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Gaspari Novedex XT

Novedex XT FACTS & FAQs

What is Novedex XT?

Novedex XT is a proprietary blend of naturally occurring, anti-aromatic compounds.  These compounds have been demonstrated to have an upward modulating effect on testosterone levels and a downward or static modulating effect on estrogen.  Two of the ingredients found in Novedex XT are patent pending.  They are exclusively licensed to Gaspari Nutrition, Incorporated for use only in Novedex XT.

Is Novedex XT safe?

Please review and read the following, independent clinical trials which utilized Novedex XT to determine whether or not you think Novedex XT is safe.

Why do I want to modulate or control my testosterone levels?

Please review the following information about testosterone and decide for yourself if you believe taking control of your testosterone level is the correct thing for you to do.

How is Novedex XT taken or used?

If you have never used Novedex XT we suggest starting out using two (2) capsules of Novedex XT per night.  We suggest trying this for 30 days before making any changes upwards in dosing.  If after 14 days you are not seeing the desired results, you may opt to increase the dosage to 3-4 capsules per day.  Experienced users interested in adding lean muscle mass can begin taking 4 Novedex XT capsules per night for up to six (6) weeks. You should never, under any circumstances, exceed four (4) capsules of Novedex XT nor should you ever, under any circumstances, use Novedex XT for longer than six (6) weeks duration without a four (4) week "break" unless explicitly directed to do so by your physician or licensed health care provider.

Who should not use Novedex XT?

Under no circumstances should any women or any person under the age of 21 years use Novedex XT for ANY reason whatsoever and the use of Novedex XT is absolutely contraindicated in these populations. The following people should not use Novedex XT without the express written permission of their physician -Anyone who has ever had any type of cancer, benign prostatic hypertrophy, liver or kidney disease, any cardiovascular disease or high blood pressure or high cholesterol, anyone who is currently being treated with hormone replacement therapy and anyone who has been or is being treated for any psychological or psychiatric problems.  You MUST consult with your physician or licensed health care provider before you use Novedex XT.

Can Novedex XT be used for PCT

(Post Cycle Therapy)?

PCT (Post Cycle Therapy) for treatment of any type of hypogonadism or symptoms associated with the use of anabolic steroids should only be implemented by a physician or licensed health care provider -preferably an individual or team with extensive experience in this aspect of endocrinology.  Why your physician or licensed health care provider might consider Novedex XT are part of a treatment strategy for ameliorating the effects of anabolic steroid use, we can not legally recommend the use of Novedex XT for the treatment or diagnosis of any medical condition.  Please talk to your physician or licensed health care provider for more information.  We encourage you to be forthright and honest with your health care team.

Can Novedex XT be "stacked" with other Gaspari Nutrition products for even better physique augmentation results?

Yes!  We suggest using Novedex XT in conjunction with our Superpump-250 product and our SizeOn product in the following manner for maximal physique augmentation -

A more "advanced" Gaspari Nutrition Stack for more experienced bodybuilders and athletes is described below

OHIO RESEARCH GROUP

Ziegenfuss T.N., Mendel R.W., and Hofheins J.E. Safety and Efficacy of a Naturally-Occurring, Orally Administered, Aromatase Inhibitor in Healthy Men. Ohio Research Group of Exercise Science and Sports Nutrition. Wadsworth, Ohio 44281, USA. tim@ohioresearchgroup.com This email address is being protected from spam bots, you need Javascript enabled to view it

Rationale: In healthy men, it is known that blocking estrogen formation stimulates the HPT axis to increase in vivo testosterone production. Recently, a new class of dietary supplements has appeared that claim to inhibit the aromatase enzyme (i.e., decrease the transformation of aromatizable androgens [androstenedione, DHEA, testosterone] into estrogens [estriol, estrone, estradiol]), thus stimulating an increase in testosterone formation.

Purpose: The purpose of this pilot study was to examine the effects of a popular aromatase inhibitor, Novedex XT (NOV-XT), on selected hormonal responses (total testosterone [TT], bioavailable testosterone [BT] and estradiol [E2]), as well as serum and plasma markers of renal, hepatic, and hematological function.

Methods: Using an open-label, proof-of-concept design, five eugonadal men (mean ¦ SD age, height, weight, body fat: 31.6 ¦ 2.8 yr, 174.3 ¦ 1.8 cm, 84.3 ¦ 3.8 kg, 11.2 ¦ 3.3 %) ingested 4 capsules of NOV-XT prior to bed for 28 consecutive days. According to the manufacturer, each capsule of NOV-XT contains 60 mg of a proprietary blend of three naturally-occurring aromatase inhibitors: 6, 17-keto-etiocholeve-3-ol tetrahydropyranol, 3, 17-keto-etiochol-triene, and 3',5,7-trihydroxy-4'-methoxyflavone (supplements were provided by an FDA-registered, pharmaceutically licensed manufacturer; confirmation by an external laboratory is pending). Blood samples obtained at baseline (prior to supplementation), and at weekly intervals thereafter for 28 days, were analyzed for TT, BT, and E2 by radioimmunometric and chemilluminetric assays. Subjects were required to maintain their normal dietary and training patterns during the study. All blood samples were obtained at the same time of day (0700-0900) to minimize diurnal variation. Hormone concentrations were statistically analyzed by ANOVA and Tukey's HSD post-hoc test. Dependent t-tests were used to compare changes in blood chemistries. Statistical significance was accepted at p<0.05.

Results: Compared to baseline, NOV-XT administration rapidly and significantly increased TT and BT. Mean changes from baseline for TT after one, two, three, and four weeks of NOV-XT administration were: +145% (p<0.006), +183% (p<0.0005), +232% (p<0.0002), and +240% (p<0.0002), respectively. Mean changes from baseline for BT after one, two, three, and four weeks of NOV-XT administration were: +300% (p<0.01), +402% (p<0.0009), +511% (p<0.0002), and +528% (p<0.0002), respectively. Despite these large increases in TT and BT, no significant aromatization to estradiol occurred (i.e., E2 concentrations remained unchanged). No significant changes in clinical blood chemistries (fasting glucose, BUN, creatinine, bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, sodium, potassium, chloride, calcium, albumin, globulin, CO2, total protein, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol) or systemic hemodynamics (heart rate, systolic blood pressure, diastolic blood pressure) were observed, nor were any adverse events noted during the study.

Data are reported as mean (¦ SD). * indicates significantly different from corresponding baseline value. Bio T = bioavailable (free+weekly bound) testosterone, BUN:Cr = blood urea nitrogen:creatinine ratio, ALP = alkaline phosphatase, AST = aspartate aminotransferase, ALT = alanine aminotransferase, Chol = total cholesterol, TAG = triglycerides, HDL = high density lipoprotein, LDL = low density lipoprotein, SBP = systolic blood pressure, DBP = diastolic blood pressure.

Conclusions: Within the framework of the current experimental design, these preliminary data indicate that four weeks of NOV-XT supplementation significantly elevates serum TT and BT, likely via the inhibition of estradiol formation. Further, NOV-XT does not appear to result in any deleterious effects on blood chemistry or systemic hemodynamics in healthy, eugonadal men. Future research is necessary to confirm and refine these results in a larger sample size, as well as examine the impact of NOV-XT on androgenic and estrogenic metabolites, body composition, and muscular performance. Supported in part by a research grant from Gaspari Nutrition (Neptune, NJ).

BAYLOR UNIVERSITY STUDY

Willoughby D. S., & Wilborn C. Eight weeks of
aromatase inhibition using the nutritional supplement Novedex XT: Effects on serum steroid hormones, body composition, and clinical safety markers in young, eugonadal males. International Journal of Sports Nutrition and Exercise Metabolism.
Manuscript Accepted for February 2007 Publication.

In yet another (the 3rd) independent clinical research study, Novedex XT shows why it is rightfully known as the #1 Testosterone Modulating Supplement of All Time and why it is the #1 Selling Testosterone Modulating Supplement... EVER! No other "supposed testosterone modulating" supplement has even one, never mind THREE (3) independent clinical research studies conducted on it to demonstrate that it works and is safe like Novedex XT does. If the other guy's supplements do not have any studies to show their product works, how do they know it works? More importantly, how do YOU know it works? Who wants to spend hard earned money for a "maybe?" In this landmark 11 week independent clinical trial conducted by Dr. Darryn Willoughy at Baylor University, Novedex XT did not cause any significant changes in any Serum Clinical Chemistry Markers (including liver studies and cholesterol/HDL/LDL) or Urine Clinical Safety Markers or even in PSA - a significant clinical marker for prostate health! But Novedex XT did cause an average of 600%+ increase in free testosterone! This change is so dramatic that if you are a "tested athlete" we strongly suggest that you discuss use of Novedex XT with your sanctioning body before using it. With results this powerful, you might be wrongfully accused of "cheating." Even more importantly, all of the clinical parameters checked, including LH/FSH and GH, everything returned back to baseline (normal) levels within 21 days of discontinuation of Novedex XT showing that even using Novedex XT for 60 days straight does not "shut you down" when you come off of it.

Figure Legends

Figure 1. Serum total testosterone levels over the course of the 11 weeks.  A group x time interaction was observed
(p = 0.001). * denotes a significant increase for the
Novedex group compared to placebo at the 4- and 8-week sampling period.

Figure 2. Serum free testosterone levels over the course of the 11 weeks.  A group x time interaction was observed
(p = 0.001). * denotes a significant increase for the
Novedex group compared to placebo at the 4- and 8-week sampling period.

Figure 3. Serum free testosterone/estradiol ratio (T/E) levels over the course of the 11 weeks.  A group x time interaction was observed (p = 0.002). * denotes a significant increase for the Novedex group compared to placebo at the 4- and 8-week sampling period.

Table 1. Four-Day Dietary Analyses for the Placebo and Novedex Groups During Weeks 0, 8, and 11.

Data are means and ¦ standard deviations. No significant differences were observed between groups throughout the 11-week study for total calories or macronutrient intakes (p > 0.05).

Table 2. Serum Hormones Values for the Placebo and Novedex Groups at Weeks 0, 4, 8, and 11.

Data are means ¦ standard deviations. No significant differences were observed between groups throughout the 11-week study for and of the hormones variables included above (p > 0.05).

Table 3. Body Composition Values for Total Body Mass, Total Body Water, Percent Fat, and Fat-Free Mass for the Placebo and Novedex Groups at Weeks 0, 4, 8, and 11.

Data are means ¦ standard deviations. No significant differences were observed between groups throughout the 11-week study for total body mass, total body water, or fat-free mass (p > 0.05).