increase muscle size and strength (Willoughby, 2001)

Increase power output (Becque, 2000)

Increase high-intensity exercise performance (Tarnopolsky, 2000)

Increase work capacity (Rico-Sanz, 2000)

Creatine is one of the most scientifically proven-effective supplements on the market, with creatine monohydrate being the form used in most studies.

VasoRush Blend

Citrulline Malate, L-Arginine Alpha KetoGlutarate 2:1, (Di-L-Arginine)-L-Malate, Citric Acid, (Di-L-Arginine) Orotate

The rate-limiting step of amino acid uptake into skeletal muscle is the transportation of the amino acids through the blood to the skeletal muscle, which is governed by blood flow (Wolfe, 2004). NO vasodilates blood vessels, thereby increasing blood flow. This increase when combined with exercises means greater blood flow and greater amino acid deliver and uptake in the working skeletal muscle. Exercise itself results in an increase in NO production, and the increased blood flow created by exercise is believed to be linked to the increase in protein synthesis post workout (Douglas et al., 2004). Di-Arginine Orotate, AAKG, Di-Arginine Malate, and Citrulline Malate all increase NO production and blood flow to skeletal muscle.

Citrulline-Malate has been shown to increase the rate of oxidative ATP production during exercise and the rate of phosphocreatine replenishment post exercise (Bendahan, 2002). Increasing the rate of ATP production during exercise would increase performance and energy.

Citrulline-Malate also has anti-fatigue properties due to its ability to decrease ammonia levels and prevent against metabolic acidosis (Callis, 1991). Decreasing the sensation of fatigue would allow one to workout harder and longer, and thereby burn more calories and lose more fat.

Both Citric Acid and Malic Acid (Malate) are intermediates in the Kreb's cycle, which produces ATP. Adding citric acid and malic acid to VasoXplode aids in ATP production.

H-Primer Blend

(Beta-Alanine, NAC)

Beta-Alanine

It has been shown that skeletal muscle carnosine levels are correlated with performance during high-intensity exercise (Suzuki, 2002). Carnosine is an important metabolic buffer in skeletal muscle (Suzuki, 2002), which means it helps maintain the acid-base balance in the presence of high H+ concentrations. High levels of H+ during exercise cause fatigue and decrease performance.

Beta-alanine is one of the two amino acids (histidine being the other) that makes up the dipeptide carnosine (L-beta-alanyl-L-histidine). Growing research shows Beta-alanine to be a very effective performance enhancers and lean mass building supplement. Research shows:

Beta-Alanine availability is the limiting factor in muscle carnosine synthesis (Hill, 2007).

Muscle carnosine levels were higher after 10 weeks of beta-alanine supplementation than after 4 weeks, showing that beta-alanine's effects are best experienced over long term supplementation (Hill, 2007).

Beta-alanine supplementation increases total work done during aerobic exercise (Hill, 2007).

Beta-alanine enhances endurance performance (Zoeller, 2006)

Beta-Alanine delays the onset of neuromuscular fatigue (Stout, 2006)

Adding beta-alanine to creatine supplementation leads to greater increases in lean mass than creatine alone (Hoffman, 2006).

It is clear that current research shows Beta-Alanine to be an effective performance enhancer and enhances lean mass gains when combined with creatine.

NAC

N-acetyl-cysteine (NAC) is derived from the non-essential amino acid cysteine. Because cysteine is very unstable, supplementing with NAC allows one to get the benefits of cysteine. NAC is an antioxidant itself (Aruoma, 1989) and is also used to synthesize the antioxidant glutathoine. Glutathione is a powerful antioxidant and also regenerates vitamin C and E (Bounous, 1999)

Since intense exercise depletes glutathione (Sen, 1999), supplementation of NAC can is beneficial to increase glutathione levels. Oxidative stress caused by free radicals (H+), causes fatigue and muscular soreness. Supplementing with NAC will enhance athletic performance by scavenging these free radicals (Lands, 1999).

BrainDrive Blend

(N-Acetyl Tyrosine, ALCAR, Caffeine)

N-Acetyl-L-Tyrosine

Tyrosine is a nonessential amino acids used to make the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine, thyroid hormones, and the skin pigment melanin. Stress, such as exercise, depletes the amount of dopamine and norepinephrine in the brain. Tyrosine supplementation has been shown

Decrease the negative effects of stress (Banderet, 1989)

Decrease fatigue and increase cognitive performance (Neri, 1995)

Decrease cardiovascular stress and enhance cognitive activity (Dollins, 1995)

ALCAR

The amino acid L-Carnitine plays a vital role in energy metabolism, specifically the transport of fatty acids into mitochondria where they can be oxidized. ALCAR is the acetylated form of carnitine and is the most popular form of supplemental carnitine. ALCAR is a potent antioxidant shown to have anti-aging, cardio-protective, cognitive enhancing, and adaptogen properties. ALCAR increases exercise performance by

Increasing fat oxidation (Hongu, 2003)

Decreasing muscle soreness (Giamberardino, 1996)

Decreasing lactic acid accumulation (Siliprandi, 1990).

Caffeine

Caffeine, a plant alkaloid belonging to the drug class methylxanthines and is found in natural sources such as coffee beans, tea leaves, cocoa beans, and other plants, is the world's most widely used stimulant. Caffeine is a Central Nervous System (CNS) stimulant shown to delay fatigue and improve cognitive performance.

Caffeine acts as an adenosine receptor antagonist. Adenosine decreases the release of stimulatory/excitatory neurotransmitters (i.e. norepinephrine [NE]). Therefore, blocking the adenosine receptor allows a greater excitation to occur by increasing NE's ability to activate the adrenergic receptors.

Caffeine inhibits phosphodiesterase (PDE), causing a build-up of cAMP levels and greater effect of NE on fatty acid lipolysis. PDE blunts lipolysis; therefore inhibiting PDE allows lipolysis to proceed at an accelerated rate. The end result is there are more fatty acids available for oxidation after consumption of caffeine, which is one of the ways caffeine is believes to increase performance.

D,L-Phenylalanine

D,L-Phenylalanine is a 50/50 mix of D-Phenylalanine and L-Phenylalanine. L-Phenylalanine is an essential amino acid while D-Phenylalanine is a non-protein amino acid that is not used in protein synthesis. Phenylalanine can be metabolized to PEA and is also a precursor for norepinephrine and dopamine.

B-Vitamins

(50mg B6, 50mg B5, 100 mcg B12, 75mg Niacin)

The B vitamins are essential to whole body energy metabolism, We included the B vitamins in VasoXplode to ensure your body has what it needs to perform at its full potential.

Wrap-Up

VasoXplode is formulated to allow you to increase the intensity of your workouts while delaying fatigue, which results in greater progress being made. VasoXplode increases energy production and power output, decreases H+ accumulation and fatigue, and increases blood flow and the deliver of amino acids to skeletal muscle, making it an all-in-one pre-workout powerhouse. We highly recommend combining 1 serving of VasoXplode with 1 serving of Primal EAA 15-20 minutes pre-workout to give your body EVERYTHING it needs to perform and progress like never before.

References:

CreaSci Blend

Becque MD. Lochmann JD. Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition. Medicine & Science in Sports & Exercise. 32(3):654-8, 2000 Mar.

Casey, A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL. (1996) Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol. Jul;271:E31-7.

Casey A, Greenhaff PL. (2000).Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance?Am J Clin Nutr. Aug;72(2 Suppl):607S-17S. Review.

Rico-Sanz J. Mendez Marco MT. Creatine enhances oxygen uptake and performance during alternating intensity exercise. Medicine & Science in Sports & Exercise. 32(2):379-85, 2000 Feb.

Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplmentation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000 Dec ;10(4) :452-63.

Willoughby DS. Rosene J. Effects of oral creatine and resistance training on myosin heavy chain expression. Medicine & Science in Sports & Exercise. 33(10):1674-81, 2001 Oct.

VasoRush Blend

Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ. Citrulline/malate promotes aerobic energy production in human exercising muscle.

Br J Sports Med. 2002 Aug;36(4):282-9.

Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung. 1991 Jun;41(6):660-3.

Douglas, Borsheim, and Wolfe. "Potential Ergogenic Effects of Arginine and Creatine Supplementation" J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S.

Wolfe, et. al., In vivo muscle amino acid transport involves two distinct processes. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E136-41.

Tyrosine

Banderet, LE, and Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull 22: 759-762, 1989..

Dollins AB, Krock LP, Storm WF, Wurtman RJ, Lieberman HR. L-tyrosine ameliorates some effects of lower body negative pressure stress. Physiol Behav. 1995 Feb;57(2):223-30.

Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med. 1995 Apr;66(4):313-9.

ALCAR

Giamberardino MA, Dragani L, Valente R, Di Lisa F, Saggini R, Vecchiet L. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 1996 Jul;17(5):320-4

Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr 2003 Jan;133(1):84-9

Siliprandi N, Di Lisa F, Pieralisi G, Ripari P, Maccari F, Menabo R, Giamberardino MA, Vecchiet L. Metabolic changes induced by maximal exercise in human subjects following L-carnitine administration. Biochim Biophys Acta 1990 Apr 23;1034(1):17-21

Beta-Alanine

Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA.

Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. 2007 Feb;32(2):225-33.

Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J.

Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. Int J Sport Nutr Exerc Metab. 2006 Aug;16(4):430-46.

Stout JR, Cramer JT, Mielke M, O'Kroy J, Torok DJ, Zoeller RF. Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold. J Strength Cond Res. 2006 Nov;20(4):928-31.

Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K. High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting. Jpn J Physiol. 2002 Apr;52(2):199-205.

Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. 2006 Sep 5

NAC

Aruoma O,et al. (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid. Free Radical Biol.Med.6:593-597.

Bounous G, Molson J. (1999) Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatuge syndrome. Med Hypothesis 53;(4): 347-349.

Lands LC, Grey VL and Smountas AA. (1999) Effect of a cysteine donor on muscular performance.J Appl Physiol. 87 (4):1381-1385.

Sen CK. (1999) Glutathione homeostasis in response to exercise training and nutritional supplements. Molecular & Cellular Biochemistry. 196:31-42.